The Experts below are selected from a list of 5403 Experts worldwide ranked by ideXlab platform
Bir Sain - One of the best experts on this subject based on the ideXlab platform.
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acetone cyanohydrin a convenient alternative of toxic Sodium Cyanide acetic acid for oxidative cyanation of tertiary amines
Catalysis Letters, 2011Co-Authors: Sanny Verma, Suman L. Jain, Bir SainAbstract:AbstractAcetone cyanohydrin was found to be a facile, convenient and comparatively safer alternative to toxic Sodium Cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines to α-aminonitriles in high yields with hydrogen peroxide using RuCl 3 as catalyst. In addition organic nature of acetone cyanohydrin makes it more suitable for an organic transformation since it is readily soluble in reaction medium and can be added in a controlled manner.Graphical Abstract[IMAGE]
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acetone cyanohydrin a convenient alternative of toxic Sodium Cyanide acetic acid for oxidative cyanation of tertiary amines
Catalysis Letters, 2011Co-Authors: Sanny Verma, Suman L. Jain, Bir SainAbstract:Acetone cyanohydrin was found to be a facile, convenient and comparatively safer alternative to toxic Sodium Cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines to α-aminonitriles in high yields with hydrogen peroxide using RuCl3 as catalyst. In addition organic nature of acetone cyanohydrin makes it more suitable for an organic transformation since it is readily soluble in reaction medium and can be added in a controlled manner.
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heterogeneously catalyzed oxidative cyanation of tertiary amines with Sodium Cyanide hydrogen peroxide using polymer supported iron ii phthalocyanines as catalyst
Advanced Synthesis & Catalysis, 2010Co-Authors: Sweety Singhal, Suman L. Jain, Bir SainAbstract:The first report on heterogeneously catalyzed oxidative cyanation of various tertiary amines to the corresponding α-amino nitriles with high yields and selectivity by using hydrogen peroxide oxidant in presence of Sodium Cyanide and Fe(II) phthalocyanine supported on a polymer as catalyst is described. The present method has the added benefits of facile recovery of the catalyst from the reaction mixture and its subsequent use without further activation. Consistent catalytic activity with no metal leaching was observed during this course.
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an efficient aerobic oxidative cyanation of tertiary amines with Sodium Cyanide using vanadium based systems as catalysts
ChemInform, 2009Co-Authors: Sweety Singhal, Suman L. Jain, Bir SainAbstract:The first report on the use of vanadium-based catalysts for oxidative cyanation of tertiary amines with molecular oxygen in the presence of Sodium Cyanide and acetic acid to afford the corresponding α-aminonitriles in good to excellent yields is described.
Suman L. Jain - One of the best experts on this subject based on the ideXlab platform.
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potassium ion cationized polyether Cyanide k peg cn as a novel Cyanide source for oxidative cyanation of tertiary amines
Tetrahedron Letters, 2015Co-Authors: Vineeta Panwar, Siddharth S Ray, Suman L. JainAbstract:Abstract Potassium ions cationized polyether Cyanide [K+{PEG}CN−] was readily synthesized by mixing potassium Cyanide and PEG400 at room temperature and used as a cost effective and comparatively safer alternative to the toxic Sodium Cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines with hydrogen peroxide using RuCl3 as catalyst. This method affords a facile approach to the synthesis of α-aminonitriles in high yields under solvent-free and acid-free reaction conditions.
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acetone cyanohydrin a convenient alternative of toxic Sodium Cyanide acetic acid for oxidative cyanation of tertiary amines
Catalysis Letters, 2011Co-Authors: Sanny Verma, Suman L. Jain, Bir SainAbstract:AbstractAcetone cyanohydrin was found to be a facile, convenient and comparatively safer alternative to toxic Sodium Cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines to α-aminonitriles in high yields with hydrogen peroxide using RuCl 3 as catalyst. In addition organic nature of acetone cyanohydrin makes it more suitable for an organic transformation since it is readily soluble in reaction medium and can be added in a controlled manner.Graphical Abstract[IMAGE]
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acetone cyanohydrin a convenient alternative of toxic Sodium Cyanide acetic acid for oxidative cyanation of tertiary amines
Catalysis Letters, 2011Co-Authors: Sanny Verma, Suman L. Jain, Bir SainAbstract:Acetone cyanohydrin was found to be a facile, convenient and comparatively safer alternative to toxic Sodium Cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines to α-aminonitriles in high yields with hydrogen peroxide using RuCl3 as catalyst. In addition organic nature of acetone cyanohydrin makes it more suitable for an organic transformation since it is readily soluble in reaction medium and can be added in a controlled manner.
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heterogeneously catalyzed oxidative cyanation of tertiary amines with Sodium Cyanide hydrogen peroxide using polymer supported iron ii phthalocyanines as catalyst
Advanced Synthesis & Catalysis, 2010Co-Authors: Sweety Singhal, Suman L. Jain, Bir SainAbstract:The first report on heterogeneously catalyzed oxidative cyanation of various tertiary amines to the corresponding α-amino nitriles with high yields and selectivity by using hydrogen peroxide oxidant in presence of Sodium Cyanide and Fe(II) phthalocyanine supported on a polymer as catalyst is described. The present method has the added benefits of facile recovery of the catalyst from the reaction mixture and its subsequent use without further activation. Consistent catalytic activity with no metal leaching was observed during this course.
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an efficient aerobic oxidative cyanation of tertiary amines with Sodium Cyanide using vanadium based systems as catalysts
ChemInform, 2009Co-Authors: Sweety Singhal, Suman L. Jain, Bir SainAbstract:The first report on the use of vanadium-based catalysts for oxidative cyanation of tertiary amines with molecular oxygen in the presence of Sodium Cyanide and acetic acid to afford the corresponding α-aminonitriles in good to excellent yields is described.
Muniswamy David - One of the best experts on this subject based on the ideXlab platform.
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in vivo studies on hepato renal impairments in freshwater fish cyprinus carpio following exposure to sublethal concentrations of Sodium Cyanide
Environmental Science and Pollution Research, 2016Co-Authors: Muniswamy David, R M KartheekAbstract:Reactive oxygen species is an inevitable composite of aerobic systems that could channelize their lethality by imparting oxidative stress under a stressful environment. Cyanide is an important environmental toxicant that could be responsible in the resulting detrimental health issues of aquatic fauna. The present effort investigates the possibilities of hepato-renal damage in freshwater fish Cyprinus carpio following exposure to sublethal concentrations of Sodium Cyanide (NaCN). Fish were exposed to 0.1 mg/L of NaCN for 10 days (E1) and 20 days (E2) and were further subjected to recovery for 14 days (R) in NaCN-free medium. Liver tissue exhibited a significant decline in activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione S-transferase enzymes in exposed fish, unlike in control (C). Subsequent levels of lipid peroxidation elevation at 'E1' and 'E2' suggested oxidative damage to hepatocytes. This was further confirmed through a histopathological evaluation which indicated important findings like lymphocytic infiltration and necrosis in liver and tubular and glomerular degeneration in renal organ. The investigation suggests biochemical and histopathological alterations in fish following exposure to NaCN. Nevertheless, fish upon the recovery period were known to exhibit incomplete recuperation which was indicated by partial restoration tendencies under biochemical and histopathological factions. The study clearly implicated the role of NaCN in emphasizing its toxicity to C. carpio, further suggesting lack of recovery transition at a limited tenure of 14 days. The study might contribute in the course of regulatory surveillance and monitoring of aquatic bodies and may also reflect the possibilities of NaCN contamination during aquaculture practices. Graphical Abstract ᅟ.
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histopathological alterations in spleen of freshwater fish cyprinus carpio exposed to sublethal concentration of Sodium Cyanide
Open veterinary journal, 2015Co-Authors: Muniswamy David, R M KartheekAbstract:Aquatic ecosystems in areas with intense mining activity are often subject to Cyanide contamination; the present study was aimed to evaluate the harmful effects of Sodium Cyanide on histoarchitechtural aspect of spleen of freshwater fish Cyprinus carpio using an in vivo approach. The fishes were exposed to a sublethal concentration of 0.2 mg/L of Sodium Cyanide for duration of 10 and 20 days and were further allowed to undergo recovery for 14 days in a toxicant free medium. From the present investigation findings like occurrence of haemosiderin pigment, melanomacrophage centers, vacuolation and necrotic eosinophils were evident in all the fishes exposed to Sodium Cyanide. However, changes were more pronounced in fish subjected to 10 days of exposure, which was followed by 20 days of exposure and 14 days of recovery. The study revealed that there seemed to be the presence of homeostatic mechanism in fish that allows them to stabilize and overcome stress, which in present case is caused by sublethal concentration of Sodium Cyanide. Since the recovery phenomenon may be adaptive and even strategic, the present investigation also throws a light on adaptive behaviour of fish under stressful environments.
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Sodium Cyanide induced modulations in the activities of some oxidative enzymes and metabolites in the fingerlings of cyprinus carpio linnaeus
Toxicological & Environmental Chemistry, 2010Co-Authors: Muniswamy David, H Ramesh, Vineetkumar K Patil, S R Marigoudar, S G ChebbiAbstract:Carp fingerlings exposed to a sublethal concentration (0.5 mg L−1) of Sodium Cyanide showed a steady decrement over a 7-day period in respiratory rate, rise in lactate dehydrogenase (LDH), and fall in succinate dehydrogenase (SDH) activities followed by variations in lactic and pyruvate levels. Changes in these enzyme activities might be due to impaired oxidative metabolism and severe cellular damage leading to the release of these enzymes. Decline in the activities of SDH and LDH clearly represents a shift from aerobic to anaerobic metabolism as evidenced by elevated lactate and decline in pyruvate levels. The shift to anaerobic metabolism is also reflected by severe drop in the respiratory rate of the fish. This may be a consequence of the blockage of electron transfer from cytochrome c oxidase to molecular oxygen, thus ceasing cellular respiration and it can lead to cellular hypoxia even in the presence of normal hemoglobin oxygenation. Hence, we indirectly reconfirm the inhibition of oxidative metabol...
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impact of Sodium Cyanide on catalase activity in the freshwater exotic carp cyprinus carpio linnaeus
Pesticide Biochemistry and Physiology, 2008Co-Authors: Muniswamy David, Vadingadu Munaswamy, Ramesh Halappa, Shambangouda R MarigoudarAbstract:Abstract The Cyprinus carpio fingerlings on exposure to lethal (1 mg/L) and sub lethal concentrations (0.066 mg/L) of Sodium Cyanide showed inhibition in the activity of catalase. The disruption of catalase activity in freshwater fish, C. carpio is demonstrated in the present study using UV–visible spectrophotometer at 240 nm using hydrogen peroxide as a substrate. It suggests toxic effects of Sodium Cyanide and consequent accumulation of hydrogen peroxide in the functionally different tissues namely, liver, gill, muscle and brain. This might lead to cellular damages, and create widespread physiological disturbance. The results suggest that catalase activity can be a good diagnostic tool for Sodium Cyanide toxicity in biomonitoring programme.
Xiangge Zhou - One of the best experts on this subject based on the ideXlab platform.
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asymmetric cyanohydrin formation from aldehydes catalyzed by manganese schiff base complexes
ChemInform, 2010Co-Authors: Yanyang Qu, Linhai Jing, Zhiqing Wu, Di Wu, Xiangge ZhouAbstract:The complex generated form Mn(O-Ac)2 and the ligand (SAL) is found to be an efficient catalyst for the asymmetric coupling of aromatic aldehydes with Sodium Cyanide.
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asymmetric cyanohydrin formation from aldehydes catalyzed by manganese schiff base complexes
Tetrahedron-asymmetry, 2010Co-Authors: Yanyang Qu, Linhai Jing, Zhiqing Wu, Di Wu, Xiangge ZhouAbstract:Abstract The catalyst generated in situ from Mn(OAc) 2 and a chiral Schiff base ligand exhibited excellent catalytic abilities in asymmetric cyanohydrin formation from aldehydes with Sodium Cyanide in up to 99% enantioselectivity and good yield.
R M Kartheek - One of the best experts on this subject based on the ideXlab platform.
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in vivo studies on hepato renal impairments in freshwater fish cyprinus carpio following exposure to sublethal concentrations of Sodium Cyanide
Environmental Science and Pollution Research, 2016Co-Authors: Muniswamy David, R M KartheekAbstract:Reactive oxygen species is an inevitable composite of aerobic systems that could channelize their lethality by imparting oxidative stress under a stressful environment. Cyanide is an important environmental toxicant that could be responsible in the resulting detrimental health issues of aquatic fauna. The present effort investigates the possibilities of hepato-renal damage in freshwater fish Cyprinus carpio following exposure to sublethal concentrations of Sodium Cyanide (NaCN). Fish were exposed to 0.1 mg/L of NaCN for 10 days (E1) and 20 days (E2) and were further subjected to recovery for 14 days (R) in NaCN-free medium. Liver tissue exhibited a significant decline in activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione S-transferase enzymes in exposed fish, unlike in control (C). Subsequent levels of lipid peroxidation elevation at 'E1' and 'E2' suggested oxidative damage to hepatocytes. This was further confirmed through a histopathological evaluation which indicated important findings like lymphocytic infiltration and necrosis in liver and tubular and glomerular degeneration in renal organ. The investigation suggests biochemical and histopathological alterations in fish following exposure to NaCN. Nevertheless, fish upon the recovery period were known to exhibit incomplete recuperation which was indicated by partial restoration tendencies under biochemical and histopathological factions. The study clearly implicated the role of NaCN in emphasizing its toxicity to C. carpio, further suggesting lack of recovery transition at a limited tenure of 14 days. The study might contribute in the course of regulatory surveillance and monitoring of aquatic bodies and may also reflect the possibilities of NaCN contamination during aquaculture practices. Graphical Abstract ᅟ.
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histopathological alterations in spleen of freshwater fish cyprinus carpio exposed to sublethal concentration of Sodium Cyanide
Open veterinary journal, 2015Co-Authors: Muniswamy David, R M KartheekAbstract:Aquatic ecosystems in areas with intense mining activity are often subject to Cyanide contamination; the present study was aimed to evaluate the harmful effects of Sodium Cyanide on histoarchitechtural aspect of spleen of freshwater fish Cyprinus carpio using an in vivo approach. The fishes were exposed to a sublethal concentration of 0.2 mg/L of Sodium Cyanide for duration of 10 and 20 days and were further allowed to undergo recovery for 14 days in a toxicant free medium. From the present investigation findings like occurrence of haemosiderin pigment, melanomacrophage centers, vacuolation and necrotic eosinophils were evident in all the fishes exposed to Sodium Cyanide. However, changes were more pronounced in fish subjected to 10 days of exposure, which was followed by 20 days of exposure and 14 days of recovery. The study revealed that there seemed to be the presence of homeostatic mechanism in fish that allows them to stabilize and overcome stress, which in present case is caused by sublethal concentration of Sodium Cyanide. Since the recovery phenomenon may be adaptive and even strategic, the present investigation also throws a light on adaptive behaviour of fish under stressful environments.
