The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Goran Sedvall - One of the best experts on this subject based on the ideXlab platform.
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studies on the binding of 3h flumazenil and 3h Sarmazenil in post mortem human brain
Human Psychopharmacology-clinical and Experimental, 1992Co-Authors: H Hall, Janeric Litton, Christer Halldin, J Kopp, Goran SedvallAbstract:Two benzodiazepine analogues, [3H]flumazenil and [3H]Sarmazenil, were used to study the GABAA/benzodiazepine receptor complex in human post-mortem brain using in vitro receptor assays on homogenates and whole hemisphere autoradiography. Both radioligands bound in a saturable manner to single binding sites in the tissue preparations from any brain region. The highest levels of binding were found in the cortical regions and in cortex cerebelli. Both [3H]flumazenil and [3H]Sarmazenil were excellent radioligands for autoradiography with high binding in cerebral and cerebellar cortex with no or very low binding in areas with white matter. The addition of a high concentration of flumazenil or clonazepam did not inhibit the binding of [3H]Sarmazenil to granule cells in the cerebellum while the binding of [3H]flumazenil was abolished completely in all regions. The results show that with the two different radioligands, one an antagonist and one a partial inverse agonist, the binding pattern to GABAA/benzodiazepine receptor complex is approximately similar in most brain regions. The additional binding seen in the cerebellum with [3H]Sarmazenil is suggested to be due to binding to an α6-containing complex.
Peretz Lavie - One of the best experts on this subject based on the ideXlab platform.
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the intrinsic effects of Sarmazenil on sleep propensity and performance level of sleep deprived subjects
Psychopharmacology, 1994Co-Authors: Rachel Nave, Paula Herer, Peretz LavieAbstract:The effect of two dosages of Sarmazenil (RO 15-3505) on sleep propensity and performance was investigated in a double-blind, placebo-controlled paradigm. The design included three 24-h testing periods, separated by at least one 7-day rest period, commencing after 24-h of sleep deprivation. Twelve normal, healthy, adult males (mean age 27±2.8 years) were paid to participate. During the experimental periods, they came to the sleep laboratory at 2100 hours and spent the night awake under close supervision. At 0700 hours, a schedule of 7 min “attempting” sleep in bed, 13 min awake outside the bedroom, began. This schedule was maintained for 24 h. Repeated administrations of 1 mg and 2 mg Sarmazenil significantly reduced the 24-h levels of total sleep. This was particularly evident during the period 0700–2300 hours. Sarmazenil also significantly improved reaction time and tended to increase the number of correct responses in the “categories search” task. Sarmazenil tended to improve reaction time in the “Stroop” test but this was significant only for the “easy” version of the test during the night.
H Hall - One of the best experts on this subject based on the ideXlab platform.
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studies on the binding of 3h flumazenil and 3h Sarmazenil in post mortem human brain
Human Psychopharmacology-clinical and Experimental, 1992Co-Authors: H Hall, Janeric Litton, Christer Halldin, J Kopp, Goran SedvallAbstract:Two benzodiazepine analogues, [3H]flumazenil and [3H]Sarmazenil, were used to study the GABAA/benzodiazepine receptor complex in human post-mortem brain using in vitro receptor assays on homogenates and whole hemisphere autoradiography. Both radioligands bound in a saturable manner to single binding sites in the tissue preparations from any brain region. The highest levels of binding were found in the cortical regions and in cortex cerebelli. Both [3H]flumazenil and [3H]Sarmazenil were excellent radioligands for autoradiography with high binding in cerebral and cerebellar cortex with no or very low binding in areas with white matter. The addition of a high concentration of flumazenil or clonazepam did not inhibit the binding of [3H]Sarmazenil to granule cells in the cerebellum while the binding of [3H]flumazenil was abolished completely in all regions. The results show that with the two different radioligands, one an antagonist and one a partial inverse agonist, the binding pattern to GABAA/benzodiazepine receptor complex is approximately similar in most brain regions. The additional binding seen in the cerebellum with [3H]Sarmazenil is suggested to be due to binding to an α6-containing complex.
Mosing M - One of the best experts on this subject based on the ideXlab platform.
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Total invtravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery
'Wildlife Disease Association', 2010Co-Authors: Auer U, Wenger S, Beigelböck C, Zenker W, Mosing MAbstract:Sixteen captive female red deer were successfully anesthetized to surgically implant a telemetry system. The deer were immobilized with (mean±SD) 1.79±0.29 mg/kg xylazine and 1.79±0.29 mg/kg tiletamine/zolazepam given intramuscularly with a dart gun. Anesthesia was maintained for 69±2 min using a total intravenous protocol with a catheter placed in the jugular vein. Group X received xylazine (0.5±0.055 mg/kg/hr) and group D, detomidine (2±0.22 µg/kg/hr), both in combination with ketamine (2±0.02 mg/kg/hr) and midazolam (0.03±0.0033 mg/kg/hr), as a constant rate infusion. Anesthesia was reversed with 0.09±0.01 mg/kg atipamezole and 8.7±1.21 µg/kg Sarmazenil given intravenously in both groups. These drug combinations provided smooth induction, stable anesthesia for surgery, and rapid recovery. Respiratory depression and mild hypoxemia were seen, and we, therefore, recommend using supplemental intranasal oxygen
Martina Mosing - One of the best experts on this subject based on the ideXlab platform.
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total intravenous anesthesia with midazolam ketamine and xylazine or detomidine following induction with tiletamine zolazepam and xylazine in red deer cervus elaphus hippelaphus undergoing surgery
Journal of Wildlife Diseases, 2010Co-Authors: Ulrike Auer, Sandra Wenger, Christoph Beigelbock, Wolfgang Zenker, Martina MosingAbstract:Sixteen captive female red deer were successfully anesthetized to surgically implant a telemetry system. The deer were immobilized with (mean±SD) 1.79±0.29 mg/kg xylazine and 1.79±0.29 mg/kg tiletamine/zolazepam given intramuscularly with a dart gun. Anesthesia was maintained for 69±2 min using a total intravenous protocol with a catheter placed in the jugular vein. Group X received xylazine (0.5±0.055 mg/kg/hr) and group D, detomidine (2±0.22 μg/kg/hr), both in combination with ketamine (2±0.02 mg/kg/hr) and midazolam (0.03±0.0033 mg/kg/hr), as a constant rate infusion. Anesthesia was reversed with 0.09±0.01 mg/kg atipamezole and 8.7±1.21 μg/kg Sarmazenil given intravenously in both groups. These drug combinations provided smooth induction, stable anesthesia for surgery, and rapid recovery. Respiratory depression and mild hypoxemia were seen, and we, therefore, recommend using supplemental intranasal oxygen.