The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Sahar Bagheri - One of the best experts on this subject based on the ideXlab platform.
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efficacy of Saussurea costus qost oil as an iranian traditional medicine product on female urinary incontinence double blinded randomized clinical trial
Research Journal of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Malihe Tabarrai, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (p<0.001). Before the intervention, thirty one patients in the placebo group and 33 patients in the qost group had mixed urinary incontinence (p=0.794). Urge symptom s(nocturia, urine frequency and urgency to urination) were completely discontinued in 25 patients in the qost group (78.1%) and 7 patients in the placebo group (22.6%) (p<0.001). Conclusion: The results suggested the oil to be effective in treatment of urinary inconsistence.
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preparation of Saussurea costus traditional oil and investigation of different parameters for standardization
Research Journal of Pharmacognosy, 2018Co-Authors: Sahar Bagheri, Nastaran Ebadi, Zahra Taghipour, Azadeh Manayi, Tayebeh Toliyat, Mehran Mirabzadeh ArdakaniAbstract:Background and objective: Medicinal oils are one of the most common and special dosage forms in oral and topical therapies of Persian medicine (PM). The oil of Saussurea costus (bitter qust) root is prominent topical oil with different applications in PM. In this study, the oil of bitter qust was prepared according to ancient Persian medical texts. Methods: To prepare traditional qust oil, 100 g of the root was soaked in 600 mL aqueous ethanol 25% overnight. The supernatant was then filtered and boiled in 800 g sesame oil until all water was evaporated. The essential oil of the root and volatile components of its traditional oil were extracted using hydro-distillation method in a Clevenger-type apparatus and were analyzed by gas chromatography-mass spectrometry (GC-MS) method. Total phenolics, flavonoids, tannins and polysaccharides were determined by spectrophotometric methods to evaluate the chemical parameters of traditional bitter qust oil. Results: The content of volatile compounds in both investigated samples was determined (0.5% and 0.1% (v/w), respectively). Dehydrocostus lactone and 1, 3-cyclooctadiene were two similar main compounds in the both analyzed samples. Total phenolics (788.290±0.61 mg/L gallic acid equivalent (GAE)), flavonoids (303.2±2.52 mg/L catechin equivalent (CE)), tannins (23.97±0.52 mg/L GAE) and polysaccharides (9.240±0.13 mg/L dextrose equivalent (DE)) contents were determined. Conclusion: According to the obtained data, dehydrocostus lactone could be used for determination and evaluation of traditional bitter qust oil.
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Efficacy of Saussurea costus (Qost) Oil as an Iranian Traditional Medicine Product on Female Urinary Incontinence; Double Blinded Randomized Clinical Trial
Iranian Society of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Malihe Tabarrai*, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (
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Determination of Scientific Name of Bitter “Qust”: an Important Controversial Plant Source in the Iranian Medicinal Plants Market for Neurological Complications
Iranian Society of Pharmacognosy, 2018Co-Authors: Nastaran Ebadi, Zahra Niktabe, Sahar Bagheri, Malihe Tabarrai, Azadeh Manayi, Tayebeh Toliyat, Sima Sadrai, Mehran Mirabzadeh Ardakani*Abstract:Background and objectives: Traditional medicine could provide a hopeful area of research to mitigate the suffering of patients. “Qust” is one of the medicinal plants that are mentioned in Persian Medicine (PM) for treatment of neurological diseases. There is diversity within the scientific name of “Qust” in different references. Some have introduced Saussurea costus (Falc.) Lipsch. (Asteraceae), while others have presented costus speciosus (J. Koenig) Sm. (Costaceae) as “Qust”. Since “Qust” is not endemic in Iran, there is difficulty to access to the whole plant for its identification. Hence, this study has aimed to identify available bitter “Qust” which is composed of roots of the plant in the Iranian market. Methods: Macroscopic characters and microscopic properties of powders and transverse sections of specimens with essential oil analysis of the Indian and one of the Iran herbal market samples using chromatography-mass spectrometry (GC-MS) were investigated for identification of bitter “Qust”. Results: Microscopic evaluation showed presence of secretory cavities and their specific size, narrow radial rows of conducting tissue alternating with broad medullary rays in the secondary phloem and xylem, presence of inulin, absence of starch and calcium oxalate crystals in the bitter “Qust” particles. Further, positive response was observed to S. costus identifying test. In the analysis of essential oils, active components of S. costus, such as dehydrocostus lactone, were identified in the examined essential oils. Conclusion: According to the results, it could be concluded that bitter “Qust” in Iran herbal market most probably is S. costus
Jinxin Liu - One of the best experts on this subject based on the ideXlab platform.
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Image3_Biological Ingredient Analysis of Traditional Herbal Patent Medicine Fuke Desheng Wan Using the Shotgun Metabarcoding Approach.TIF
'Frontiers Media SA', 2021Co-Authors: Hongbo Xie, Qing Zhao, Mengmeng Shi, Weijun Kong, Jingyi Zhao, Chunying Zhao, Jing Jia, Jinxin LiuAbstract:With the widespread use of traditional medicine around the world, the safety and efficacy of traditional herbal patent medicine have become an increasing concern to the public. However, it is difficult to supervise the authenticity of herbal materials in mixed herbal products according to the current quality standards, especially for traditional herbal patent medicine, with a distinct variance in the dosage of herbal materials. This study utilized the shotgun metabarcoding approach to analyze the biological ingredients of Fuke Desheng Wan (FKDSW), which is an effective traditional herbal product for the treatment of dysmenorrhea. Six herbal materials were collected, and a lab-made mock FKDSW sample was produced to establish a method for the authentication assessment of biological ingredients in traditional herbal patent medicine based on shotgun metabarcoding. Furthermore, four commercial FKDSW samples were collected to verify the practicality of the shotgun metabarcoding approach. Then, a total of 52.16 Gb raw data for 174 million paired-end reads was generated using the Illumina NovaSeq sequencing platform. Meanwhile, 228, 23, and 14 operational taxonomic units (OTUs) were obtained for the ITS2, matK, and rbcL regions, respectively, after bioinformatic analysis. Moreover, no differences were evident between the assembly sequences obtained via shotgun metabarcoding and their corresponding reference sequences of the same species obtained via Sanger sequencing, except for part of the ITS2 and matK assembly sequences of Paeonia lactiflora Pall., Saussurea costus (Falc.) Lipsch. and Bupleurum chinense DC. with 1–6 different bases. The identification results showed that all six prescribed ingredients were successfully detected and that the non-authentic ingredient of Bupleuri Radix (Chaihu, Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd.) was found in all the commercial samples, namely Bupleurum falcatum L. Here, 25 weed species representing 16 genera of ten families were detected. Moreover, 26 fungal genera belonging to 17 families were found in both lab-made and commercial FKDSW samples. This study demonstrated that the shotgun metabarcoding approach could overcome the biased PCR amplification and authenticate the biological ingredients of traditional herbal patent medicine with a distinct variance in the dosage of the herbal materials. Therefore, this provides an appropriate evaluation method for improving the safety and efficacy of traditional herbal patent medicine.
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DataSheet1_Biological Ingredient Analysis of Traditional Herbal Patent Medicine Fuke Desheng Wan Using the Shotgun Metabarcoding Approach.docx
'Frontiers Media SA', 2021Co-Authors: Hongbo Xie, Qing Zhao, Mengmeng Shi, Weijun Kong, Jingyi Zhao, Chunying Zhao, Jing Jia, Jinxin LiuAbstract:With the widespread use of traditional medicine around the world, the safety and efficacy of traditional herbal patent medicine have become an increasing concern to the public. However, it is difficult to supervise the authenticity of herbal materials in mixed herbal products according to the current quality standards, especially for traditional herbal patent medicine, with a distinct variance in the dosage of herbal materials. This study utilized the shotgun metabarcoding approach to analyze the biological ingredients of Fuke Desheng Wan (FKDSW), which is an effective traditional herbal product for the treatment of dysmenorrhea. Six herbal materials were collected, and a lab-made mock FKDSW sample was produced to establish a method for the authentication assessment of biological ingredients in traditional herbal patent medicine based on shotgun metabarcoding. Furthermore, four commercial FKDSW samples were collected to verify the practicality of the shotgun metabarcoding approach. Then, a total of 52.16 Gb raw data for 174 million paired-end reads was generated using the Illumina NovaSeq sequencing platform. Meanwhile, 228, 23, and 14 operational taxonomic units (OTUs) were obtained for the ITS2, matK, and rbcL regions, respectively, after bioinformatic analysis. Moreover, no differences were evident between the assembly sequences obtained via shotgun metabarcoding and their corresponding reference sequences of the same species obtained via Sanger sequencing, except for part of the ITS2 and matK assembly sequences of Paeonia lactiflora Pall., Saussurea costus (Falc.) Lipsch. and Bupleurum chinense DC. with 1–6 different bases. The identification results showed that all six prescribed ingredients were successfully detected and that the non-authentic ingredient of Bupleuri Radix (Chaihu, Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd.) was found in all the commercial samples, namely Bupleurum falcatum L. Here, 25 weed species representing 16 genera of ten families were detected. Moreover, 26 fungal genera belonging to 17 families were found in both lab-made and commercial FKDSW samples. This study demonstrated that the shotgun metabarcoding approach could overcome the biased PCR amplification and authenticate the biological ingredients of traditional herbal patent medicine with a distinct variance in the dosage of the herbal materials. Therefore, this provides an appropriate evaluation method for improving the safety and efficacy of traditional herbal patent medicine.
Zahra Niktabe - One of the best experts on this subject based on the ideXlab platform.
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efficacy of Saussurea costus qost oil as an iranian traditional medicine product on female urinary incontinence double blinded randomized clinical trial
Research Journal of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Malihe Tabarrai, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (p<0.001). Before the intervention, thirty one patients in the placebo group and 33 patients in the qost group had mixed urinary incontinence (p=0.794). Urge symptom s(nocturia, urine frequency and urgency to urination) were completely discontinued in 25 patients in the qost group (78.1%) and 7 patients in the placebo group (22.6%) (p<0.001). Conclusion: The results suggested the oil to be effective in treatment of urinary inconsistence.
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Efficacy of Saussurea costus (Qost) Oil as an Iranian Traditional Medicine Product on Female Urinary Incontinence; Double Blinded Randomized Clinical Trial
Iranian Society of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Malihe Tabarrai*, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (
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Determination of Scientific Name of Bitter “Qust”: an Important Controversial Plant Source in the Iranian Medicinal Plants Market for Neurological Complications
Iranian Society of Pharmacognosy, 2018Co-Authors: Nastaran Ebadi, Zahra Niktabe, Sahar Bagheri, Malihe Tabarrai, Azadeh Manayi, Tayebeh Toliyat, Sima Sadrai, Mehran Mirabzadeh Ardakani*Abstract:Background and objectives: Traditional medicine could provide a hopeful area of research to mitigate the suffering of patients. “Qust” is one of the medicinal plants that are mentioned in Persian Medicine (PM) for treatment of neurological diseases. There is diversity within the scientific name of “Qust” in different references. Some have introduced Saussurea costus (Falc.) Lipsch. (Asteraceae), while others have presented costus speciosus (J. Koenig) Sm. (Costaceae) as “Qust”. Since “Qust” is not endemic in Iran, there is difficulty to access to the whole plant for its identification. Hence, this study has aimed to identify available bitter “Qust” which is composed of roots of the plant in the Iranian market. Methods: Macroscopic characters and microscopic properties of powders and transverse sections of specimens with essential oil analysis of the Indian and one of the Iran herbal market samples using chromatography-mass spectrometry (GC-MS) were investigated for identification of bitter “Qust”. Results: Microscopic evaluation showed presence of secretory cavities and their specific size, narrow radial rows of conducting tissue alternating with broad medullary rays in the secondary phloem and xylem, presence of inulin, absence of starch and calcium oxalate crystals in the bitter “Qust” particles. Further, positive response was observed to S. costus identifying test. In the analysis of essential oils, active components of S. costus, such as dehydrocostus lactone, were identified in the examined essential oils. Conclusion: According to the results, it could be concluded that bitter “Qust” in Iran herbal market most probably is S. costus
Nastaran Ebadi - One of the best experts on this subject based on the ideXlab platform.
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efficacy of Saussurea costus qost oil as an iranian traditional medicine product on female urinary incontinence double blinded randomized clinical trial
Research Journal of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Malihe Tabarrai, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (p<0.001). Before the intervention, thirty one patients in the placebo group and 33 patients in the qost group had mixed urinary incontinence (p=0.794). Urge symptom s(nocturia, urine frequency and urgency to urination) were completely discontinued in 25 patients in the qost group (78.1%) and 7 patients in the placebo group (22.6%) (p<0.001). Conclusion: The results suggested the oil to be effective in treatment of urinary inconsistence.
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preparation of Saussurea costus traditional oil and investigation of different parameters for standardization
Research Journal of Pharmacognosy, 2018Co-Authors: Sahar Bagheri, Nastaran Ebadi, Zahra Taghipour, Azadeh Manayi, Tayebeh Toliyat, Mehran Mirabzadeh ArdakaniAbstract:Background and objective: Medicinal oils are one of the most common and special dosage forms in oral and topical therapies of Persian medicine (PM). The oil of Saussurea costus (bitter qust) root is prominent topical oil with different applications in PM. In this study, the oil of bitter qust was prepared according to ancient Persian medical texts. Methods: To prepare traditional qust oil, 100 g of the root was soaked in 600 mL aqueous ethanol 25% overnight. The supernatant was then filtered and boiled in 800 g sesame oil until all water was evaporated. The essential oil of the root and volatile components of its traditional oil were extracted using hydro-distillation method in a Clevenger-type apparatus and were analyzed by gas chromatography-mass spectrometry (GC-MS) method. Total phenolics, flavonoids, tannins and polysaccharides were determined by spectrophotometric methods to evaluate the chemical parameters of traditional bitter qust oil. Results: The content of volatile compounds in both investigated samples was determined (0.5% and 0.1% (v/w), respectively). Dehydrocostus lactone and 1, 3-cyclooctadiene were two similar main compounds in the both analyzed samples. Total phenolics (788.290±0.61 mg/L gallic acid equivalent (GAE)), flavonoids (303.2±2.52 mg/L catechin equivalent (CE)), tannins (23.97±0.52 mg/L GAE) and polysaccharides (9.240±0.13 mg/L dextrose equivalent (DE)) contents were determined. Conclusion: According to the obtained data, dehydrocostus lactone could be used for determination and evaluation of traditional bitter qust oil.
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Efficacy of Saussurea costus (Qost) Oil as an Iranian Traditional Medicine Product on Female Urinary Incontinence; Double Blinded Randomized Clinical Trial
Iranian Society of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Malihe Tabarrai*, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (
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Determination of Scientific Name of Bitter “Qust”: an Important Controversial Plant Source in the Iranian Medicinal Plants Market for Neurological Complications
Iranian Society of Pharmacognosy, 2018Co-Authors: Nastaran Ebadi, Zahra Niktabe, Sahar Bagheri, Malihe Tabarrai, Azadeh Manayi, Tayebeh Toliyat, Sima Sadrai, Mehran Mirabzadeh Ardakani*Abstract:Background and objectives: Traditional medicine could provide a hopeful area of research to mitigate the suffering of patients. “Qust” is one of the medicinal plants that are mentioned in Persian Medicine (PM) for treatment of neurological diseases. There is diversity within the scientific name of “Qust” in different references. Some have introduced Saussurea costus (Falc.) Lipsch. (Asteraceae), while others have presented costus speciosus (J. Koenig) Sm. (Costaceae) as “Qust”. Since “Qust” is not endemic in Iran, there is difficulty to access to the whole plant for its identification. Hence, this study has aimed to identify available bitter “Qust” which is composed of roots of the plant in the Iranian market. Methods: Macroscopic characters and microscopic properties of powders and transverse sections of specimens with essential oil analysis of the Indian and one of the Iran herbal market samples using chromatography-mass spectrometry (GC-MS) were investigated for identification of bitter “Qust”. Results: Microscopic evaluation showed presence of secretory cavities and their specific size, narrow radial rows of conducting tissue alternating with broad medullary rays in the secondary phloem and xylem, presence of inulin, absence of starch and calcium oxalate crystals in the bitter “Qust” particles. Further, positive response was observed to S. costus identifying test. In the analysis of essential oils, active components of S. costus, such as dehydrocostus lactone, were identified in the examined essential oils. Conclusion: According to the results, it could be concluded that bitter “Qust” in Iran herbal market most probably is S. costus
Mehran Mirabzadeh Ardakani - One of the best experts on this subject based on the ideXlab platform.
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efficacy of Saussurea costus qost oil as an iranian traditional medicine product on female urinary incontinence double blinded randomized clinical trial
Research Journal of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Malihe Tabarrai, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (p<0.001). Before the intervention, thirty one patients in the placebo group and 33 patients in the qost group had mixed urinary incontinence (p=0.794). Urge symptom s(nocturia, urine frequency and urgency to urination) were completely discontinued in 25 patients in the qost group (78.1%) and 7 patients in the placebo group (22.6%) (p<0.001). Conclusion: The results suggested the oil to be effective in treatment of urinary inconsistence.
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preparation of Saussurea costus traditional oil and investigation of different parameters for standardization
Research Journal of Pharmacognosy, 2018Co-Authors: Sahar Bagheri, Nastaran Ebadi, Zahra Taghipour, Azadeh Manayi, Tayebeh Toliyat, Mehran Mirabzadeh ArdakaniAbstract:Background and objective: Medicinal oils are one of the most common and special dosage forms in oral and topical therapies of Persian medicine (PM). The oil of Saussurea costus (bitter qust) root is prominent topical oil with different applications in PM. In this study, the oil of bitter qust was prepared according to ancient Persian medical texts. Methods: To prepare traditional qust oil, 100 g of the root was soaked in 600 mL aqueous ethanol 25% overnight. The supernatant was then filtered and boiled in 800 g sesame oil until all water was evaporated. The essential oil of the root and volatile components of its traditional oil were extracted using hydro-distillation method in a Clevenger-type apparatus and were analyzed by gas chromatography-mass spectrometry (GC-MS) method. Total phenolics, flavonoids, tannins and polysaccharides were determined by spectrophotometric methods to evaluate the chemical parameters of traditional bitter qust oil. Results: The content of volatile compounds in both investigated samples was determined (0.5% and 0.1% (v/w), respectively). Dehydrocostus lactone and 1, 3-cyclooctadiene were two similar main compounds in the both analyzed samples. Total phenolics (788.290±0.61 mg/L gallic acid equivalent (GAE)), flavonoids (303.2±2.52 mg/L catechin equivalent (CE)), tannins (23.97±0.52 mg/L GAE) and polysaccharides (9.240±0.13 mg/L dextrose equivalent (DE)) contents were determined. Conclusion: According to the obtained data, dehydrocostus lactone could be used for determination and evaluation of traditional bitter qust oil.
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Efficacy of Saussurea costus (Qost) Oil as an Iranian Traditional Medicine Product on Female Urinary Incontinence; Double Blinded Randomized Clinical Trial
Iranian Society of Pharmacognosy, 2018Co-Authors: Zahra Niktabe, Tahereh Eftekhaar, Malihe Tabarrai*, Mehran Mirabzadeh Ardakani, Mir Saeed Yekaninejad, Laila Shirbeigi, Nastaran Ebadi, Nematollah Masoudi, Sahar BagheriAbstract:Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment methods on female urinary incontinence. Methods: A parallel double blinded placebo-controlled study was conducted. Thirty to 70 years old women with urinary incontinence were allocated in placebo and intervention groups, 41 patients in each group.Intervention and placebo groups received qost oil and placebo, respectively by local application twice daily below the navel without massage. The results were evaluated with valid questionnaires (ICIQ-SF and I-QOL). For evaluation, Chi-square test, independent-sample t-test and repeated measure analysis of variance were used. Significant p value was Results: A significant decrease in mean scores of the questionnaires during the study was noted in the qost group compared to the placebo group (
