The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Peter M Dunn - One of the best experts on this subject based on the ideXlab platform.
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Perinatal lessons from the past: Sir Norman Gregg, ChM, MC, of Sydney (1892-1966) and Rubella embryopathy.
Archives of Disease in Childhood-fetal and Neonatal Edition, 2007Co-Authors: Peter M DunnAbstract:By identifying Rubella infection in early pregnancy as a cause of congenital malformations and disabilities, Gregg alerted the medical profession to the importance of the prenatal environment.
G Mansi - One of the best experts on this subject based on the ideXlab platform.
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Rubella embryopathy after maternal reinfection
Neonatology, 1994Co-Authors: R Paludetto, J Van Den Heuvel, A Stagni, L Grappone, G MansiAbstract:Reinfection with Rubella is possible. The real risk for fetus and newborn is not known, as are the incidences of Rubella reinfection during pregnancy and congenital Rubella infection after maternal re
Eduardo E Castilla - One of the best experts on this subject based on the ideXlab platform.
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sentinel phenotype for Rubella embryopathy time space distribution in brazil
Cadernos De Saude Publica, 2011Co-Authors: Ieda M Orioli, Jorge Santiago Lopez Camelo, Monica Rittler, Eduardo E CastillaAbstract:The dyad comprising eye anomalies and congenital heart defects in the same newborn has been proposed as the best sentinel phenotype for the early detection of Rubella embryopathy. Time-space birth prevalence distributions of the eye-heart dyad were described in 36 Brazilian hospitals from the Latin-American Collaborative Study of Congenital Anomalies - ECLAMC network, for the period 1994-2008. Seventy dyad cases observed among 554,531 births showed seasonal variation (Χ2 = 5.84; p < 0.05), suggesting an environmental etiology, with an increase in cases in October-March and acrophase in December. The secular distribution of dyad prevalence rates was consistent with the distribution of Rubella cases in Brazil, showing a decrease from 1994 to 2004, followed by an increase until 2008. Two geographic clusters were identified, one with high and the other with low dyad prevalence. In the high prevalence cluster, a secular increase was observed, starting in 1999, matching the Rubella epidemic waves observed in Brazil in 1998-2000 and 2006.
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monitoring congenital Rubella embryopathy
Birth Defects Research Part A-clinical and Molecular Teratology, 2004Co-Authors: Monica Rittler, Jorge S Lopezcamelo, Eduardo E CastillaAbstract:BACKGROUND Currently, all developed countries include Rubella vaccination in their immunization programs, targeting the complete elimination of congenital Rubella syndrome (CRS). In the underdeveloped world, where this severely disabling condition still exists, only a few countries have implemented vaccination policies, and almost no data on their effectiveness or on prevalence rates are available. The aims of the present work were to search for the best phenotype to be used as a sentinel for CRS in a large series of malformed newborns and to propose a CRS surveillance system, based only on clinical data. METHODS A total of 43 infants diagnosed as having CRS were obtained from 19,184 multimalformed infants, ascertained by the Latin-American Collaborative Study of Congenital Malformations, World Health Organization (WHO) Collaborating Centre for the Prevention of Birth Defects (ECLAMC), over 3,883,165 consecutive births, between 1982 and 2003. They were distributed by country and the most frequent birth defects were identified. From the 19,184 multimalformed infants, all cases presenting the birth defects identified were selected. The sensitivity, specificity, and likelihood ratio (LR) in detecting CRS were determined for these birth defects, alone and in combination. The sample size of multimalformed infants required to detect different levels of increase in the rate of CRS was determined for three sentinel phenotypes. RESULTS The rate of CRS was highest in Brazil. Based on the best possible combination of sensitivity, specificity, and LR, the dyad comprising eye anomalies and congenital heart defects was shown to be the most appropriate sentinel, with the lowest sample size required, to detect CRS in neonates. CONCLUSIONS A surveillance system for CRS, based on clinical data in newborns, is being proposed, in an attempt to monitor ongoing vaccination policies, aimed at eliminating CRS in developing countries. Birth Defects Research (Part A), 2004. © 2004 Wiley-Liss, Inc.
R Paludetto - One of the best experts on this subject based on the ideXlab platform.
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Rubella embryopathy after maternal reinfection
Neonatology, 1994Co-Authors: R Paludetto, J Van Den Heuvel, A Stagni, L Grappone, G MansiAbstract:Reinfection with Rubella is possible. The real risk for fetus and newborn is not known, as are the incidences of Rubella reinfection during pregnancy and congenital Rubella infection after maternal re
Monica Rittler - One of the best experts on this subject based on the ideXlab platform.
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sentinel phenotype for Rubella embryopathy time space distribution in brazil
Cadernos De Saude Publica, 2011Co-Authors: Ieda M Orioli, Jorge Santiago Lopez Camelo, Monica Rittler, Eduardo E CastillaAbstract:The dyad comprising eye anomalies and congenital heart defects in the same newborn has been proposed as the best sentinel phenotype for the early detection of Rubella embryopathy. Time-space birth prevalence distributions of the eye-heart dyad were described in 36 Brazilian hospitals from the Latin-American Collaborative Study of Congenital Anomalies - ECLAMC network, for the period 1994-2008. Seventy dyad cases observed among 554,531 births showed seasonal variation (Χ2 = 5.84; p < 0.05), suggesting an environmental etiology, with an increase in cases in October-March and acrophase in December. The secular distribution of dyad prevalence rates was consistent with the distribution of Rubella cases in Brazil, showing a decrease from 1994 to 2004, followed by an increase until 2008. Two geographic clusters were identified, one with high and the other with low dyad prevalence. In the high prevalence cluster, a secular increase was observed, starting in 1999, matching the Rubella epidemic waves observed in Brazil in 1998-2000 and 2006.
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monitoring congenital Rubella embryopathy
Birth Defects Research Part A-clinical and Molecular Teratology, 2004Co-Authors: Monica Rittler, Jorge S Lopezcamelo, Eduardo E CastillaAbstract:BACKGROUND Currently, all developed countries include Rubella vaccination in their immunization programs, targeting the complete elimination of congenital Rubella syndrome (CRS). In the underdeveloped world, where this severely disabling condition still exists, only a few countries have implemented vaccination policies, and almost no data on their effectiveness or on prevalence rates are available. The aims of the present work were to search for the best phenotype to be used as a sentinel for CRS in a large series of malformed newborns and to propose a CRS surveillance system, based only on clinical data. METHODS A total of 43 infants diagnosed as having CRS were obtained from 19,184 multimalformed infants, ascertained by the Latin-American Collaborative Study of Congenital Malformations, World Health Organization (WHO) Collaborating Centre for the Prevention of Birth Defects (ECLAMC), over 3,883,165 consecutive births, between 1982 and 2003. They were distributed by country and the most frequent birth defects were identified. From the 19,184 multimalformed infants, all cases presenting the birth defects identified were selected. The sensitivity, specificity, and likelihood ratio (LR) in detecting CRS were determined for these birth defects, alone and in combination. The sample size of multimalformed infants required to detect different levels of increase in the rate of CRS was determined for three sentinel phenotypes. RESULTS The rate of CRS was highest in Brazil. Based on the best possible combination of sensitivity, specificity, and LR, the dyad comprising eye anomalies and congenital heart defects was shown to be the most appropriate sentinel, with the lowest sample size required, to detect CRS in neonates. CONCLUSIONS A surveillance system for CRS, based on clinical data in newborns, is being proposed, in an attempt to monitor ongoing vaccination policies, aimed at eliminating CRS in developing countries. Birth Defects Research (Part A), 2004. © 2004 Wiley-Liss, Inc.
