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Ben Z. Pilch - One of the best experts on this subject based on the ideXlab platform.
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Chronic sclerosing Sialadenitis (Küttner tumor) is an IgG4-associated disease.
The American journal of surgical pathology, 2010Co-Authors: Julia T. Geyer, Judith A. Ferry, Nancy L. Harris, John H. Stone, Lawrence R. Zukerberg, Gregory Y. Lauwers, Ben Z. Pilch, Vikram DeshpandeAbstract:BackgroundChronic sclerosing Sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior Asian study proposed that chronic sclerosing Sialadenitis is a part of the spectrum of IgG4-associated disease. This association has not been conf
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marginal zone b cell lymphoma of the salivary gland arising in chronic sclerosing Sialadenitis kuttner tumor
The American Journal of Surgical Pathology, 2001Co-Authors: Erin R Ochoa, Nancy Lee Harris, Ben Z. PilchAbstract:We report a case of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type of the salivary gland arising in a background of chronic sclerosing Sialadenitis. Chronic sclerosing Sialadenitis is a common fibrosing chronic inflammatory lesion of the submandibular gland, which is thought to be the result of sialolithiasis, and is not associated with a systemic autoimmune disease. Salivary MALT lymphomas are typically associated with lymphoepithelial Sialadenitis (LESA) in a patient with or without Sjogren's syndrome. Our case of salivary MALT lymphoma was neither preceded by Sjogren's syndrome nor accompanied by LESA. This case suggests that chronic inflammatory processes other than Sjogren's syndrome may provide a substrate for the development of MALT lymphoma.
Timo Atula - One of the best experts on this subject based on the ideXlab platform.
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Sclerosing Sialadenitis of the submandibular gland is rarely an immunoglobulin G4-related disease in the Finnish population
Modern Pathology, 2020Co-Authors: Elin Peuraharju, Riitta Saarinen, Katri Aro, Laura K. Mäkinen, Jussi Tarkkanen, Antti Mäkitie, Caj Haglund, Jaana Hagström, Timo AtulaAbstract:Chronic sclerosing Sialadenitis may represent one of many manifestations of an immunoglobulin G4–related disease. However, existing studies typically consist of small patient cohorts rarely conducted in Western populations. The clinical behavior of chronic sclerosing Sialadenitis, including follow-up data, warrants further study. Thus, we aimed to determine whether chronic sclerosing Sialadenitis always presents as IgG4-related disease or associates with autoimmune diseases and to determine which additional examinations patients may require. Between 2000 and 2017, 51 patients undergoing submandibular gland resection within the Helsinki University Hospital area were diagnosed with chronic sclerosing Sialadenitis. We re-evaluated all specimens and performed immunostaining for IgG4. IgG and CD31 stainings were performed for IgG4-positive specimens. IgG4-related disease diagnosis was defined by the Boston consensus statement criteria. We revised clinical data, distributing a follow-up questionnaire to patients to register symptoms of IgG4-related disease or autoimmune disease during follow-up. The chronic sclerosing Sialadenitis criteria were fulfilled in 34 patients, whereby 17 were diagnosed as non-sclerosing chronic Sialadenitis. In 19 cases, a sialolith associated with a salivary gland lesion. In total, 12 of 51 cases were recognized as IgG4-positive, while two met the criteria for IgG4-related disease. These two cases belonged to the non-sclerosing chronic Sialadenitis group, and both involved other organs. The histopathological features between chronic sclerosing Sialadenitis and non-sclerosing chronic Sialadenitis overlapped regarding the degree of fibrosis and inflammatory infiltrates. In the Finnish population, chronic sclerosing Sialadenitis of the submandibular gland does not appear to present as IgG4-related disease. Non-sclerosing chronic Sialadenitis can associate with IgG4-related disease. A histopathological distinction between chronic sclerosing Sialadenitis and non-sclerosing chronic Sialadenitis is not always unequivocal and the presence of a sialolith does not exclude IgG4-positivity. Therefore, immunostaining for IgG4 should be performed when dense plasma cell infiltration is present in either non-sclerosing chronic Sialadenitis or chronic sclerosing Sialadenitis.
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Sclerosing Sialadenitis of the submandibular gland is rarely an immunoglobulin G4-related disease in the Finnish population.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology Inc, 2019Co-Authors: Elin Peuraharju, Riitta Saarinen, Katri Aro, Laura K. Mäkinen, Jussi Tarkkanen, Antti Mäkitie, Caj Haglund, Jaana Hagström, Timo AtulaAbstract:Chronic sclerosing Sialadenitis may represent one of many manifestations of an immunoglobulin G4–related disease. However, existing studies typically consist of small patient cohorts rarely conducted in Western populations. The clinical behavior of chronic sclerosing Sialadenitis, including follow-up data, warrants further study. Thus, we aimed to determine whether chronic sclerosing Sialadenitis always presents as IgG4-related disease or associates with autoimmune diseases and to determine which additional examinations patients may require. Between 2000 and 2017, 51 patients undergoing submandibular gland resection within the Helsinki University Hospital area were diagnosed with chronic sclerosing Sialadenitis. We re-evaluated all specimens and performed immunostaining for IgG4. IgG and CD31 stainings were performed for IgG4-positive specimens. IgG4-related disease diagnosis was defined by the Boston consensus statement criteria. We revised clinical data, distributing a follow-up questionnaire to patients to register symptoms of IgG4-related disease or autoimmune disease during follow-up. The chronic sclerosing Sialadenitis criteria were fulfilled in 34 patients, whereby 17 were diagnosed as non-sclerosing chronic Sialadenitis. In 19 cases, a sialolith associated with a salivary gland lesion. In total, 12 of 51 cases were recognized as IgG4-positive, while two met the criteria for IgG4-related disease. These two cases belonged to the non-sclerosing chronic Sialadenitis group, and both involved other organs. The histopathological features between chronic sclerosing Sialadenitis and non-sclerosing chronic Sialadenitis overlapped regarding the degree of fibrosis and inflammatory infiltrates. In the Finnish population, chronic sclerosing Sialadenitis of the submandibular gland does not appear to present as IgG4-related disease. Non-sclerosing chronic Sialadenitis can associate with IgG4-related disease. A histopathological distinction between chronic sclerosing Sialadenitis and non-sclerosing chronic Sialadenitis is not always unequivocal and the presence of a sialolith does not exclude IgG4-positivity. Therefore, immunostaining for IgG4 should be performed when dense plasma cell infiltration is present in either non-sclerosing chronic Sialadenitis or chronic sclerosing Sialadenitis.
William R. Ryan - One of the best experts on this subject based on the ideXlab platform.
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Sialadenitis without sialolithiasis prospective outcomes after sialendoscopy assisted salivary duct surgery
Laryngoscope, 2017Co-Authors: Elise A. Delagnes, Jolie L. Chang, Annick Aubinpouliot, Melissa Zheng, William R. RyanAbstract:Objectives To prospectively assess symptoms before and after sialendoscopy-assisted salivary duct surgery (SASDS) in patients with symptomatic Sialadenitis without sialolithiasis. Study Design Prospective cohort study. Methods Patients with chronic obstructive Sialadenitis without sialolithiasis (COSWS) completed the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire prior to SASDS and 3 months postoperatively. Results Of 80 consecutive patients in a 20-month period, 20 surveyed patients underwent SASDS for COSWS in 37 symptomatic glands. Major symptom improvement (> 10 COSS score reduction) was reported in 24 of 37 (65%) of all glands, including 14 of 21 (67%) of radioactive iodine (RAI)-induced cases and 10 of 13 (77%) of idiopathic Sialadenitis cases. A significant reduction in postoperative mean COSS scores was seen overall (12.6 points, standard deviation [SD] 19.3, P < 0.05 to a post-SASDS mean score of 26.6). However, 19 of 37 (51%) glands demonstrated postoperative COSS scores above 25, denoting persistent disease. Mean COSS score reductions in RAI-induced Sialadenitis (12.4 points, SD 22.7, P < 0.05) and idiopathic Sialadenitis (16.3 points, SD 13.7, P < 0.005) groups were significant, with post-SASDS COSS mean scores of 30.6 (SD 19.8) and 20.8 (SD 13.8), respectively. Ducts with stenoses treated with dilation or sialodochoplasty showed significant COSS improvements of 21.1 (SD 17.9) and 12.4 points (SD 10.7), respectively (P < 0.05). In a multivariate analysis, both the presence of stenosis and sialodochoplasty were independent predictors of complete or partial resolution (post-COSS score < 25) and major symptom improvement (P < 0.05). Conclusion SASDS provides short-term symptom reduction in patients with COSWS; particularly in RAI-induced and idiopathic Sialadenitis, and in duct stenosis amenable to dilation or sialodochoplasty. However, approximately half of the glands did not achieve meaningful symptom resolution. Level of Evidence 4 Laryngoscope, 127:1073–1079, 2017
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Sialendoscopy-assisted surgery and the chronic obstructive Sialadenitis symptoms questionnaire: A prospective study
The Laryngoscope, 2016Co-Authors: Annick Aubin-pouliot, Elise A. Delagnes, Jolie L. Chang, William R. RyanAbstract:Objectives/Hypothesis To prospectively assess symptoms of obstructive Sialadenitis before and after sialendoscopy-assisted salivary duct surgery (SASDS) using the chronic obstructive Sialadenitis symptoms (COSS) questionnaire to determine and predict impact of interventions. Study Design Prospective cohort study. Methods Adult patients with chronic obstructive Sialadenitis who underwent SASDS were asked to complete the COSS questionnaire and the Short-Form-8 (SF-8) quality-of-life (QOL) survey prior to surgery and 3 months postoperatively. Chronic obstructive Sialadenitis symptoms surveys were scored on a scale from 0 to 100. Results Forty patients undergoing SASDS, including 54 glands, completed preoperative and postoperative surveys. Overall, the mean COSS score improved from 36.1 (standard error of the mean [SEM] 2.6) preoperatively to 13.5 (SEM 2.4) 3 months postoperatively (p < 0.001). Submandibular gland cases had a significant mean score reduction of 27.8 (from 38.1 to 10.3; p < 0.005). Parotid gland cases had a significant mean score reduction of 13.6 (from 32.6 to 19.0; p < 0.0001). Patients with sialolithiasis-related Sialadenitis had greater COSS score improvement after surgery than those with radioactive iodine- or inflammatory-related disease. An improvement in symptoms was seen for 100% and 47% of patients with sialolithiasis and inflammatory etiologies, respectively. The pre- and post-SASDS SF-8 QOL scores were not significantly different. Conclusions Obstructive Sialadenitis-related symptoms significantly declined 3 months after SASDS. The COSS questionnaire was able to measure changes in Sialadenitis symptoms not captured in the SF-8 QOL survey. This is the first study to prospectively survey Sialadenitis-specific symptoms to determine impact of surgical interventions. Level of Evidence 4. Laryngoscope, 2016
Vikram Deshpande - One of the best experts on this subject based on the ideXlab platform.
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Chronic sclerosing Sialadenitis (Küttner tumor) is an IgG4-associated disease.
The American journal of surgical pathology, 2010Co-Authors: Julia T. Geyer, Judith A. Ferry, Nancy L. Harris, John H. Stone, Lawrence R. Zukerberg, Gregory Y. Lauwers, Ben Z. Pilch, Vikram DeshpandeAbstract:BackgroundChronic sclerosing Sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior Asian study proposed that chronic sclerosing Sialadenitis is a part of the spectrum of IgG4-associated disease. This association has not been conf
Young-mo Kim - One of the best experts on this subject based on the ideXlab platform.
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salivary gland function after sialendoscopy for treatment of chronic radioiodine induced Sialadenitis
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2016Co-Authors: Young-mo Kim, Jeong-seok Choi, In Young Hyun, Seong Bin Hong, Jaeyoul LimAbstract:Background The purpose of this study was to determine whether sialendoscopy could ameliorate radioactive iodine-induced obstructive Sialadenitis and restore the salivary gland dysfunction in recalcitrant radioactive iodine Sialadenitis. Methods Ten patients with 15 parotid glands of chronic radioactive iodine Sialadenitis who did not respond to medical treatment were enrolled in this prospective study. We assessed subjective symptom scores and evaluated the objective salivary gland functions before and 3 months after sialendoscopy. Results The post-sialendoscopic obstructive symptoms were significantly improved relative to pre-sialendoscopy (p = .009). Xerostomia-related symptom scores post-sialendoscopy did not differ significantly from the pre-sialendoscopy scores. Stimulated salivary flow rate post-sialendoscopy tended to increase relative to pre-sialendoscopy. No pre-sialendoscopic parameters associated with salivary uptake and secretion by salivary gland scintigraphy were significantly improved post-sialendoscopy. Conclusion These results show that sialendoscopy can improve obstructive symptoms; however, it seems to have some limitations for relief of xerostomia and improvement of salivary gland dysfunctions in recalcitrant chronic radioactive iodine Sialadenitis. © 2015 Wiley Periodicals, Inc. Head Neck 38: 51–58, 2016
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Salivary gland function after sialendoscopy for treatment of chronic radioiodine‐induced Sialadenitis
Head & neck, 2015Co-Authors: Young-mo Kim, Jeong-seok Choi, Seong Bin Hong, In Young Hyun, Jaeyoul LimAbstract:Background The purpose of this study was to determine whether sialendoscopy could ameliorate radioactive iodine-induced obstructive Sialadenitis and restore the salivary gland dysfunction in recalcitrant radioactive iodine Sialadenitis. Methods Ten patients with 15 parotid glands of chronic radioactive iodine Sialadenitis who did not respond to medical treatment were enrolled in this prospective study. We assessed subjective symptom scores and evaluated the objective salivary gland functions before and 3 months after sialendoscopy. Results The post-sialendoscopic obstructive symptoms were significantly improved relative to pre-sialendoscopy (p = .009). Xerostomia-related symptom scores post-sialendoscopy did not differ significantly from the pre-sialendoscopy scores. Stimulated salivary flow rate post-sialendoscopy tended to increase relative to pre-sialendoscopy. No pre-sialendoscopic parameters associated with salivary uptake and secretion by salivary gland scintigraphy were significantly improved post-sialendoscopy. Conclusion These results show that sialendoscopy can improve obstructive symptoms; however, it seems to have some limitations for relief of xerostomia and improvement of salivary gland dysfunctions in recalcitrant chronic radioactive iodine Sialadenitis. © 2015 Wiley Periodicals, Inc. Head Neck 38: 51–58, 2016
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Sialoendoscopic treatment for radioiodine induced Sialadenitis.
The Laryngoscope, 2007Co-Authors: Jae-won Kim, Gil Soo Han, Seung Ho Lee, Dong Yul Lee, Young-mo KimAbstract:Background and Objective: The use of radioiodine (RI) for the ablation of residual thyroid tissue and metastatic thyroid cancer lesions after thyroidectomy has become established as standard treatment in the management of differentiated thyroid cancer and subsequent Sialadenitis is the most common complication of RI therapy. The purpose of this study was to establish a new treatment modality for RI-induced Sialadenitis. Method: The study group consisted of 115 patients with a mean age of 47.7 (range, 24–78) years. All patients received RI therapy after total thyroidectomy. The incidence of RI-induced Sialadenitis, salivary gland involvement, administered RI dose, treatment modality, and result of treatment by interventional sialoendoscopy were evaluated. Results: The incidence of RI-induced Sialadenitis was 18% (21/115), with involvement of the parotid more frequent than the submandibular gland. The average development period of RI-induced Sialadenitis was 4.8 months. The average RI dosage for the Sialadenitis group was higher than for the nonSialadenitis group, suggesting that RI-induced Sialadenitis may be dose related, although the data were not statistically significant because of the small numbers in the high-dose group. Conservative management was effective in 71% (15/21) of the cases, and interventional sialoendoscopy was successful in 50% of those cases that did not respond to conservative treatment. The causes of treatment failure in the remaining cases were a totally obstructed parotid duct and stenosis at the bifurcation site. Conclusion: Sialadenitis is the most common complication after RI therapy. Sialadenitis was successfully managed by conservative treatment in most cases, and interventional sialoendoscopy is an alternative method of treatment in selected cases such as in partial ductal stenosis.
