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Alexander G. Ophir - One of the best experts on this subject based on the ideXlab platform.
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Social Recognition in paired, but not single, male prairie voles
Animal behaviour, 2015Co-Authors: Tomica D. Blocker, Alexander G. OphirAbstract:Social Recognition is an integral component of behaviour that underlies many much larger behavioural suites. For example, monogamous pair bonding is relatively meaningless if an individual cannot recall with whom the bond was with. The prairie vole, Microtus ochrogaster, is a Socially monogamous rodent, well known for its long-term pair bonds between males and females. Although previous work has shown that bonded males reliably spend more time with their pair-mate over an unfamiliar female, recent work has demonstrated that single male prairie voles do not discriminate between females. This discrepancy raises the important question: do paired males distinguish between nonmate females? We asked whether pair bonding alters the expression of Social Recognition in male voles by comparing Social Recognition of single and pair-bonded males using the habituation/dishabituation paradigm. We found that pair-bonded, but not single male prairie voles showed Social Recognition of (nonmate) females, suggesting a shift in cognitive behaviour after pair bond formation. This difference was not due to differences in motivation to engage in Social exchanges, as males attempted to contact unfamiliar females at similar levels. Based on these data, we speculate that the stage of life (single or bonded) influences the relevance of attending to Social information of same- and opposite-sex conspecifics.
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Social Recognition is context dependent in single male prairie voles
Animal behaviour, 2013Co-Authors: Da-jiang Zheng, Lauren Foley, Asad Rehman, Alexander G. OphirAbstract:Single males might benefit from knowing the identity of neighbouring males when establishing and defending boundaries. Similarly, males should discriminate between individual females if this leads to more reproductive opportunities. Contextual Social cues may alter the value of learning identity. Knowing the identity of competitors that intrude into an animal's territory may be more salient than knowing the identity of individuals on whose territory an animal is trespassing. Hence, Social and environmental context could affect Social Recognition in many ways. Here we test Social Recognition of Socially monogamous single male prairie voles, Microtus ochrogaster. In experiment 1 we tested Recognition of male or female conspecifics and found that males discriminated between different males but not between different females. In experiment 2 we asked whether Recognition of males is influenced when males are tested in their own cage (familiar), in a clean cage (neutral) or in the home cage of another male (unfamiliar). Although focal males discriminated between male conspecifics in all three contexts, individual variation in Recognition was lower when males were tested in their home cage (in the presence of familiar Social cues) compared to when the context lacked Social cues (neutral). Experiment 1 indicates that selective pressures may have operated to enhance male territorial behaviour and indiscriminate mate selection. Experiment 2 suggests that the presence of a conspecific cue heightens Social Recognition and that home-field advantages might extend to Social cognition. Taken together, our results indicate Social Recognition depends on the Social and possibly territorial context.
Alcino J. Silva - One of the best experts on this subject based on the ideXlab platform.
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Long-term memory underlying hippocampus-dependent Social Recognition in mice.
Hippocampus, 2000Co-Authors: Jeffrey H. Kogan, Paul W. Frankland, Alcino J. SilvaAbstract:The ability to learn and remember individuals is critical for the stability of Social groups. Social Recognition reflects the ability of mice to identify and remember conspecifics. Social Recognition is assessed as a decrease in spontaneous investigation behaviors observed in a mouse reexposed to a familiar conspecific. Our results demonstrate that group-housed mice show Social memory for a familiar juvenile when tested immediately, 30 min, 24 h, 3 days, and 7 days after a single 2-min-long interaction. Interestingly, chronic Social isolation disrupts long-term, but not 30-min, Social memory. Even a 24-h period of isolation disrupts long-term Social memory, a result that may explain why previous investigators only observed short-term Social memory in individually housed rodents. Although it has no obvious configural, relational, or spatial characteristics, here we show that Social memory shares characteristics of other hippocampus-dependent memories. Ibotenic acid lesions of the hippocampus disrupt Social Recognition at 30 min, but not immediately after training. Furthermore, long-term, but not short-term Social memory is dependent on protein synthesis and cyclic AMP responsive element binding protein (CREB) function. These results outline behavioral, systems, and molecular determinants of Social Recognition in mice, and they suggest that it is a powerful paradigm to investigate hippocampal learning and memory.
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long term memory underlying hippocampus dependent Social Recognition in mice
Hippocampus, 2000Co-Authors: Jeffrey H. Kogan, Paul W Franklandand, Alcino J. SilvaAbstract:The ability to learn and remember individuals is critical for the stability of Social groups. Social Recognition reflects the ability of mice to identify and remember conspecifics. Social Recognition is assessed as a decrease in spontaneous investigation behaviors observed in a mouse reexposed to a familiar conspecific. Our results demonstrate that group- housed mice show Social memory for a familiar juvenile when tested immediately, 30 min, 24 h, 3 days, and 7 days after a single 2-min-long interaction. Interestingly, chronic Social isolation disrupts long-term, but not 30-min, Social memory. Even a 24-h period of isolation disrupts long-term Social memory, a result that may explain why previous investiga- tors only observed short-term Social memory in individually housed rodents. Although it has no obvious configural, relational, or spatial characteristics, here we show that Social memory shares characteristics of other hippocampus-dependent memories. Ibotenic acid lesions of the hippocampus disrupt Social Recognition at 30 min, but not immediately after training. Furthermore, long-term, but not short-term Social memory is dependent on protein synthesis and cyclic AMP responsive element binding protein (CREB) function. These results outline behavioral, systems, and molecular determinants of Social Recognition in mice, and they suggest that it is a powerful paradigm to investigate hippocampal learning and memory. Hippocampus 2000;10:47-56. ! 2000 Wiley-Liss, Inc.
Jeffrey H. Kogan - One of the best experts on this subject based on the ideXlab platform.
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Long-term memory underlying hippocampus-dependent Social Recognition in mice.
Hippocampus, 2000Co-Authors: Jeffrey H. Kogan, Paul W. Frankland, Alcino J. SilvaAbstract:The ability to learn and remember individuals is critical for the stability of Social groups. Social Recognition reflects the ability of mice to identify and remember conspecifics. Social Recognition is assessed as a decrease in spontaneous investigation behaviors observed in a mouse reexposed to a familiar conspecific. Our results demonstrate that group-housed mice show Social memory for a familiar juvenile when tested immediately, 30 min, 24 h, 3 days, and 7 days after a single 2-min-long interaction. Interestingly, chronic Social isolation disrupts long-term, but not 30-min, Social memory. Even a 24-h period of isolation disrupts long-term Social memory, a result that may explain why previous investigators only observed short-term Social memory in individually housed rodents. Although it has no obvious configural, relational, or spatial characteristics, here we show that Social memory shares characteristics of other hippocampus-dependent memories. Ibotenic acid lesions of the hippocampus disrupt Social Recognition at 30 min, but not immediately after training. Furthermore, long-term, but not short-term Social memory is dependent on protein synthesis and cyclic AMP responsive element binding protein (CREB) function. These results outline behavioral, systems, and molecular determinants of Social Recognition in mice, and they suggest that it is a powerful paradigm to investigate hippocampal learning and memory.
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long term memory underlying hippocampus dependent Social Recognition in mice
Hippocampus, 2000Co-Authors: Jeffrey H. Kogan, Paul W Franklandand, Alcino J. SilvaAbstract:The ability to learn and remember individuals is critical for the stability of Social groups. Social Recognition reflects the ability of mice to identify and remember conspecifics. Social Recognition is assessed as a decrease in spontaneous investigation behaviors observed in a mouse reexposed to a familiar conspecific. Our results demonstrate that group- housed mice show Social memory for a familiar juvenile when tested immediately, 30 min, 24 h, 3 days, and 7 days after a single 2-min-long interaction. Interestingly, chronic Social isolation disrupts long-term, but not 30-min, Social memory. Even a 24-h period of isolation disrupts long-term Social memory, a result that may explain why previous investiga- tors only observed short-term Social memory in individually housed rodents. Although it has no obvious configural, relational, or spatial characteristics, here we show that Social memory shares characteristics of other hippocampus-dependent memories. Ibotenic acid lesions of the hippocampus disrupt Social Recognition at 30 min, but not immediately after training. Furthermore, long-term, but not short-term Social memory is dependent on protein synthesis and cyclic AMP responsive element binding protein (CREB) function. These results outline behavioral, systems, and molecular determinants of Social Recognition in mice, and they suggest that it is a powerful paradigm to investigate hippocampal learning and memory. Hippocampus 2000;10:47-56. ! 2000 Wiley-Liss, Inc.
Robert Dantzer - One of the best experts on this subject based on the ideXlab platform.
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Vasopressin, gonadal steroids and Social Recognition.
Progress in brain research, 1998Co-Authors: Robert DantzerAbstract:Rodents exposed for a short amount of time to conspecific juveniles spend less time investigating familiar than unfamiliar juveniles. This is based on the formation of an olfactory image of juveniles, which involves an androgen-dependent vasopressinergic pathway in males, as demonstrated by the ability of the vasopressin receptor antagonist dPTyr(Me)VP to block Social Recognition in intact male but not in female and castrated rats and mice. The involvement of sexually dimorphic vasopressinergic neurons appears to be dependent on the processing of Social olfactory cues by the vomeronasal organ since removal of this organ in male rats mimics the effects of castration. These findings are discussed in relation to the role of vasopressin in learning and memory.
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Role of the vomeronasal system in vasopressinergic modulation of Social Recognition in rats
Brain research, 1993Co-Authors: Rose Marie Bluthé, Robert DantzerAbstract:Abstract To assess the role of the vomeronasal organ (VNO) in the dependence of Social Recognition on vasopressinergic transmission, vomerectomized rats were compared to intact and castrated male rats. Removal of the VNO significantly decreased the duration of Social investigation and temporarily impaired Social Recognition. In contrast to sham-operated animals and non-operated animals, lesioned rats were no longer responsive to the blocking effect of the antagonist of the vasopressor receptors of vasopressin (dPTyr(Me)AVP, 30 μg/kg subcutaneously) on Social Recognition. Consequently, VNO-lesioned rats behave like castrates, in spite of the lack of effect of removal of the VNO on plasma testosterone levels. These results suggest that androgen-dependent vasopressinergic neurons are part of the VNO pathway and that the VNO system is important for processing and storage of Socially relevant information in male rat.
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Gonadal steroids influence the involvement of arginine vasopressin in Social Recognition in mice
Psychoneuroendocrinology, 1993Co-Authors: Rose Marie Bluthé, Gilles Gheusi, Robert DantzerAbstract:Abstract Gonadal steroids have been shown to modulate the involvement of vasopressinergic neurotransmission in Social Recognition in rats. To assess whether the same phenomenon occurs in another species showing sexual dimorphism of vasopressinergic neurons, Social Recognition was studied in DBA2 male mice. Social Recognition was inferred from the reduction in investigation time of a juvenile conspecific when this Social stimulus was presented for the second time at different intervening intervals after the initial exposure. Such a reduction occurred when the interval was 20 min or 1 hr but not 2 hr. This effect was stimulus-specific, because it did not occur when a different juvenile was presented on the second exposure. AVP (0.4 μg/mouse, SC) injected immediately after the first exposure to the juvenile prolonged Social Recognition, whereas SC injection of an antagonist of the vasopressor receptors of AVP, dPTyr(Me)AVP (2 μg/mouse) impaired it. Compared with intact males, castrated mice spent less time investigating juveniles but were still able to recognize them after a 2-hr interval. However, this Recognition was no longer sensitive to dPTyr(Me)AVP. These results confirm that androgen-dependent vasopressinergic transmission modulates Social Recognition in mice.
Elena Choleris - One of the best experts on this subject based on the ideXlab platform.
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Estrogens and their receptors in the medial amygdala rapidly facilitate Social Recognition in female mice.
Psychoneuroendocrinology, 2017Co-Authors: Jennifer M. Lymer, Paul A.s. Sheppard, Talya Kuun, Andrea Blackman, Nilay Jani, Sahnon Mahbub, Elena CholerisAbstract:Abstract Estrogens have been shown to rapidly (within 1 h) affect learning and memory processes, including Social Recognition. Both systemic and hippocampal administration of 17β-estradiol facilitate Social Recognition in female mice within 40 min of administration. These effects were likely mediated by estrogen receptor (ER) α and the G-protein coupled estrogen receptor (GPER), as administration of the respective receptor agonists (PPT and G-1) also facilitated Social Recognition on a rapid time scale. The medial amygdala has been shown to be necessary for Social Recognition and long-term manipulations in rats have implicated medial amygdalar ERα. As such, our objective was to investigate whether estrogens and different ERs within the medial amygdala play a role in the rapid facilitation of Social Recognition in female mice. 17β-estradiol, G-1, PPT, or ERβ agonist DPN was infused directly into the medial amygdala of ovariectomized female mice. Mice were then tested in a Social Recognition paradigm, which was completed within 40 min, thus allowing the assessment of rapid effects of treatments. 17β-estradiol (10, 25, 50, 100 nM), PPT (300 nM), DPN (150 nM), and G-1 (50 nM) each rapidly facilitated Social Recognition. Therefore, estrogens in the medial amygdala rapidly facilitate Social Recognition in female mice, and the three main estrogen receptors: ERα, ERβ, and the GPER all are involved in these effects. This research adds to a network of brain regions, including the medial amygdala and the dorsal hippocampus, that are involved in mediating the rapid estrogenic facilitation of Social Recognition in female mice.
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Estrogenic involvement in Social learning, Social Recognition and pathogen avoidance
Frontiers in neuroendocrinology, 2012Co-Authors: Elena Choleris, Anna Phan, Amy E. Clipperton-allen, Paola Valsecchi, Martin KavaliersAbstract:Sociality comes with specific cognitive skills that allow the proper processing of information about others (Social Recognition), as well as of information originating from others (Social learning). Because Sociality and Social interactions can also facilitate the spread of infection among individuals the ability to recognize and avoid pathogen threat is also essential. We review here various studies primarily from the rodent literature supporting estrogenic involvement in the regulation of Social Recognition, Social learning (Socially acquired food preferences and mate choice copying) and the Recognition and avoidance of infected and potentially infected individuals. We consider both genomic and rapid estrogenic effects involving estrogen receptors α and β, and G-protein coupled estrogen receptor 1, along with their interactions with neuropeptide systems in the processing of Social stimuli and the regulation and expression of these various Socially relevant behaviors.
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Interplay of oxytocin, vasopressin, and sex hormones in the regulation of Social Recognition.
Behavioral neuroscience, 2011Co-Authors: Christopher S. Gabor, Martin Kavaliers, Anna Phan, Amy E. Clipperton-allen, Elena CholerisAbstract:Social Recognition is a fundamental skill that forms the basis of behaviors essential to the proper functioning of pair or group living in most Social species. We review here various neurobiological and genetic studies that point to an interplay of oxytocin (OT), arginine-vasopressin (AVP), and the gonadal hormones, estrogens and testosterone, in the mediation of Social Recognition. Results of a number of studies have shown that OT and its actions at the medial amygdala seem to be essential for Social Recognition in both sexes. Estrogens facilitate Social Recognition, possibly by regulating OT production in the hypothalamus and the OT receptors at the medial amygdala. Estrogens also affect Social Recognition on a rapid time scale, likely through nongenomic actions. The mechanisms of these rapid effects are currently unknown but available evidence points at the hippocampus as the possible site of action. Male rodents seem to be more dependent on AVP acting at the level of the lateral septum for Social Recognition than female rodents. Results of various studies suggest that testosterone and its metabolites (including estradiol) influence Social Recognition in males primarily through the AVP V1a receptor. Overall, it appears that gonadal hormone modulation of OT and AVP regulates and fine tunes Social Recognition and those behaviors that depend upon it (e.g., Social bonds, Social hierarchies) in a sex specific manner. This points at an important role for these neuroendocrine systems in the regulation of the sex differences that are evident in Social behavior and of Sociality as a whole.
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Oxytocin, vasopressin and estrogen receptor gene expression in relation to Social Recognition in female mice
Physiology & behavior, 2011Co-Authors: Amy E. Clipperton-allen, Donald W Pfaff, Anna Phan, Anna W. Lee, Anny Reyes, Nino Devidze, Elena CholerisAbstract:Inter- and intra-species differences in Social behavior and Recognition-related hormones and receptors suggest that different distribution and/or expression patterns may relate to Social Recognition. We used qRT-PCR to investigate naturally occurring differences in expression of estrogen receptor-alpha (ERα), ER-beta (ERβ), progesterone receptor (PR), oxytocin (OT) and receptor, and vasopressin (AVP) and receptors in proestrous female mice. Following four 5 min exposures to the same two conspecifics, one was replaced with a novel mouse in the final trial (T5). Gene expression was examined in mice showing high (85–100%) and low (40–60%) Social Recognition scores (i.e., preferential novel mouse investigation in T5) in eight Socially-relevant brain regions. Results supported OT and AVP involvement in Social Recognition, and suggest that in the medial preoptic area, increased OT and AVP mRNA, together with ERα and ERβ gene activation, relate to improved Social Recognition. Initial Social investigation correlated with ERs, PR and OTR in the dorsolateral septum, suggesting that these receptors may modulate Social interest without affecting Social Recognition. Finally, increased lateral amygdala gene activation in the LR mice may be associated with general learning impairments, while decreased lateral amygdala activity may indicate more efficient cognitive mechanisms in the HR mice.
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microparticle based delivery of oxytocin receptor antisense dna in the medial amygdala blocks Social Recognition in female mice
Proceedings of the National Academy of Sciences of the United States of America, 2007Co-Authors: Elena Choleris, Steven R Little, Jessica A Mong, Sidharth V Puram, Robert Langer, Donald W PfaffAbstract:Social Recognition constitutes the basis of Social life. In male mice and rats, Social Recognition is known to be governed by the neuropeptide oxytocin (OT) through its action on OT receptors (OTRs) in the medial amygdala. In female rats and mice, which have sociosexual behaviors controlling substantial investment in reproduction, an important role for OT in sociosexual behaviors has also been shown. However, the site in the female brain for OT action on Social Recognition is still unknown. Here we used a customized, controlled release system of biodegradable polymeric microparticles to deliver, in the medial amygdala of female mice, “locked nucleic acid” antisense (AS) oligonucleotides with sequences specific for the mRNA of the OTR gene. We found that single bilateral intraamygdala injections of OTR AS locked nucleic acid oligonucleotides several days before behavioral testing reduced Social Recognition. Thus, we showed that gene expression for OTR specifically in the amygdala is required for normal Social Recognition in female mice. Importantly, during the same experiment, we performed a detailed ethological analysis of mouse behavior revealing that OTR AS-treated mice underwent an initial increase in ambivalent risk-assessment behavior. Other behaviors were not affected, thus revealing specific roles for amygdala OTR in female Social Recognition potentially mediated by anxiety in a Social context. Understanding the functional genomics of OT and OTR in Social Recognition should help elucidate the neurobiological bases of human disorders of Social behavior (e.g., autism).
