The Experts below are selected from a list of 16629 Experts worldwide ranked by ideXlab platform
Ralf Paus - One of the best experts on this subject based on the ideXlab platform.
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the role of p cadherin in Skin biology and Skin Pathology lessons from the hair follicle
Cell and Tissue Research, 2015Co-Authors: Liat Samuelov, Ralf Paus, Eli SprecherAbstract:Adherens junctions (AJs) are one of the major intercellular junctions in various epithelia including the epidermis and the follicular epithelium. AJs connect the cell surface to the actin cytoskeleton and comprise classic transmembrane cadherins, such as P-cadherin, armadillo family proteins, and actin microfilaments. Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes. Both syndromes feature sparse hair heralding progressive macular dystrophy. EEM syndrome is characterized in addition by ectodermal and limb defects. Recent studies have demonstrated that, together with its involvement in cell-cell adhesion, P-cadherin plays a crucial role in regulating cell signaling, malignant transformation, and other major intercellular processes. Here, we review the roles of P-cadherin in Skin and hair biology, with emphasize on human hair growth, cycling and pigmentation.
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the role of p cadherin in Skin biology and Skin Pathology lessons from the hair follicle
Cell and Tissue Research, 2015Co-Authors: Liat Samuelov, Ralf Paus, Eli SprecherAbstract:Adherens junctions (AJs) are one of the major intercellular junctions in various epithelia including the epidermis and the follicular epithelium. AJs connect the cell surface to the actin cytoskeleton and comprise classic transmembrane cadherins, such as P-cadherin, armadillo family proteins, and actin microfilaments. Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes. Both syndromes feature sparse hair heralding progressive macular dystrophy. EEM syndrome is characterized in addition by ectodermal and limb defects. Recent studies have demonstrated that, together with its involvement in cell-cell adhesion, P-cadherin plays a crucial role in regulating cell signaling, malignant transformation, and other major intercellular processes. Here, we review the roles of P-cadherin in Skin and hair biology, with emphasize on human hair growth, cycling and pigmentation.
Bernard Têtu - One of the best experts on this subject based on the ideXlab platform.
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Online teaching of inflammatory Skin Pathology by a French-speaking International University Network.
Diagnostic pathology, 2014Co-Authors: Emilie Perron, Maxime Battistella, Béatrice Vergier, Maryse Fiche, Philippe Bertheau, Bernard TêtuAbstract:Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic Pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Québec, Switzerland and Ivory Coast. One of the first steps of the project was to build a learning module on inflammatory Skin Pathology for interns and residents in Pathology and dermatology. A Pathology resident from Québec spent 6 weeks in France and Switzerland to develop the contents and build the module on an e-learning Moodle platform under the supervision of two dermatopathologists. The learning module contains text, interactive clinical cases, tests with feedback, virtual slides, images and clinical photographs. For that module, the virtual slides are decentralized in 2 universities (Bordeaux and Paris 7). Each university is responsible of its own slide scanning, image storage and online display with virtual slide viewers. The module on inflammatory Skin Pathology includes more than 50 web pages with French original content, tests and clinical cases, links to over 45 virtual images and more than 50 microscopic and clinical photographs. The whole learning module is being revised by four dermatopathologists and two senior pathologists. It will be accessible to interns and residents in the spring of 2014. The experience and knowledge gained from that work will be transferred to the next international resident whose work will be aimed at creating lung and breast Pathology learning modules. The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting Pathology education through the use of multi-media technology including whole slide imaging.
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online teaching of inflammatory Skin Pathology by a french speaking international university network
Diagnostic Pathology, 2014Co-Authors: Emilie Perron, Maxime Battistella, Béatrice Vergier, Maryse Fiche, Philippe Bertheau, Bernard TêtuAbstract:Introduction: Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic Pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Quebec, Switzerland and Ivory Coast. Method: One of the first steps of the project was to build a learning module on inflammatory Skin Pathology for interns and residents in Pathology and dermatology. A Pathology resident from Quebec spent 6 weeks in France and Switzerland to develop the contents and build the module on an e-learning Moodle platform under the supervision of two dermatopathologists. The learning module contains text, interactive clinical cases, tests with feedback, virtual slides, images and clinical photographs. For that module, the virtual slides are decentralized in 2 universities (Bordeaux and Paris 7). Each university is responsible of its own slide scanning, image storage and online display with virtual slide viewers. Results: The module on inflammatory Skin Pathology includes more than 50 web pages with French original content, tests and clinical cases, links to over 45 virtual images and more than 50 microscopic and clinical photographs. The whole learning module is being revised by four dermatopathologists and two senior pathologists. It will be accessible to interns and residents in the spring of 2014. The experience and knowledge gained from that work will be transferred to the next international resident whose work will be aimed at creating lung and breast Pathology learning modules. Conclusion: The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting Pathology education through the use of multi-media technology including whole slide imaging.
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Online teaching of inflammatory Skin Pathology by a French-speaking International University Network.
Diagnostic Pathology, 2014Co-Authors: Emilie Perron, Maxime Battistella, Béatrice Vergier, Maryse Fiche, Philippe Bertheau, Bernard TêtuAbstract:Introduction Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic Pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Quebec, Switzerland and Ivory Coast.
Michele A. Grimbaldeston - One of the best experts on this subject based on the ideXlab platform.
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evidence that vitamin d3 promotes mast cell dependent reduction of chronic uvb induced Skin Pathology in mice
Journal of Experimental Medicine, 2010Co-Authors: Lisa Biggs, Stephen J. Galli, Boris Fedoric, Angel F. Lopez, Michele A. GrimbaldestonAbstract:Mast cell production of interleukin-10 (IL-10) can limit the Skin Pathology induced by chronic low-dose ultraviolet (UV)-B irradiation. Although the mechanism that promotes mast cell IL-10 production in this setting is unknown, exposure of the Skin to UVB irradiation induces increased production of the immune modifying agent 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3). We now show that 1α,25(OH)2D3 can up-regulate IL-10 mRNA expression and induce IL-10 secretion in mouse mast cells in vitro. To investigate the roles of 1α,25(OH)2D3 and mast cell vitamin D receptor (VDR) expression in chronically UVB-irradiated Skin in vivo, we engrafted the Skin of genetically mast cell–deficient WBB6F1-KitW/W-v mice with bone marrow–derived cultured mast cells derived from C57BL/6 wild-type or VDR−/− mice. Optimal mast cell–dependent suppression of the inflammation, local production of proinflammatory cytokines, epidermal hyperplasia, and epidermal ulceration associated with chronic UVB irradiation of the Skin in KitW/W-v mice required expression of VDR by the adoptively transferred mast cells. Our findings suggest that 1α,25(OH)2D3/VDR-dependent induction of IL-10 production by cutaneous mast cells can contribute to the mast cell’s ability to suppress inflammation and Skin Pathology at sites of chronic UVB irradiation.
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Evidence that vitamin D3 promotes mast cell–dependent reduction of chronic UVB-induced Skin Pathology in mice
Journal of Experimental Medicine, 2010Co-Authors: Lisa Biggs, Stephen J. Galli, Boris Fedoric, Angel F. Lopez, Michele A. GrimbaldestonAbstract:Mast cell production of interleukin-10 (IL-10) can limit the Skin Pathology induced by chronic low-dose ultraviolet (UV)-B irradiation. Although the mechanism that promotes mast cell IL-10 production in this setting is unknown, exposure of the Skin to UVB irradiation induces increased production of the immune modifying agent 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3). We now show that 1α,25(OH)2D3 can up-regulate IL-10 mRNA expression and induce IL-10 secretion in mouse mast cells in vitro. To investigate the roles of 1α,25(OH)2D3 and mast cell vitamin D receptor (VDR) expression in chronically UVB-irradiated Skin in vivo, we engrafted the Skin of genetically mast cell–deficient WBB6F1-KitW/W-v mice with bone marrow–derived cultured mast cells derived from C57BL/6 wild-type or VDR−/− mice. Optimal mast cell–dependent suppression of the inflammation, local production of proinflammatory cytokines, epidermal hyperplasia, and epidermal ulceration associated with chronic UVB irradiation of the Skin in KitW/W-v mice required expression of VDR by the adoptively transferred mast cells. Our findings suggest that 1α,25(OH)2D3/VDR-dependent induction of IL-10 production by cutaneous mast cells can contribute to the mast cell’s ability to suppress inflammation and Skin Pathology at sites of chronic UVB irradiation.
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Mast cell-derived interleukin 10 limits Skin Pathology in contact dermatitis and chronic irradiation with ultraviolet B.
Nature Immunology, 2007Co-Authors: Michele A. Grimbaldeston, Susumu Nakae, Janet Kalesnikoff, Mindy Tsai, Stephen J. GalliAbstract:Mast cell–derived interleukin 10 limits Skin Pathology in contact dermatitis and chronic irradiation with ultraviolet B
Emilie Perron - One of the best experts on this subject based on the ideXlab platform.
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Online teaching of inflammatory Skin Pathology by a French-speaking International University Network.
Diagnostic pathology, 2014Co-Authors: Emilie Perron, Maxime Battistella, Béatrice Vergier, Maryse Fiche, Philippe Bertheau, Bernard TêtuAbstract:Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic Pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Québec, Switzerland and Ivory Coast. One of the first steps of the project was to build a learning module on inflammatory Skin Pathology for interns and residents in Pathology and dermatology. A Pathology resident from Québec spent 6 weeks in France and Switzerland to develop the contents and build the module on an e-learning Moodle platform under the supervision of two dermatopathologists. The learning module contains text, interactive clinical cases, tests with feedback, virtual slides, images and clinical photographs. For that module, the virtual slides are decentralized in 2 universities (Bordeaux and Paris 7). Each university is responsible of its own slide scanning, image storage and online display with virtual slide viewers. The module on inflammatory Skin Pathology includes more than 50 web pages with French original content, tests and clinical cases, links to over 45 virtual images and more than 50 microscopic and clinical photographs. The whole learning module is being revised by four dermatopathologists and two senior pathologists. It will be accessible to interns and residents in the spring of 2014. The experience and knowledge gained from that work will be transferred to the next international resident whose work will be aimed at creating lung and breast Pathology learning modules. The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting Pathology education through the use of multi-media technology including whole slide imaging.
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online teaching of inflammatory Skin Pathology by a french speaking international university network
Diagnostic Pathology, 2014Co-Authors: Emilie Perron, Maxime Battistella, Béatrice Vergier, Maryse Fiche, Philippe Bertheau, Bernard TêtuAbstract:Introduction: Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic Pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Quebec, Switzerland and Ivory Coast. Method: One of the first steps of the project was to build a learning module on inflammatory Skin Pathology for interns and residents in Pathology and dermatology. A Pathology resident from Quebec spent 6 weeks in France and Switzerland to develop the contents and build the module on an e-learning Moodle platform under the supervision of two dermatopathologists. The learning module contains text, interactive clinical cases, tests with feedback, virtual slides, images and clinical photographs. For that module, the virtual slides are decentralized in 2 universities (Bordeaux and Paris 7). Each university is responsible of its own slide scanning, image storage and online display with virtual slide viewers. Results: The module on inflammatory Skin Pathology includes more than 50 web pages with French original content, tests and clinical cases, links to over 45 virtual images and more than 50 microscopic and clinical photographs. The whole learning module is being revised by four dermatopathologists and two senior pathologists. It will be accessible to interns and residents in the spring of 2014. The experience and knowledge gained from that work will be transferred to the next international resident whose work will be aimed at creating lung and breast Pathology learning modules. Conclusion: The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting Pathology education through the use of multi-media technology including whole slide imaging.
-
Online teaching of inflammatory Skin Pathology by a French-speaking International University Network.
Diagnostic Pathology, 2014Co-Authors: Emilie Perron, Maxime Battistella, Béatrice Vergier, Maryse Fiche, Philippe Bertheau, Bernard TêtuAbstract:Introduction Developments in technology, web-based teaching and whole slide imaging have broadened the teaching horizon in anatomic Pathology. Creating online learning material including many types of media such as radiologic images, whole slides, videos, clinical and macroscopic photographs, is now accessible to most universities. Unfortunately, a major limiting factor to maintain and update the learning material is the amount of resources needed. In this perspective, a French-national university network was initiated in 2011 to build joint online teaching modules consisting of clinical cases and tests. The network has since expanded internationally to Quebec, Switzerland and Ivory Coast.
Eli Sprecher - One of the best experts on this subject based on the ideXlab platform.
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the role of p cadherin in Skin biology and Skin Pathology lessons from the hair follicle
Cell and Tissue Research, 2015Co-Authors: Liat Samuelov, Ralf Paus, Eli SprecherAbstract:Adherens junctions (AJs) are one of the major intercellular junctions in various epithelia including the epidermis and the follicular epithelium. AJs connect the cell surface to the actin cytoskeleton and comprise classic transmembrane cadherins, such as P-cadherin, armadillo family proteins, and actin microfilaments. Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes. Both syndromes feature sparse hair heralding progressive macular dystrophy. EEM syndrome is characterized in addition by ectodermal and limb defects. Recent studies have demonstrated that, together with its involvement in cell-cell adhesion, P-cadherin plays a crucial role in regulating cell signaling, malignant transformation, and other major intercellular processes. Here, we review the roles of P-cadherin in Skin and hair biology, with emphasize on human hair growth, cycling and pigmentation.
-
the role of p cadherin in Skin biology and Skin Pathology lessons from the hair follicle
Cell and Tissue Research, 2015Co-Authors: Liat Samuelov, Ralf Paus, Eli SprecherAbstract:Adherens junctions (AJs) are one of the major intercellular junctions in various epithelia including the epidermis and the follicular epithelium. AJs connect the cell surface to the actin cytoskeleton and comprise classic transmembrane cadherins, such as P-cadherin, armadillo family proteins, and actin microfilaments. Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes. Both syndromes feature sparse hair heralding progressive macular dystrophy. EEM syndrome is characterized in addition by ectodermal and limb defects. Recent studies have demonstrated that, together with its involvement in cell-cell adhesion, P-cadherin plays a crucial role in regulating cell signaling, malignant transformation, and other major intercellular processes. Here, we review the roles of P-cadherin in Skin and hair biology, with emphasize on human hair growth, cycling and pigmentation.
