The Experts below are selected from a list of 462 Experts worldwide ranked by ideXlab platform
Clare J Fowler - One of the best experts on this subject based on the ideXlab platform.
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visceral Sensory Neuroscience interoception
Brain, 2003Co-Authors: Clare J FowlerAbstract:VISCERAL Sensory Neuroscience: INTEROCEPTION By Oliver G. Cameron 2002. Oxford: Oxford University Press Price £39.50. pp. 372. ISBN 0‐19‐513601‐2 Interoception: it is perhaps surprising that this word is not common medical parlance since amongst the other terms introduced by Sherrington, proprioception certainly is. As originally defined interoception encompassed just visceral sensations but now the term is used to include the physiological condition of the entire body and the ability of visceral afferent information to reach awareness and affect behaviour, either directly or indirectly. The system of interoception as a whole constitutes “the material me” and relates to how we perceive feelings from our bodies that determine our mood, sense of well‐being and emotions. Clearly this is a field of great relevance to many areas of medicine, to all branches of “internal medicine” as well medical psychology and possibly some branches of psychiatry. The reason why this term is probably missing from our clinical vocabulary so far is that although we have been aware of the underlying concepts of interoception for decades there have been few methods of systematically studying the underlying principles in humans until the advent of functional imaging. Certainly it has been one of the disappointed aims of clinical neurophysiological research that has been unable to contribute much to our understanding of self‐awareness. This is because all that is accessible to that discipline is the response of large, heavily myelinated fibres, usually to electrical stimuli, whereas the interceptive system afferents are small diameter fibres that can usefully be considered as the afferent limb of the autonomic nervous system. I accepted the offer to …
Patrick Haggard - One of the best experts on this subject based on the ideXlab platform.
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Sensory Neuroscience from skin to object in the somatoSensory cortex
Current Biology, 2006Co-Authors: Patrick HaggardAbstract:Humans can perceive the shape of objects by touch alone, by extracting geometric features such as edges. Recently recorded responses of single neurons in the secondary somatoSensory cortex of monkeys suggest how the brain integrates tactile shape information across different regions of skin and builds up a representation of tactile objects.
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Sensory Neuroscience from skin to object in the somatoSensory
2006Co-Authors: Patrick HaggardAbstract:of FtsZ are regulated by GTP hydrolysis.J. Bacteriol. 182, 164–170.18. Thanedar, S., and Margolin, W. (2004).FtsZ exhibits rapid movement andoscillation waves in helix-like patternsin Escherichia coli. Curr. Biol. 14,1167–1173.19. Michie, K.A., Monahan, L.G., Beech, P.L.,and Harry, E.J. (2006). Trapping ofa spiral-like intermediate of the bacterialcytokinetic protein FtsZ. J. Bacteriol. 188,1680–1690.20. Quardokus, E., Din, N., and Brun, Y.V.(1996). Cell cycle regulation and celltype-specific localization of the FtsZdivision initiation protein in Caulobacter.Proc. Natl. Acad. Sci. USA 93,6314–6319.
Theodore J Price - One of the best experts on this subject based on the ideXlab platform.
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comparative transcriptome profiling of the human and mouse dorsal root ganglia an rna seq based resource for pain and Sensory Neuroscience research
Pain, 2018Co-Authors: A Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Michael Q Zhang, Gregory Dussor, Theodore J PriceAbstract:Molecular neurobiological insight into human nervous tissues is needed to generate next-generation therapeutics for neurological disorders such as chronic pain. We obtained human dorsal root ganglia (hDRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the hDRG transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterized the hDRG transcriptional profile in terms of tissue-restricted gene coexpression patterns and putative transcriptional regulators, and formulated an information-theoretic framework to quantify DRG enrichment. Relevant gene families and pathways were also analyzed, including transcription factors, G-protein-coupled receptors, and ion channels. Our analyses reveal an hDRG-enriched protein-coding gene set (∼140), some of which have not been described in the context of DRG or pain signaling. Most of these show conserved enrichment in mDRG and were mined for known drug-gene product interactions. Conserved enrichment of the vast majority of transcription factors suggests that the mDRG is a faithful model system for studying hDRG, because of evolutionarily conserved regulatory programs. Comparison of hDRG and tibial nerve transcriptomes suggests trafficking of neuronal mRNA to axons in adult hDRG, and are consistent with studies of axonal transport in rodent Sensory neurons. We present our work as an online, searchable repository (https://www.utdallas.edu/bbs/painNeurosciencelab/Sensoryomics/drgtxome), creating a valuable resource for the community. Our analyses provide insight into DRG biology for guiding development of novel therapeutics and a blueprint for cross-species transcriptomic analyses.
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comparative transcriptome profiling of the human and mouse dorsal root ganglia an rna seq based resource for pain and Sensory Neuroscience research
bioRxiv, 2017Co-Authors: A Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Michael Q Zhang, Gregory Dussor, Theodore J PriceAbstract:Molecular neurobiological insight into human nervous tissues is needed to generate next generation therapeutics for neurological disorders like chronic pain. We obtained human Dorsal Root Ganglia (DRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the human DRG (hDRG) transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterize the hDRG transcriptional profile in terms of tissue-restricted gene co-expression patterns and putative transcriptional regulators, and formulate an information-theoretic framework to quantify DRG enrichment. Our analyses reveal an hDRG-enriched protein-coding gene set (~140), some of which have not been described in the context of DRG or pain signaling. A majority of these show conserved enrichment in mDRG, and were mined for known drug - gene product interactions. Comparison of hDRG and tibial nerve transcriptomes suggest pervasive mRNA transport of Sensory neuronal genes to axons in adult hDRG, with potential implications for mechanistic insight into chronic pain in patients. Relevant gene families and pathways were also analyzed, including transcription factors (TFs), g-protein coupled receptors (GCPRs) and ion channels. We present our work as an online, searchable repository (http://www.utdallas.edu/bbs/painNeurosciencelab/DRGtranscriptome), creating a valuable resource for the community. Our analyses provide insight into DRG biology for guiding development of novel therapeutics, and a blueprint for cross-species transcriptomic analyses.
A Torck - One of the best experts on this subject based on the ideXlab platform.
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Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and Sensory Neuroscience research
Pain, 2018Co-Authors: A Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Michael Q ZhangAbstract:Molecular neurobiological insight into human nervous tissues is needed to generate next-generation therapeutics for neurological disorders such as chronic pain. We obtained human dorsal root ganglia (hDRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the hDRG transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterized the hDRG transcriptional profile in terms of tissue-restricted gene coexpression patterns and putative transcriptional regulators, and formulated an information-theoretic framework to quantify DRG enrichment. Relevant gene families and pathways were also analyzed, including transcription factors, G-protein-coupled receptors, and ion channels. Our analyses reveal an hDRG-enriched protein-coding gene set (∼140), some of which have not been described in the context of DRG or pain signaling. Most of these show conserved enrichment in mDRG and were mined for known drug-gene product interactions. Conserved enrichment of the vast majority of transcription factors suggests that the mDRG is a faithful model system for studying hDRG, because of evolutionarily conserved regulatory programs. Comparison of hDRG and tibial nerve transcriptomes suggests trafficking of neuronal mRNA to axons in adult hDRG, and are consistent with studies of axonal transport in rodent Sensory neurons. We present our work as an online, searchable repository (https://www.utdallas.edu/bbs/painNeurosciencelab/Sensoryomics/drgtxome), creating a valuable resource for the community. Our analyses provide insight into DRG biology for guiding development of novel therapeutics and a blueprint for cross-species transcriptomic analyses.
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comparative transcriptome profiling of the human and mouse dorsal root ganglia an rna seq based resource for pain and Sensory Neuroscience research
Pain, 2018Co-Authors: A Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Michael Q Zhang, Gregory Dussor, Theodore J PriceAbstract:Molecular neurobiological insight into human nervous tissues is needed to generate next-generation therapeutics for neurological disorders such as chronic pain. We obtained human dorsal root ganglia (hDRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the hDRG transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterized the hDRG transcriptional profile in terms of tissue-restricted gene coexpression patterns and putative transcriptional regulators, and formulated an information-theoretic framework to quantify DRG enrichment. Relevant gene families and pathways were also analyzed, including transcription factors, G-protein-coupled receptors, and ion channels. Our analyses reveal an hDRG-enriched protein-coding gene set (∼140), some of which have not been described in the context of DRG or pain signaling. Most of these show conserved enrichment in mDRG and were mined for known drug-gene product interactions. Conserved enrichment of the vast majority of transcription factors suggests that the mDRG is a faithful model system for studying hDRG, because of evolutionarily conserved regulatory programs. Comparison of hDRG and tibial nerve transcriptomes suggests trafficking of neuronal mRNA to axons in adult hDRG, and are consistent with studies of axonal transport in rodent Sensory neurons. We present our work as an online, searchable repository (https://www.utdallas.edu/bbs/painNeurosciencelab/Sensoryomics/drgtxome), creating a valuable resource for the community. Our analyses provide insight into DRG biology for guiding development of novel therapeutics and a blueprint for cross-species transcriptomic analyses.
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comparative transcriptome profiling of the human and mouse dorsal root ganglia an rna seq based resource for pain and Sensory Neuroscience research
bioRxiv, 2017Co-Authors: A Torck, Lilyana Quigley, Andi Wangzhou, Matthew Neiman, Michael Q Zhang, Gregory Dussor, Theodore J PriceAbstract:Molecular neurobiological insight into human nervous tissues is needed to generate next generation therapeutics for neurological disorders like chronic pain. We obtained human Dorsal Root Ganglia (DRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the human DRG (hDRG) transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterize the hDRG transcriptional profile in terms of tissue-restricted gene co-expression patterns and putative transcriptional regulators, and formulate an information-theoretic framework to quantify DRG enrichment. Our analyses reveal an hDRG-enriched protein-coding gene set (~140), some of which have not been described in the context of DRG or pain signaling. A majority of these show conserved enrichment in mDRG, and were mined for known drug - gene product interactions. Comparison of hDRG and tibial nerve transcriptomes suggest pervasive mRNA transport of Sensory neuronal genes to axons in adult hDRG, with potential implications for mechanistic insight into chronic pain in patients. Relevant gene families and pathways were also analyzed, including transcription factors (TFs), g-protein coupled receptors (GCPRs) and ion channels. We present our work as an online, searchable repository (http://www.utdallas.edu/bbs/painNeurosciencelab/DRGtranscriptome), creating a valuable resource for the community. Our analyses provide insight into DRG biology for guiding development of novel therapeutics, and a blueprint for cross-species transcriptomic analyses.
Lukas Van Oudenhove - One of the best experts on this subject based on the ideXlab platform.
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visceral Sensory and cognitive affective Neuroscience towards integration
Gut, 2010Co-Authors: Lukas Van OudenhoveAbstract:Despite rapidly growing evidence supporting a link between psychological processes—both cognitive and affective—and visceral sensation in health as well as functional gastrointestinal disorders (FGIDs), the neural mechanisms underlying these interactions remain infrequently studied within the field of ‘neurogastroenterology’ and therefore rather poorly understood.1 The somatic pain field, in contrast, has already made considerable progress in unravelling these complex brain mechanisms by which emotion (eg, anxiety) and cognition (eg, attention) influence the processing and perception of bodily signals.2 More specifically, the amygdala, insula, and cingulate and prefrontal subregions have been shown to be involved in pain–emotion interactions. This knowledge is the result of a fruitful integration between different branches of science within the somatic pain field over the past decades, including psychology, psychiatry, anaesthesiology and the affective, cognitive and Sensory branches of Neuroscience. Such a degree of integration has not been achieved yet within ‘visceral Sensory Neuroscience’ but is, in my opinion, much needed if we really want to move the field forward. This may be especially critical if we want to make progress in the understanding of the multifactorial pathophysiology of complex, symptom-based disorders including FGIDs. Although rather sparse, recent attempts towards such integration have been made, and I will try to situate these against a long tradition of studying the interactions between mind, brain and body underlying visceral sensation. In the present issue of Gut , Elsenbruch and colleagues ( see page 489 ) report on a functional MRI study showing that, in irritable bowel syndrome (IBS), anxiety and …
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Functional brain imaging of gastrointestinal sensation in health and disease
World Journal of Gastroenterology, 2007Co-Authors: Lukas Van Oudenhove, Steven J. Coen, Qasim AzizAbstract:It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive-exert an influence on gastrointestinal sensorimotor function. More specifically, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral Sensory Neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain-gut axis) will be briefly outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted.
