The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Julie E Buring - One of the best experts on this subject based on the ideXlab platform.

  • Sleep Debt the impact of weekday Sleep deprivation on cardiovascular health in older women
    Sleep, 2019
    Co-Authors: Tomas Cabeza De Baca, Koharu Loulou Chayama, Susan Redline, Natalie Slopen, Fumika Matsushita, Aric A Prather, David R Williams, Julie E Buring
    Abstract:

    STUDY OBJECTIVES Short Sleep duration is associated with increased cardiovascular disease (CVD) risk. However, it is uncertain whether Sleep Debt, a measure of Sleep deficiency during the week compared to the weekend, confers increased cardiovascular risk. Because Sleep disturbances increase with age particularly in women, we examined the relationship between Sleep Debt and ideal cardiovascular health (ICH) in older women. METHODS Sleep Debt is defined as the difference between self-reported total weekday and weekend Sleep hours of at least 2 hours among women without apparent CVD and cancer participating in the Women's Health Stress Study follow-up cohort of female health professionals (N = 22 082). The ICH consisted of seven health factors and behaviors as defined by the American Heart Association Strategic 2020 goals including body mass index, smoking, physical activity, diet, blood pressure, total cholesterol, and glucose. RESULTS Mean age was 72.1 ± 6.0 years. Compared to women with no Sleep Debt, women with Sleep Debt were more likely to be obese and have hypertension (pall < .05). Linear regression models adjusted for age and race/ethnicity revealed that Sleep Debt was significantly associated with poorer ICH (B = -0.13 [95% CI = -0.18 to -0.08]). The relationship was attenuated but remained significant after adjustment for education, income, depression/anxiety, cumulative stress, and snoring. CONCLUSION Sleep Debt was associated with poorer ICH, despite taking into account socioeconomic status and psychosocial factors. These results suggest that weekly Sleep duration variation, possibly leading to circadian misalignment, may be associated with cardiovascular risk in older women.

  • abstract 16588 relationship between Sleep Debt and obesity in older women findings from the women s health study
    Circulation, 2018
    Co-Authors: Stephanie Child, Susan Redline, Natalie Slopen, Aric A Prather, David R Williams, Julie E Buring, Alan M Zaslavsky, Eva M Durazo, Tiffany M Powellwiley, Michelle A Albert
    Abstract:

    Background: Obesity is increasingly prevalent in older women and is associated with heightened risk of cardiovascular disease (CVD) and Type II diabetes (diabetes). Sleep disturbance has been shown...

  • abstract p323 Sleep Debt and type ii diabetes mellitus in middle aged and older women
    Circulation, 2018
    Co-Authors: Jonathan Z Butler, Susan Redline, Natalie Slopen, David R Williams, Julie E Buring, Alan M Zaslavsky, Aruna D Pradhan, Michelle A Albert
    Abstract:

    Background: Sleep disturbances can be both a cause and consequence of circadian disruption resulting in cardiometabolic dysregulation. However, little is known about Sleep Debt, defined as the aver...

  • abstract 20467 Sleep Debt weekday and weekend Sleep differences in ideal cardiovascular health in women
    Circulation, 2017
    Co-Authors: Tomas Cabeza De Baca, Susan Redline, Fumika Matsushita, Julie E Buring, Alan M Zaslavsky, Michelle A Albert
    Abstract:

    Background: Short Sleep duration is associated with increased cardiovascular disease risk. However, whether Sleep Debt, a measure of Sleep deficiency during the week compared to the weekend, confer...

Derkjan Dijk - One of the best experts on this subject based on the ideXlab platform.

  • identifying and validating blood mrna biomarkers for acute and chronic insufficient Sleep in humans a machine learning approach
    Sleep, 2019
    Co-Authors: Emma Laing, Carla S Mollerlevet, Derkjan Dijk, Simon Archer
    Abstract:

    Acute and chronic insufficient Sleep are associated with adverse health outcomes and risk of accidents. There is therefore a need for biomarkers to monitor Sleep Debt status. None are currently available. We applied Elastic-net and Ridge regression to entire and pre-filtered transcriptome samples collected in healthy young adults during acute total Sleep deprivation and following 1 week of either chronic insufficient (< 6 h) or sufficient Sleep (~8.6 h) to identify panels of mRNA biomarkers of Sleep Debt status. The size of identified panels ranged from 9-74 biomarkers. Panel performance, assessed by leave-one-subject-out cross-validation and independent validation, varied between Sleep Debt conditions. Using between-subject assessments based on one blood sample, the accuracy of classifying ‘Acute Sleep loss’ was 92%, but only 57% for classifying ‘Chronic Sleep insufficiency’. A reasonable accuracy for classifying ‘chronic Sleep insufficiency’ could only be achieved by a within-subject comparison of blood samples. Biomarkers for Sleep Debt status showed little overlap with previously identified biomarkers for circadian phase. Biomarkers for acute and chronic Sleep loss also showed little overlap but were associated with common functions related to the cellular stress response, such as heat shock protein activity, the unfolded protein response, protein ubiquitination and endoplasmic reticulum associated protein degradation, and apoptosis. This characteristic response of whole blood to Sleep loss can further aid our understanding of how Sleep insufficiencies negatively affect health. Further development of these novel biomarkers for research and clinical practice requires validation in other protocols and age groups.

  • PER3 polymorphism and cardiac autonomic control : effects of Sleep Debt and circadian phase
    American journal of physiology. Heart and circulatory physiology, 2008
    Co-Authors: Antoine U Viola, Simon Archer, Lynette M. James, Derkjan Dijk
    Abstract:

    A variable number tandem repeat polymorphism in the coding region of the circadian clock PERIOD3 (PER3) gene has been shown to affect Sleep. Because circadian rhythms and Sleep are known to modulat...

  • interindividual variation in Sleep duration and its association with Sleep Debt in young adults
    Sleep, 2005
    Co-Authors: Elizabeth B Klerman, Derkjan Dijk
    Abstract:

    Study Objective To determine whether variation in Sleep duration reflects variation in Sleep need or self-imposed Sleep restriction.

Eve Van Cauter - One of the best experts on this subject based on the ideXlab platform.

  • of Sleep Debt adaptation of the 24 h growth hormone profile to a state
    2013
    Co-Authors: Eve Van Cauter, Rachel Leproult, E F Colecchia, Mireille Lhermitebaleriaux, Z Nie, K Spiegel, Georges Copinschi
    Abstract:

    You might find this additional info useful...This article cites€35 articles, 18 of which you can access for free at: http://ajpregu.physiology.org/content/279/3/R874.full#ref-list-1This article has been cited by€5 other HighWire-hosted articles: http://ajpregu.physiology.org/content/279/3/R874#cited-by Updated information and services including high resolution figures, can be found at: http://ajpregu.physiology.org/content/279/3/R874.fulland Comparative Physiology can be found at: Additional material and information about American Journal of Physiology - Regulatory, Integrativehttp://www.the-aps.org/publications/ajpreguThis information is current as of May 29, 2013.

  • role of Sleep duration and quality in the risk and severity of type 2 diabetes mellitus
    JAMA Internal Medicine, 2006
    Co-Authors: Kristen L Knutson, Armand Ryden, Bryce A Mander, Eve Van Cauter
    Abstract:

    Background Evidence from laboratory and epidemiologic studies suggests that decreased Sleep duration or quality may increase diabetes risk. We examined whether short or poor Sleep is associated with glycemic control in African Americans with type 2 diabetes mellitus. Methods We conducted a cross-sectional study of volunteers with type 2 diabetes interviewed at the University of Chicago Hospitals, Chicago, Ill. The final analysis included 161 participants. Glycemic control was assessed by hemoglobin A 1c (HbA 1c ) level obtained from medical charts. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Perceived Sleep Debt was calculated as the difference between preferred and actual weekday Sleep duration. Results The mean ± SD Sleep duration was 6.0 ± 1.6 hours, and 71% of the participants were classified as having poor quality Sleep (PSQI score >5). We excluded patients with Sleep frequently disrupted by pain (n = 39). In patients without diabetic complications, glycemic control was associated with perceived Sleep Debt but not PSQI score. The predicted increase in HbA 1c level for a perceived Sleep Debt of 3 hours per night was 1.1% above the median. In patients with at least 1 complication, HbA 1c level was associated with PSQI score but not perceived Sleep Debt. The predicted increase in HbA 1c level for a 5-point increase in PSQI was 1.9% above the median. Conclusions In our sample, Sleep duration and quality were significant predictors of HbA 1c , a key marker of glycemic control. Combined with existing evidence linking Sleep loss to increased diabetes risk, these data suggest that optimizing Sleep duration and quality should be tested as an intervention to improve glucose control in patients with type 2 diabetes.

  • adaptation of the 24 h growth hormone profile to a state of Sleep Debt
    American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2000
    Co-Authors: Karine Spiegel, Rachel Leproult, E F Colecchia, Mireille Lhermitebaleriaux, Z Nie, Georges Copinschi, Eve Van Cauter
    Abstract:

    In normal men, the majority of GH secretion occurs in a single large postSleep onset pulse that is suppressed during total Sleep deprivation. We examined the impact of semichronic partial Sleep loss, a highly prevalent condition, on the 24-h growth hormone profile. Eleven young men were studied after six nights of restricted bedtimes (0100-0500) and after 7 nights of extended bedtimes (2100-0900). Slow-wave Sleep (SWS) was estimated as the duration of stages III and IV. Slow-wave activity (SWA) was calculated as electroencephalogram power density in the 0.5- to 3-Hz frequency range. During the state of Sleep Debt, the GH secretory pattern was biphasic, with both a preSleep onset "circadian" pulse and a postSleep onset pulse. PostSleep onset GH secretion was negatively related to preSleep onset secretion and tended to be positively correlated with the amount of concomitant SWA. When Sleep was restricted, both SWS and SWA were increased during early Sleep. Unexpectedly, the increase in SWA affected the second, rather than the first, SWA cycle, suggesting that preSleep onset GH secretion may have limited SWA in the first cycle, possibly via an inhibition of central GH-releasing hormone activity. Thus neither the GH profile nor the distribution of SWA conformed with predictions from acute Sleep deprivation studies, indicating that adaptation mechanisms are operative during chronic partial Sleep loss.

  • Impact of Sleep Debt on metabolic and endocrine function
    Lancet (London England), 1999
    Co-Authors: Karine Spiegel, Rachel Leproult, Eve Van Cauter
    Abstract:

    Summary Background Chronic Sleep Debt is becoming increasingly common and affects millions of people in more-developed countries. Sleep Debt is currently believed to have no adverse effect on health. We investigated the effect of Sleep Debt on metabolic and endocrine functions. Methods We assessed carbohydrate metabolism, thyrotropic function, activity of the hypothalamo-pituitary-adrenal axis, and sympathovagal balance in 11 young men after time in bed had been restricted to 4 h per night for 6 nights. We compared the Sleep-Debt condition with measurements taken at the end of a Sleep-recovery period when participants were allowed 12 h in bed per night for 6 nights. Findings Glucose tolerance was lower in the Sleep-Debt condition than in the fully rested condition (p Interpretation Sleep Debt has a harmful impact on carbohydrate metabolism and endocrine function. The effects are similar to those seen in normal ageing and, therefore, Sleep Debt may increase the severity of age-related chronic disorders.

Michelle A Albert - One of the best experts on this subject based on the ideXlab platform.

Till Roenneberg - One of the best experts on this subject based on the ideXlab platform.

  • a unique fast forwards rotating schedule with 12 h long shifts prevents chronic Sleep Debt
    Chronobiology International, 2016
    Co-Authors: Dorothee Fischer, Celine Vetter, Christoph Oberlinner, Sven Wegener, Till Roenneberg
    Abstract:

    Sleep Debt--together with circadian misalignment--is considered a central factor for adverse health outcomes associated with shift work. Here, we describe in detail Sleep-wake behavior in a fast-forward rotating 12-h shift schedule, which involves at least 24 hours off after each shift and thus allows examining the role of immediate recovery after shift-specific Sleep Debt. Thirty-five participants at two chemical plants in Germany were chronotyped using the Munich ChronoType Questionnaire for Shift-Workers (MCTQ(Shift)) and wore actimeters throughout the two-week study period. From these actimetry recordings, we computed Sleep and nap duration, social jetlag (a measure of circadian misalignment), and the daily timing of activity and Sleep (center of gravity and mid-Sleep, respectively). We observed that the long off-work periods between each shift create a fast alternation between shortened (mean ± standard deviation, 5h 17min ± 56min) and extended (8h 25min ± 72min) Sleep episodes resulting in immanent reductions of Sleep Debt. Additionally, extensive napping of early chronotypes (up to 3 hours before the night shift) statistically compensated short Sleep durations after the night shift. Partial rank correlations showed chronotype-dependent patterns of Sleep and activity that were similar to those previously described in 8-h schedules; however, Sleep before the day shift did not differ between chronotypes. Our findings indicate that schedules preventing a build-up of chronic Sleep Debt may reduce detrimental effects of shift work irrespective of shift duration. Prospective studies are needed to further elucidate the relationship between Sleep, the circadian system, and health and safety hazards.

  • validity of the japanese version of the munich chronotype questionnaire
    Chronobiology International, 2014
    Co-Authors: Shingo Kitamura, Minori Enomoto, Akiko Hida, Shigekazu Higuchi, Celine Vetter, Till Roenneberg, Sayaka Aritake, Mie Kato, Kazuo Mishima
    Abstract:

    To assess circadian preference with a score, the Morningness-Eveningness Questionnaire (MEQ) has been used for more than 3 decades now. More recently, the Munich ChronoType Questionnaire (MCTQ) was developed: it asks for Sleep-wake behavior on work and free days and uses the midpoint of Sleep on free days (MSF), corrected for Sleep Debt accumulated during the work week as an indicator of chronotype (MSFsc). In this study, we developed a Japanese version of the MCTQ by using a translation/back-translation approach including an examination of its semantic validity. In a subsequent questionnaire survey, 450 adult men and women completed the Japanese versions of the MCTQ and MEQ. Results showed that MEQ scores were significantly negatively correlated with mid-Sleep parameters assessed by the MCTQ, on both, work and free days, as well as with the chronotype measure MSFsc (r = −0.580 to −0.652, all p < 0.001). As in the original German version, the strongest correlation was observed between MEQ score and MSF. A...

  • the munich chronotype questionnaire for shift workers mctqshift
    Journal of Biological Rhythms, 2013
    Co-Authors: Celine Vetter, Myriam Juda, Till Roenneberg
    Abstract:

    Sleep is systematically modulated by chronotype in day-workers. Therefore, investigations into how shift-work affects Sleep, health, and cognition may provide more reliable insights if they consider individual circadian time (chronotype). The Munich ChronoType Questionnaire (MCTQ) is a useful tool for determining chronotype. It assesses chronotype based on Sleep behavior, specifically on the local time of mid-Sleep on free days corrected for Sleep Debt accumulated over the workweek (MSFsc). Because the original MCTQ addresses people working standard hours, we developed an extended version that accommodates shift-work (MCTQShift). We first present the validation of this new version with daily Sleep logs (n = 52) and actimetry (n = 27). Next, we evaluated 371 MCTQShift entries of shift-workers (rotating through 8-h shifts starting at 0600 h, 1400 h, and 2200 h). Our results support experimental findings showing that Sleep is difficult to initiate and to maintain under the constraints of shift-work. Sleep ti...