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Inger Kjaer - One of the best experts on this subject based on the ideXlab platform.

  • Abnormal Sella turcica morphology in individuals with congenital innerear hearing deficits
    Global Dentistry, 2018
    Co-Authors: Inger Kjaer
    Abstract:

    Introduction: The present study focusses on the interrelationship between medically diagnosed congenital inner-ear hearing deficits and Sella turcica morphology. Based on former prenatal studies it is hypothesized that the posterior wall and the floor of the Sella turcica are malformed in patients with congenital inner-ear hearing deficits. Material and Methods:The study is based on profile radiographs from 7 patients (10-17 years of age) with congenital inner-ear hearing deficits and hearing aids. The Sella turcica was identified and described in these profile radiographs. Results: The posterior walls and the floors of the Sella turcicae are malformed in all 7 cases and the anterior wall appear close to normalin all cases. This observation proofs the involvement of the cranialoccipital field in congenital inner ear hearing deficits. Conclusion: The observation of posterior wall and Sella floor malformation observed on profile radiographs from patients with congenital inner-ear deficits has seemingly not been published before. In future analyses of profile radiographs, the morphology of the anterior wall, the posterior wall, and the floor of Sella turcica should receive specific attention. Absence or malformation of the posterior wall could be a sign of congenital hearing deficit.

  • the morphology of the Sella turcica in monozygotic twins
    Twin Research and Human Genetics, 2009
    Co-Authors: Mette Toft Brockjacobsen, Carsten Pallisgaard, Inger Kjaer
    Abstract:

    The purpose was to compare the Sella turcica morphology of individuals within pairs of monozygotic twins with normal karyotype and to analyze the similarity between the observed morphology and the morphology of non-twins at the same age with normal karyotype. Profile radiographs from 84 individuals of 42 twin pairs (18 male and 24 female pairs, aged 18–23 years) comprised the material. Sella turcica measurements from non-twins aged 6–21 years were used as normal reference. Length, depth and diameter of the Sella turcica were measured and controlled by re-measurements. Pearson's correlation coefficient was used for comparison of individuals within twin pairs. For comparison of twins and non-twins, normal standard values for length, depth and diameter were subtracted from the twin values. For the mean values of these differences, confidence limits p values and t values were calculated. The study showed that the size of the Sella turcica may be partly similar and partly dissimilar within the pair of monozygotic twins. Statistical evaluation of the data showed correlations between length, depth and diameter of the Sella turcica between the two twin individuals in the same twin pair. Differences in sizes are observed between individuals in the twin material and individuals in the non-twin material. As a conclusion, the twin males were more similar within the twin pair, but deviated more from the non-twin material than the females. Female twins had more discrepancy within the twin pair, but deviated less from the non-twin material than the males.

  • post natal size and morphology of the Sella turcica in williams syndrome
    European Journal of Ophthalmology, 2004
    Co-Authors: Stefan Axelsson, Kari Storhaug, Inger Kjaer
    Abstract:

    Williams syndrome (WS) is a rare congenital disorder with distinctive craniofacial features, cardiovascular abnormalities, mental retardation, and behaviour characteristics. The purpose of this study was to investigate the size and morphology of the Sella turcica on profile cephalograms in a group of individuals with WS. The material consisted of radiographic cephalograms of 62 Norwegian children, adolescents, and adults with an age range of 4.7–44.4 years. The length, depth, and diameter of the Sella turcica were measured and the mean values were compared with normal reference material from the Oslo University Craniofacial Growth Archive. In total, the two-dimensional size of the Sella turcica in the WS group was smaller in length, depth, and diameter compared with the control group, but only occasionally reached a significance level of 5 per cent (Student's t -test). The morphology of the Sella turcica was assessed and five different morphological types were identified; oblique anterior wall, extremely low Sella turcica, Sella turcica bridging, irregularity (notching) in the posterior part of the dorsum Sellae, and pyramidal shape of the dorsum Sellae. The occurrence of these morphological types was more frequent in the WS subjects compared with the reference material, except for Sella turcica bridging, which was equally frequent. The females with WS had more dysmorphic Sella turcicas than males. This study has demonstrated morphological aberrations in the Sella turcica in Norwegian individuals with WS, which should be further elucidated in future research and combined with neurological andendocrinological investigations.

  • a Sella turcica bridge in subjects with severe craniofacial deviations
    European Journal of Ophthalmology, 2000
    Co-Authors: Jonas P Becktor, Sanna Einersen, Inger Kjaer
    Abstract:

    In earlier studies, a Sella turcica bridge was stated to occur in 1.75 to 6 per cent of the population. The occurrence of a Sella turcica bridge has not previously been studied in a group of patients with craniofacial deviations treated by surgery. Profile radiographs from 177 individuals who had undergone combine orthodontic and surgical treatment at the Copenhagen School of Dentistry were studied. A Sella turcica bridge was registered in those subjects where the radiograph revealed a continuous band of bony tissue from the anterior cranial fossa to the posterior cranial fossa across the Sella turcica. Two types of Sella turcica bridge were identified. A Sella turcica bridge occurred in 18.6 per cent of the subjects.

  • postnatal structure of the Sella turcica in down syndrome
    American Journal of Medical Genetics, 1999
    Co-Authors: Bjorn G Russell, Inger Kjaer
    Abstract:

    The purpose of this study was to analyze the shape of the Sella turcica in a group of patients with Down syndrome and compare the findings with those made earlier in human fetuses with Down syndrome. Profile radiographs from 78 patients (age 4 months to 50 3/12 years) were analyzed. A tracing was made of each Sella turcica, and the shape was compared with that of a normal Sella, including the normal growth pattern from childhood to adulthood. Sella turcica structure could be classified into three morphological types, defined as: type I, almost normal appearance; type II, deviations in the anterior wall; and type III, deviations in the floor of the Sella turcica. Compared with previously registered prenatal structural deviations in the Sella turcica, it can be concluded that the postnatal radiographic material reflects the prenatal findings, because type I, both prenatally and postnatally, is by far the most common, whereas the remaining types are uncommon, both prenatally and postnatally. The study confirms the relevance of prenatal investigations for postnatal diagnostics as previously documented in Sella turcica analyses of prenatal and postnatal myelomeningocele cases.

Evren Öztaş - One of the best experts on this subject based on the ideXlab platform.

  • Incidence of bridging and dimensions of Sella turcica in Class I and III Turkish adult female patients.
    World journal of orthodontics, 2009
    Co-Authors: Gülnaz Marşan, Evren Öztaş
    Abstract:

    : Mineralization of the interclinoid ligament of the Sella turcica, or Sella turcica bridging, has been associated with severe craniofacial deviations. The aim of this study was to evaluate the incidence of Sella turcica bridging, Sella turcica dimensions, and skeletal variables in 57 Class I (mean age, 27.2 ± 5.3 years) and 61 Class III (mean age, 25.8 ± 4.6 years) Turkish adult females. Sella bridging was found in three (5%) of the Class I and 11 (18%) of the Class III individuals (P

  • incidence of bridging and dimensions of Sella turcica in class i and iii turkish adult female patients
    World journal of orthodontics, 2009
    Co-Authors: Gülnaz Marşan, Evren Öztaş
    Abstract:

    : Mineralization of the interclinoid ligament of the Sella turcica, or Sella turcica bridging, has been associated with severe craniofacial deviations. The aim of this study was to evaluate the incidence of Sella turcica bridging, Sella turcica dimensions, and skeletal variables in 57 Class I (mean age, 27.2 ± 5.3 years) and 61 Class III (mean age, 25.8 ± 4.6 years) Turkish adult females. Sella bridging was found in three (5%) of the Class I and 11 (18%) of the Class III individuals (P<.010). The association between Sella turcica bridging and manifest skeletal Class III malocclusions was statistically significant according to the chi-square test (P<.050). No significant differences in Sella turcica dimensions were found between the Class I and Class III patients. Skeletal variables that differed significantly were SNB (P=.004), ANB (P=.002), and NAPg (P=.000) angles and N-B (P=.030), N-Pg (P=.003), Go-Pg (P=.007), and TM-Pg (P=.002) dimensions.

Angelika Stellzigeisenhauer - One of the best experts on this subject based on the ideXlab platform.

  • bridging of the Sella turcica in skeletal class iii subjects
    European Journal of Ophthalmology, 2010
    Co-Authors: Philipp Meyermarcotty, Tobias Reuther, Angelika Stellzigeisenhauer
    Abstract:

    SUMMARY Several investigations have analysed the frequency of Sella turcica anomalies in patients with severe craniofacial deviations. Until now, there have been no studies concerning the prevalence of Sella turcica bridging in homogenous groups of patients. Therefore, the aims of this controlled study were to analyse the prevalence of Sella turcica bridging and measure the size of the Sella turcica in two welldefined groups of Caucasian individuals. In a multicentre retrospective study, 400 pre-treatment lateral cephalograms of adult patients (over 17 years of age) with a skeletal Class III (n = 250, 132 females and 118 males) or a skeletal Class I (n = 150, 94 females and 56 males) malocclusion were analysed. The morphology, length, depth, and diameter of the Sella turcica were investigated. For statistical analysis, chi-square and t-tests were used. Skeletal Class III patients presented a significantly higher rate of Sella turcica bridging, 16.8 per cent ( P = 0.031), in comparison with skeletal Class I patients, whose rate was 9.4 per cent. No differences between females and males were detected for the length, depth, and diameter of the Sella turcica. Bridging of the Sella turcica could be seen radiographically in skeletal Class III subjects.

  • morphology of the Sella turcica in axenfeld rieger syndrome with pitx2 mutation
    Journal of Oral Pathology & Medicine, 2008
    Co-Authors: Philipp Meyermarcotty, Nicole Weisschuh, P Dressler, Jutta Hartmann, Angelika Stellzigeisenhauer
    Abstract:

    Background:  Axenfeld–Rieger syndrome (ARS) is a rare autosomal dominant disorder with an incidence of 1:200 000. Genotype and phenotype are heterogeneous and clinical morphology impresses with variable expressivity. Additionally to the typical craniofacial and dental aberrations anomalies in the morphology of Sella turcica are discussed. Method:  In a multidisciplinary genetic and clinical study four patients of a family with ARS were screened by direct DNA sequencing. Radiographic analysis of the patients was performed for evaluating cranial and dental structures. Additionally, a specific analysis of the morphology of the Sella turcica was made on the radiographs. Results:  Screening for PITX2 and FOXC1 mutations revealed a P64L missense mutation in PITX2 in all four patients. The cephalometric analysis showed a midface hypoplasia associated with a skeletal Class III. All patients showed a Sella turcica bridge combined with a prominent posterior clinoid process followed by a steep clivus and an elongated Sella turcica. Conclusion:  The incidence of a Sella turcica bridge in combination with a PITX2 mutation would suspect that Sella turcica anomalies are typical symptoms of the syndrome. Sella turcica anomalies in association with craniofacial and dental aberrations, such as maxillary retrognathia, skeletal Class III relationship and hypoplasia of teeth, might be important indicators for ARS caused by PITX2 mutation.

Birgit Fischer Hansen - One of the best experts on this subject based on the ideXlab platform.

  • pituitary gland and Sella turcica in human trisomy 21 fetuses related to axial skeletal development
    American Journal of Medical Genetics, 1998
    Co-Authors: Inger Kjaer, Jean W Keeling, Ingermarie Reintoft, Dorrit Nolting, Birgit Fischer Hansen
    Abstract:

    The purpose of the present investigation was to study the Sella turcica/pituitary gland region in trisomy 21 fetuses and to relate the findings in the region to the ossification pattern in the axial skeleton formed by the cranial base and spine. Material from 22 human fetuses with trisomy 21, CRL 80 mm to CRL 190 mm, corresponding to gestational ages from 14 to 21 weeks, was examined and compared with material from gestation-matched normal controls. After radiography, tissue blocks from the cranial base, including the pituitary gland, were examined and compared with those of normal fetuses. Four different types of Sella turcica/pituitary gland morphology were observed. Thirteen fetuses (Type I) were morphologically normal. Minor abnormalities occurred in the Sella turcica and pituitary gland (adenopituitary gland tissue pharyngeally) in six fetuses (Types II and III). There was agreement between the histologically recorded deviations in the Sella turcica and the radiographic observations of the basisphenoid bone. In three cases (Type IV) out of 22, more pronounced structural abnormalities occurred in the Sella turcica, and radiographically the basisphenoid bone appeared cleft. All Sella turcica changes observed in trisomy 21 were situated anteriorly in the base of the Sella. In all cases the basilar part of the occipital bone was normal. Minor changes in the Sella turcica region were mainly accompanied by cervical vertebral abnormalities, while the most severe abnormalities occurred in association with malformations in the lumbar vertebrae. There was no association between Sella turcica malformations and the absence or presence of the nasal bone. Am. J. Med. Genet. 80:494–500, 1998. © 1998 Wiley-Liss, Inc.

  • pituitary gland and Sella turcica in human trisomy 18 fetuses
    American Journal of Medical Genetics, 1998
    Co-Authors: Inger Kjaer, Jean W Keeling, Ingermarie Reintoft, Helle Hjalgrim, Dorrit Nolting, Birgit Fischer Hansen
    Abstract:

    : The purpose of this study was to elucidate the phenotypic conditions in the Sella turcica/pituitary gland complex in human trisomy 18 fetuses. Fourteen human fetuses with gestational ages from 12 to 39 weeks were included in the study. Normal fetuses at corresponding ages were used as controls. Whole body and special radiographic examination was undertaken before the midsagittal cranial base block, including the pituitary gland, was excised and analyzed histologically and immunohistochemically (keratin wide spectrum [KWS], thyroid-stimulating hormone [TSH], and neurophysin [Nph]). In all trisomy 18 fetuses, TSH-positive adenopituitary tissue was present in the Sella and in greater or lesser amounts pharyngeally. The neurohypophysis was Nph-positive and located normally in the Sella turcica. The adenohypophyseal tissue reacted either KWS-faint or KWS-negative, whereas KWS-positive reaction occurs in normal fetuses. This circumstance might suggest an altered cytoskeletal structure of the surface ectoderm in the pituitary placode in trisomy 18. The Sella turcica was malformed in all the fetuses. Very broad craniopharyngeal canals were observed in some of the fetuses. Because endocrine disorders occur in many congenital malformations, it is essential in future studies to chart the Sella turcica/pituitary gland region systematically in different genotypes.

Jonathan C Horton - One of the best experts on this subject based on the ideXlab platform.

  • enlargement of the Sella turcica in pseudotumor cerebri
    Journal of Neurosurgery, 2014
    Co-Authors: Sungeun E Kyung, James V Botelho, Jonathan C Horton
    Abstract:

    Object The Sella turcica usually appears partially empty in MR images obtained from patients with chronic elevation of intracranial pressure. The authors measured the size of the Sella turcica to determine if enlargement of the pituitary fossa explains the partially empty Sella associated with pseudotumor cerebri. Methods The medical records from 2005 to 2011 of a single neuro-ophthalmologist were searched to identify consecutive patients with pseudotumor cerebri. Age-matched control patients were selected from the same practice. The Sella turcica and pituitary gland were measured on sagittal T1-weighted MR images. Results Measurements were obtained for 48 patients with pseudotumor cerebri and 48 controls. The cross-sectional area of the Sella was 38% greater in the patients with pseudotumor cerebri, with only a slight reduction in mean pituitary gland size. Conclusions Chronic elevation of intracranial pressure is associated with bony enlargement of the Sella turcica. Enlargement of the Sella turcica con...

  • enlargement of the Sella turcica in pseudotumor cerebri clinical article escholarship
    2014
    Co-Authors: See Kyung, James V Botelho, Jonathan C Horton
    Abstract:

    Object. The Sella turcica usually appears partially empty in MR images obtained from patients with chronic elevation of intracranial pressure. The authors measured the size of the Sella turcica to determine if enlargement of the pituitary fossa explains the partially empty Sella associated with pseudotumor cerebri. Methods. The medical records from 2005 to 2011 of a single neuro-ophthalmologist were searched to identify consecutive patients with pseudotumor cerebri. Age-matched control patients were selected from the same practice. The Sella turcica and pituitary gland were measured on sagittal T1-weighted MR images. Results. Measurements were obtained for 48 patients with pseudotumor cerebri and 48 controls. The cross-sectional area of the Sella was 38% greater in the patients with pseudotumor cerebri, with only a slight reduction in mean pituitary gland size. Conclusions. Chronic elevation of intracranial pressure is associated with bony enlargement of the Sella turcica. Enlargement of the Sella turcica contributes to its partially empty appearance. ©AANS, 2014.