The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform
Jhillu S. Yadav - One of the best experts on this subject based on the ideXlab platform.
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Crafts
2014Co-Authors: Jhillu S. Yadav, Divya C. Vani, N. Bhasker, B. Subba V. ReddyAbstract:A very short and efficient stereoselective total synthesis of a macrocyclic ketone, 11β-methoxy-curvularin was achieved by employing the Sharpless Asymmetric Epoxidation, formation of propargyl alcohols from an epoxy-chloride, and intramolecular Friedel-Crafts acylation as the key steps
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Stereoselective Total Synthesis of (+)‐Hyptolide.
ChemInform, 2014Co-Authors: Gowravaram Sabitha, Atla Raju, C. Nagendra Reddy, Jhillu S. YadavAbstract:The total synthesis of (+)-(I) was completed from 3-butyn-1-ol with an overall yield of 7% relying on regioselective epoxide opening, Sharpless Asymmetric Epoxidation, aldehyde-alkyne coupling, and ring-closing metathesis reactions as key steps.
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Stereoselective Synthesis of the C31–C41 Spirolactam Fragment of Sanglifehrin A
European Journal of Organic Chemistry, 2013Co-Authors: Jhillu S. Yadav, Aala Kavita, Debendra K. MohapatraAbstract:A stereoselective synthesis of the spirolactam fragment (C31–C41) of a highly-potent immunosuppressant sanglifehrin A is described. The key steps involved in this synthesis are a desymmetrization protocol, Sharpless Asymmetric Epoxidation, Crimmins syn aldol reaction, Barton–McCombie deoxygenation, and acid-mediated spirolactamization.
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Toward the synthesis of tulearin C: stereoselective synthesis of the C1–C18 macrolactone core
Tetrahedron Letters, 2013Co-Authors: Jhillu S. Yadav, M. Venkatesh, N. Swapnil, Attaluri R. PrasadAbstract:The Asymmetric and convergent synthesis of fully functionalized macrocyclic core of tulearin C is described. Sharpless Asymmetric Epoxidation, Gillman’s reaction, olefin cross metathesis, α aminoxylation, and ring closing metathesis reactions are the key steps utilized in the synthesis of macrolactone.
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First stereoselective total synthesis of decytospolides A and B
Tetrahedron Letters, 2012Co-Authors: P. Janardhan Reddy, Jhillu S. Yadav, A. Srinivas Reddy, B. V. Subba ReddyAbstract:The first stereoselective total synthesis of decytospolides A and B has been accomplished starting from n-hexanal. The key steps involved in this synthesis are Horner–Wittig reaction, Sharpless Asymmetric Epoxidation, and oxa-Michael reaction.
Srivari Chandrasekhar - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective synthesis of the C5–C23 segment of biselyngbyaside
Tetrahedron Letters, 2013Co-Authors: Srivari Chandrasekhar, Gontla Rajesh, Tumma NareshAbstract:Abstract Stereo and enantioselective synthesis of C5–C23 fragment of cytotoxic marine natural product biselyngbyaside is achieved using E -selective methyl lithium addition onto enyne, Crimmin’s acetate aldol reaction, Sharpless Asymmetric Epoxidation, and Julia–Kocienski olefination as the key steps.
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Asymmetric Syntheses of All Stereoisomers of 3-Hydroxyproline; A Constituent of Several Bioactive Compounds
Synthesis, 2012Co-Authors: Togapur Pavan Kumar, Srivari ChandrasekharAbstract:Synthesis of an unusual β-hydroxy-α-amino acid, 3-hydroxyproline, and its derivatives have been achieved enantioselectively by employing Sharpless Asymmetric Epoxidation and reductive cyclization as the key steps.
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Total synthesis of arenamide A and its diastereomer
Tetrahedron Letters, 2009Co-Authors: Srivari Chandrasekhar, Gangireddy Pavankumarreddy, Kurapati SathishAbstract:Arenamide A and its diastereomer have been synthesized in a convergent fashion. The key steps involved in this synthesis are Sharpless Asymmetric Epoxidation, C-C bond formation, and macrolactamization.
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Spirastrellolide B: the synthesis of southern (C9-C25) region.
Organic letters, 2008Co-Authors: Srivari Chandrasekhar, Chegondi Rambabu, Annareddy Syamprasad ReddyAbstract:A combination of “chiron” and “Asymmetric” approaches is utilized to construct the southern (C9−C25) region of marine natural product spirastrellolide B. The key functionalities are derived from d-glucose and Sharpless Asymmetric Epoxidation and dihydroxylation.
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Total synthesis of (−)-lentiginosine
Tetrahedron: Asymmetry, 2008Co-Authors: Srivari Chandrasekhar, B.v.d. Vijaykumar, T.v. PratapAbstract:Abstract The total synthesis of (−)-lentignosine is achieved from d -glyceraldehyde in good yields involving a Sharpless Asymmetric Epoxidation and a one-pot indolizidine construction strategy.
Pradeep Kumar - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective synthesis of (+)-L-733,060
Tetrahedron: Asymmetry, 2007Co-Authors: Shijo K. Cherian, Pradeep KumarAbstract:Abstract An efficient enantioselective synthesis of (+)- l -733,060 from cinnamyl alcohol is described. The key steps include a Sharpless Asymmetric Epoxidation, a regioselective allyl opening of an epoxide and piperidine ring formation via a one pot Staudinger/aza-Wittig reaction.
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Enantio- and diastereocontrolled total synthesis of (+)-boronolide.
The Journal of organic chemistry, 2006Co-Authors: Pradeep Kumar, S. Vasudeva NaiduAbstract:An efficient stereoselective total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless Asymmetric hydroxylation, a chelation-controlled vinyl Grignard reaction followed by a Sharpless Asymmetric Epoxidation, hydrolytic kinetic resolution, and a ring-closing metathesis.
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Stereoselective synthesis of (+)-boronolide
Tetrahedron Letters, 2005Co-Authors: S. Vasudeva Naidu, Priti Gupta, Pradeep KumarAbstract:Abstract An efficient enantio- and stereocontrolled total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless Asymmetric dihydroxylation, a chelation controlled Grignard reaction followed by Sharpless Asymmetric Epoxidation and a ring closing metathesis.
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Enantioselective synthesis of (−)-galantinic acid
Tetrahedron Letters, 2004Co-Authors: Satyendra Kumar Pandey, Subbarao V. Kandula, Pradeep KumarAbstract:Abstract An efficient enantioselective synthesis of (−)-galantinic acid 1 , a non-proteogenic amino acid is described using Sharpless Asymmetric Epoxidation, dihydroxylation and the regioselective nucleophilic opening of a cyclic sulfite as the key steps.
Kunio Ogasawara - One of the best experts on this subject based on the ideXlab platform.
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Chiral modification of adamantane
Tetrahedron Letters, 2002Co-Authors: Masatoshi Shibuya, Michiyasu Takahashi, Takahiko Taniguchi, Kunio OgasawaraAbstract:Abstract Three optically active adamantane derivatives have been constructed starting from meso 7-methylidenebicyclo[3.3.1]nonan-3-one by employing two chirality induction processes, Asymmetric aldolization and Sharpless Asymmetric Epoxidation.
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Katsuki–Sharpless Asymmetric Epoxidation of alkenylethylene glycols: the origin of inverted stereoselection
J. Chem. Soc. Chem. Commun., 1994Co-Authors: T. Yoshimitsu, Kunio OgasawaraAbstract:The Katsuki–Sharpless Asymmetric Epoxidation of linear and cyclic alkenylethylene glycols has led to a conclusion that the origin of the inverted stereoselection is due to the simultaneous coordination between both hydroxy groups of the glycol substrates and both titanium atoms in the Ti2(tartrate)2 complex.
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katsuki Sharpless Asymmetric Epoxidation of alkenylethylene glycols the origin of inverted stereoselection
Journal of The Chemical Society Chemical Communications, 1994Co-Authors: T. Yoshimitsu, Kunio OgasawaraAbstract:The Katsuki–Sharpless Asymmetric Epoxidation of linear and cyclic alkenylethylene glycols has led to a conclusion that the origin of the inverted stereoselection is due to the simultaneous coordination between both hydroxy groups of the glycol substrates and both titanium atoms in the Ti2(tartrate)2 complex.
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Katsuki-Sharpless Asymmetric Epoxidation of allylic-homoallylic alcohols sharing the central olefinic bond
Tetrahedron Letters, 1992Co-Authors: Seiichi Takano, M. Setoh, Michiyasu Takahashi, Kunio OgasawaraAbstract:Abstract Katsuki-Sharpless Asymmetric Epoxidation of four isomeric chiral allylic-homoallylic diols sharing the central olefinic bond has been examined. Among these, three heptenediols having (3 E ,2 R ,6 R ), (3 E ,2 R ,6 S ), and (3 Z ,2 R ,6 R ) configurations underwent diastereospecific Epoxidation to give the corresponding epoxides each as a single epimer in the presence of L-DIPT, but the diol having (3 Z ,2 R ,6 S ) configuration did not show high diastereoselection in the presence of either L- or D-DIPT. Interestingly, (3 Z ,2 R ,6 R )-diol afforded the same epoxide irrespective of the chirality of DIPT used.
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an enantio and stereo controlled synthesis of l erythro and d threo c18 sphingosines via the anomalous version of the katsuki Sharpless Asymmetric Epoxidation reaction
Journal of The Chemical Society Chemical Communications, 1991Co-Authors: Seiichi Takano, Yoshiharu Iwabuchi, Kunio OgasawaraAbstract:A new enantiocontrolled synthesis of L-erythro- and D-threo-sphingosines has been established starting from (R,R)- and meso-1,2-divinylethylene glycols via the anomalous version of the Katsuki–Sharpless Asymmetric Epoxidation reaction as the key step.
Wei-shan Zhou - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of the natural goniodiol-8-monoacetate from cinnamyl alcohol
Journal of The Chemical Society Chemical Communications, 1995Co-Authors: Zhi-cai Yang, Wei-shan ZhouAbstract:The first total synthesis of goniodiol-8-monoacetate, using the Sharpless Asymmetric Epoxidation starting from cinnamyl alcohol in twelve steps with an overall yield of 7%, is achieved.
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Preparation of optically active α-pyrryl carbinols by kinetic resolution using the modified Sharpless Asymmetric Epoxidation reagent
Tetrahedron: Asymmetry, 1991Co-Authors: Wei-shan Zhou, Dong WeiAbstract:Abstract Kinetic resolution of α-pyrryl carbinol was carried out by using the modified Sharpless Asymmetric Epoxidation reagent to give the slow-reacting enantioners, (R)- 3 a–f and (S)-3b,d in high enantioselectivity (>90%e.e.) and high chemical yield (30–43%).
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An efficient preparation of optically active α-furfuryl amide by kinetic resolution using the modified Sharpless Asymmetric Epoxidation reagent
Tetrahedron Letters, 1991Co-Authors: Wei-shan Zhou, Zhi-min WangAbstract:Abstract Kinetic resolution of α-furfuryl amide was first carried out by using the modified Sharpless Asymmetric Epoxidation reagent to give the slow-reacting enantiomers, (S)-1a–h and (R)-1b,f in high enantioselectivity(90–100% e.e) and high chemical yield (45–50%). Similar results were obtained from the fast-reacting enantiomers. This kinetic resolution exhibits the reversed enantioselectivity.