The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Carole Ichai - One of the best experts on this subject based on the ideXlab platform.
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hyperosmolar Sodium Lactate in the icu vascular filling and cellular feeding
Critical Care, 2014Co-Authors: Eric Fontaine, Jeanchristophe Orban, Carole IchaiAbstract:Hyperosmolar Lactate-based solutions have been used for fluid resuscitation in ICU patients. The positive effects observed with these fluids have been attributed to both Lactate metabolism and the hypertonic nature of the solutions. In a recent issue of Critical Care, Duburcq and colleagues studied three types of fluid infused at the same volume in a porcine model of endotoxic shock. The control group was resuscitated with 0.9% NaCl, and the two other groups received either hypertonic Sodium-Lactate or hypertonic Sodium-bicarbonate. The two hypertonic fluids proved to be more effective than 0.9% NaCl for resuscitation in this model. However, some parameters were more effectively corrected by hypertonic Sodium-Lactate than by hypertonic Sodium-bicarbonate, suggesting that Lactate metabolism was beneficial in these cases.
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Sodium Lactate for fluid resuscitation the preferred solution for the coming decades
Critical Care, 2014Co-Authors: Carole Ichai, Jeanchristophe Orban, Eric FontaineAbstract:In a recent issue of Critical Care, 0.5 M Sodium Lactate infusion for 24 hours was reported to increase cardiac output in patients with acute heart failure. This effect was associated with a concomitant metabolic alkalosis and a negative water balance. Growing data strongly support the role of Lactate as a preferential oxidizable substrate to supply energy metabolism leading to improved organ function (heart and brain especially) in ischemic conditions. Due to its Sodium/chloride imbalance, this solution prevents hyperchloremic acidosis and limits fluid overload despite the obligatory high Sodium load. Sodium Lactate solution therefore shows many advantages and appears a very promising means for resuscitation of critically ill patients. Further studies are needed to establish the most appropriate dose and indications for Sodium Lactate infusion in order to prevent the occurrence of severe hypernatremia and metabolic alkalosis.
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Sodium Lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain injured patients
Intensive Care Medicine, 2009Co-Authors: Carole Ichai, Jeanchristophe Orban, Guy Armando, Frederic Berthier, Laurent Rami, Corine Samatlong, D Grimaud, Xavier LeverveAbstract:Objectives Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids, hypothermia and hypertonic saline. We investigated the effect of a new hyperosmolar solution based on Sodium Lactate in controlling raised intracranial pressure (ICP).
Xavier Leverve - One of the best experts on this subject based on the ideXlab platform.
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half molar Sodium Lactate infusion improves cardiac performance in acute heart failure a pilot randomised controlled clinical trial
Critical Care, 2014Co-Authors: Marek Nalos, Xavier Leverve, Stephen J Huang, Leonie Weisbrodt, Ray Parkin, Ian Seppelt, Iris Ting, Anthony S McleanAbstract:Introduction: Acute heart failure (AHF) is characterized by inadequate cardiac output (CO), congestive symptoms, poor peripheral perfusion and end-organ dysfunction. Treatment often includes a combination of diuretics, oxygen, positive pressure ventilation, inotropes and vasodilators or vasopressors. Lactate is a marker of illness severity but is also an important metabolic substrate for the myocardium at rest and during stress. We tested the effects of half-molar Sodium Lactate infusion on cardiac performance in AHF. Methods: We conducted a prospective, randomised, controlled, open-label, pilot clinical trial in 40 patients fulfilling two of the following three criteria for AHF: (1) left ventricular ejection fraction <40%, (2) acute pulmonary oedema or respiratory failure of predominantly cardiac origin requiring mechanical ventilation and (3) currently receiving vasopressor and/or inotropic support. Patients in the intervention group received a 3 ml/kg bolus of half-molar Sodium Lactate over the course of 15 minutes followed by 1 ml/kg/h continuous infusion for 24 hours. The control group received only a 3 ml/kg bolus of Hartmann’s solution without continuous infusion. The primary outcome was CO assessed by transthoracic echocardiography 24 hours after randomisation. Secondary outcomes included a measure of right ventricular systolic function (tricuspid annular plane systolic excursion (TAPSE)), acid-base balance, electrolyte and organ function parameters, along with length of stay and mortality. Results: The infusion of half-molar Sodium Lactate increased (mean±SD) CO from 4.05±1.37 L/min to 5.49±1.9 L/min (P<0.01) and TAPSE from 14.7±5.5 mm to 18.3±7 mm (P= 0.02). Plasma Sodium and pH increased (136 ± 4 to 146 ± 6 and 7.40 ± 0.06 to 7.53 ± 0.03, respectively; both P< 0.01), but potassium, chloride and phosphate levels decreased. There were no significant differences in the need for vasoactive therapy, respiratory support, renal or liver function tests, duration of ICU and hospital stay or 28- and 90-day mortality. Conclusions: Infusion of half-molar Sodium Lactate improved cardiac performance and led to metabolic alkalosis in AHF patients without any detrimental effects on organ function.
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Sodium Lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain injured patients
Intensive Care Medicine, 2009Co-Authors: Carole Ichai, Jeanchristophe Orban, Guy Armando, Frederic Berthier, Laurent Rami, Corine Samatlong, D Grimaud, Xavier LeverveAbstract:Objectives Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids, hypothermia and hypertonic saline. We investigated the effect of a new hyperosmolar solution based on Sodium Lactate in controlling raised intracranial pressure (ICP).
Jeanchristophe Orban - One of the best experts on this subject based on the ideXlab platform.
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hyperosmolar Sodium Lactate in the icu vascular filling and cellular feeding
Critical Care, 2014Co-Authors: Eric Fontaine, Jeanchristophe Orban, Carole IchaiAbstract:Hyperosmolar Lactate-based solutions have been used for fluid resuscitation in ICU patients. The positive effects observed with these fluids have been attributed to both Lactate metabolism and the hypertonic nature of the solutions. In a recent issue of Critical Care, Duburcq and colleagues studied three types of fluid infused at the same volume in a porcine model of endotoxic shock. The control group was resuscitated with 0.9% NaCl, and the two other groups received either hypertonic Sodium-Lactate or hypertonic Sodium-bicarbonate. The two hypertonic fluids proved to be more effective than 0.9% NaCl for resuscitation in this model. However, some parameters were more effectively corrected by hypertonic Sodium-Lactate than by hypertonic Sodium-bicarbonate, suggesting that Lactate metabolism was beneficial in these cases.
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Sodium Lactate for fluid resuscitation the preferred solution for the coming decades
Critical Care, 2014Co-Authors: Carole Ichai, Jeanchristophe Orban, Eric FontaineAbstract:In a recent issue of Critical Care, 0.5 M Sodium Lactate infusion for 24 hours was reported to increase cardiac output in patients with acute heart failure. This effect was associated with a concomitant metabolic alkalosis and a negative water balance. Growing data strongly support the role of Lactate as a preferential oxidizable substrate to supply energy metabolism leading to improved organ function (heart and brain especially) in ischemic conditions. Due to its Sodium/chloride imbalance, this solution prevents hyperchloremic acidosis and limits fluid overload despite the obligatory high Sodium load. Sodium Lactate solution therefore shows many advantages and appears a very promising means for resuscitation of critically ill patients. Further studies are needed to establish the most appropriate dose and indications for Sodium Lactate infusion in order to prevent the occurrence of severe hypernatremia and metabolic alkalosis.
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Sodium Lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain injured patients
Intensive Care Medicine, 2009Co-Authors: Carole Ichai, Jeanchristophe Orban, Guy Armando, Frederic Berthier, Laurent Rami, Corine Samatlong, D Grimaud, Xavier LeverveAbstract:Objectives Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids, hypothermia and hypertonic saline. We investigated the effect of a new hyperosmolar solution based on Sodium Lactate in controlling raised intracranial pressure (ICP).
Khalid Ibrahim Sallam - One of the best experts on this subject based on the ideXlab platform.
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antimicrobial and antioxidant effects of Sodium acetate Sodium Lactate and Sodium citrate in refrigerated sliced salmon
Food Control, 2007Co-Authors: Khalid Ibrahim SallamAbstract:This study was carried out to evaluate the microbiological quality and lipid oxidation of fresh salmon slices treated by dipping in 2.5% (w/v) aqueous solution of Sodium acetate (NaA), Sodium Lactate (NaL), or Sodium citrate (NaC) and stored at 1 °C. The results revealed that these salts were efficient (P Sodium Lactate > Sodium citrate. Lipid oxidation, as expressed by peroxide value (PV) and thiobarbituric acid (TBA) value, was significantly (P NaA > NaL. The shelf life of the treated products was extended by 4–7 days more than that of the control. Therefore, Sodium acetate, Sodium Lactate, and Sodium citrate can be utilized as safe organic preservatives for fish under refrigerated storage.
F Lutin - One of the best experts on this subject based on the ideXlab platform.
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Nanofiltration of glucose and Sodium Lactate solutionsVariations of retention between single- and mixed-solute solutions
Journal of Membrane Science, 2005Co-Authors: A Bouchoux, H Balmann, F LutinAbstract:The aim of this work was to investigate NF as a purificatio step, i.e. sugar removal, in the production process of lactic acid from Sodium Lactate fermentation broth. Experiments were carried out with the Desal 5 DK membrane and solutions of increasing complexity, i.e. single-solute solutions of Sodium Lactate and glucose and mixed-solute solutions containing both solutes. Concentrations close to those of a fermentation broth were chosen. Experimental results were used to get the variations of the intrinsic retention versus the permeation flu in order to achieve comparisons without the interference of concentration polarization. Quite distinct retentions were obtained for glucose and Sodium Lactate in single-solute solutions so that the purificatio was expected to be feasible. However, it is pointed out that glucose retention is significantl lower in mixed-solute solutions, i.e. when Sodium Lactate is present. This decrease is such that the retentions of both solutes become comparable so that any purificatio is unachievable. Experiments were also performed with a salt of a different nature (mineral salt, NaCl). Again, it was found that the presence of NaCl tends to decrease glucose retention. Moreover, the phenomenon is shown to be related to the salt concentration in both cases, i.e. with Sodium Lactate and NaCl. Some possible explanations of this effect are provided in this paper. Further investigations are still in progress to improve the knowledge of the mechanisms involved
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nanofiltration of glucose and Sodium Lactate solutions variations of retention between single and mixed solute solutions
Journal of Membrane Science, 2005Co-Authors: A Bouchoux, H Balmann, F LutinAbstract:The aim of this work was to investigate NF as a purificatio step, i.e. sugar removal, in the production process of lactic acid from Sodium Lactate fermentation broth. Experiments were carried out with the Desal 5 DK membrane and solutions of increasing complexity, i.e. single-solute solutions of Sodium Lactate and glucose and mixed-solute solutions containing both solutes. Concentrations close to those of a fermentation broth were chosen. Experimental results were used to get the variations of the intrinsic retention versus the permeation flu in order to achieve comparisons without the interference of concentration polarization. Quite distinct retentions were obtained for glucose and Sodium Lactate in single-solute solutions so that the purificatio was expected to be feasible. However, it is pointed out that glucose retention is significantl lower in mixed-solute solutions, i.e. when Sodium Lactate is present. This decrease is such that the retentions of both solutes become comparable so that any purificatio is unachievable. Experiments were also performed with a salt of a different nature (mineral salt, NaCl). Again, it was found that the presence of NaCl tends to decrease glucose retention. Moreover, the phenomenon is shown to be related to the salt concentration in both cases, i.e. with Sodium Lactate and NaCl. Some possible explanations of this effect are provided in this paper. Further investigations are still in progress to improve the knowledge of the mechanisms involved.
