The Experts below are selected from a list of 40122 Experts worldwide ranked by ideXlab platform
Digambara Patra - One of the best experts on this subject based on the ideXlab platform.
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interaction of curcumin with 1 2 dioctadecanoyl sn glycero 3 phosphocholine liposomes intercalation of rhamnolipids enhances membrane fluidity permeability and stability of drug molecule
Colloids and Surfaces B: Biointerfaces, 2017Co-Authors: Zeinab Moussa, Mazhar Chebl, Digambara PatraAbstract:Stability of curcumin in neutral and alkaline buffer conditions has been a serious concern for its medicinal applications. We demonstrate that the stability of curucmin can be improved in 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine (DSPC) liposomes. Curcumin strongly partition into liquid crystalline phase compared to Solid Gel phase of DSPC liposomes. Variation of fluorescence intensity of curcumin associated with liposomes with temperature successfully determines phase transition temperature of DSPC liposomes. However, at higher molar ratio curcumin can influence phase transition temperature by intercalating into deep hydrophobic layer of liposomes and facilitating fusion of two membrane phases. Rhamnolipids (RLs) are recently being applied for various biomedical applications. Here, we have explored new insight on intercalation of rhamnolipids with DSPC liposomes. Intercalation of rhamnolipids exceptionally increases partition of curcumin into Solid Gel phase of DSPC liposomes, whereas this increase is moderate in liquid crystalline phase. Fluorescence quenching study establishes that permeability and fluidity of the DSPC liposomes are enhanced in the presence of RLs. Membrane permeability and fluidity can be improved further by increasing the percentage of RLs in DSPC liposomes. The phase transition temperature of DSPC liposomes decreases with increase in percentage of RLs in DSPC liposomes by encouraging fusion between Solid Gel and liquid crystalline phases. Intercalation of RLs is found to further boost stability of drug, curcumin, in DSPC liposomes. Thus, mixing RLs with DSPC liposomes could potentially serve as a good candidate for drug delivery application.
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study on interaction of bile salts with curcumin and curcumin embedded in dipalmitoyl sn glycero 3 phosphocholine liposome
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: Digambara Patra, Diana Ahmadieh, Riwa AridiAbstract:Curcumin, often used as a food spice, is a natural polyphenol that has various medicinal benefits such as anti-cancer, anti-amyloid, anti-oxidant, and anti-inflammatory properties, among others. The interaction between bile salts having physiological significance and curcumin suggests the aggregation of bile salts dramatically alters the absorption and fluorescence parameters of curcumin. The fluorescence emission maximum as well as the intensity can easily detect critical micellar concentration of sodium cholate and sodium deoxycholate respectively to be 16 and 6mM at room temperature. The mechanism of interaction of curcumin with bile salts has been presented at low, intermediate and high bile salt concentrations and depends on temperature. In the presence of bile salts the DPPH scavenging activity was preserved, though less than in the presence of curcumin alone. The effect of submicellar concentration, 5-50μM, of bile salt with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes in Solid Gel and liquid crystalline phases has been investigated using curcumin as an embedded probe in the membrane. The curcumin based fluorescence probing method indicates even at very low concentration, ∼5μM, incorporation of monomeric bile salt molecules disorders the membrane properties. Expulsion of curcumin from the membrane in the presence of bile salt is ruled out, suggesting wetting of membrane. Alteration of membrane fluidity by bile salts is found to have an opposing effect in the liquid crystalline phase compared to in the Solid Gel phase, and is sensitive to the nature of bile salt. The permeability in the liquid crystalline phase decreases in the presence of bile salt. The phase transition temperature of the membrane is influenced by bile salt.
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ionic liquid expedites partition of curcumin into Solid Gel phase but discourages partition into liquid crystalline phase of 1 2 dimyristoyl sn glycero 3 phosphocholine liposomes
Journal of Physical Chemistry B, 2013Co-Authors: Elsy El Khoury, Digambara PatraAbstract:The hydrolysis of curcumin in alkaline and neutral buffer conditions is of interest because of the therapeutic applicability of curcumin. We show that hydrolysis of curcumin can be remarkably suppressed in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes. The fluorescence of curcumin sensitively detects the phase transition temperature of liposomes. However, at greater concentrations, curcumin affects the phase transition temperature, encouraging fusion of two membrane phases. The interaction of curcumin with DMPC is found to be strong, with a partition coefficient value of Kp = 2.78 × 105 in the Solid Gel phase, which dramatically increases in the liquid crystalline phase to Kp = 1.15 × 106. The importance of ionic liquids as green solvents has drawn interest because of their toxicological effect on human health; however, the impact of ionic liquids (ILs) on liposomes is not yet understood. The present study establishes that ILs such as 1-methyl-3-octylimidazolium chloride (moic) affect the p...
Zhong Lin Wang - One of the best experts on this subject based on the ideXlab platform.
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a flexible lithium ion battery with quasi Solid Gel electrolyte for storing pulsed energy generated by triboelectric nanogenerator
Energy Storage Materials, 2018Co-Authors: Dan Zhang, Xiaoyi Meng, Qiuan Huang, Chunwen Sun, Zhong Lin WangAbstract:Abstract Sustainable operation of flexible and wearable electronic devices is possible with energy harvested from environment, but such power could be in the form of pulses with varying amplitude and frequency. In this work, we prepared quasi-Solid lithium-ion batteries (LIBs) for storing the energy generated by a triboelectric nanogenerator (TENG). The lithium-ion batteries composed of a Gel electrolyte, LiFePO4 cathode and metallic lithium anode can deliver a capacity of ~ 140 mA h g−1 at 0.2 C rate and ~ 120 mA h g−1 at 1 C rate. A flexible pouch cell was further fabricated with this quasi-Solid electrolyte, which shows good flexibility, high mechanical strength and excellent safety against the nail puncture. The flexible LIB was used to store the pulse form energy harvested by a TENG to provide more stable power output sustainably. The quasi-Solid LIB can be charged by TENG directly for three times with a capacity loss of 17%. Importantly, a power management unit (PMU) was designed to make the output of TENG to be more suitable for charging the flexible LIBs. Our results show that this PMU is beneficial for decreasing the output voltage of TENGs, thus improving the cyclability of the cell, which may be utilized in various systems consisting of different batteries and TENGs.
Pramod K Singh - One of the best experts on this subject based on the ideXlab platform.
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Solid Gellan gum polymer electrolyte for energy application
International Journal of Hydrogen Energy, 2015Co-Authors: Rahul Singh, B Bhattacharya, Heewoo Rhee, Pramod K SinghAbstract:Abstract In this paper a carbohydrate polymer (PhytaGel/Gellan gum) based Solid Gel electrolyte synthesis and its application in dye sensitized solar cell is reported. Potassium iodide has been added in Gelrite/PhytaGel biopolymer matrix to develop Solid Gel electrolyte. Complex impedance spectroscopy shows liquid like ionic conductivity, with maximum conductivity 2.5 × 10−2 S cm−1 at 60:40 composition. Infrared spectroscopy (IR) confirms the formation of complex nature while x-ray diffraction (XRD) affirms the composite nature and suppression in crystallinity by salt doping. Polarized microscopy (POM) shows enhancement in amorphousity of Gel matrix by salt doping which is a known favourable condition for ionic conductivity enhancement in Gel electrolyte system and supported by our XRD data. A dye sensitized solar cell (DSSC) has been fabricated using maximum conductivity which shows with Jsc = 3.2 × 10−3 mA/cm2, Voc = 0.57, FF = 0.90, ɳ = 1.47 at 1 sun condition.
Ashok Kumar Mishra - One of the best experts on this subject based on the ideXlab platform.
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Effect of Indole-3-Carbinol on Dimyristoylphosphatidylcholine Multilamellar Vesicles
Langmuir : the ACS journal of surfaces and colloids, 2018Co-Authors: Jhili Mishra, Ashok Kumar MishraAbstract:This study reports the interaction of indole-3-carbinol (I3C), which is a chemopreventive reagent, with an artificial model membrane {(dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLVs)}, using the intrinsic fluorescence properties of I3C, extrinsic fluorescence properties of Nile Red (NR), differential scanning calorimetry (DSC), dynamic light scattering (DLS), and confocal microscopy. The intrinsic fluorescence of I3C helps to provide information about its location, partitioning ability, and sensitivity toward the phase-transition temperature of liposomes, confirmed by cetylpyridinium chloride (CPC) quenching study, partition coefficient values {(4.60 ± 0.1) × 105 (Solid Gel phase) and (7.29 ± 0.1) × 105 M–1 (liquid crystalline phase)} and temperature-dependent emission behavior of I3C. I3C perturbs the DMPC MLVs above 15 mol %, as observed using the fluorescence properties of NR, DSC, and DLS data. This perturbation occurs as a consequence of interfacial hydration of the DMPC MLVs, whi...
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Effect of Indole-3-Carbinol on Dimyristoylphosphatidylcholine Multilamellar Vesicles
2018Co-Authors: Jhili Mishra, Ashok Kumar MishraAbstract:This study reports the interaction of indole-3-carbinol (I3C), which is a chemopreventive reagent, with an artificial model membrane {(dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLVs)}, using the intrinsic fluorescence properties of I3C, extrinsic fluorescence properties of Nile Red (NR), differential scanning calorimetry (DSC), dynamic light scattering (DLS), and confocal microscopy. The intrinsic fluorescence of I3C helps to provide information about its location, partitioning ability, and sensitivity toward the phase-transition temperature of liposomes, confirmed by cetylpyridinium chloride (CPC) quenching study, partition coefficient values {(4.60 ± 0.1) × 105 (Solid Gel phase) and (7.29 ± 0.1) × 105 M–1 (liquid crystalline phase)} and temperature-dependent emission behavior of I3C. I3C perturbs the DMPC MLVs above 15 mol %, as observed using the fluorescence properties of NR, DSC, and DLS data. This perturbation occurs as a consequence of interfacial hydration of the DMPC MLVs, which was clearly indicated by the fluorescence properties (emission intensity, fluorescence lifetime, and nonextensive distribution analysis) of NR
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location partitioning behavior and interaction of capsaicin with lipid bilayer membrane study using its intrinsic fluorescence
Journal of Physical Chemistry B, 2015Co-Authors: Jitendriya Swain, Ashok Kumar MishraAbstract:Capsaicin is an ingredient of a wide variety of red peppers, and it has various pharmacological and biological applications. The present study explores the interaction of capsaicin with dimyristoylphosphatidylcholine (DMPC) lipid bilayer membrane by monitoring various photophysical parameters using its intrinsic fluorescence. In order to have a clearer understanding of the photophysical responses of capsaicin, studies involving (i) its solvation behavior in different solvents, (ii) the partition coefficient of capsaicin in different thermotropic phase states of lipid bilayer membrane, and (iii) its location inside lipid bilayer membrane have been carried out. Capsaicin has a reasonably high partition coefficient for DMPC liposome membrane, in both Solid Gel (2.8 ± 0.1 × 10(5)) and liquid crystalline (2.6 ± 0.1 × 10(5)) phases. Fluorescence quenching study using cetylpyridinium chloride (CPC) as quencher suggests that the phenolic group of capsaicin molecule is generally present near the headgroup region and hydrophobic tail present inside hydrophobic core region of the lipid bilayer membrane. The intrinsic fluorescence intensity and lifetime of capsaicin sensitively respond to the temperature dependent phase changes of liposome membrane. Above 15 mol %, capsaicin in the aqueous liposome suspension medium lowers the thermotropic phase transition temperature by about 3 °C, and above 30 mol %, the integrity of the membrane is significantly lost.
Elsy El Khoury - One of the best experts on this subject based on the ideXlab platform.
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ionic liquid expedites partition of curcumin into Solid Gel phase but discourages partition into liquid crystalline phase of 1 2 dimyristoyl sn glycero 3 phosphocholine liposomes
Journal of Physical Chemistry B, 2013Co-Authors: Elsy El Khoury, Digambara PatraAbstract:The hydrolysis of curcumin in alkaline and neutral buffer conditions is of interest because of the therapeutic applicability of curcumin. We show that hydrolysis of curcumin can be remarkably suppressed in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes. The fluorescence of curcumin sensitively detects the phase transition temperature of liposomes. However, at greater concentrations, curcumin affects the phase transition temperature, encouraging fusion of two membrane phases. The interaction of curcumin with DMPC is found to be strong, with a partition coefficient value of Kp = 2.78 × 105 in the Solid Gel phase, which dramatically increases in the liquid crystalline phase to Kp = 1.15 × 106. The importance of ionic liquids as green solvents has drawn interest because of their toxicological effect on human health; however, the impact of ionic liquids (ILs) on liposomes is not yet understood. The present study establishes that ILs such as 1-methyl-3-octylimidazolium chloride (moic) affect the p...