The Experts below are selected from a list of 3108 Experts worldwide ranked by ideXlab platform

Eminy H Y Lee - One of the best experts on this subject based on the ideXlab platform.

  • novel role and mechanism of protein inhibitor of activated stat1 in spatial learning
    The EMBO Journal, 2011
    Co-Authors: Derek J C Tai, Wei L Hsu, Yen C Liu, Yun L, Eminy H Y Lee
    Abstract:

    By using differential display PCR, we have previously identified 98 cDNA fragments from rat dorsal hippocampus, which are expressed differentially between the fast Learners and Slow Learners from water-maze learning task. One cDNA fragment, which showed a higher expression level in fast Learners, encodes the rat protein inhibitor of activated STAT1 (pias1) gene. Spatial training induced a significant increase in PIAS1 expression in rat hippocampus. Transient transfection of the wild-type (WT) PIAS1 plasmid to CA1 neurons facilitated, whereas transfection of PIAS1 siRNA impaired spatial learning in rats. Meanwhile, PIAS1WT increased STAT1 sumoylation, decreased STAT1 DNA binding and decreased STAT1 phosphorylation at Tyr-701 associated with spatial learning facilitation. But PIAS1 siRNA transfection produced an opposite effect on these measures associated with spatial learning impairment. Further, transfection of STAT1 sumoylation mutant impaired spatial acquisition, whereas transfection of STAT1 phosphorylation mutant blocked the impairing effect of PIAS1 siRNA on spatial learning. In this study, we first demonstrate the role of PIAS1 in spatial learning. Both posttranslational modifications (increased sumoylation and decreased phosphorylation) mediate the effect of PIAS1 on spatial learning facilitation.

  • sgk a primary glucocorticoid induced gene facilitates memory consolidation of spatial learning in rats
    Proceedings of the National Academy of Sciences of the United States of America, 2002
    Co-Authors: Kuen J Tsai, Wei L Hsu, Yun L, Shau K Chen, Eminy H Y Lee
    Abstract:

    By using differential display PCR, we have identified 98 cDNA fragments from the rat dorsal hippocampus that are expressed differentially between the fast Learners and Slow Learners in the water maze learning task. One of these cDNA fragments encodes the rat serum- and glucocorticoid-inducible kinase (sgk) gene. Northern blot analysis revealed that the sgk mRNA level was approximately 4-fold higher in the hippocampus of fast Learners than Slow Learners. In situ hybridization results indicated that sgk mRNA level was increased markedly in CA1, CA3, and dentate gyrus of hippocampus in fast Learners. Transient transfection of the sgk mutant DNA to the CA1 area impaired, whereas transfection of the sgk wild-type DNA facilitated water maze performance in rats. These results provide direct evidence that enhanced sgk expression facilitates memory consolidation of spatial learning in rats. These results also elucidate the molecular mechanism of glucocorticoid-induced memory facilitation in mammals.

Emelia Akashah Patah Akhir - One of the best experts on this subject based on the ideXlab platform.

  • development and usability study of multimedia courseware for Slow Learners komputer saya
    International Conference on Computer and Information Science, 2012
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    The growth of learning courseware which exploits the use of multimedia presents an active learning environment for the Slow Learners. This method of learning is proven to be an effective tool to be used to educate children with learning disability. This research was carried out to develop a multimedia courseware namely “Komputer Saya”, which was specially designed for the Slow Learners. This courseware integrates Special Education Syllabus for Learning Disabled with the learning multimedia theme. This paper discusses the framework used for the courseware evaluation and results of the usability evaluation; efficiency, ease of learning and satisfaction attributes. The evaluation conducted was divided into two types; the first evaluation is known as user testing and the second one is heuristic evaluation. Eight Slow Learners from special education were selected as the participants for the first evaluation while four teachers and one parent were involved in heuristic evaluation. The results of the usability evaluation indicate that “Komputer Saya” can be used as a leaning tool for the Slow Learners as it meets the requirement for its usability in terms of efficiency, ease of learning and satisfaction.

  • usability evaluation for komputer saya multimedia courseware for Slow Learners
    International Visual Informatics Conference, 2011
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    Computer-based learning has been proven as an effective tool in education and implemented for its various advantages and capabilities. One of computer-based application is multimedia courseware which has been increasingly developed not only for teaching and learning in normal class setting, but also proven beneficial for those with learning disabilities including Slow Learners. The aim of this research is to develop a multimedia courseware namely 'Komputer Saya' consists of learning theme of multimedia, as referring to Special Education Syllabus for Learning Disabled. This paper discusses on the courseware evaluation design and the quantitative results for the parts of usability and courseware content evaluations. The evaluations have been conducted involving eight Slow Learners from special education for learning disabilities for user testing, while four teachers and one parent for heuristic evaluation. The results have shown that the courseware has met the requirement for usability part on engaging of the multimedia elements, ease of learn of the courseware design as well the suitability of the courseware contents for Slow Learners. This analysis is believed can be beneficial for future reference and improvement for future research.

  • multimedia courseware for Slow Learners a preliminary analysis
    International Symposium on Information Technology, 2010
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    Emergences of technology had enabled the development of various innovative teaching-learning tools in education. The enjoyment offered by multimedia can increase learner's motivation and participation thus allowing them to retain the learning process in longer period compared to using traditional classroom method. As Slow Learners are difficult to maintain their learning attentions for long time span, multimedia courseware is believe to assist them. This paper presents the findings from a preliminary analysis of Slow Learners conducted in special education schools. In this study, qualitative methodology using interview with special education teachers and class observations were conducted to understand the Slow learner's teaching-learning situations as a whole. The key findings from the analysis are Slow learner's learning interest and behavior while using computer and the potential that multimedia courseware can bring in motivating and increasing their interest in learning. Several guidelines for designing multimedia courseware for Slow Learners are proposed. Conceptual framework is also being illustrated in this paper as guide in conducting further research. All these preliminary findings will assist in designing multimedia courseware and will successfully facilitate the Slow Learners as well as special education teachers.

  • multimedia design and development in komputer saya courseware for Slow Learners
    International Conference on Computer Research and Development, 2010
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    Multimedia offers lots of advantages in the field of education. With the ability to combine multiple media elements in a package, learning environment can be customized according to the Learners to meet their individual learning requirements. Slow Learners are individuals with limited cognitive abilities, whose thinking skills develop Slower than the norm for their ages and have difficulties in learning. Researches have proven that these special individuals can gain advantages by incorporating multimedia into their learning. This paper is one part of research project of developing a multimedia courseware to facilitate Slow learner's learning in their special education class. In this paper, the design and development part of the multimedia courseware for Slow Learners is discussed. The courseware is developed based on ADDIE methodology and used Macromedia Flash as the main platform, as well as Adobe Illustrator and Adobe Photoshop for interfaces and graphics design. The developed courseware will be based on the "Sukatan Pelajaran Pendidikan Khas Bermasalah Pembelajaran Sekolah Rendah & Menengah', which focus on functional academic skills based on the curriculum of Multimedia Component. Methodological development model and modules of the courseware are presented in this paper.

Marsigit Marsigit - One of the best experts on this subject based on the ideXlab platform.

  • is it effective using peer tutoring with realistic mathematics education approach to improve Slow Learners mathematics attitudes
    International Journal on Emerging Mathematics Education, 2018
    Co-Authors: Sumbaji Putranto, Marsigit Marsigit
    Abstract:

    This study was aimed to describe the effectiveness of peer tutoring method with Realistic Mathematics Education approach applied in inclusive classes to improve Slow Learners' mathematics attitudes. Type of this research was quasi experiment with one-group pretest-posttest design. The sample was chosen by using convenience sampling from Slow Learners of VII Grade Junior High School which consisted of 31 students scattered into 3 inclusive classes. The instrument used in this study was a non-test instrument in form of questionnaires. The effectiveness criteria in this study was based on 1) the average score of final questionnaire was higher than the initial questionnaire score, 2) the final questionnaire score shows that more than 75% of the whole students gained the minimum “good” criteria. The result shows that applying peer tutoring learning method with Realistic Mathematics Education approach in inclusive classes was effective to improve Slow Learners' mathematics attitudes.

Norfarhana Abdollah - One of the best experts on this subject based on the ideXlab platform.

  • development and usability study of multimedia courseware for Slow Learners komputer saya
    International Conference on Computer and Information Science, 2012
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    The growth of learning courseware which exploits the use of multimedia presents an active learning environment for the Slow Learners. This method of learning is proven to be an effective tool to be used to educate children with learning disability. This research was carried out to develop a multimedia courseware namely “Komputer Saya”, which was specially designed for the Slow Learners. This courseware integrates Special Education Syllabus for Learning Disabled with the learning multimedia theme. This paper discusses the framework used for the courseware evaluation and results of the usability evaluation; efficiency, ease of learning and satisfaction attributes. The evaluation conducted was divided into two types; the first evaluation is known as user testing and the second one is heuristic evaluation. Eight Slow Learners from special education were selected as the participants for the first evaluation while four teachers and one parent were involved in heuristic evaluation. The results of the usability evaluation indicate that “Komputer Saya” can be used as a leaning tool for the Slow Learners as it meets the requirement for its usability in terms of efficiency, ease of learning and satisfaction.

  • usability evaluation for komputer saya multimedia courseware for Slow Learners
    International Visual Informatics Conference, 2011
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    Computer-based learning has been proven as an effective tool in education and implemented for its various advantages and capabilities. One of computer-based application is multimedia courseware which has been increasingly developed not only for teaching and learning in normal class setting, but also proven beneficial for those with learning disabilities including Slow Learners. The aim of this research is to develop a multimedia courseware namely 'Komputer Saya' consists of learning theme of multimedia, as referring to Special Education Syllabus for Learning Disabled. This paper discusses on the courseware evaluation design and the quantitative results for the parts of usability and courseware content evaluations. The evaluations have been conducted involving eight Slow Learners from special education for learning disabilities for user testing, while four teachers and one parent for heuristic evaluation. The results have shown that the courseware has met the requirement for usability part on engaging of the multimedia elements, ease of learn of the courseware design as well the suitability of the courseware contents for Slow Learners. This analysis is believed can be beneficial for future reference and improvement for future research.

  • multimedia courseware for Slow Learners a preliminary analysis
    International Symposium on Information Technology, 2010
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    Emergences of technology had enabled the development of various innovative teaching-learning tools in education. The enjoyment offered by multimedia can increase learner's motivation and participation thus allowing them to retain the learning process in longer period compared to using traditional classroom method. As Slow Learners are difficult to maintain their learning attentions for long time span, multimedia courseware is believe to assist them. This paper presents the findings from a preliminary analysis of Slow Learners conducted in special education schools. In this study, qualitative methodology using interview with special education teachers and class observations were conducted to understand the Slow learner's teaching-learning situations as a whole. The key findings from the analysis are Slow learner's learning interest and behavior while using computer and the potential that multimedia courseware can bring in motivating and increasing their interest in learning. Several guidelines for designing multimedia courseware for Slow Learners are proposed. Conceptual framework is also being illustrated in this paper as guide in conducting further research. All these preliminary findings will assist in designing multimedia courseware and will successfully facilitate the Slow Learners as well as special education teachers.

  • multimedia design and development in komputer saya courseware for Slow Learners
    International Conference on Computer Research and Development, 2010
    Co-Authors: Norfarhana Abdollah, Wan Fatimah Wan Ahmad, Emelia Akashah Patah Akhir
    Abstract:

    Multimedia offers lots of advantages in the field of education. With the ability to combine multiple media elements in a package, learning environment can be customized according to the Learners to meet their individual learning requirements. Slow Learners are individuals with limited cognitive abilities, whose thinking skills develop Slower than the norm for their ages and have difficulties in learning. Researches have proven that these special individuals can gain advantages by incorporating multimedia into their learning. This paper is one part of research project of developing a multimedia courseware to facilitate Slow learner's learning in their special education class. In this paper, the design and development part of the multimedia courseware for Slow Learners is discussed. The courseware is developed based on ADDIE methodology and used Macromedia Flash as the main platform, as well as Adobe Illustrator and Adobe Photoshop for interfaces and graphics design. The developed courseware will be based on the "Sukatan Pelajaran Pendidikan Khas Bermasalah Pembelajaran Sekolah Rendah & Menengah', which focus on functional academic skills based on the curriculum of Multimedia Component. Methodological development model and modules of the courseware are presented in this paper.

Sumbaji Putranto - One of the best experts on this subject based on the ideXlab platform.

  • is it effective using peer tutoring with realistic mathematics education approach to improve Slow Learners mathematics attitudes
    International Journal on Emerging Mathematics Education, 2018
    Co-Authors: Sumbaji Putranto, Marsigit Marsigit
    Abstract:

    This study was aimed to describe the effectiveness of peer tutoring method with Realistic Mathematics Education approach applied in inclusive classes to improve Slow Learners' mathematics attitudes. Type of this research was quasi experiment with one-group pretest-posttest design. The sample was chosen by using convenience sampling from Slow Learners of VII Grade Junior High School which consisted of 31 students scattered into 3 inclusive classes. The instrument used in this study was a non-test instrument in form of questionnaires. The effectiveness criteria in this study was based on 1) the average score of final questionnaire was higher than the initial questionnaire score, 2) the final questionnaire score shows that more than 75% of the whole students gained the minimum “good” criteria. The result shows that applying peer tutoring learning method with Realistic Mathematics Education approach in inclusive classes was effective to improve Slow Learners' mathematics attitudes.