The Experts below are selected from a list of 1704 Experts worldwide ranked by ideXlab platform
A Strauss - One of the best experts on this subject based on the ideXlab platform.
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long term course of schizophrenic affective and Schizoaffective Psychosis focus on negative symptoms and their impact on global indicators of outcome
Acta Psychiatrica Scandinavica, 2000Co-Authors: Hansjurgen Moller, Ronald Bottlender, U Wegner, Johannes Wittmann, A StraussAbstract:Objective: The aim of this study was to compare indicators of outcome between different types of Psychosis and to verify whether or not negative symptoms (NS) have a special relevance for schizophrenia. Method: This is a follow-up study on functional Psychosis according to ICD-9. Patients were assessed standardized at the time of first hospitalization and about 12.5 years later. Results: Comparison of global outcome parameters and NS revealed that schizophrenia had the poorest outcome of all types of Psychosis. NS had the highest impact on global functioning and the severity of illness in schizophrenia. NS assessed at the first hospitalization were associated with the different outcome parameters only in schizophrenia at follow-up. Conclusion: The course of schizophrenia is a more deteriorating one than that of affective or Schizoaffective Psychosis. The findings point to the special relevance of NS for the outcome and their relative specificity for schizophrenia.
P V Bologov - One of the best experts on this subject based on the ideXlab platform.
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clinical genetic parameters and the nosological evaluation of Schizoaffective Psychosis in systematics of attack like endogenous psychoses
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2011Co-Authors: G P Panteleeva, P V Bologov, V V Artiukh, G I Kopeĭko, Iu I Nikiforova, K E ShchekalAbstract:Authors studied 1013 first- and second degree relatives in families of 193 probands. The probands were stratified by clinical diagnosis into 6 groups: 1) nuclear variant of Schizoaffective Psychosis (SAP); 2) "marginal" (intermediate) variant of SAP; 3) Schizoaffective variant of schizophrenia; 4) recurrent schizophrenia; 5) attack-like progressive schizophrenia; 6) bipolar affective disorder or manic-depressive Psychosis (MDP). Probands (n=109) and their relatives were studied using the direct clinical examination; the study of 84 probands and their relatives was based on the medical records from the genetic archive of Mental Health Research Center, Russian Academy of Medical Sciences. Mental pathology was found in 72,5% of relatives; 27,5% were healthy. Prevalence of endogenous and non-endogenous psychoses, personality disorders and cases of alcoholism and suicides in the families of probands was studied. A "set" of these psychopathologies was similar in families of all probands and their frequency was higher than that in the general population that confirmed the affiliation of SAP with endogenous diseases by genetic characteristics. In patients with SAP, hereditary characteristics differed by the frequency, correlation and preference of some types of mental pathology compared to families of patients with schizophrenia and MDP, in particular, hereditary characteristics of patients with recurrent schizophrenia and MDP which were identified with SAP by many authors. The clinical-genetic patterns revealed in the study are considered as an argument for nosological independence of SAP.
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Schizoaffective Psychosis nosological evaluation and differential diagnosis
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2008Co-Authors: G P Panteleeva, P V BologovAbstract:Basing on the peculiarities of psychopathological presentations and dynamics of disease in 253 patients with an ICD-10 diagnosis of Schizoaffective disorder (F25), the authors argue for the diagnostic validity of this disease. Schizoaffective Psychosis (SAP) is considered in the context of endoform schizophrenic reaction in people with schizotypal personality with signs of reactive lability. In the dynamics of a Schizoaffective episode, this reaction is formed in the period, but not in the structure, of endogenous phasic affective disorders and emerges itself as psychotic symptoms characteristic of schizophrenia which are independent from circulatory affective symptoms pathogenetically and pathokinetically. The clinical peculiarity and specifics of clinical-psychopathological presentations of SAP as a diagnostically valid entity are discussed. Diagnostic criteria of its differentiation from affective disorders and Schizoaffective variants of episodic and recurrent schizophrenia are presented.
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clinical and nosological approach to diagnosis of Schizoaffective Psychosis
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2002Co-Authors: G P Panteleeva, P V BologovAbstract:Using clinical and psychopathological method, 134 patients who met the ICD-10 criteria of diagnosis of Schizoaffective Psychosis (F25), were examined. Relatively small prognostic informative value of standard Schizoaffective Psychosis differentiation into affective- and schizo-dominant types was found. Subtyping of Schizoaffective Psychosis according to peculiarities of delusion formation in the picture of the disease attacks proved to be more significant. Given clinico-psychopathological features of circular affective and delusional disorders and their pathokinesis, as well as dynamics types and disease outcome, a Schizoaffective Psychosis systematization has been elaborated. That includes 3 nosologic types: "nuclear" type with non-progressive phase dynamics; "marginal" (intermediate) type and Schizoaffective type of attack-like progressive schizophrenia. The concept of nosologic independence of Schizoaffective Psychosis ("nuclear" type) is discussed.
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specific aspects of thrombocyte system of serotonin in patients with different manifestations of Schizoaffective Psychosis
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2000Co-Authors: O S Brusov, P V Bologov, V I Dikaia, G P Zlobina, M I Faktor, O A Pavlova, A N KorenevAbstract:45 women with different manifestations of Schizoaffective Psychosis (SAP) were examined. The diagnosis corresponded to ICD-10 (F25). According to the classification elaborated in Mental Health Research Centre of Russian Academy of Medical Sciences, groups of patients were identified with different variants of the psychoses course: a nuclear SAP type; a borderline SAP variation with phasic-recurrent course; SAP with progredient variation (Schizoaffective variation of schizophrenia). The patients were examined both during the attack and remission. A rate of serotonine uptake (Vmax) in blood platelets, a specific imipramine binding (Bmax) and the level of serotonin in blood platelets were evaluated. It was found that dynamics of both Vmax and the level of serotonin in different SAP types were different, that was related to clinical and biological SAP heterogeneity. A tendency to decreasing of serotonin system functional activity was found in progredient SAP variations, especially during the remission, which was of low quality in these cases. On the contrary, in the borderline variations the indices of the decreased function of serotonin system corresponded well to those of acute Psychosis. In nuclear type--a type with the most favourable course of Psychosis--any significant changes weren't revealed as compared with the normal parameters.
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typological characteristics of manifest states of schizo dominant form of Schizoaffective Psychosis
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 1998Co-Authors: P V BologovAbstract:On the basis of a clinical and psychopathological analysis of 77 patients with schizodominant form of Schizoaffective Psychosis their typological division is suggested according to predominant mechanism of delusion formation. Two types are described: 1) with formation of an acute sensitive delusion; 2) with predominance of acute interpretative delusion. It was established the interrelationship of a psychopathologic structure of the delusional disturbances with the special features of affective disorders in their formation and development in the structure of manifest schizodominant states. Clinical heterogeneity of these disturbances and their differentiation accounting for different characteristics of delusion formation is discussed. The conclusion is also made about the necessity of a further comparison of the described types with both the course and prognosis of the disease.
Stephanie Fryarwilliams - One of the best experts on this subject based on the ideXlab platform.
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fundamental role of methylenetetrahydrofolate reductase 677 c t genotype and flavin compounds in biochemical phenotypes for schizophrenia and Schizoaffective Psychosis
Frontiers in Psychiatry, 2016Co-Authors: Stephanie FryarwilliamsAbstract:The Mental Health Biomarker Project (2010-2016) explored variables for Psychosis in schizophrenia and Schizoaffective disorder. Blood samples from 67, highly-characterized symptomatic cases and 67 gender and age matched control participants were analysed for methyl tetrahydrofolate reductase (MTHFR) 677C->T gene variants and for vitamin B6, B12 and D, folate, unbound copper, zinc cofactors for enzymes in the methylation cycle and related catecholamine pathways. Urine samples were analysed for indole-catecholamines, their metabolites and oxidative-stress marker, hydroxylpyrolline-2-one (HPL). Rating scales were Brief Psychiatric Rating Scale, Positive and Negative Syndrome Scale, Global Assessment of Function scale, Clinical Global Impression score and Social and Occupational Functioning Scale. Analysis used Spearman’s correlates, Receiver Operating Characteristics and structural equation modelling (SEM). The correlative pattern of variables in the overall participant sample strongly implicated Monoamine Oxidase (MAO) enzyme inactivity so the significant role of MAO’s cofactor flavin adenine nucleotide (FAD) and its precursor flavin adenine mononucleotide (FMN) within the biochemical pathways was investigated and confirmed as 70% on SEM of the total sample. Splitting the data sets for MTHFR 677C->T polymorphism variants coding for the MTHFR enzyme, discovered that biochemistry variables relating to the wild-type enzyme differed markedly in pattern from those coded by the homozygous variant and that the hereozygous-variant pattern resembled the wild type-coded pattern. The MTHFR 677C->T -wild and -heterozygous gene variants have a pattern of depleted vitamin cofactors characteristic of flavin insufficiency with under-methylation and severe oxidative stress. The second homozygous MTHFR 677TT pattern related to elevated copper:zinc ratio and a vitamin pattern related to flavin sufficiency and risk of over-methylation. The two gene variants and their different biochemical phenotypes govern findings in relationship to case-identification, illness severity, duration of illness and functional disability in schizophrenia and Schizoaffective Psychosis and establish a basis for gene variation guided precision treatment for the management of Psychosis.
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biomarkers of a five domain translational substrate for schizophrenia and Schizoaffective Psychosis
Biomarker research, 2015Co-Authors: Stephanie Fryarwilliams, Jorg StrobelAbstract:The Mental Health Biomarker Project (2010–2014) selected commercial biochemistry markers related to monoamine synthesis and metabolism and measures of visual and auditory processing performance. Within a case–control discovery design with exclusion criteria designed to produce a highly characterised sample, results from 67 independently DSM IV-R-diagnosed cases of schizophrenia and Schizoaffective disorder were compared with those from 67 control participants selected from a local hospital, clinic and community catchment area. Participants underwent protocol-based diagnostic-checking, functional-rating, biological sample-collection for thirty candidate markers and sensory-processing assessment. Fifteen biomarkers were identified on ROC analysis. Using these biomarkers, odds ratios, adjusted for a case–control design, indicated that schizophrenia and Schizoaffective disorder were highly associated with dichotic listening disorder, delayed visual processing, low visual span, delayed auditory speed of processing, low reverse digit span as a measure of auditory working memory and elevated levels of catecholamines. Other nutritional and biochemical biomarkers were identified as elevated hydroxyl pyrroline-2-one as a marker of oxidative stress, vitamin D, B6 and folate deficits with elevation of serum B12 and free serum copper to zinc ratio. When individual biomarkers were ranked by odds ratio and correlated with clinical severity, five functional domains of visual processing, auditory processing, oxidative stress, catecholamines and nutritional-biochemical variables were formed. When the strengths of their inter-domain relationships were predicted by Lowess (non-parametric) regression, predominant bidirectional relationships were found between visual processing and catecholamine domains. At a cellular level, the nutritional-biochemical domain exerted a pervasive influence on the auditory domain as well as on all other domains. The findings of this biomarker research point towards a much-required advance in Psychiatry: quantification of some theoretically-understandable, translationally-informative, treatment-relevant underpinnings of serious mental illness. This evidence reveals schizophrenia and Schizoaffective disorder in a somewhat different manner, as a conglomerate of several disorders many of which are not currently being assessed-for or treated in clinical settings. Currently available remediation techniques for these underlying conditions have potential to reduce treatment-resistance, relapse-prevention, cost burden and social stigma in these conditions. If replicated and validated in prospective trials, such findings will improve progress-monitoring and treatment-response for schizophrenia and Schizoaffective disorder.
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biomarker symptom profiles for schizophrenia and Schizoaffective Psychosis
Open Journal of Psychiatry, 2015Co-Authors: Stephanie Fryarwilliams, Jorg StrobelAbstract:Background: Neuroscience can assist clinical understanding and therapy by finding neurobiological markers for mental illness symptoms. Objectives: To quantify biomarkers for schizophrenia and Schizoaffective disorder and relate these to discrete symptoms of Psychosis. Methods: Within a case-control design with multiple exclusion criteria to exclude organic causes and confounding variables, 67 DSM IV-R diagnosed and 67 control participants from a defined hospital, clinic and community catchment area were investigated for candidate markers. Participants underwent protocol-based diagnostic-checking and symptom rating via Brief Psychiatric Rating Scale and Positive and Negative Syndrome Scale, functional-rating scales, biological sample-collection and sensory-processing assessment. Blood and urine samples were analysed for monoamine neurotransmitters, their metabolites, vitamin cofactors and intermediate-substances related to oxidative stress and metabolism of monoamines. Neurocognitive assessment of visual and auditory processing was conducted at both peripheral and central levels. Biomarkers were defined by Receiver Operating Curve (ROC) analysis. Spearman’s analysis explored correlations between discrete symptoms and the biomarkers. Results: Receiver Operating Curve (ROC) analysis identified twenty-one biomarkers: elevated urinary dopamine, noradrenaline, adrenaline and hydroxy pyrroline-2-one as a marker of oxidative stress. Other biomarkers were deficits in vitamins D, B6 and folate, elevation of serum B12 and free serum copper to zinc ratio, along with deficits in dichotic listening, distance vision, visual and auditory speed of processing, visual and auditory working memory and six middle ear acoustic reflex parameters. Discrete symptoms such as delusions, hostility, suicidality and auditory hallucinations were biomarker-defined and symptom biomarker correlations assumed an understandable pattern in terms of the catecholamines and their relationship to biochemistry, brain function and disconnectivity. Conclusions: In the absence of a full diagnosis, biomarker-symptom-signatures inform psychiatry about the structure of Psychosis and provide an understandable pattern that points in the direction of a new neurobiological system of
Hansjurgen Moller - One of the best experts on this subject based on the ideXlab platform.
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long term course of schizophrenic affective and Schizoaffective Psychosis focus on negative symptoms and their impact on global indicators of outcome
Acta Psychiatrica Scandinavica, 2000Co-Authors: Hansjurgen Moller, Ronald Bottlender, U Wegner, Johannes Wittmann, A StraussAbstract:Objective: The aim of this study was to compare indicators of outcome between different types of Psychosis and to verify whether or not negative symptoms (NS) have a special relevance for schizophrenia. Method: This is a follow-up study on functional Psychosis according to ICD-9. Patients were assessed standardized at the time of first hospitalization and about 12.5 years later. Results: Comparison of global outcome parameters and NS revealed that schizophrenia had the poorest outcome of all types of Psychosis. NS had the highest impact on global functioning and the severity of illness in schizophrenia. NS assessed at the first hospitalization were associated with the different outcome parameters only in schizophrenia at follow-up. Conclusion: The course of schizophrenia is a more deteriorating one than that of affective or Schizoaffective Psychosis. The findings point to the special relevance of NS for the outcome and their relative specificity for schizophrenia.
G P Panteleeva - One of the best experts on this subject based on the ideXlab platform.
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clinical genetic parameters and the nosological evaluation of Schizoaffective Psychosis in systematics of attack like endogenous psychoses
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2011Co-Authors: G P Panteleeva, P V Bologov, V V Artiukh, G I Kopeĭko, Iu I Nikiforova, K E ShchekalAbstract:Authors studied 1013 first- and second degree relatives in families of 193 probands. The probands were stratified by clinical diagnosis into 6 groups: 1) nuclear variant of Schizoaffective Psychosis (SAP); 2) "marginal" (intermediate) variant of SAP; 3) Schizoaffective variant of schizophrenia; 4) recurrent schizophrenia; 5) attack-like progressive schizophrenia; 6) bipolar affective disorder or manic-depressive Psychosis (MDP). Probands (n=109) and their relatives were studied using the direct clinical examination; the study of 84 probands and their relatives was based on the medical records from the genetic archive of Mental Health Research Center, Russian Academy of Medical Sciences. Mental pathology was found in 72,5% of relatives; 27,5% were healthy. Prevalence of endogenous and non-endogenous psychoses, personality disorders and cases of alcoholism and suicides in the families of probands was studied. A "set" of these psychopathologies was similar in families of all probands and their frequency was higher than that in the general population that confirmed the affiliation of SAP with endogenous diseases by genetic characteristics. In patients with SAP, hereditary characteristics differed by the frequency, correlation and preference of some types of mental pathology compared to families of patients with schizophrenia and MDP, in particular, hereditary characteristics of patients with recurrent schizophrenia and MDP which were identified with SAP by many authors. The clinical-genetic patterns revealed in the study are considered as an argument for nosological independence of SAP.
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Schizoaffective Psychosis nosological evaluation and differential diagnosis
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2008Co-Authors: G P Panteleeva, P V BologovAbstract:Basing on the peculiarities of psychopathological presentations and dynamics of disease in 253 patients with an ICD-10 diagnosis of Schizoaffective disorder (F25), the authors argue for the diagnostic validity of this disease. Schizoaffective Psychosis (SAP) is considered in the context of endoform schizophrenic reaction in people with schizotypal personality with signs of reactive lability. In the dynamics of a Schizoaffective episode, this reaction is formed in the period, but not in the structure, of endogenous phasic affective disorders and emerges itself as psychotic symptoms characteristic of schizophrenia which are independent from circulatory affective symptoms pathogenetically and pathokinetically. The clinical peculiarity and specifics of clinical-psychopathological presentations of SAP as a diagnostically valid entity are discussed. Diagnostic criteria of its differentiation from affective disorders and Schizoaffective variants of episodic and recurrent schizophrenia are presented.
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clinical and nosological approach to diagnosis of Schizoaffective Psychosis
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2002Co-Authors: G P Panteleeva, P V BologovAbstract:Using clinical and psychopathological method, 134 patients who met the ICD-10 criteria of diagnosis of Schizoaffective Psychosis (F25), were examined. Relatively small prognostic informative value of standard Schizoaffective Psychosis differentiation into affective- and schizo-dominant types was found. Subtyping of Schizoaffective Psychosis according to peculiarities of delusion formation in the picture of the disease attacks proved to be more significant. Given clinico-psychopathological features of circular affective and delusional disorders and their pathokinesis, as well as dynamics types and disease outcome, a Schizoaffective Psychosis systematization has been elaborated. That includes 3 nosologic types: "nuclear" type with non-progressive phase dynamics; "marginal" (intermediate) type and Schizoaffective type of attack-like progressive schizophrenia. The concept of nosologic independence of Schizoaffective Psychosis ("nuclear" type) is discussed.
