The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Taro Kishi - One of the best experts on this subject based on the ideXlab platform.
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Serotonin 6 Receptor gene and schizophrenia case control study and meta analysis
Human Psychopharmacology-clinical and Experimental, 2012Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M Musso, John M Kane, Christoph U CorrellAbstract:Objectives Several lines of evidence suggest that genetic alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 Receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 Receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. Copyright © 2012 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene is associated with methamphetamine induced psychosis in a japanese population
Drug and Alcohol Dependence, 2011Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Hiroshi Naitoh, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa UchimuraAbstract:Abstract Background Altered serotonergic neural transmission is hypothesized to be a susceptibility factor for psychotic disorders such as schizophrenia. The Serotonin 6 (5-HT6) Receptor is therapeutically targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d -amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-HT6 Receptor antagonist. In addition, the disrupted prepulse inhibition induced by d -amphetamine or phencyclidine was restored by 5-HT6 Receptor antagonist in an animal study using rats. These animal models were considered to reflect the positive symptoms of schizophrenia, and the above evidence suggests that altered 5-HT6 Receptors are involved in the pathophysiology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis. Method Using five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), we conducted a genetic association analysis of case–control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results rs6693503 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this association remained significant after Bonferroni correction. In the haplotype-wise analysis, we detected an association between two markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis patients, respectively. Conclusion HTR6 may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population.
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pharmacogenetic study of Serotonin 6 Receptor gene with antidepressant response in major depressive disorder in the japanese population
Human Psychopharmacology-clinical and Experimental, 2010Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Norio Ozaki, Reiji Yoshimura, Hiroshi Naitoh, Wakako Umenenakano, Jun Nakamura, Nakao IwataAbstract:Objective Several investigations have suggested that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of major depressive disorder (MDD), and that 5-HT6 Receptors might be a therapeutic target for Serotonin selective reuptake inhibitor (SSRI) in MDD. To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample. Methods We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), and performed an association analysis of HTR6 and the efficacy of SSRI treatment in 260 MDD patients. Results We did not detect an association between tagging SNPs in HTR6 and the therapeutic response to SSRI in MDD in allele/genotype or haplotype analysis. Conclusions HTR6 may not play an important role in the pathophysiology of SSRI response in the Japanese population. Because our sample was relatively small, statistical errors were possible in the results of our association analyses. To overcome these limitations, a replication study using a larger sample may be required for conclusive results. Copyright © 2010 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene and mood disorders case control study and meta analysis
Neuroscience Research, 2010Co-Authors: Yasuhisa Fukuo, Taro Kishi, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Wakako UmenenakanoAbstract:Several evidence suggests that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this Receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this Receptor and mood disorders in the future.
Yasuhisa Fukuo - One of the best experts on this subject based on the ideXlab platform.
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Serotonin 6 Receptor gene and schizophrenia case control study and meta analysis
Human Psychopharmacology-clinical and Experimental, 2012Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M Musso, John M Kane, Christoph U CorrellAbstract:Objectives Several lines of evidence suggest that genetic alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 Receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 Receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. Copyright © 2012 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene is associated with methamphetamine induced psychosis in a japanese population
Drug and Alcohol Dependence, 2011Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Hiroshi Naitoh, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa UchimuraAbstract:Abstract Background Altered serotonergic neural transmission is hypothesized to be a susceptibility factor for psychotic disorders such as schizophrenia. The Serotonin 6 (5-HT6) Receptor is therapeutically targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d -amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-HT6 Receptor antagonist. In addition, the disrupted prepulse inhibition induced by d -amphetamine or phencyclidine was restored by 5-HT6 Receptor antagonist in an animal study using rats. These animal models were considered to reflect the positive symptoms of schizophrenia, and the above evidence suggests that altered 5-HT6 Receptors are involved in the pathophysiology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis. Method Using five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), we conducted a genetic association analysis of case–control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results rs6693503 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this association remained significant after Bonferroni correction. In the haplotype-wise analysis, we detected an association between two markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis patients, respectively. Conclusion HTR6 may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population.
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pharmacogenetic study of Serotonin 6 Receptor gene with antidepressant response in major depressive disorder in the japanese population
Human Psychopharmacology-clinical and Experimental, 2010Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Norio Ozaki, Reiji Yoshimura, Hiroshi Naitoh, Wakako Umenenakano, Jun Nakamura, Nakao IwataAbstract:Objective Several investigations have suggested that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of major depressive disorder (MDD), and that 5-HT6 Receptors might be a therapeutic target for Serotonin selective reuptake inhibitor (SSRI) in MDD. To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample. Methods We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), and performed an association analysis of HTR6 and the efficacy of SSRI treatment in 260 MDD patients. Results We did not detect an association between tagging SNPs in HTR6 and the therapeutic response to SSRI in MDD in allele/genotype or haplotype analysis. Conclusions HTR6 may not play an important role in the pathophysiology of SSRI response in the Japanese population. Because our sample was relatively small, statistical errors were possible in the results of our association analyses. To overcome these limitations, a replication study using a larger sample may be required for conclusive results. Copyright © 2010 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene and mood disorders case control study and meta analysis
Neuroscience Research, 2010Co-Authors: Yasuhisa Fukuo, Taro Kishi, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Wakako UmenenakanoAbstract:Several evidence suggests that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this Receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this Receptor and mood disorders in the future.
Tsuyoshi Kitajima - One of the best experts on this subject based on the ideXlab platform.
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Serotonin 6 Receptor gene and schizophrenia case control study and meta analysis
Human Psychopharmacology-clinical and Experimental, 2012Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M Musso, John M Kane, Christoph U CorrellAbstract:Objectives Several lines of evidence suggest that genetic alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 Receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 Receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. Copyright © 2012 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene is associated with methamphetamine induced psychosis in a japanese population
Drug and Alcohol Dependence, 2011Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Hiroshi Naitoh, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa UchimuraAbstract:Abstract Background Altered serotonergic neural transmission is hypothesized to be a susceptibility factor for psychotic disorders such as schizophrenia. The Serotonin 6 (5-HT6) Receptor is therapeutically targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d -amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-HT6 Receptor antagonist. In addition, the disrupted prepulse inhibition induced by d -amphetamine or phencyclidine was restored by 5-HT6 Receptor antagonist in an animal study using rats. These animal models were considered to reflect the positive symptoms of schizophrenia, and the above evidence suggests that altered 5-HT6 Receptors are involved in the pathophysiology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis. Method Using five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), we conducted a genetic association analysis of case–control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results rs6693503 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this association remained significant after Bonferroni correction. In the haplotype-wise analysis, we detected an association between two markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis patients, respectively. Conclusion HTR6 may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population.
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pharmacogenetic study of Serotonin 6 Receptor gene with antidepressant response in major depressive disorder in the japanese population
Human Psychopharmacology-clinical and Experimental, 2010Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Norio Ozaki, Reiji Yoshimura, Hiroshi Naitoh, Wakako Umenenakano, Jun Nakamura, Nakao IwataAbstract:Objective Several investigations have suggested that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of major depressive disorder (MDD), and that 5-HT6 Receptors might be a therapeutic target for Serotonin selective reuptake inhibitor (SSRI) in MDD. To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample. Methods We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), and performed an association analysis of HTR6 and the efficacy of SSRI treatment in 260 MDD patients. Results We did not detect an association between tagging SNPs in HTR6 and the therapeutic response to SSRI in MDD in allele/genotype or haplotype analysis. Conclusions HTR6 may not play an important role in the pathophysiology of SSRI response in the Japanese population. Because our sample was relatively small, statistical errors were possible in the results of our association analyses. To overcome these limitations, a replication study using a larger sample may be required for conclusive results. Copyright © 2010 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene and mood disorders case control study and meta analysis
Neuroscience Research, 2010Co-Authors: Yasuhisa Fukuo, Taro Kishi, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Wakako UmenenakanoAbstract:Several evidence suggests that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this Receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this Receptor and mood disorders in the future.
Tomo Okochi - One of the best experts on this subject based on the ideXlab platform.
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Serotonin 6 Receptor gene and schizophrenia case control study and meta analysis
Human Psychopharmacology-clinical and Experimental, 2012Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M Musso, John M Kane, Christoph U CorrellAbstract:Objectives Several lines of evidence suggest that genetic alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 Receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 Receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. Copyright © 2012 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene is associated with methamphetamine induced psychosis in a japanese population
Drug and Alcohol Dependence, 2011Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Hiroshi Naitoh, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa UchimuraAbstract:Abstract Background Altered serotonergic neural transmission is hypothesized to be a susceptibility factor for psychotic disorders such as schizophrenia. The Serotonin 6 (5-HT6) Receptor is therapeutically targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d -amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-HT6 Receptor antagonist. In addition, the disrupted prepulse inhibition induced by d -amphetamine or phencyclidine was restored by 5-HT6 Receptor antagonist in an animal study using rats. These animal models were considered to reflect the positive symptoms of schizophrenia, and the above evidence suggests that altered 5-HT6 Receptors are involved in the pathophysiology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis. Method Using five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), we conducted a genetic association analysis of case–control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results rs6693503 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this association remained significant after Bonferroni correction. In the haplotype-wise analysis, we detected an association between two markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis patients, respectively. Conclusion HTR6 may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population.
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pharmacogenetic study of Serotonin 6 Receptor gene with antidepressant response in major depressive disorder in the japanese population
Human Psychopharmacology-clinical and Experimental, 2010Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Norio Ozaki, Reiji Yoshimura, Hiroshi Naitoh, Wakako Umenenakano, Jun Nakamura, Nakao IwataAbstract:Objective Several investigations have suggested that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of major depressive disorder (MDD), and that 5-HT6 Receptors might be a therapeutic target for Serotonin selective reuptake inhibitor (SSRI) in MDD. To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample. Methods We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), and performed an association analysis of HTR6 and the efficacy of SSRI treatment in 260 MDD patients. Results We did not detect an association between tagging SNPs in HTR6 and the therapeutic response to SSRI in MDD in allele/genotype or haplotype analysis. Conclusions HTR6 may not play an important role in the pathophysiology of SSRI response in the Japanese population. Because our sample was relatively small, statistical errors were possible in the results of our association analyses. To overcome these limitations, a replication study using a larger sample may be required for conclusive results. Copyright © 2010 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene and mood disorders case control study and meta analysis
Neuroscience Research, 2010Co-Authors: Yasuhisa Fukuo, Taro Kishi, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Wakako UmenenakanoAbstract:Several evidence suggests that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this Receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this Receptor and mood disorders in the future.
Kunihiro Kawashima - One of the best experts on this subject based on the ideXlab platform.
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Serotonin 6 Receptor gene and schizophrenia case control study and meta analysis
Human Psychopharmacology-clinical and Experimental, 2012Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M Musso, John M Kane, Christoph U CorrellAbstract:Objectives Several lines of evidence suggest that genetic alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 Receptors and schizophrenia both in a case-control study and a meta-analysis. Methods We conducted an association study of the 5-HT6 Receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011. Results There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia. Conclusions Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. Copyright © 2012 John Wiley & Sons, Ltd.
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Serotonin 6 Receptor gene is associated with methamphetamine induced psychosis in a japanese population
Drug and Alcohol Dependence, 2011Co-Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Hiroshi Naitoh, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa UchimuraAbstract:Abstract Background Altered serotonergic neural transmission is hypothesized to be a susceptibility factor for psychotic disorders such as schizophrenia. The Serotonin 6 (5-HT6) Receptor is therapeutically targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d -amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-HT6 Receptor antagonist. In addition, the disrupted prepulse inhibition induced by d -amphetamine or phencyclidine was restored by 5-HT6 Receptor antagonist in an animal study using rats. These animal models were considered to reflect the positive symptoms of schizophrenia, and the above evidence suggests that altered 5-HT6 Receptors are involved in the pathophysiology of psychotic disorders. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis. Method Using five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), we conducted a genetic association analysis of case–control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results rs6693503 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this association remained significant after Bonferroni correction. In the haplotype-wise analysis, we detected an association between two markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis patients, respectively. Conclusion HTR6 may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population.
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Serotonin 6 Receptor gene and mood disorders case control study and meta analysis
Neuroscience Research, 2010Co-Authors: Yasuhisa Fukuo, Taro Kishi, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Wakako UmenenakanoAbstract:Several evidence suggests that alterations in Serotonin 6 (5-HT6) Receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this Receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this Receptor and mood disorders in the future.
