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Louk J. M. J. Vanderschuren - One of the best experts on this subject based on the ideXlab platform.
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the neurobiology of Social Play and its rewarding value in rats
Neuroscience & Biobehavioral Reviews, 2016Co-Authors: Louk J. M. J. Vanderschuren, E Marijke J Achterberg, Viviana TrezzaAbstract:In the young of many mammalian species, including humans, a vigorous and highly rewarding Social activity is abundantly expressed, known as Social Play behaviour. Social Play is thought to be important for the development of Social, cognitive and emotional processes and their neural underpinnings, and it is disrupted in pediatric psychiatric disorders. Here, we summarize recent progress in our understanding of the brain mechanisms of Social Play behaviour, with a focus on its rewarding properties. Opioid, endocannabinoid, dopamine and noradrenaline systems Play a prominent role in the modulation of Social Play. Of these, dopamine is particularly important for the motivational properties of Social Play. The nucleus accumbens has been identified as a key site for opioid and dopamine modulation of Social Play. Endocannabinoid influences on Social Play rely on the basolateral amygdala, whereas noradrenaline modulates Social Play through the basolateral amygdala, habenula and prefrontal cortex. In sum, Social Play behaviour is the result of coordinated activity in a network of corticolimbic structures, and its monoamine, opioid and endocannabinoid innervation.
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Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats
Neuropsychopharmacology, 2016Co-Authors: Antonia Manduca, Ruth Damsteegt, Patrizia Campolongo, Louk J. M. J. Vanderschuren, Michela Servadio, Viviana TrezzaAbstract:Social Play behavior is a highly rewarding form of Social interaction disPlayed by young mammals. Social Play is important for neurobehavioral development and it has been found to be impaired in several developmental psychiatric disorders. In line with the rewarding properties of Social Play, we have previously identified the nucleus accumbens (NAc) as an important site of action for endocannabinoid and opioid modulation of this behavior. NAc dopamine has a well-known role in certain components of reward processes, such as incentive motivation. However, its contribution to the positive emotional aspects of Social interactions is less clear. Therefore, we investigated the role of dopaminergic neurotransmission in the NAc in Social Play behavior in rats. We found that intra-NAc infusion of the dopamine releaser/reuptake inhibitor amphetamine increased Social Play behavior that was dependent on activation of both D1 and D2 dopamine receptors. This increase in Social Play behavior was mimicked by intra-NAc infusion of the dopamine receptor agonist apomorphine, but not of the dopamine reuptake inhibitor GBR-12909. Blockade of either D1 or D2 NAc dopamine receptors reduced Social Play in animals highly motivated to Play as a result of longer Social isolation before testing. Last, blockade of NAc dopamine receptors prevented the Play-enhancing effects of endocannabinoid and opioid receptor stimulation. These findings demonstrate an important modulatory role of NAc dopaminergic neurotransmission in Social Play. Thus, functional activity in the mesolimbic dopamine pathway Plays an important role in adaptive Social development, whereas abnormal NAc dopamine function may underlie the Social impairments observed in developmental psychiatric disorders such as autism, attention deficit hyperactivity disorder or early-onset schizophrenia.
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contrasting roles of dopamine and noradrenaline in the motivational properties of Social Play behavior in rats
Neuropsychopharmacology, 2016Co-Authors: E Marijke J Achterberg, Viviana Trezza, Linda W M Van Kerkhof, Michela Servadio, Maaike M H Van Swieten, Danielle J Houwing, Mandy Aalderink, Nina V Driel, Louk J. M. J. VanderschurenAbstract:Social Play behavior, abundant in the young of most mammalian species, is thought to be important for Social and cognitive development. Social Play is highly rewarding, and as such, the expression of Social Play depends on its pleasurable and motivational properties. Since the motivational properties of Social Play have only sporadically been investigated, we developed a setup in which rats responded for Social Play under a progressive ratio schedule of reinforcement. Dopaminergic neurotransmission Plays a key role in incentive motivational processes, and both dopamine and noradrenaline have been implicated in the modulation of Social Play behavior. Therefore, we investigated the role of dopamine and noradrenaline in the motivation for Social Play. Treatment with the psychostimulant drugs methylphenidate and cocaine increased responding for Social Play, but suppressed its expression during reinforced Play periods. The dopamine reuptake inhibitor GBR-12909 increased responding for Social Play, but did not affect its expression, whereas the noradrenaline reuptake inhibitor atomoxetine decreased responding for Social Play as well as its expression. The effects of methylphenidate and cocaine on responding for Social Play, but not their Play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol. In contrast, pretreatment with the α2-adrenoceptor antagonist RX821002 prevented the Play-suppressant effect of methylphenidate, but left its effect on responding for Social Play unaltered. In sum, the present study introduces a novel method to study the incentive motivational properties of Social Play behavior in rats. Using this paradigm, we demonstrate dissociable roles for dopamine and noradrenaline in Social Play behavior: dopamine stimulates the motivation for Social Play, whereas noradrenaline negatively modulates the motivation for Social Play behavior and its expression.
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methylphenidate and atomoxetine inhibit Social Play behavior through prefrontal and subcortical limbic mechanisms in rats
The Journal of Neuroscience, 2015Co-Authors: E Marijke J Achterberg, Ruth Damsteegt, Viviana Trezza, Linda W M Van Kerkhof, Louk J. M. J. VanderschurenAbstract:Positive Social interactions during the juvenile and adolescent phases of life, in the form of Social Play behavior, are important for Social and cognitive development. However, the neural mechanisms of Social Play behavior remain incompletely understood. We have previously shown that methylphenidate and atomoxetine, drugs widely used for the treatment of attention-deficit hyperactivity disorder (ADHD), suppress Social Play in rats through a noradrenergic mechanism of action. Here, we aimed to identify the neural substrates of the Play-suppressant effects of these drugs. Methylphenidate is thought to exert its effects on cognition and emotion through limbic corticostriatal systems. Therefore, methylphenidate was infused into prefrontal and orbitofrontal cortical regions as well as into several subcortical limbic areas implicated in Social Play. Infusion of methylphenidate into the anterior cingulate cortex, infralimbic cortex, basolateral amygdala, and habenula inhibited Social Play, but not Social exploratory behavior or locomotor activity. Consistent with a noradrenergic mechanism of action of methylphenidate, infusion of the noradrenaline reuptake inhibitor atomoxetine into these same regions also reduced Social Play. Methylphenidate administration into the prelimbic, medial/ventral orbitofrontal, and ventrolateral orbitofrontal cortex, mediodorsal thalamus, or nucleus accumbens shell was ineffective. Our data show that the inhibitory effects of methylphenidate and atomoxetine on Social Play are mediated through a distributed network of prefrontal and limbic subcortical regions implicated in cognitive control and emotional processes. These findings increase our understanding of the neural underpinnings of this developmentally important Social behavior, as well as the mechanism of action of two widely used treatments for ADHD.
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What the laboratory rat has taught us about Social Play behavior: role in behavioral development and neural mechanisms.
Current topics in behavioral neurosciences, 2014Co-Authors: Louk J. M. J. Vanderschuren, Viviana TrezzaAbstract:Social Play behavior is the most vigorous and characteristic form of Social interaction disPlayed by developing mammals. The laboratory rat is an ideal species to study this behavior, since it shows ample Social Play that can be easily recognized and quantified. In this chapter, we will first briefly describe the structure of Social Play behavior in rats. Next, we will discuss studies that used Social isolation rearing during the period in life when Social Play is most abundant to investigate the developmental functions of Social Play behavior in rats, focusing on the consequences of Play deprivation on Social, cognitive, emotional, and sensorimotor development. Last, we will discuss the neural substrates of Social Play behavior in rats, with emphasis on the limbic corticostriatal circuits that underlie emotions and their influence on behavior.
Miguel Martin Kowalewski - One of the best experts on this subject based on the ideXlab platform.
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Social Play among black and gold howler monkey alouatta caraya immatures during intergroup encounters
American Journal of Primatology, 2018Co-Authors: Maria Sol Gennuso, Melina Victoria Brividoro, Romina Pave, Mariana Rano, Miguel Martin KowalewskiAbstract:We studied intergroup Social Play (IGSP) among immatures in wild black and gold howler monkeys (Alouatta caraya) in northeastern Argentina. IGSP events are one form of affiliative interaction that can occur during intergroup encounters. The main goal of this study was to analyze IGSP in A. caraya immatures and assess how intrinsic (e.g., age and sex) and extrinsic (e.g., seasonality) factors can influence the development of this type of Social behavior. We followed 12 groups between 2008 and 2015 and recorded 182 encounters and 61 events of IGSP. Considering the composition of Play partners, most IGSP events occurred among juveniles of both sexes (33%), followed by juveniles that were only-male (31%), and finally between mixed-sex juveniles and infants (20%) interactions. Additionally, most IGSP events occurred mainly in summer (56%), followed by spring (29%), with fewer events occurring in autumn (15%) and no IGSP events recorded in winter. Our results suggest that IGSP constitutes a beneficial activity in wild A. caraya that promotes behavioral flexibility, where immatures acquire Social skills, such as tolerance, by interacting with unknown individuals. Moreover, the higher participation of young males in IGSP is consistent with the fact that adult black and gold howler males tend to be more actively involved in group encounters than females, supporting the hypothesis that Social Play provides benefits in the development of motor and Social skills. Finally, seasonality in the frequencies of IGSP might be related to availability of foods with high and easily mobilized energy content in summer and spring.
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Social Play among black and gold howler monkey alouatta caraya immatures during intergroup encounters
American Journal of Primatology, 2018Co-Authors: Maria Sol Gennuso, Melina Victoria Brividoro, Romina Pave, Mariana Rano, Miguel Martin KowalewskiAbstract:Fil: Gennuso, Maria Sol. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estacion Biologica de Usos Multiples (Sede Corrientes); Argentina
Viviana Trezza - One of the best experts on this subject based on the ideXlab platform.
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the neurobiology of Social Play and its rewarding value in rats
Neuroscience & Biobehavioral Reviews, 2016Co-Authors: Louk J. M. J. Vanderschuren, E Marijke J Achterberg, Viviana TrezzaAbstract:In the young of many mammalian species, including humans, a vigorous and highly rewarding Social activity is abundantly expressed, known as Social Play behaviour. Social Play is thought to be important for the development of Social, cognitive and emotional processes and their neural underpinnings, and it is disrupted in pediatric psychiatric disorders. Here, we summarize recent progress in our understanding of the brain mechanisms of Social Play behaviour, with a focus on its rewarding properties. Opioid, endocannabinoid, dopamine and noradrenaline systems Play a prominent role in the modulation of Social Play. Of these, dopamine is particularly important for the motivational properties of Social Play. The nucleus accumbens has been identified as a key site for opioid and dopamine modulation of Social Play. Endocannabinoid influences on Social Play rely on the basolateral amygdala, whereas noradrenaline modulates Social Play through the basolateral amygdala, habenula and prefrontal cortex. In sum, Social Play behaviour is the result of coordinated activity in a network of corticolimbic structures, and its monoamine, opioid and endocannabinoid innervation.
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Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats
Neuropsychopharmacology, 2016Co-Authors: Antonia Manduca, Ruth Damsteegt, Patrizia Campolongo, Louk J. M. J. Vanderschuren, Michela Servadio, Viviana TrezzaAbstract:Social Play behavior is a highly rewarding form of Social interaction disPlayed by young mammals. Social Play is important for neurobehavioral development and it has been found to be impaired in several developmental psychiatric disorders. In line with the rewarding properties of Social Play, we have previously identified the nucleus accumbens (NAc) as an important site of action for endocannabinoid and opioid modulation of this behavior. NAc dopamine has a well-known role in certain components of reward processes, such as incentive motivation. However, its contribution to the positive emotional aspects of Social interactions is less clear. Therefore, we investigated the role of dopaminergic neurotransmission in the NAc in Social Play behavior in rats. We found that intra-NAc infusion of the dopamine releaser/reuptake inhibitor amphetamine increased Social Play behavior that was dependent on activation of both D1 and D2 dopamine receptors. This increase in Social Play behavior was mimicked by intra-NAc infusion of the dopamine receptor agonist apomorphine, but not of the dopamine reuptake inhibitor GBR-12909. Blockade of either D1 or D2 NAc dopamine receptors reduced Social Play in animals highly motivated to Play as a result of longer Social isolation before testing. Last, blockade of NAc dopamine receptors prevented the Play-enhancing effects of endocannabinoid and opioid receptor stimulation. These findings demonstrate an important modulatory role of NAc dopaminergic neurotransmission in Social Play. Thus, functional activity in the mesolimbic dopamine pathway Plays an important role in adaptive Social development, whereas abnormal NAc dopamine function may underlie the Social impairments observed in developmental psychiatric disorders such as autism, attention deficit hyperactivity disorder or early-onset schizophrenia.
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contrasting roles of dopamine and noradrenaline in the motivational properties of Social Play behavior in rats
Neuropsychopharmacology, 2016Co-Authors: E Marijke J Achterberg, Viviana Trezza, Linda W M Van Kerkhof, Michela Servadio, Maaike M H Van Swieten, Danielle J Houwing, Mandy Aalderink, Nina V Driel, Louk J. M. J. VanderschurenAbstract:Social Play behavior, abundant in the young of most mammalian species, is thought to be important for Social and cognitive development. Social Play is highly rewarding, and as such, the expression of Social Play depends on its pleasurable and motivational properties. Since the motivational properties of Social Play have only sporadically been investigated, we developed a setup in which rats responded for Social Play under a progressive ratio schedule of reinforcement. Dopaminergic neurotransmission Plays a key role in incentive motivational processes, and both dopamine and noradrenaline have been implicated in the modulation of Social Play behavior. Therefore, we investigated the role of dopamine and noradrenaline in the motivation for Social Play. Treatment with the psychostimulant drugs methylphenidate and cocaine increased responding for Social Play, but suppressed its expression during reinforced Play periods. The dopamine reuptake inhibitor GBR-12909 increased responding for Social Play, but did not affect its expression, whereas the noradrenaline reuptake inhibitor atomoxetine decreased responding for Social Play as well as its expression. The effects of methylphenidate and cocaine on responding for Social Play, but not their Play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol. In contrast, pretreatment with the α2-adrenoceptor antagonist RX821002 prevented the Play-suppressant effect of methylphenidate, but left its effect on responding for Social Play unaltered. In sum, the present study introduces a novel method to study the incentive motivational properties of Social Play behavior in rats. Using this paradigm, we demonstrate dissociable roles for dopamine and noradrenaline in Social Play behavior: dopamine stimulates the motivation for Social Play, whereas noradrenaline negatively modulates the motivation for Social Play behavior and its expression.
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methylphenidate and atomoxetine inhibit Social Play behavior through prefrontal and subcortical limbic mechanisms in rats
The Journal of Neuroscience, 2015Co-Authors: E Marijke J Achterberg, Ruth Damsteegt, Viviana Trezza, Linda W M Van Kerkhof, Louk J. M. J. VanderschurenAbstract:Positive Social interactions during the juvenile and adolescent phases of life, in the form of Social Play behavior, are important for Social and cognitive development. However, the neural mechanisms of Social Play behavior remain incompletely understood. We have previously shown that methylphenidate and atomoxetine, drugs widely used for the treatment of attention-deficit hyperactivity disorder (ADHD), suppress Social Play in rats through a noradrenergic mechanism of action. Here, we aimed to identify the neural substrates of the Play-suppressant effects of these drugs. Methylphenidate is thought to exert its effects on cognition and emotion through limbic corticostriatal systems. Therefore, methylphenidate was infused into prefrontal and orbitofrontal cortical regions as well as into several subcortical limbic areas implicated in Social Play. Infusion of methylphenidate into the anterior cingulate cortex, infralimbic cortex, basolateral amygdala, and habenula inhibited Social Play, but not Social exploratory behavior or locomotor activity. Consistent with a noradrenergic mechanism of action of methylphenidate, infusion of the noradrenaline reuptake inhibitor atomoxetine into these same regions also reduced Social Play. Methylphenidate administration into the prelimbic, medial/ventral orbitofrontal, and ventrolateral orbitofrontal cortex, mediodorsal thalamus, or nucleus accumbens shell was ineffective. Our data show that the inhibitory effects of methylphenidate and atomoxetine on Social Play are mediated through a distributed network of prefrontal and limbic subcortical regions implicated in cognitive control and emotional processes. These findings increase our understanding of the neural underpinnings of this developmentally important Social behavior, as well as the mechanism of action of two widely used treatments for ADHD.
-
What the laboratory rat has taught us about Social Play behavior: role in behavioral development and neural mechanisms.
Current topics in behavioral neurosciences, 2014Co-Authors: Louk J. M. J. Vanderschuren, Viviana TrezzaAbstract:Social Play behavior is the most vigorous and characteristic form of Social interaction disPlayed by developing mammals. The laboratory rat is an ideal species to study this behavior, since it shows ample Social Play that can be easily recognized and quantified. In this chapter, we will first briefly describe the structure of Social Play behavior in rats. Next, we will discuss studies that used Social isolation rearing during the period in life when Social Play is most abundant to investigate the developmental functions of Social Play behavior in rats, focusing on the consequences of Play deprivation on Social, cognitive, emotional, and sensorimotor development. Last, we will discuss the neural substrates of Social Play behavior in rats, with emphasis on the limbic corticostriatal circuits that underlie emotions and their influence on behavior.
Alexa H Veenema - One of the best experts on this subject based on the ideXlab platform.
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dynamic changes in extracellular release of gaba and glutamate in the lateral septum during Social Play behavior in juvenile rats implications for sex specific regulation of Social Play behavior
Neuroscience, 2015Co-Authors: Remco Bredewold, J K Schiavo, M Van Der Hart, M Verreij, Alexa H VeenemaAbstract:Abstract Social Play is a motivated and rewarding behavior that is disPlayed by nearly all mammals and peaks in the juvenile period. Moreover, Social Play is essential for the development of Social skills and is impaired in Social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulation of Social Play behavior in juvenile male and female rats. The LS is largely modulated by GABA and glutamate neurotransmission, but their role in Social Play behavior is unknown. Here, we determined whether Social Play behavior is associated with changes in the extracellular release of GABA and glutamate in the LS and to what extent such changes modulate Social Play behavior in male and female juvenile rats. Using intracerebral microdialysis in freely behaving rats, we found no sex difference in extracellular GABA concentrations, but extracellular glutamate concentrations are higher in males than in females under baseline conditions and during Social Play. This resulted in a higher glutamate/GABA concentration ratio in males vs. females and thus, an excitatory predominance in the LS of males. Furthermore, Social Play behavior in both sexes is associated with significant increases in extracellular release of GABA and glutamate in the LS. Pharmacological blockade of GABA-A receptors in the LS with bicuculline (100 ng/0.5 μl, 250 ng/0.5 μl) dose-dependently decreased the duration of Social Play behavior in both sexes. In contrast, pharmacological blockade of ionotropic glutamate receptors (NMDA and AMPA/kainate receptors) in the LS with AP-5 + CNQX (2 mM + 0.4 mM/0.5 μl, 30 mM + 3 mM/0.5 μl) dose-dependently decreased the duration of Social Play behavior in females, but did not alter Social Play behavior in males. Together, these data suggest a role for GABA neurotransmission in the LS in the regulation of juvenile Social Play behavior in both sexes, while glutamate neurotransmission in the LS is involved in the sex-specific regulation of juvenile Social Play behavior.
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sex specific modulation of juvenile Social Play behavior by vasopressin and oxytocin depends on Social context
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Remco Bredewold, Caroline J Smith, Kelly M Dumais, Alexa H VeenemaAbstract:−as compared to the home cage. AVP enhanced anxiety-related behavior in males (tested on the elevated plus-maze), but failed to do so in females, suggesting that exogenous AVP alters Social Play and anxiety-related behavior via distinct and sex-specific mechanisms. Moreover, none of the other drug treatments that altered Social Play had an effect on anxiety, suggesting that these drug-induced behavioral alterations are relatively specific to Social behavior. Overall, we showed that AVP and OXT systems in the lateral septum modulate Social Play in juvenile rats in neuropeptide-, sex- and Social context-specific ways. These findings underscore the importance of considering not only sex, but also Social context, in how AVP and OXT modulate Social behavior.
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sex specific modulation of juvenile Social Play by vasopressin
Psychoneuroendocrinology, 2013Co-Authors: Alexa H Veenema, Remco Bredewold, Geert J De VriesAbstract:Summary Social Play activities among juveniles are thought to contribute to the development of Social and emotional skills in humans and animals. Conversely, Social Play deficits are observed in developmental neuropsychiatric disorders. Importantly, many of these disorders show sex differences in incidence, course of the disease, and severity of symptoms. We hypothesized that sex differences in the neural systems controlling Social behavior can contribute to these differences. We therefore studied the involvement of the sexually dimorphic vasopressin and oxytocin systems, which have been implicated in these disorders, in juvenile Social Play behavior. Single-housed 5-week-old juvenile male and female rats were exposed in their home cage to an age-and sex-matched novel conspecific for 10 min, and Social Play behaviors were recorded. We found no consistent sex differences in duration or elements of Social Play in vehicle-treated rats. However, intracerebroventricular injection of the specific vasopressin 1a receptor (V1aR) antagonist (CH2)5Tyr(Me 2 )AVP significantly reduced Social Play behaviors in males while increasing them in females. Intracerebroventricular injection of the specific oxytocin receptor antagonist desGly-NH2,d(CH2)5[Tyr(Me) 2 ,Thr 4 ]OVT did not alter Social Play in either sex. To locate the effects of V1aR blockade on Social Play, we targeted the lateral septum, a sexually dimorphic brain region showing denser vasopressin fibers in males than in females and an abundant expression of V1aR in both sexes. Surprisingly, blockade of V1aR in the lateral septum increased Social Play behaviors in males, but decreased them in females. These findings suggest sex- and brain region-specific roles for vasopressin in the regulation of Social Play behavior in juvenile rats.
Maria Sol Gennuso - One of the best experts on this subject based on the ideXlab platform.
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Social Play among black and gold howler monkey alouatta caraya immatures during intergroup encounters
American Journal of Primatology, 2018Co-Authors: Maria Sol Gennuso, Melina Victoria Brividoro, Romina Pave, Mariana Rano, Miguel Martin KowalewskiAbstract:We studied intergroup Social Play (IGSP) among immatures in wild black and gold howler monkeys (Alouatta caraya) in northeastern Argentina. IGSP events are one form of affiliative interaction that can occur during intergroup encounters. The main goal of this study was to analyze IGSP in A. caraya immatures and assess how intrinsic (e.g., age and sex) and extrinsic (e.g., seasonality) factors can influence the development of this type of Social behavior. We followed 12 groups between 2008 and 2015 and recorded 182 encounters and 61 events of IGSP. Considering the composition of Play partners, most IGSP events occurred among juveniles of both sexes (33%), followed by juveniles that were only-male (31%), and finally between mixed-sex juveniles and infants (20%) interactions. Additionally, most IGSP events occurred mainly in summer (56%), followed by spring (29%), with fewer events occurring in autumn (15%) and no IGSP events recorded in winter. Our results suggest that IGSP constitutes a beneficial activity in wild A. caraya that promotes behavioral flexibility, where immatures acquire Social skills, such as tolerance, by interacting with unknown individuals. Moreover, the higher participation of young males in IGSP is consistent with the fact that adult black and gold howler males tend to be more actively involved in group encounters than females, supporting the hypothesis that Social Play provides benefits in the development of motor and Social skills. Finally, seasonality in the frequencies of IGSP might be related to availability of foods with high and easily mobilized energy content in summer and spring.
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Social Play among black and gold howler monkey alouatta caraya immatures during intergroup encounters
American Journal of Primatology, 2018Co-Authors: Maria Sol Gennuso, Melina Victoria Brividoro, Romina Pave, Mariana Rano, Miguel Martin KowalewskiAbstract:Fil: Gennuso, Maria Sol. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estacion Biologica de Usos Multiples (Sede Corrientes); Argentina
