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Chandhita Pruksananonda - One of the best experts on this subject based on the ideXlab platform.
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Background media exposure prolongs nighttime Sleep Latency in Thai infants
Pediatric Research, 2017Co-Authors: Weerasak Chonchaiya, Tanaporn Wilaisakditipakorn, Nakul Vijakkhana, Chandhita PruksananondaAbstract:Background: Less is known about the effect of screen time and Sleep at a younger age on current Sleep outcome in infants. Therefore, we examined whether Sleep parameter at a younger age and daily exposure of electronic media could predict Sleep outcomes in 12-mo-old Thai infants. Methods: There were 208 typically developing infants enrolled since 6 mo old. Each main caregiver completed a Sleep questionnaire and was interviewed for the infant’s screen exposure at 6 and 12 mo of age. Nighttime Sleep Latency and Sleep duration were calculated. Electronic media and Sleep outcomes were analyzed using multiple linear regressions and path analysis. Results: Longer Sleep Latency at age 12 mo was predicted by longer daily duration of media exposure and longer 6-mo-old Sleep Latency. Infants who were exposed to electronic media above the median at both ages had longer 12-mo-old nighttime Sleep Latency compared with those who were exposed to the screen below the median at both ages. Conclusion: Six-month-old nighttime Sleep Latency and 12-mo-old electronic media exposure could predict 12-mo-old nighttime Sleep Latency. Relative changes in media exposure over time can provide a better prediction of nighttime Sleep Latency in Thai infants than screen exposure at either time point.
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Background media exposure prolongs nighttime Sleep Latency in Thai infants
Pediatric research, 2016Co-Authors: Weerasak Chonchaiya, Tanaporn Wilaisakditipakorn, Nakul Vijakkhana, Chandhita PruksananondaAbstract:Less is known about the effect of screen time and Sleep at a younger age on current Sleep outcome in infants. Therefore, we examined whether Sleep parameter at a younger age and daily exposure of electronic media could predict Sleep outcomes in 12-mo-old Thai infants. There were 208 typically developing infants enrolled since 6 mo old. Each main caregiver completed a Sleep questionnaire and was interviewed for the infant’s screen exposure at 6 and 12 mo of age. Nighttime Sleep Latency and Sleep duration were calculated. Electronic media and Sleep outcomes were analyzed using multiple linear regressions and path analysis. Longer Sleep Latency at age 12 mo was predicted by longer daily duration of media exposure and longer 6-mo-old Sleep Latency. Infants who were exposed to electronic media above the median at both ages had longer 12-mo-old nighttime Sleep Latency compared with those who were exposed to the screen below the median at both ages. Six-month-old nighttime Sleep Latency and 12-mo-old electronic media exposure could predict 12-mo-old nighttime Sleep Latency. Relative changes in media exposure over time can provide a better prediction of nighttime Sleep Latency in Thai infants than screen exposure at either time point.
Weerasak Chonchaiya - One of the best experts on this subject based on the ideXlab platform.
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Background media exposure prolongs nighttime Sleep Latency in Thai infants
Pediatric Research, 2017Co-Authors: Weerasak Chonchaiya, Tanaporn Wilaisakditipakorn, Nakul Vijakkhana, Chandhita PruksananondaAbstract:Background: Less is known about the effect of screen time and Sleep at a younger age on current Sleep outcome in infants. Therefore, we examined whether Sleep parameter at a younger age and daily exposure of electronic media could predict Sleep outcomes in 12-mo-old Thai infants. Methods: There were 208 typically developing infants enrolled since 6 mo old. Each main caregiver completed a Sleep questionnaire and was interviewed for the infant’s screen exposure at 6 and 12 mo of age. Nighttime Sleep Latency and Sleep duration were calculated. Electronic media and Sleep outcomes were analyzed using multiple linear regressions and path analysis. Results: Longer Sleep Latency at age 12 mo was predicted by longer daily duration of media exposure and longer 6-mo-old Sleep Latency. Infants who were exposed to electronic media above the median at both ages had longer 12-mo-old nighttime Sleep Latency compared with those who were exposed to the screen below the median at both ages. Conclusion: Six-month-old nighttime Sleep Latency and 12-mo-old electronic media exposure could predict 12-mo-old nighttime Sleep Latency. Relative changes in media exposure over time can provide a better prediction of nighttime Sleep Latency in Thai infants than screen exposure at either time point.
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Background media exposure prolongs nighttime Sleep Latency in Thai infants
Pediatric research, 2016Co-Authors: Weerasak Chonchaiya, Tanaporn Wilaisakditipakorn, Nakul Vijakkhana, Chandhita PruksananondaAbstract:Less is known about the effect of screen time and Sleep at a younger age on current Sleep outcome in infants. Therefore, we examined whether Sleep parameter at a younger age and daily exposure of electronic media could predict Sleep outcomes in 12-mo-old Thai infants. There were 208 typically developing infants enrolled since 6 mo old. Each main caregiver completed a Sleep questionnaire and was interviewed for the infant’s screen exposure at 6 and 12 mo of age. Nighttime Sleep Latency and Sleep duration were calculated. Electronic media and Sleep outcomes were analyzed using multiple linear regressions and path analysis. Longer Sleep Latency at age 12 mo was predicted by longer daily duration of media exposure and longer 6-mo-old Sleep Latency. Infants who were exposed to electronic media above the median at both ages had longer 12-mo-old nighttime Sleep Latency compared with those who were exposed to the screen below the median at both ages. Six-month-old nighttime Sleep Latency and 12-mo-old electronic media exposure could predict 12-mo-old nighttime Sleep Latency. Relative changes in media exposure over time can provide a better prediction of nighttime Sleep Latency in Thai infants than screen exposure at either time point.
Michael S Aldrich - One of the best experts on this subject based on the ideXlab platform.
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Sleep onset rem periods during multiple Sleep Latency tests in patients evaluated for Sleep apnea
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Ronald D. Chervin, Michael S AldrichAbstract:Although 2 or more Sleep onset rapid eye movement (REM) periods (2omSOREMPs) on a Multiple Sleep Latency Test (MSLT) raise the possibility of narcolepsy, patients with obstructive Sleep apnea (OSA) also can have 2omSOREMPs, which may then cause diagnostic uncertainty. To explore what features among OSA patients predict 2omSOREMPs on an MSLT that follows nocturnal polysomnography, we reviewed data from 1,145 consecutively studied patients suspected or confirmed to have OSA rather than narcolepsy. Overall, 4.7% of the subjects had 2omSOREMPs. Variables that were independently predictive of 2omSOREMPs in logistic regression models included male gender (OR = 4.4, 95% CI = 1.9 to 12.7), a 5-min decrease in the MSLT-derived mean Sleep Latency (OR = 1.9, 95% CI = 1.3 to 2.8), a 90-min decrease in nocturnal Latency to REM Sleep (OR = 1.6, 95% CI = 1.1 to 2.5), and a 15-unit decrease in minimal recorded oxygen saturation (OR = 1.6, 95% CI = 1.3 to 2.0). We conclude that among patients suspected or confirmed to hav...
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value of the multiple Sleep Latency test mslt for the diagnosis of narcolepsy
Sleep, 1997Co-Authors: Michael S Aldrich, Ronald D. Chervin, Beth A MalowAbstract:Since its introduction, the multiple Sleep Latency test (MSLT) has played a major role in the diagnosis of narcolepsy. We assessed its diagnostic value in a series of 2,083 subjects of whom 170 (8.2%) were diagnosed with narcolepsy. The sensitivity of the combination of two or more Sleep onset rapid eye movement (REM) periods (SOREMPs) with a mean Sleep Latency of < 5 minutes on an initial MSLT was 70% with a specificity of 97%, but 30% of all subjects with this combination of findings did not have narcolepsy. In some narcoleptics who had more than one MSLT, the proportion of naps with SOREMPs varied substantially from the initial MSLT to the follow-up test. The highest specificity (99.2%) and positive predictive value (PPV) (87%) for MSLT findings was obtained with the criteria of three or more SOREMPs combined with a mean Sleep Latency of < 5 minutes, but the sensitivity of this combination was only 46%. The combination of a SOREMP with a Sleep Latency < 10 minutes on polysomnography yielded a specificity (98.9%) and PPV (73%) almost equal to those obtained from combinations of MSLT findings, but the sensitivity was much lower. Our results suggest that the MSLT cannot be used in isolation to confirm or exclude narcolepsy, is indicated only in selected patients with excessive daytime Sleepiness, and is most valuable when interpreted in conjunction with clinical findings.
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Comparison of the results of the Epworth Sleepiness Scale and the Multiple Sleep Latency Test
Journal of psychosomatic research, 1997Co-Authors: Ronald D. Chervin, Michael S Aldrich, Roberta Pickett, Christian GuilleminaultAbstract:The Epworth Sleepiness Scale (ESS), which asks patients to estimate the likelihood that they would doze off or fall aSleep in sedentary situations, has been proposed to be a quick, inexpensive way to assess Sleepiness. We analyzed relations among ESS scores, mean Sleep latencies on the Multiple Sleep Latency Test (MSLT), and subjective assessments of severity of Sleepiness in 60 patients (34 women) with suspected excessive daytime Sleepiness. Mean scores were 14.2 +/- 5.9 on the ESS and 8.3 +/- 5.2 minutes on the MSLT. ESS scores correlated negatively, but not strongly, with MSLT scores (rho = -0.37, p = 0.0042) and ESS scores of 14 and above predicted a low mean Sleep Latency on the MSLT. The ESS score correlated with the degree to which patients complained of Sleepiness and may be useful as an otherwise elusive link between patients' complaints and their objective findings on MSLT.
Ronald D. Chervin - One of the best experts on this subject based on the ideXlab platform.
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Sleep onset rem periods during multiple Sleep Latency tests in patients evaluated for Sleep apnea
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Ronald D. Chervin, Michael S AldrichAbstract:Although 2 or more Sleep onset rapid eye movement (REM) periods (2omSOREMPs) on a Multiple Sleep Latency Test (MSLT) raise the possibility of narcolepsy, patients with obstructive Sleep apnea (OSA) also can have 2omSOREMPs, which may then cause diagnostic uncertainty. To explore what features among OSA patients predict 2omSOREMPs on an MSLT that follows nocturnal polysomnography, we reviewed data from 1,145 consecutively studied patients suspected or confirmed to have OSA rather than narcolepsy. Overall, 4.7% of the subjects had 2omSOREMPs. Variables that were independently predictive of 2omSOREMPs in logistic regression models included male gender (OR = 4.4, 95% CI = 1.9 to 12.7), a 5-min decrease in the MSLT-derived mean Sleep Latency (OR = 1.9, 95% CI = 1.3 to 2.8), a 90-min decrease in nocturnal Latency to REM Sleep (OR = 1.6, 95% CI = 1.1 to 2.5), and a 15-unit decrease in minimal recorded oxygen saturation (OR = 1.6, 95% CI = 1.3 to 2.0). We conclude that among patients suspected or confirmed to hav...
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value of the multiple Sleep Latency test mslt for the diagnosis of narcolepsy
Sleep, 1997Co-Authors: Michael S Aldrich, Ronald D. Chervin, Beth A MalowAbstract:Since its introduction, the multiple Sleep Latency test (MSLT) has played a major role in the diagnosis of narcolepsy. We assessed its diagnostic value in a series of 2,083 subjects of whom 170 (8.2%) were diagnosed with narcolepsy. The sensitivity of the combination of two or more Sleep onset rapid eye movement (REM) periods (SOREMPs) with a mean Sleep Latency of < 5 minutes on an initial MSLT was 70% with a specificity of 97%, but 30% of all subjects with this combination of findings did not have narcolepsy. In some narcoleptics who had more than one MSLT, the proportion of naps with SOREMPs varied substantially from the initial MSLT to the follow-up test. The highest specificity (99.2%) and positive predictive value (PPV) (87%) for MSLT findings was obtained with the criteria of three or more SOREMPs combined with a mean Sleep Latency of < 5 minutes, but the sensitivity of this combination was only 46%. The combination of a SOREMP with a Sleep Latency < 10 minutes on polysomnography yielded a specificity (98.9%) and PPV (73%) almost equal to those obtained from combinations of MSLT findings, but the sensitivity was much lower. Our results suggest that the MSLT cannot be used in isolation to confirm or exclude narcolepsy, is indicated only in selected patients with excessive daytime Sleepiness, and is most valuable when interpreted in conjunction with clinical findings.
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Comparison of the results of the Epworth Sleepiness Scale and the Multiple Sleep Latency Test
Journal of psychosomatic research, 1997Co-Authors: Ronald D. Chervin, Michael S Aldrich, Roberta Pickett, Christian GuilleminaultAbstract:The Epworth Sleepiness Scale (ESS), which asks patients to estimate the likelihood that they would doze off or fall aSleep in sedentary situations, has been proposed to be a quick, inexpensive way to assess Sleepiness. We analyzed relations among ESS scores, mean Sleep latencies on the Multiple Sleep Latency Test (MSLT), and subjective assessments of severity of Sleepiness in 60 patients (34 women) with suspected excessive daytime Sleepiness. Mean scores were 14.2 +/- 5.9 on the ESS and 8.3 +/- 5.2 minutes on the MSLT. ESS scores correlated negatively, but not strongly, with MSLT scores (rho = -0.37, p = 0.0042) and ESS scores of 14 and above predicted a low mean Sleep Latency on the MSLT. The ESS score correlated with the degree to which patients complained of Sleepiness and may be useful as an otherwise elusive link between patients' complaints and their objective findings on MSLT.
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Overestimation of Sleep Latency by Patients With Suspected Hypersomnolence
Sleep, 1996Co-Authors: Ronald D. Chervin, Christian GuilleminaultAbstract:The Latency to Sleep onset has been reported to be overestimated by chronic insomniacs. Observing that some patients evaluated for suspected hypersomnolence complain of insomnia and others fail to report that they are Sleepy, we wondered whether overestimation of Sleep Latency could be occurring in these subjects as well. Since polysomnography (PSG) only provides one Sleep onset with which to assess a patient's estimation, we investigated the use of the multiple Sleep Latency test (MSLT) for this purpose. Among 147 patients who had an MSLT, 137 of whom had a preceding PSG, overestimation of Sleep Latency occurred on 78% and 74% of the respective tests. The magnitude of overestimation averaged 3 minutes and 27 minutes, respectively, and was not dependent on diagnosis. Subjects who had reported a history of difficulty falling aSleep, compared to those who did not, tended to show equivalent objective Sleep latencies, longer subjective nocturnal Sleep latencies and less overall accuracy in their estimates. Those who denied having a problem with excessive daytime Sleepiness (EDS) showed objective Sleep latencies nearly identical to those who complained of EDS but had only a trend toward higher overestimation on the MSLT. Overestimation of Sleep Latency is therefore more readily part of an explanation for why hypersomnolent patients sometimes complain of insomnia than it is for failure to recognize EDS. The MSLT as well as nocturnal recordings can provide data with which to assess overestimation of Sleep Latency.
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Correlates of Sleep Latency on the multiple Sleep Latency test in a clinical population
Electroencephalography and clinical neurophysiology, 1995Co-Authors: Ronald D. Chervin, Helena C. Kraemer, Christian GuilleminaultAbstract:The multiple Sleep Latency test (MSLT) is commonly used as an objective measure of Sleepiness. We retrospectively correlated MSLT scores from 147 patients with other information relating to Sleepiness, namely demographic information, data from nocturnal polysomnograms (PSGs), and subjective assessments. The only variable that showed a valid and statistically significant correlation with the MSLT score was Sleep Latency on the PSG. The results were largely similar within subgroups focusing on (1) individuals with the ability to fall aSleep on every nap, (2) subjects with abnormally short MSLT scores, (3) nap attempts that were successful, and (4) patients with particular diagnoses. We conclude that the mean Sleep Latency on the MSLT, in a clinical population, does not correlate well with a number of variables expected to influence Sleepiness. While the validated utility of the MSLT in separating patients from normals or in identifying narcolepsy is not disputed, the accuracy of the MSLT as a measure of Sleepiness appears to be limited.
Thomas Roth - One of the best experts on this subject based on the ideXlab platform.
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Multiple Sleep Latency Test
Sleep Disorders Medicine, 2017Co-Authors: Thomas Roth, Timothy A. RoehrsAbstract:Representative surveys of the populations of industrialized countries have found that between 11 and 32 % of respondents reported that Sleepiness interferes with activities almost daily. Normal and pathologic variations in daytime Sleepiness and alertness can now be directly assessed and quantified by the multiple Sleep Latency test (MSLT), a test of the rapidity with which a subject falls aSleep in a standardized, Sleep-conducive setting, repeated at 2-h intervals throughout the day. The MSLT uses standard Sleep recording methods to document both the rate of Sleep onset and the appearance of rapid eye movement (REM) episodes at Sleep onset. Several studies of the reliability of the MSLT have been conducted. In healthy controls who maintained consistent Sleep–wake schedules, the test–retest reliability of a four-test MSLT was 0.97 over a 4- to 14-month test–retest interval. Of particular interest is the finding that the REM Latency on SOREMPs during the initial evaluation was also correlated with that during retesting (r = 0.64, P < 0.02). The validity of the MSLT has been establishing its sensitivity to Sleep duration and continuity, circadian phase, sedating and stimulating drugs including alcohol and caffeine, and a variety of Sleep and other disorders. These data, both in selected and in unselected populations, suggest that the population mean for a five-test MSLT is about 11 min with an approximate 5-min standard deviation. Clinically, evidence of pathologic Sleepiness is considered to be an average daily Sleep Latency of 8 min or less. An average Latency between 8 and 10 min is considered borderline pathologic, and latencies of 10 min and greater are considered normal.
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Multiple Sleep Latency test
Sleep Disorders Medicine: Basic Science Technical Considerations and Clinical Aspects: Fourth Edition, 2017Co-Authors: Thomas Roth, Timothy A. RoehrsAbstract:Daytime Sleepiness is such a familiar thing for most Japanese, dozing off in a commuting train is regarded as completely normal. Sleepiness, however, can yield a lot of problems. Not only deteriorating efficiency of the work, it sometimes leads to traffic accidents, and also serves as a cause for disastrous accidents. Although excessive daytime Sleepiness has been gradually known to Japanese health workers as one of the symptoms of Sleep apnea syndrome, some patients cannot recognize Sleepiness, and even neglect it, feeling others are Sleepy as well. In this respect multiple Sleep Latency test is a valuable tool as an objective measures of daytime Sleepiness, and commonly used procedures of this testing was described in details.
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effects of ramelteon on patient reported Sleep Latency in older adults with chronic insomnia
Sleep Medicine, 2006Co-Authors: Thomas Roth, David Seiden, Stephen Sainati, Sherry Wangweigand, Jeffrey Zhang, Phyllis C ZeeAbstract:Abstract Background and purpose To assess the efficacy and safety of ramelteon, a selective MT 1 /MT 2 receptor agonist, for chronic insomnia treatment. Patients and methods Randomized, double-blind, placebo-controlled 35-night outpatient trial with weekly clinic visits at multiple centers. Patients include older adults (≥65 years; N =829) with chronic insomnia. Placebo, ramelteon 4mg, or ramelteon 8mg were taken nightly for five weeks, and patient-reported Sleep data were collected using Sleep diaries. Primary efficacy was Sleep Latency at week 1. Sustained efficacy was examined at weeks 3 and 5. Rebound insomnia and withdrawal effects were evaluated during a 7-day placebo run-out. Results Both doses of ramelteon produced statistically significant reductions in Sleep Latency vs. placebo at week 1 (ramelteon 4mg: 70.2 vs. 78.5min, P =.008; ramelteon 8mg: 70.2 vs. 78.5min, P =.008). Patients continued to report reduced Sleep Latency at week 3 with ramelteon 8mg (60.3 vs. 69.3min, P =.003), and at week 5 with ramelteon 4mg (63.4 vs. 70.6min, P =.028) and ramelteon 8mg (57.7 vs. 70.6min; P P =.004) and week 3 (336.0 vs. 324.3min, P =.007) compared with placebo. There was no evidence of significant rebound insomnia or withdrawal effects following treatment discontinuation. The incidence of adverse events was similar among all treatment groups; most were mild or moderate. Conclusions In older adults with chronic insomnia, ramelteon significantly reduced patient reports of Sleep Latency over five weeks of treatment with no significant rebound insomnia or withdrawal effects.
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Effects of ramelteon on patient-reported Sleep Latency in older adults with chronic insomnia ☆
Sleep medicine, 2006Co-Authors: Thomas Roth, David Seiden, Stephen Sainati, Jeffrey Zhang, Sherry Wang-weigand, Phyllis C ZeeAbstract:Abstract Background and purpose To assess the efficacy and safety of ramelteon, a selective MT 1 /MT 2 receptor agonist, for chronic insomnia treatment. Patients and methods Randomized, double-blind, placebo-controlled 35-night outpatient trial with weekly clinic visits at multiple centers. Patients include older adults (≥65 years; N =829) with chronic insomnia. Placebo, ramelteon 4mg, or ramelteon 8mg were taken nightly for five weeks, and patient-reported Sleep data were collected using Sleep diaries. Primary efficacy was Sleep Latency at week 1. Sustained efficacy was examined at weeks 3 and 5. Rebound insomnia and withdrawal effects were evaluated during a 7-day placebo run-out. Results Both doses of ramelteon produced statistically significant reductions in Sleep Latency vs. placebo at week 1 (ramelteon 4mg: 70.2 vs. 78.5min, P =.008; ramelteon 8mg: 70.2 vs. 78.5min, P =.008). Patients continued to report reduced Sleep Latency at week 3 with ramelteon 8mg (60.3 vs. 69.3min, P =.003), and at week 5 with ramelteon 4mg (63.4 vs. 70.6min, P =.028) and ramelteon 8mg (57.7 vs. 70.6min; P P =.004) and week 3 (336.0 vs. 324.3min, P =.007) compared with placebo. There was no evidence of significant rebound insomnia or withdrawal effects following treatment discontinuation. The incidence of adverse events was similar among all treatment groups; most were mild or moderate. Conclusions In older adults with chronic insomnia, ramelteon significantly reduced patient reports of Sleep Latency over five weeks of treatment with no significant rebound insomnia or withdrawal effects.
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Scoring reliability of the multiple Sleep Latency test in a clinical population.
Sleep, 2000Co-Authors: Christopher L. Drake, Timothy A. Roehrs, Leon Rosenthal, Matthew F. Rice, Peter Guido, Thomas RothAbstract:Study Objectives: To determine intrarater and interrater scoring reliability of the multiple Sleep Latency test (MSLT) in a population of Sleep clinic patients. Design: N/A Setting: Urban Sleep center. Patients: 200 consecutive Sleep center patients (diagnoses included: obstructive Sleep apnea, narcolepsy, periodic-limb-movement, and individuals with no diagnosis). Interventions: N/A Measurements and Results: MSLTs were recorded and scored according to standard clinical procedures. One of four clinical polysomnographers and one of seven polysomnographic technologists scored each MSLT. All MSLTs were then rescored by the same polysomnographer. The intrarater reliability coefficient for mean MSLT score was .87 and interrater reliability was .90. Coefficients for the mean number of REM onsets during the MSLT were .81 for intrarater and .88 for interrater reliability. Intrarater and interrater agreement (kappa coefficients) for the presence of at least one REM onset during the MSLT was .78 and .86, respectively. For the presence of greater than one REM onset, a kappa of .78 was obtained for intrarater agreement and .91 for interrater agreement. Conclusions: The clinical MSLT displays excellent interrater and intrarater reliability estimates for both Sleep Latency and REM onset scores in a Sleep-disordered population.
