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Volodymyr I Lushchak - One of the best experts on this subject based on the ideXlab platform.
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Sodium Chromate demonstrates some insulin-mimetic properties in the fruit fly Drosophila melanogaster Toxicology & pharmacology
Comparative Biochemistry and Physiology, 2020Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster
Comparative Biochemistry and Physiology C-toxicology & Pharmacology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:Abstract The effects of food supplementation with Sodium Chromate at concentrations of 1–500 μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25 μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500 μM Chromate decreased food consumption. The data show that: (1) Cr6 + has many of the same effects as Cr3 + suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr6 + ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster toxicology pharmacology
Comparative Biochemistry and Physiology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
Zygmunt Kowalski - One of the best experts on this subject based on the ideXlab platform.
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multi criteria analysis for optimization of Sodium Chromate production from chromic waste
Clean-soil Air Water, 2011Co-Authors: Agnieszka Generowicz, Zygmunt Kowalski, Joanna Kulczycka, Agnieszka MakaraAbstract:The proposal of application of multi-criteria analysis and technological quality method for optimization of technological processes on the case study of Sodium Chromate production variants from waste was presented. The research on the use of chromic waste for the production of Sodium Chromate made it possible to determine the optimal process parameters. Technological quality method was used to define the value of criterions for multi-criteria analysis while multi-criteria analysis allowed determining the impact of criterions weights for ranking variants of technological process. Both methods in a complex way evaluate the degree of modernization of technologies, describing them qualitatively within the area of environmental, technical, and the economic effects of the proposed technological variants. Based on the proposed evaluating criteria both methods yield comparable results. The most advantageous alternatives provided realization of the Sodium Chromate production process with the use of in-process recycling of chromic mud, off-site recycling of chromic tannery waste and on-site recycling of waste from the old chromic heaps.
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life cycle assessment of different variants of Sodium Chromate production in poland
Journal of Cleaner Production, 2007Co-Authors: Zygmunt Kowalski, Joanna Kulczycka, Zbigniew WzorekAbstract:Abstract Chromium chemicals are made from Sodium Chromate, a basic intermediate product for the production of all other chromium compounds. This article presents application of the Life Cycle Assessment (LCA) methodology to choose the best method of production of Sodium Chromate. Three variants of Sodium Chromate production were considered: the classic method with the use of dolomite (DM), the implemented method with chromic mud recycling (W1) and the target waste-free method (W2). The method for evaluating the impact of Sodium Chromate production on the environment proposes the subcategories that should be taken into consideration in order to establish the final impact of the production process on the environment. The LCA showed further possibilities for reducing the impact of Sodium Chromate process on the natural environment through the implementation of new technological solutions, especially those concerning the decrease of energy consumption.
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an analysis of the Sodium Chromate production process with chromic waste recycling
Management of Environmental Quality: An International Journal, 2005Co-Authors: Zygmunt Kowalski, Joanna Kulczycka, Malgorzata GoralczykAbstract:Purpose – This work seeks to present results of research which allowed the development of a technological system for the Sodium Chromate production process on the basis of a semi‐empirical equation.Design/methodology/approach – The proposed technological method is based on determining the defined process parameters (independent variables) which allow the complicated process to be controlled using only a few parameters that determine the Chromate charge compositionFindings – By using the equation it is possible to determine the composition of this charge, knowing only the results of analyses of the main component of the chromic ore (i.e. Cr2O3) and the values of coefficients X, a and b. In this way, the process parameters X, a and b can be adopted as independent control variables of the Sodium Chromate process.Practical implications – The proposed method for the Sodium Chromate production process includes the substitution of natural chromic raw material with waste from different recycling types of chromic ...
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utilisation of chromic waste in the Sodium Chromate vi production process
Journal of Loss Prevention in The Process Industries, 2002Co-Authors: Zygmunt Kowalski, Zbigniew WzorekAbstract:Abstract This work presents research results on the utilisation of chromic waste in the production of Sodium Chromate (VI). The optimal parameters of the Sodium Chromate (VI) process which make it possible to select the best technological solution were determined. This allowed the values useful for a practical estimation of the process, such as mass balances, technological figures and especially the quantity of the produced chromic waste, to be determined. Research on the on-site recycling of the chromic waste from old chromic heaps resulted in working out of the dry enrichment method of the waste stream which was returned to the Sodium Chromate process. Satisfactory enrichment resulted in the separation of the fraction 63–200 μm, where the enrichment rate was 1.27 at a separation degree of 0.32.
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research on the utilisation of waste chromic materials in the Sodium Chromate production process
Waste Management & Research, 2002Co-Authors: Zygmunt Kowalski, Barbara WalawskaAbstract:The results of investigations on the utilisation of waste chromic materials for the production of Sodium Chromate have been presented. The optimal parameters of the Sodium Chromate production, which make it possible to select the best technological solutions, have been determined. A mathematical model based on a system of equations describing the process of Sodium Chromate production as a function of selected process parameters has been devised. This allows the values useful for a practical estimation of the process, such as mass balances, technological indicators and especially the quantity of the produced chromic waste, to be determined.
Natalia V Perkhulyn - One of the best experts on this subject based on the ideXlab platform.
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Sodium Chromate demonstrates some insulin-mimetic properties in the fruit fly Drosophila melanogaster Toxicology & pharmacology
Comparative Biochemistry and Physiology, 2020Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster
Comparative Biochemistry and Physiology C-toxicology & Pharmacology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:Abstract The effects of food supplementation with Sodium Chromate at concentrations of 1–500 μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25 μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500 μM Chromate decreased food consumption. The data show that: (1) Cr6 + has many of the same effects as Cr3 + suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr6 + ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster toxicology pharmacology
Comparative Biochemistry and Physiology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
Bohdana M Rovenko - One of the best experts on this subject based on the ideXlab platform.
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Sodium Chromate demonstrates some insulin-mimetic properties in the fruit fly Drosophila melanogaster Toxicology & pharmacology
Comparative Biochemistry and Physiology, 2020Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster
Comparative Biochemistry and Physiology C-toxicology & Pharmacology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:Abstract The effects of food supplementation with Sodium Chromate at concentrations of 1–500 μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25 μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500 μM Chromate decreased food consumption. The data show that: (1) Cr6 + has many of the same effects as Cr3 + suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr6 + ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster toxicology pharmacology
Comparative Biochemistry and Physiology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
Tetyana V Zvarych - One of the best experts on this subject based on the ideXlab platform.
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Sodium Chromate demonstrates some insulin-mimetic properties in the fruit fly Drosophila melanogaster Toxicology & pharmacology
Comparative Biochemistry and Physiology, 2020Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster
Comparative Biochemistry and Physiology C-toxicology & Pharmacology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:Abstract The effects of food supplementation with Sodium Chromate at concentrations of 1–500 μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25 μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500 μM Chromate decreased food consumption. The data show that: (1) Cr6 + has many of the same effects as Cr3 + suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr6 + ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.
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Sodium Chromate demonstrates some insulin mimetic properties in the fruit fly drosophila melanogaster toxicology pharmacology
Comparative Biochemistry and Physiology, 2015Co-Authors: Natalia V Perkhulyn, Bohdana M Rovenko, Tetyana V Zvarych, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I LushchakAbstract:The effects of food supplementation with Sodium Chromate at concentrations of 1–500μM on development of Drosophila melanogaster larvae and food intake, carbohydrate and lipid pools in adult fruit flies were investigated. Food supplementation with hexavalent chromium (Na2CrO4) at high concentrations delayed larval development and decreased the percentage of larvae that pupated which indicated a relatively low toxicity. The supplement decreased glucose levels in fly hemolymph, but at concentrations of 5–25μM increased fly carbohydrate reserves: hemolymph trehalose and whole body trehalose and glycogen. The data on parameters of carbohydrate metabolism show that Chromate possesses some insulin-mimetic properties. The changes in metabolism of carbohydrates under Chromate exposure were also accompanied by an increase in total lipid levels and in the portion of triacylglycerides among all lipids. Chromate addition to fly food did not affect male or female body mass, but reduced food consumption by females at all concentrations used, whereas in males only 500μM Chromate decreased food consumption. The data show that: (1) Cr⁶⁺ has many of the same effects as Cr³⁺ suggesting that it might be just as effective to treat diabetic states, likely as a result of intracellular reduction of Cr⁶⁺ ions, and (2) the Drosophila model can be used to develop new approaches to investigate the molecular mechanisms of chromium as an insulin-mimetic. Although it is usually believed that hexavalent chromium possesses higher toxicity than the trivalent ion, due to its easier penetration into the cell, application of hexavalent chromium may substantially decrease the chromium doses needed to get the desired effects.