The Experts below are selected from a list of 17469 Experts worldwide ranked by ideXlab platform
Moon-koo Chung - One of the best experts on this subject based on the ideXlab platform.
-
Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers
Elsevier, 2019Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion: No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day. Keywords: Angelica gigas, Deer antlers, Developmental and reproductive toxicology, KGC-HJ3, Korean Red Ginsen
-
developmental and reproductive toxicity assessment in rats with kgc hj3 korean red ginseng with angelica gigas and deer antlers
Journal of Ginseng Research, 2018Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Abstract Background Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.
Z Muhammed - One of the best experts on this subject based on the ideXlab platform.
-
diuretic activity of the stem bark extracts of steganotaenia araliacea hochst apiaceae
Journal of Ethnopharmacology, 2005Co-Authors: Abdulkarim Agunu, E M Abdurahman, G O Andrew, Z MuhammedAbstract:Abstract The diuretic activity of the stem-bark extracts of Steganotaenia araliacea (SbESa) and Effects on urine electrolytes in rats was studied. Furthermore, a Toxicological Effect of the SbESa on several tissues was investigated. Groups of male Wister albino rats (170 ± 0.77 g) were employed. Four doses of 20 mg/kg body weight (b.w.), of SbESa (water, methanol, ethanol) and furosemide were administered intraperitoneally (IP). The control group received normal saline alone by oral administration. The 24-h urine outputs per day (in ml) were: normal saline (1.57 ± 0.11); water extract (3.18 ± 0.24); methanol extract (3.22 ± 0.29); ethanol extract (3.62 ± 0.27) and furosemide (4.22 ± 0.23). The urine output among the extracts (water, methanol, ethanol) and the furosemide against the control was statistically significant, (P The authors conclude that though there are compelling evidence of diuretic potentials in the use of the stem-bark of Steganotaenia araliacea, the toxic Effects on vital organs is a drawback to its recommendation for use as a diuretic agent.
-
diuretic activity of the stem bark extracts of steganotaenia araliacea hochst apiaceae
Journal of Ethnopharmacology, 2005Co-Authors: Abdulkarim Agunu, E M Abdurahman, G O Andrew, Z MuhammedAbstract:Abstract The diuretic activity of the stem-bark extracts of Steganotaenia araliacea (SbESa) and Effects on urine electrolytes in rats was studied. Furthermore, a Toxicological Effect of the SbESa on several tissues was investigated. Groups of male Wister albino rats (170 ± 0.77 g) were employed. Four doses of 20 mg/kg body weight (b.w.), of SbESa (water, methanol, ethanol) and furosemide were administered intraperitoneally (IP). The control group received normal saline alone by oral administration. The 24-h urine outputs per day (in ml) were: normal saline (1.57 ± 0.11); water extract (3.18 ± 0.24); methanol extract (3.22 ± 0.29); ethanol extract (3.62 ± 0.27) and furosemide (4.22 ± 0.23). The urine output among the extracts (water, methanol, ethanol) and the furosemide against the control was statistically significant, (P The authors conclude that though there are compelling evidence of diuretic potentials in the use of the stem-bark of Steganotaenia araliacea, the toxic Effects on vital organs is a drawback to its recommendation for use as a diuretic agent.
Jinsoo Lee - One of the best experts on this subject based on the ideXlab platform.
-
Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers
Elsevier, 2019Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion: No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day. Keywords: Angelica gigas, Deer antlers, Developmental and reproductive toxicology, KGC-HJ3, Korean Red Ginsen
-
developmental and reproductive toxicity assessment in rats with kgc hj3 korean red ginseng with angelica gigas and deer antlers
Journal of Ginseng Research, 2018Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Abstract Background Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.
Ji-seong Jeong - One of the best experts on this subject based on the ideXlab platform.
-
Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers
Elsevier, 2019Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion: No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day. Keywords: Angelica gigas, Deer antlers, Developmental and reproductive toxicology, KGC-HJ3, Korean Red Ginsen
-
developmental and reproductive toxicity assessment in rats with kgc hj3 korean red ginseng with angelica gigas and deer antlers
Journal of Ginseng Research, 2018Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Abstract Background Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.
Kyung-jin Cho - One of the best experts on this subject based on the ideXlab platform.
-
Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers
Elsevier, 2019Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion: No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day. Keywords: Angelica gigas, Deer antlers, Developmental and reproductive toxicology, KGC-HJ3, Korean Red Ginsen
-
developmental and reproductive toxicity assessment in rats with kgc hj3 korean red ginseng with angelica gigas and deer antlers
Journal of Ginseng Research, 2018Co-Authors: Jinsoo Lee, Ji-seong Jeong, Kyung-jin Cho, Kyeong-nang Moon, Sang Yun Kim, Byungcheol Han, Yong-soon Kim, Eun Ju Jeong, Moon-koo ChungAbstract:Abstract Background Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological Effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods This study was conducted to evaluate the potential Toxicological Effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague–Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague–Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential Toxicological Effect on maternal function and embryo-fetal development. Results and conclusion No test item–related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have Toxicological potential on developmental and reproductive functions. Therefore, no observed adverse Effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.