The Experts below are selected from a list of 79584 Experts worldwide ranked by ideXlab platform
Philippe Menasche - One of the best experts on this subject based on the ideXlab platform.
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stem cell therapy for heart failure are arrhythmias a real Safety Concern
Circulation, 2009Co-Authors: Philippe MenascheAbstract:So far, the major Safety issue raised by the use of stem cells for cardiac repair has been the occurrence of ventricular arrhythmias, particularly after skeletal myoblast transplantation. Although one cannot refute a potential intrinsic arrhythmogenicity of stem cells, primarily related to their common lack of electromechanical integration into the recipient myocardium, it is also important to recognize that patients eligible for cell replacement therapy are prone to develop arrhythmias because of their underlying ischemic heart disease. Another confounding factor is the method used for the intramyocardial delivery of the cells, which can cause enough inflammatory tissue damage to further increase ventricular irritability on top of an already high baseline level. Thus any strategy designed to minimize the risk of stem cell-associated ventricular arrhythmias should take into account, besides the cell-specific ability to appropriately couple with host cardiomyocytes, the method of cell transfer and the nature of the myocardial environment targeted for cell engraftment. A more accurate characterization of the baseline risk of arrhythmias in these patients would thus be helpful for better assessing the respective contribution of the donor cells and the host myocardium to these complications. The risk-to-benefit ratio of stem cell therapy will finally have to be revisited in light of the fact that because this baseline risk is usually high, most of these patients will in any way be fitted with an implantable defibrillator.
Yanjie Hu - One of the best experts on this subject based on the ideXlab platform.
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Variance Analysis of Factors That Affected Traffic Safety in Highway Work Zones
ICTIS 2011, 2011Co-Authors: Yanyan Zhang, Hong Wang, Yanjie HuAbstract:Highway work zones result in descent of road capacity and traffic-jam for part of lanes closed, and all of that would create Safety Concern. On the basis of crashes data which classified by different factors in Virginia highway work zones, the data that work zone crash levels and entire highway crash levels are analyzed with One-way analysis of variance (ANOVA) in SPSS. The data analysis in this study involved two major steps. First, identify the prominent variable that followed too closely and other 7 significant variables. Then, the 7 significant variables, corresponding entire highway crash levels and the prominent variant form 7 triple tables. One-way ANOVA is used to identify the secondary prominent factors such as lane change, speed too fast and inattentive drive. At last, investigate all the prominent variables using Grey Relational Analysis (GRA), and distinguish the relationship between different crashes type and drive behavior. The result of this study will provide theoretical basis for work zone Safety guarantee technology. Owing to long-term operation or natural disaster, highway system will appear different degree of functions reduced and facility impaired. Numbers of work zones appeared to guarantee road normal operation. The major effect of work zones is descent road capacity for lane closure, which results in traffic-jam and delay and creating Safety Concern. In America, more than 700 fatal crashes happened, about 24000 injury crashes and 52000 property damages only due to crashes.
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The Variance Analysis of Factors Affected Traffic Safety in Highway Work Zones
2011Co-Authors: Yanyan Zhang, Hong Wang, Yanjie HuAbstract:Highway work zones result in descent of road capacity and traffic-jam for part of lanes closed, and all of that would create Safety Concern. On the basis of crashes data which classified by different factors in Virginia highway work zones, the data that work zone crash levels and entire highway crash levels are analyzed with One-way analysis of variance (ANOVA) in SPSS. The data analysis in this study involved two major steps. First, identify the prominent variable that followed too closely and other 7 significant variables. Then, the 7 significant variables, corresponding entire highway crash levels and the prominent variant form 7 triple tables. One-way ANOVA is used to identify the secondary prominent factors such as lane change, speed too fast and inattentive drive. At last, investigate all the prominent variables using Grey Relational Analysis (GRA), and distinguish the relationship between different crashes type and drive behavior. The result of this study will provide theoretical basis for work zone Safety guarantee technology. Owing to long-term operation or natural disaster, highway system will appear different degree of functions reduced and facility impaired. Numbers of work zones appeared to guarantee road normal operation. The major effect of work zones is descent road capacity for lane closure, which results in traffic-jam and delay and creating Safety Concern. In America, more than 700 fatal crashes happened, about 24000 injury crashes and 52000 property damages only due to crashes.
Jian Yang - One of the best experts on this subject based on the ideXlab platform.
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uv inactivation and characteristics after photoreactivation of escherichia coli with plasmid health Safety Concern about uv disinfection
Water Research, 2012Co-Authors: Meiting Guo, Jingjing Huang, Wenjun Liu, Jian YangAbstract:Abstract Occurrence and degree of photoreactivation after ultraviolet (UV) exposure have been widely studied. However, the characteristics of photoreactivated microorganisms were rarely investigated. Hence, in this study, Escherichia coli with plasmids of ampicillin (amp)-resistance or fluorescence was used as indicators to examine the UV inactivation efficiencies and variations of characteristics of E. coli after subsequent photoreactivation. The experimental results indicate that the amp-resistant bacteria and the fluorescent bacteria used in this study had similar trends of UV dose–response curves. 3.5-log10 and 3-log10 reductions were achieved with a UV dose of 5 mJ/cm2 for the amp-resistant and fluorescent E. coli, respectively. There was no significant difference in the UV inactivation behavior, as compared with common strains of E. coli. For the amp-resistant E. coli and the fluorescent E. coli, after exposures with UV doses of 5, 15, 25, 40 and 80 mJ/cm2, the corresponding percent photoreactivations after a 4 h exposure to photoreactivating light were 1% and 46% respectively for a UV dose of 5 mJ/cm2, and essentially negligible for all other UV doses. Furthermore, the photoreactivated amp-resistant bacteria still have the ability of amp-resistance. And the revived fluorescent E. coli showed similar fluorescent behavior, compared with the untreated bacteria. The experimental results imply that after UV inactivation and subsequent photoreactivation, the bacteria retained the initial characteristics coded in the plasmid. This reveals a possibility that some characteristics of bacteria can retain or recover through photoreactivation, and a Safety Concern about pathogenicity revival might need to be considered with UV disinfection and photoreactivation.
P Perrot - One of the best experts on this subject based on the ideXlab platform.
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Safety Concern between autologous fat graft mesenchymal stem cell and osteosarcoma recurrence
PLOS ONE, 2010Co-Authors: P Perrot, Julie Rousseau, Annelaure Bouffaut, Francoise Redini, Elisabeth Cassagnau, Frederic DeschaseauxAbstract:Background Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect consecutive to surgery and/or tumor treatment, autologous fat graft has been proposed in plastic and reconstructive surgery.
Yanyan Zhang - One of the best experts on this subject based on the ideXlab platform.
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Variance Analysis of Factors That Affected Traffic Safety in Highway Work Zones
ICTIS 2011, 2011Co-Authors: Yanyan Zhang, Hong Wang, Yanjie HuAbstract:Highway work zones result in descent of road capacity and traffic-jam for part of lanes closed, and all of that would create Safety Concern. On the basis of crashes data which classified by different factors in Virginia highway work zones, the data that work zone crash levels and entire highway crash levels are analyzed with One-way analysis of variance (ANOVA) in SPSS. The data analysis in this study involved two major steps. First, identify the prominent variable that followed too closely and other 7 significant variables. Then, the 7 significant variables, corresponding entire highway crash levels and the prominent variant form 7 triple tables. One-way ANOVA is used to identify the secondary prominent factors such as lane change, speed too fast and inattentive drive. At last, investigate all the prominent variables using Grey Relational Analysis (GRA), and distinguish the relationship between different crashes type and drive behavior. The result of this study will provide theoretical basis for work zone Safety guarantee technology. Owing to long-term operation or natural disaster, highway system will appear different degree of functions reduced and facility impaired. Numbers of work zones appeared to guarantee road normal operation. The major effect of work zones is descent road capacity for lane closure, which results in traffic-jam and delay and creating Safety Concern. In America, more than 700 fatal crashes happened, about 24000 injury crashes and 52000 property damages only due to crashes.
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The Variance Analysis of Factors Affected Traffic Safety in Highway Work Zones
2011Co-Authors: Yanyan Zhang, Hong Wang, Yanjie HuAbstract:Highway work zones result in descent of road capacity and traffic-jam for part of lanes closed, and all of that would create Safety Concern. On the basis of crashes data which classified by different factors in Virginia highway work zones, the data that work zone crash levels and entire highway crash levels are analyzed with One-way analysis of variance (ANOVA) in SPSS. The data analysis in this study involved two major steps. First, identify the prominent variable that followed too closely and other 7 significant variables. Then, the 7 significant variables, corresponding entire highway crash levels and the prominent variant form 7 triple tables. One-way ANOVA is used to identify the secondary prominent factors such as lane change, speed too fast and inattentive drive. At last, investigate all the prominent variables using Grey Relational Analysis (GRA), and distinguish the relationship between different crashes type and drive behavior. The result of this study will provide theoretical basis for work zone Safety guarantee technology. Owing to long-term operation or natural disaster, highway system will appear different degree of functions reduced and facility impaired. Numbers of work zones appeared to guarantee road normal operation. The major effect of work zones is descent road capacity for lane closure, which results in traffic-jam and delay and creating Safety Concern. In America, more than 700 fatal crashes happened, about 24000 injury crashes and 52000 property damages only due to crashes.
