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Stephen J Bartels - One of the best experts on this subject based on the ideXlab platform.
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sarcopenia Sarcopenic Obesity and inflammation results from the 1999 2004 national health and nutrition examination survey
Clinical Nutrition, 2016Co-Authors: John A. Batsis, Francisco Lopezjimenez, Todd A Mackenzie, Jonathan D Jones, Stephen J BartelsAbstract:Summary Background The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals at risk for functional impairment. Recognizing possible underlying mechanisms between adipose tissue and muscle, we sought to apply the recent definitions and determine the relationship with markers of glucose homeostasis and inflammation in individuals with sarcopenia and Sarcopenic Obesity. Methods The National Health and Nutrition Examination Surveys 1999–2004 were used to identify 4984 adults aged ≥60 years with DEXA measures. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity was defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). We assessed the association between ALM and ALM:BMI with inflammatory and markers of glucose homeostasis, both as continuous variables but also classifying as having Sarcopenic Obesity or not after adjusting for confounding variables including pro-inflammatory chronic diseases such as diabetes and cancer. Results Mean age was 71.1 years (56.5%) females. Prevalence of sarcopenia and Sarcopenic Obesity were (ALM definition: 29.9 and 24.4%; ALM:BMI definition: 23.0 and 22.7%). There were significant associations with ALM and ln C-reactive protein (β = 0.0287; p = 0.001), fibrinogen (β = 0.519; p Conclusions Biologically plausible associations exist between ALM:BMI and inflammation and HOMA-IR that were not observed when using ALM alone. Future study should validate each of these definitions to prevent disparate results from being determined.
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sarcopenia Sarcopenic Obesity and functional impairments in older adults national health and nutrition examination surveys 1999 2004
Nutrition Research, 2015Co-Authors: John A. Batsis, Francisco Lopezjimenez, Stephen J Bartels, Todd A MackenzieAbstract:Abstract The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals with functional impairment. We hypothesized that the prevalence of sarcopenia and Sarcopenic Obesity would be similar based on the different Foundation for the National Institutes of Health criteria, increase with age, and be associated with risk of impairment limitations. We identified 4984 subjects at least 60 years of age from the National Health and Nutrition Examination Surveys 1999-2004. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity is defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). Prevalence rates of both sarcopenia and Sarcopenic Obesity were evaluated with respect to sex, age category (60-69, 70-79, and >80 years) and race. We assessed the association of physical limitations, basic and instrumental activities of daily living and sarcopenia status. The mean age was 70.5 years in men and 71.6 years in women. Half (50.8%; n=2531) were female, and mean BMI was 28 kg/m 2 in both sexes. Appendicular lean mass was higher in men than in women (24.1 vs 16.3; P P
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sarcopenia Sarcopenic Obesity and mortality in older adults results from the national health and nutrition examination survey iii
European Journal of Clinical Nutrition, 2014Co-Authors: John A. Batsis, Todd Mackenzie, Laura K Barre, Francisco Lopezjimenez, Stephen J BartelsAbstract:Sarcopenia, Sarcopenic Obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III
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variation in the prevalence of sarcopenia and Sarcopenic Obesity in older adults associated with different research definitions dual energy x ray absorptiometry data from the national health and nutrition examination survey 1999 2004
Journal of the American Geriatrics Society, 2013Co-Authors: John A. Batsis, Laura K Barre, Francisco Lopezjimenez, Todd A Mackenzie, Sarah I Pratt, Stephen J BartelsAbstract:Objectives To determine the prevalence range for Sarcopenic Obesity and its relationship with sex, age, and ethnicity. Design Cross-sectional analysis of a population-based sample. Setting Noninstitutionalized persons in the United States participating in the National Health and Nutrition Examination Surveys 1999–2004. Participants Subsample of 4,984 subjects aged 60 and older with dual-energy X-ray absorptiometry body composition data. Measurements Eight definitions of Sarcopenic Obesity identified from six studies found using a systematic literature review (Baumgartner, Bouchard, Davison, Zoico, Levine, Kim-1,2,3) were applied to the sample. Results were stratified according to sex, age, and ethnicity. Results Prevalence of Sarcopenic Obesity ranged from 4.4% to 84.0% in men and from 3.6% to 94.0% in women. Prevalence was higher in men using definitions from Baumgartner (17.9% vs 13.3%, P < .001), Levine (14.2% vs 6.6%, P < .001), and Kim-1 (30.0% vs 9.3%, P < .001); lower for men using the Davison (4.4% vs 11.1%, P < .001) and Kim-2 (83.7% vs 94.0%) definitions; and the same for men and women using the Bouchard (45.3% vs 44.3%, P = .32) and Kim-3 (75.6% vs 77.0%, P = .51) definitions. For all but one definition, Sarcopenic Obesity increased with each decade and was lower in non-Hispanic blacks than whites. Conclusion Prevalence of Sarcopenic Obesity in older adults varies up to 26-fold depending on current research definitions. Such a high degree of variability suggests the need to establish consensus criteria that can be reliably applied across clinical and research settings.
John A. Batsis - One of the best experts on this subject based on the ideXlab platform.
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Sarcopenic Obesity in older adults aetiology epidemiology and treatment strategies
Nature Reviews Endocrinology, 2018Co-Authors: John A. Batsis, Dennis T VillarealAbstract:The prevalence of Obesity in combination with sarcopenia (the age-related loss of muscle mass and strength or physical function) is increasing in adults aged 65 years and older. A major subset of adults over the age of 65 is now classified as having Sarcopenic Obesity, a high-risk geriatric syndrome predominantly observed in an ageing population that is at risk of synergistic complications from both sarcopenia and Obesity. This Review discusses pathways and mechanisms leading to muscle impairment in older adults with Obesity. We explore sex-specific hormonal changes, inflammatory pathways and myocellular mechanisms leading to the development of Sarcopenic Obesity. We discuss the evolution, controversies and challenges in defining Sarcopenic Obesity and present current body composition modalities used to assess this condition. Epidemiological surveys form the basis of defining its prevalence and consequences beyond comorbidity and mortality. Current treatment strategies, and the evidence supporting them, are outlined, with a focus on calorie restriction, protein supplementation and aerobic and resistance exercises. We also describe weight loss-induced complications in patients with Sarcopenic Obesity that are relevant to clinical management. Finally, we review novel and potential future therapies including testosterone, selective androgen receptor modulators, myostatin inhibitors, ghrelin analogues, vitamin K and mesenchymal stem cell therapy.
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sarcopenia Sarcopenic Obesity and inflammation results from the 1999 2004 national health and nutrition examination survey
Clinical Nutrition, 2016Co-Authors: John A. Batsis, Francisco Lopezjimenez, Todd A Mackenzie, Jonathan D Jones, Stephen J BartelsAbstract:Summary Background The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals at risk for functional impairment. Recognizing possible underlying mechanisms between adipose tissue and muscle, we sought to apply the recent definitions and determine the relationship with markers of glucose homeostasis and inflammation in individuals with sarcopenia and Sarcopenic Obesity. Methods The National Health and Nutrition Examination Surveys 1999–2004 were used to identify 4984 adults aged ≥60 years with DEXA measures. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity was defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). We assessed the association between ALM and ALM:BMI with inflammatory and markers of glucose homeostasis, both as continuous variables but also classifying as having Sarcopenic Obesity or not after adjusting for confounding variables including pro-inflammatory chronic diseases such as diabetes and cancer. Results Mean age was 71.1 years (56.5%) females. Prevalence of sarcopenia and Sarcopenic Obesity were (ALM definition: 29.9 and 24.4%; ALM:BMI definition: 23.0 and 22.7%). There were significant associations with ALM and ln C-reactive protein (β = 0.0287; p = 0.001), fibrinogen (β = 0.519; p Conclusions Biologically plausible associations exist between ALM:BMI and inflammation and HOMA-IR that were not observed when using ALM alone. Future study should validate each of these definitions to prevent disparate results from being determined.
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sarcopenia and Sarcopenic Obesity do they predict inferior oncologic outcomes after gastrointestinal cancer surgery
Perioperative medicine (London England), 2016Co-Authors: Kimberly L Mei, John A. Batsis, Jeannine B Mills, Stefan D HolubarAbstract:Sarcopenia, or loss of skeletal muscle mass and quality, has been studied as part of aging and adverse health outcomes in elderly patients but has only recently been evaluated as a separate condition in cancer patients and important indicator of adverse outcomes. Currently, its definition and method of assessment are still being debated. Sarcopenia within an increasingly obese population has led to a subgroup with Sarcopenic Obesity, at even higher risk of adverse outcomes. Yet, sarcopenia often goes undiagnosed in these patients, hidden beneath higher body mass index. Identifying Sarcopenic and Sarcopenic obese subpopulations would allow for more effective treatment plans and potential avoidance of suboptimal outcomes, as well as the chance to intervene and combat these modifiable risk factors. This review will examine available literature on the definition and methods of evaluating sarcopenia and Sarcopenic Obesity, summarize the effectiveness of sarcopenia and Sarcopenic Obesity as predictors of outcomes after gastrointestinal cancer surgery, including colorectal cancer resection, liver resection, and pancreatic resection, and outline strategies to minimize the impact of sarcopenia. It is clear that untreated sarcopenia and Sarcopenic Obesity can be associated with suboptimal post-operative outcomes, especially infections and disease-free or overall survival.
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sarcopenia Sarcopenic Obesity and functional impairments in older adults national health and nutrition examination surveys 1999 2004
Nutrition Research, 2015Co-Authors: John A. Batsis, Francisco Lopezjimenez, Stephen J Bartels, Todd A MackenzieAbstract:Abstract The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals with functional impairment. We hypothesized that the prevalence of sarcopenia and Sarcopenic Obesity would be similar based on the different Foundation for the National Institutes of Health criteria, increase with age, and be associated with risk of impairment limitations. We identified 4984 subjects at least 60 years of age from the National Health and Nutrition Examination Surveys 1999-2004. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity is defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). Prevalence rates of both sarcopenia and Sarcopenic Obesity were evaluated with respect to sex, age category (60-69, 70-79, and >80 years) and race. We assessed the association of physical limitations, basic and instrumental activities of daily living and sarcopenia status. The mean age was 70.5 years in men and 71.6 years in women. Half (50.8%; n=2531) were female, and mean BMI was 28 kg/m 2 in both sexes. Appendicular lean mass was higher in men than in women (24.1 vs 16.3; P P
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sarcopenia Sarcopenic Obesity and mortality in older adults results from the national health and nutrition examination survey iii
European Journal of Clinical Nutrition, 2014Co-Authors: John A. Batsis, Todd Mackenzie, Laura K Barre, Francisco Lopezjimenez, Stephen J BartelsAbstract:Sarcopenia, Sarcopenic Obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III
David Scott - One of the best experts on this subject based on the ideXlab platform.
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falls fractures and areal bone mineral density in older adults with Sarcopenic Obesity a systematic review and meta analysis
Obesity Reviews, 2021Co-Authors: Anoohya Gandham, David Scott, Jakub Mesinovic, Peter R Ebeling, Paul Jansons, Ayse Zengin, Maxine P BonhamAbstract:Sarcopenia and Obesity are common conditions in older adults that may have differing effects on falls and fracture risk. This systematic review and meta-analysis aimed to determine whether older adults with Sarcopenic Obesity have increased risk of falls and fractures or lower bone mass compared with older adults with sarcopenia, Obesity, or neither condition. Twenty-six studies (n = 37,124) were included in the systematic review and 17 (n = 31,540) were included in the meta-analysis. Older adults with Sarcopenic Obesity had lower femoral neck areal bone mineral density (aBMD) compared with those with Obesity alone but had higher femoral neck aBMD compared with counterparts with sarcopenia alone (both P < 0.05). Older adults with Sarcopenic Obesity had higher nonvertebral fracture rates (incidence rate ratio: 1.88; 95% confidence intervals: 1.09, 3.23; based on two studies), compared with those with sarcopenia alone, and also had higher falls risk compared with controls (risk ratio: 1.30; 95% confidence intervals: 1.10, 1.54) and Obesity alone (risk ratio: 1.17; 95% confidence intervals: 1.01, 1.36). In conclusion, this systematic review and meta-analysis has demonstrated that older adults with Sarcopenic Obesity are at increased risk of adverse musculoskeletal outcomes compared with individuals with Obesity, sarcopenia, or neither condition. These data support the need for developing interventions to improve bone health and physical function in this population.
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associations of Sarcopenic Obesity with the metabolic syndrome and insulin resistance over five years in older men the concord health and ageing in men project
Experimental Gerontology, 2018Co-Authors: David Scott, Robert G Cumming, Vasi Naganathan, Fiona M Blyth, David Le G Couteur, David J Handelsman, Markus J Seibel, Louise M Waite, Vasant HiraniAbstract:Abstract Purpose Previous cross-sectional studies investigating associations of Sarcopenic Obesity with metabolic syndrome (MetS) and insulin resistance have not utilised consensus definitions of sarcopenia. We aimed to determine associations of Sarcopenic Obesity with MetS and insulin resistance over five years in community-dwelling older men. Methods 1231 men aged ≥70 years had appendicular lean mass (ALM) and body fat percentage assessed by dual-energy X-ray absorptiometry and hand grip strength and gait speed tests. Sarcopenia was defined as low ALM/height (m2) and low hand grip strength or gait speed (European Working Group definition); Obesity was defined as body fat percentage ≥30%. MetS was assessed at baseline and 5-years later. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was assessed at 5-years only. Results Men with Sarcopenic Obesity (odds ratio, 95% CI: 2.07, 1.21–3.55) and non-Sarcopenic Obesity (4.19, 3.16–5.57) had higher MetS likelihood than those with non-Sarcopenic non-Obesity at baseline. Higher gait speed predicted lower odds for prevalent MetS (0.45, 0.21–0.96 per m/s). Higher body fat predicted increased odds for prevalent and incident MetS (1.14, 1.11–1.17 and 1.11, 1.02–1.20 per kg, respectively) and deleterious 5-year changes in MetS fasting glucose, high-density lipoprotein cholesterol and triglycerides (all P Conclusions Sarcopenic Obesity does not appear to confer greater risk for incident MetS or insulin resistance than Obesity alone in community-dwelling older men.
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associations of components of Sarcopenic Obesity with bone health and balance in older adults
Archives of Gerontology and Geriatrics, 2018Co-Authors: David Scott, Catherine Shorelorenti, Lachlan Mcmillan, Jakub Mesinovic, Ross A Clark, Alan Hayes, Kerrie M Sanders, Gustavo Duque, Peter R EbelingAbstract:Abstract Objectives To determine characteristics of Sarcopenic Obesity that are independently associated with bone health and balance in older adults. Study design Cross-sectional study of 168 community-dwelling older adults (mean age 67.7 ± 8.4 years; 55% women). Main outcome measures Appendicular lean mass (ALM), whole-body areal BMD (aBMD) and body fat percentage were assessed by dual-energy X-ray absorptiometry. Peripheral quantitative computed tomography assessed muscle density and cortical volumetric BMD (vBMD), area, thickness, and strength-strain index (SSI) at 66% tibial length. Hand grip strength (dynamometry) and balance path length (computerised posturography) were assessed. Obesity was defined as high body fat percentage. Results Greater lower-leg muscle density was associated with lower balance path length in men (r = −0.36; P Conclusions Amongst components of Sarcopenic Obesity, higher ALM is a consistent independent predictor of better bone health. Low muscle density may also compromise bone health and balance. Interventions which improve muscle mass and composition may lower fracture risk in Sarcopenic Obesity.
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Sarcopenic Obesity and its temporal associations with changes in bone mineral density incident falls and fractures in older men the concord health and ageing in men project
Journal of Bone and Mineral Research, 2017Co-Authors: David Scott, Robert G Cumming, Vasi Naganathan, Fiona M Blyth, David Le G Couteur, David J Handelsman, Markus J Seibel, Louise M Waite, Vasant HiraniAbstract:Body composition and muscle function have important implications for falls and fractures in older adults. We aimed to investigate longitudinal associations between Sarcopenic Obesity and its components with bone mineral density (BMD) and incident falls and fractures in Australian community-dwelling older men. A total of 1486 men aged ≥70 years from the Concord Health and Ageing in Men Project (CHAMP) study were assessed at baseline (2005–2007), 2-year follow-up (2007–2009; n = 1238), and 5-year follow-up (2010–2013; n = 861). At all three time points, measurements included appendicular lean mass (ALM), body fat percentage and total hip BMD, hand-grip strength, and gait speed. Participants were contacted every 4 months for 6.1 ± 2.1 years to ascertain incident falls and fractures, the latter being confirmed by radiographic reports. Sarcopenic Obesity was defined using sarcopenia algorithms of the European Working Group on Sarcopenia (EWGSOP) and the Foundation for the National Institutes of Health (FNIH) and total body fat ≥30% of total mass. Sarcopenic obese men did not have significantly different total hip BMD over 5 years compared with non-Sarcopenic non-obese men (p > 0.05). EWGSOP-defined Sarcopenic Obesity at baseline was associated with significantly higher 2-year fall rates (incidence rate ratio [IRR] 1.66; 95% confidence interval [CI] 1.16–2.37), as were non-Sarcopenic Obesity (1.30; 1.04–1.62) and Sarcopenic non-Obesity (1.58; 1.14–2.17), compared with non-Sarcopenic non-obese. No association with falls was found for Sarcopenic Obesity using the FNIH definition (1.01; 0.63–1.60), but after multivariable adjustment, the FNIH-defined non-Sarcopenic obese group had a reduced hazard for any 6-year fracture compared with Sarcopenic obese men (hazard ratio 0.44; 95% CI 0.23–0.86). In older men, EWGSOP-defined Sarcopenic Obesity is associated with increased fall rates over 2 years, and FNIH-defined Sarcopenic obese men have increased fracture risk over 6 years compared with non-Sarcopenic obese men. © 2016 American Society for Bone and Mineral Research.
Francisco Lopezjimenez - One of the best experts on this subject based on the ideXlab platform.
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sarcopenia Sarcopenic Obesity and inflammation results from the 1999 2004 national health and nutrition examination survey
Clinical Nutrition, 2016Co-Authors: John A. Batsis, Francisco Lopezjimenez, Todd A Mackenzie, Jonathan D Jones, Stephen J BartelsAbstract:Summary Background The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals at risk for functional impairment. Recognizing possible underlying mechanisms between adipose tissue and muscle, we sought to apply the recent definitions and determine the relationship with markers of glucose homeostasis and inflammation in individuals with sarcopenia and Sarcopenic Obesity. Methods The National Health and Nutrition Examination Surveys 1999–2004 were used to identify 4984 adults aged ≥60 years with DEXA measures. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity was defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). We assessed the association between ALM and ALM:BMI with inflammatory and markers of glucose homeostasis, both as continuous variables but also classifying as having Sarcopenic Obesity or not after adjusting for confounding variables including pro-inflammatory chronic diseases such as diabetes and cancer. Results Mean age was 71.1 years (56.5%) females. Prevalence of sarcopenia and Sarcopenic Obesity were (ALM definition: 29.9 and 24.4%; ALM:BMI definition: 23.0 and 22.7%). There were significant associations with ALM and ln C-reactive protein (β = 0.0287; p = 0.001), fibrinogen (β = 0.519; p Conclusions Biologically plausible associations exist between ALM:BMI and inflammation and HOMA-IR that were not observed when using ALM alone. Future study should validate each of these definitions to prevent disparate results from being determined.
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sarcopenia Sarcopenic Obesity and functional impairments in older adults national health and nutrition examination surveys 1999 2004
Nutrition Research, 2015Co-Authors: John A. Batsis, Francisco Lopezjimenez, Stephen J Bartels, Todd A MackenzieAbstract:Abstract The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals with functional impairment. We hypothesized that the prevalence of sarcopenia and Sarcopenic Obesity would be similar based on the different Foundation for the National Institutes of Health criteria, increase with age, and be associated with risk of impairment limitations. We identified 4984 subjects at least 60 years of age from the National Health and Nutrition Examination Surveys 1999-2004. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity is defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). Prevalence rates of both sarcopenia and Sarcopenic Obesity were evaluated with respect to sex, age category (60-69, 70-79, and >80 years) and race. We assessed the association of physical limitations, basic and instrumental activities of daily living and sarcopenia status. The mean age was 70.5 years in men and 71.6 years in women. Half (50.8%; n=2531) were female, and mean BMI was 28 kg/m 2 in both sexes. Appendicular lean mass was higher in men than in women (24.1 vs 16.3; P P
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sarcopenia Sarcopenic Obesity and mortality in older adults results from the national health and nutrition examination survey iii
European Journal of Clinical Nutrition, 2014Co-Authors: John A. Batsis, Todd Mackenzie, Laura K Barre, Francisco Lopezjimenez, Stephen J BartelsAbstract:Sarcopenia, Sarcopenic Obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III
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variation in the prevalence of sarcopenia and Sarcopenic Obesity in older adults associated with different research definitions dual energy x ray absorptiometry data from the national health and nutrition examination survey 1999 2004
Journal of the American Geriatrics Society, 2013Co-Authors: John A. Batsis, Laura K Barre, Francisco Lopezjimenez, Todd A Mackenzie, Sarah I Pratt, Stephen J BartelsAbstract:Objectives To determine the prevalence range for Sarcopenic Obesity and its relationship with sex, age, and ethnicity. Design Cross-sectional analysis of a population-based sample. Setting Noninstitutionalized persons in the United States participating in the National Health and Nutrition Examination Surveys 1999–2004. Participants Subsample of 4,984 subjects aged 60 and older with dual-energy X-ray absorptiometry body composition data. Measurements Eight definitions of Sarcopenic Obesity identified from six studies found using a systematic literature review (Baumgartner, Bouchard, Davison, Zoico, Levine, Kim-1,2,3) were applied to the sample. Results were stratified according to sex, age, and ethnicity. Results Prevalence of Sarcopenic Obesity ranged from 4.4% to 84.0% in men and from 3.6% to 94.0% in women. Prevalence was higher in men using definitions from Baumgartner (17.9% vs 13.3%, P < .001), Levine (14.2% vs 6.6%, P < .001), and Kim-1 (30.0% vs 9.3%, P < .001); lower for men using the Davison (4.4% vs 11.1%, P < .001) and Kim-2 (83.7% vs 94.0%) definitions; and the same for men and women using the Bouchard (45.3% vs 44.3%, P = .32) and Kim-3 (75.6% vs 77.0%, P = .51) definitions. For all but one definition, Sarcopenic Obesity increased with each decade and was lower in non-Hispanic blacks than whites. Conclusion Prevalence of Sarcopenic Obesity in older adults varies up to 26-fold depending on current research definitions. Such a high degree of variability suggests the need to establish consensus criteria that can be reliably applied across clinical and research settings.
Todd A Mackenzie - One of the best experts on this subject based on the ideXlab platform.
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sarcopenia Sarcopenic Obesity and inflammation results from the 1999 2004 national health and nutrition examination survey
Clinical Nutrition, 2016Co-Authors: John A. Batsis, Francisco Lopezjimenez, Todd A Mackenzie, Jonathan D Jones, Stephen J BartelsAbstract:Summary Background The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals at risk for functional impairment. Recognizing possible underlying mechanisms between adipose tissue and muscle, we sought to apply the recent definitions and determine the relationship with markers of glucose homeostasis and inflammation in individuals with sarcopenia and Sarcopenic Obesity. Methods The National Health and Nutrition Examination Surveys 1999–2004 were used to identify 4984 adults aged ≥60 years with DEXA measures. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity was defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). We assessed the association between ALM and ALM:BMI with inflammatory and markers of glucose homeostasis, both as continuous variables but also classifying as having Sarcopenic Obesity or not after adjusting for confounding variables including pro-inflammatory chronic diseases such as diabetes and cancer. Results Mean age was 71.1 years (56.5%) females. Prevalence of sarcopenia and Sarcopenic Obesity were (ALM definition: 29.9 and 24.4%; ALM:BMI definition: 23.0 and 22.7%). There were significant associations with ALM and ln C-reactive protein (β = 0.0287; p = 0.001), fibrinogen (β = 0.519; p Conclusions Biologically plausible associations exist between ALM:BMI and inflammation and HOMA-IR that were not observed when using ALM alone. Future study should validate each of these definitions to prevent disparate results from being determined.
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sarcopenia Sarcopenic Obesity and functional impairments in older adults national health and nutrition examination surveys 1999 2004
Nutrition Research, 2015Co-Authors: John A. Batsis, Francisco Lopezjimenez, Stephen J Bartels, Todd A MackenzieAbstract:Abstract The Foundation for the National Institutes of Health Sarcopenia Project validated cutpoints for appendicular lean mass (ALM) to identify individuals with functional impairment. We hypothesized that the prevalence of sarcopenia and Sarcopenic Obesity would be similar based on the different Foundation for the National Institutes of Health criteria, increase with age, and be associated with risk of impairment limitations. We identified 4984 subjects at least 60 years of age from the National Health and Nutrition Examination Surveys 1999-2004. Sarcopenia was defined using ALM (men 2 , women 2 ). Sarcopenic Obesity is defined as subjects fulfilling the criteria for sarcopenia and Obesity by body fat (men ≥25%, women ≥35%). Prevalence rates of both sarcopenia and Sarcopenic Obesity were evaluated with respect to sex, age category (60-69, 70-79, and >80 years) and race. We assessed the association of physical limitations, basic and instrumental activities of daily living and sarcopenia status. The mean age was 70.5 years in men and 71.6 years in women. Half (50.8%; n=2531) were female, and mean BMI was 28 kg/m 2 in both sexes. Appendicular lean mass was higher in men than in women (24.1 vs 16.3; P P
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variation in the prevalence of sarcopenia and Sarcopenic Obesity in older adults associated with different research definitions dual energy x ray absorptiometry data from the national health and nutrition examination survey 1999 2004
Journal of the American Geriatrics Society, 2013Co-Authors: John A. Batsis, Laura K Barre, Francisco Lopezjimenez, Todd A Mackenzie, Sarah I Pratt, Stephen J BartelsAbstract:Objectives To determine the prevalence range for Sarcopenic Obesity and its relationship with sex, age, and ethnicity. Design Cross-sectional analysis of a population-based sample. Setting Noninstitutionalized persons in the United States participating in the National Health and Nutrition Examination Surveys 1999–2004. Participants Subsample of 4,984 subjects aged 60 and older with dual-energy X-ray absorptiometry body composition data. Measurements Eight definitions of Sarcopenic Obesity identified from six studies found using a systematic literature review (Baumgartner, Bouchard, Davison, Zoico, Levine, Kim-1,2,3) were applied to the sample. Results were stratified according to sex, age, and ethnicity. Results Prevalence of Sarcopenic Obesity ranged from 4.4% to 84.0% in men and from 3.6% to 94.0% in women. Prevalence was higher in men using definitions from Baumgartner (17.9% vs 13.3%, P < .001), Levine (14.2% vs 6.6%, P < .001), and Kim-1 (30.0% vs 9.3%, P < .001); lower for men using the Davison (4.4% vs 11.1%, P < .001) and Kim-2 (83.7% vs 94.0%) definitions; and the same for men and women using the Bouchard (45.3% vs 44.3%, P = .32) and Kim-3 (75.6% vs 77.0%, P = .51) definitions. For all but one definition, Sarcopenic Obesity increased with each decade and was lower in non-Hispanic blacks than whites. Conclusion Prevalence of Sarcopenic Obesity in older adults varies up to 26-fold depending on current research definitions. Such a high degree of variability suggests the need to establish consensus criteria that can be reliably applied across clinical and research settings.
