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Sylvaine Cordier - One of the best experts on this subject based on the ideXlab platform.
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Prenatal Solvent Exposure and Motor Inhibition Function at the Age of 10 – 12 in the PELAGIE Mother-Child Cohort
ISEE Conference Abstracts, 2018Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Fabienne PeléAbstract:Background/Aim: Epidemiological studies reported that prenatal Solvent Exposure was associated with higher frequency of attention deficit and higher levels of hyperactivity or impulsivity in expose...
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Prenatal Solvent Exposure Association with motor Inhibition Functional MRI at the Age of 10-12 in the PELAGIE Mother-Child Cohort
ISEE Conference Abstracts, 2018Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Dave Saint-amour, G. Simon, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Background/Aim: Epidemiological studies reported that prenatal Solvent Exposure was associated with adverse neurobehavioral outcomes that suggest impaired motor inhibition function. Using functiona...
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Prenatal Solvent Exposure and motor inhibition function at the age of 10 – 12 in the PELAGIE mother-child cohort
2017Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Fabienne PeléAbstract:Background/Aim Epidemiological studies reported that prenatal Solvent Exposure was associated with higher frequency of attention deficit and higher levels of hyperactivity or impulsivity in exposed children which suggest impaired motor inhibition function. The purpose of the present work is to investigate the effect of prenatal Exposure to Solvents on the motor inhibition function measured by neuropsychological test performed in children of 10-12 years old.
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Prenatal Solvent Exposure association with motor inhibition functional MRI at the age of 10-12 in the PELAGIE mother-child cohort
2017Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Dave Saint-amour, G. Simon, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Background/Aim Epidemiological studies reported that prenatal Solvent Exposure was associated with adverse neurobehavioral outcomes that suggest impaired motor inhibition function. Using functional Magnetic Resonance Imaging (fMRI) among children aged 10-12 years old, we aimed at investigating the effect of prenatal Exposure to Solvents on the activation of cerebral regions involved in the motor inhibition function.
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Occupational Solvent Exposure during pregnancy and child behaviour at age 2.
Occupational and Environmental Medicine, 2013Co-Authors: Fabienne Pelé, Ronan Garlantézec, Gina Muckle, Nathalie Costet, Christine Monfort, Luc Multigner, Florence Rouget, Sylvaine CordierAbstract:OBJECTIVES: Many women who work during pregnancy are occupationally exposed to toxicants. The developing central nervous system is highly vulnerable to neurotoxicants such as Solvents. Although the neurotoxicity of Solvents to adults is well established, very few studies have examined their effects on children's behaviour following prenatal Exposure. METHODS: Women from the Perturbateurs endocriniens: Étude Longitudinale sur les Anomalies de la Grossesse, l'Infertilité et l'Enfance (PELAGIE) mother-child cohort (including 3005 working women) were recruited in Brittany (France) between 2002 and 2006, at the beginning of pregnancy, to assess occupational Exposure to Solvents at that time. Child behaviour was documented at age 2 by mothers (n=1278) assessing components of attention deficit/hyperactivity, aggression, opposition and emotionality. We used a multiple linear regression analysis to evaluate the association between occupational Solvent Exposure and children's behaviour. Complementary sensitivity analyses allowed us to handle missing data, due mostly to attrition. RESULTS: 20% of women reported occasional Exposure and 31% regular Exposure to Solvents. Children prenatally exposed were more likely to have higher scores of attention deficit/hyperactivity and aggression, and dose-response relations were observed. CONCLUSIONS: The dose-response effect and the high prevalence of children potentially exposed to Solvents from their mother's workplace Exposure underline the public health relevance of this result. Our results should be replicated in further studies designed to identify which Solvents are most deleterious and to assess child behaviour at school age.
Bénédicte Stengel - One of the best experts on this subject based on the ideXlab platform.
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effect of organic Solvent Exposure on chronic kidney disease progression the gn progress cohort study
Journal of The American Society of Nephrology, 2007Co-Authors: Sophie Jacob, Jean-claude Protois, M. Hery, Jerome Rossert, Bénédicte StengelAbstract:It has been suggested that Solvent Exposure may have a role in the progression of glomerulonephritis (GN) to ESRD, but this has never been tested with an appropriate cohort study design. A total of 338 non-ESRD patients with a first biopsy for primary GN between 1994 and 2001 were included: 194 IgA nephropathies (IgAN), 75 membranous nephropathies (MN), and 69 FSGS. ESRD, defined as an estimated GFR <15 ml/min per 1.73 m2 or dialysis, was registered during a mean follow-up period of 5 yr. Patients' lifelong Solvent Exposures before and after diagnosis were recorded by interview and assessed by industrial hygienist experts. Cox models were used to estimate adjusted hazard ratios (HR) of ESRD related to Exposures. Overall, 15 and 14% of the patients had been exposed at a low and a high level before diagnosis, respectively. Forty-two with IgAN, 12 with MN, and 22 with FSGS reached ESRD. A graded relationship was observed for MN (age- and gender-adjusted HR [95% confidence interval] for low Exposure versus none was 3.1 [0.5 to 18.2] and for high Exposure versus none was 8.2 [1.9 to 34.7]) and for IgAN (1.6 [0.7 to 3.9] and 2.2 [1.0 to 4.8]) but not for FSGS. Solvent risk was mediated only partly by baseline proteinuria: Adjusted HR for high Exposure versus none was 5.5 (1.3 to 23.9) for MN and 1.8 (0.8 to 3.9) for IgAN. In patients with IgAN, there was a trend in increasing HR with Exposure duration before and its persistence after diagnosis. These findings support the hypothesized association of Solvent Exposure with the progression of GN to ESRD. They should prompt clinicians to give greater attention to patients' occupational Exposures and possibly to consider professional reclassification.
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Effect of Organic Solvent Exposure on Chronic Kidney Disease Progression: The GN-PROGRESS Cohort Study
Journal of the American Society of Nephrology : JASN, 2006Co-Authors: Sophie Jacob, Jean-claude Protois, M. Hery, Jerome Rossert, Bénédicte StengelAbstract:It has been suggested that Solvent Exposure may have a role in the progression of glomerulonephritis (GN) to ESRD, but this has never been tested with an appropriate cohort study design. A total of 338 non-ESRD patients with a first biopsy for primary GN between 1994 and 2001 were included: 194 IgA nephropathies (IgAN), 75 membranous nephropathies (MN), and 69 FSGS. ESRD, defined as an estimated GFR
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Organic Solvent Exposure May Increase the Risk of Glomerular Nephropathies with Chronic Renal Failure
International journal of epidemiology, 1995Co-Authors: Bénédicte Stengel, Sylvie Cénée, Jean-claude Limasset, Jean-claude Protois, Alinen Marcelli, Patrick Brochard, Denis HémonAbstract:Background Several studies have suggested that Exposure to organic Solvents is associated with glomerular nephropathies (GN), but this relationship remains controversial. Methods A case-control study of 298 biopsy-proven cases and 298 hospital controls, matched for year of birth, sex, origin, and place of residence, was conducted between 1989 and 1991 in five hospitals in the Paris area: 82 cases of membranous glomerulopathy were included; 100, nephrotic syndrome with either minimal change nephropathy or focal and segmental hyalinosis (MCN/FSH); and 116, IgA nephropathy (IgA N). Subjects were interviewed about their lifelong occupational and non-occupational activities. A 'blind' assessment of type, level, and duration of Solvent Exposure was carried out by two industrial hygienists. Human leucocyte antigen (HLA) phenotypes were determined. Results Among males, a clear association, which was not explained by social class, was observed between chronic renal failure and high Exposure to Solvents for both MCN/FSH (OR = 7.7, 95% CI: 1.4-41.6) and IgA N (OR = 3.5, 95% CI: 1.0-11.8). The odds ratios increased with duration of Exposure. No relationship was observed between such Exposure and GN cases with normal renal function. No evidence was found that the HLA phenotype plays a role in the association between Solvent Exposure and the disease. Conclusions These results support the hypothesis of a causal relationship between high Solvent Exposure, which concerned 15% of the males in this study, and the development of GN with chronic renal failure.
Fabienne Pelé - One of the best experts on this subject based on the ideXlab platform.
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Prenatal Solvent Exposure and Motor Inhibition Function at the Age of 10 – 12 in the PELAGIE Mother-Child Cohort
ISEE Conference Abstracts, 2018Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Fabienne PeléAbstract:Background/Aim: Epidemiological studies reported that prenatal Solvent Exposure was associated with higher frequency of attention deficit and higher levels of hyperactivity or impulsivity in expose...
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Prenatal Solvent Exposure Association with motor Inhibition Functional MRI at the Age of 10-12 in the PELAGIE Mother-Child Cohort
ISEE Conference Abstracts, 2018Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Dave Saint-amour, G. Simon, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Background/Aim: Epidemiological studies reported that prenatal Solvent Exposure was associated with adverse neurobehavioral outcomes that suggest impaired motor inhibition function. Using functiona...
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Prenatal Solvent Exposure and motor inhibition function at the age of 10 – 12 in the PELAGIE mother-child cohort
2017Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Fabienne PeléAbstract:Background/Aim Epidemiological studies reported that prenatal Solvent Exposure was associated with higher frequency of attention deficit and higher levels of hyperactivity or impulsivity in exposed children which suggest impaired motor inhibition function. The purpose of the present work is to investigate the effect of prenatal Exposure to Solvents on the motor inhibition function measured by neuropsychological test performed in children of 10-12 years old.
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Prenatal Solvent Exposure association with motor inhibition functional MRI at the age of 10-12 in the PELAGIE mother-child cohort
2017Co-Authors: Anne-claire Binter, Elise Bannier, Sylvaine Cordier, Jean-françois Viel, Cécile Chevrier, Dave Saint-amour, G. Simon, Jean-christophe Ferré, Christian Barillot, Fabienne PeléAbstract:Background/Aim Epidemiological studies reported that prenatal Solvent Exposure was associated with adverse neurobehavioral outcomes that suggest impaired motor inhibition function. Using functional Magnetic Resonance Imaging (fMRI) among children aged 10-12 years old, we aimed at investigating the effect of prenatal Exposure to Solvents on the activation of cerebral regions involved in the motor inhibition function.
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Occupational Solvent Exposure during pregnancy and child behaviour at age 2.
Occupational and Environmental Medicine, 2013Co-Authors: Fabienne Pelé, Ronan Garlantézec, Gina Muckle, Nathalie Costet, Christine Monfort, Luc Multigner, Florence Rouget, Sylvaine CordierAbstract:OBJECTIVES: Many women who work during pregnancy are occupationally exposed to toxicants. The developing central nervous system is highly vulnerable to neurotoxicants such as Solvents. Although the neurotoxicity of Solvents to adults is well established, very few studies have examined their effects on children's behaviour following prenatal Exposure. METHODS: Women from the Perturbateurs endocriniens: Étude Longitudinale sur les Anomalies de la Grossesse, l'Infertilité et l'Enfance (PELAGIE) mother-child cohort (including 3005 working women) were recruited in Brittany (France) between 2002 and 2006, at the beginning of pregnancy, to assess occupational Exposure to Solvents at that time. Child behaviour was documented at age 2 by mothers (n=1278) assessing components of attention deficit/hyperactivity, aggression, opposition and emotionality. We used a multiple linear regression analysis to evaluate the association between occupational Solvent Exposure and children's behaviour. Complementary sensitivity analyses allowed us to handle missing data, due mostly to attrition. RESULTS: 20% of women reported occasional Exposure and 31% regular Exposure to Solvents. Children prenatally exposed were more likely to have higher scores of attention deficit/hyperactivity and aggression, and dose-response relations were observed. CONCLUSIONS: The dose-response effect and the high prevalence of children potentially exposed to Solvents from their mother's workplace Exposure underline the public health relevance of this result. Our results should be replicated in further studies designed to identify which Solvents are most deleterious and to assess child behaviour at school age.
Markku Sainio - One of the best experts on this subject based on the ideXlab platform.
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1713 Adverse neurologic health effects of occupational Solvent Exposure– from recognition to prevention
Neurotoxicology and Psychophysiology, 2018Co-Authors: Markku Sainio, Christoph Van ThrielAbstract:Aim of the special session The typical adverse neurological effect of long-term occupational Solvent Exposure is called chronic Solvent encephalopathy, characterised by persistent neurocognitive symptoms, often leading to early retirement. Surprisingly, under detection of CSE occurs even in targeted health screens by occupational health services. The non-specific cognitive findings are challenging to interpret for clinicians and thus the improvement of protocols for the neuropsychological assessment are necessary. Not all exposed develop neurological dysfunction, does epigenetics reveal why neurobehavioural disorders develop. And finally, the question is addressed, does occupational Solvent Exposure increase the risk of neurodegenerative disease, such as Parkinson disease. Heidi Furu 1 , Prof. Christoph van Thriel 2 , Lode Godderis 3 , Brad Racette 4 1 Doctagon Oy and Finnish Institute of Occupational Health, Helsinki, Finland 2 Leibniz Research Centre for Working Environment and Human Factors, TU Dortmund, Dortmund, Germany 3 Environment and Health, Department of Public Health and Primary Care, KU Leuven and IDEWE, External Service for Prevention and Protection at Work, Belgium 4 Washington University School of Medicine, St. Louis, USA, and University of the Witwatersrand School of Public Health, Johannesburg, South Africa
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Effects of long-term occupational Solvent Exposure on contrast sensitivity and performance in visual search.
Environmental toxicology and pharmacology, 2005Co-Authors: Risto Näsänen, Ari Kaukiainen, Ville Hero, Juha Päällysaho, Kiti Müller, Riitta Hari, Ritva Akila, Markku SainioAbstract:Sensitive and easily applicable screening tests are greatly needed for the early detection of nervous system dysfunction in people working with neurotoxic substances. Previous studies have shown that long-term Solvent Exposure may cause deficits in visual perception. We, therefore, studied the effects of long-term occupational Solvent Exposure and chronic encephalopathy on performance in three vision tests novel in the present context. Two visual search tasks were used: the letter search test measured the speed of finding a letter in an array of numerals, and the pop-out search test required the observer to detect the presence or absence of a tilted line segment in an array of vertical line segments. With the letter contrast sensitivity test we measured the contrast threshold for the identification of band-pass filtered letters. Before testing, comprehensive eye examination was carried out to reveal any structural or functional abnormality and to ensure correct refraction. The patients had healthy eyes, 2 out of 14 had reduced contrast sensitivity (Vistech) and 5 out of 14 had deficits in colour vision (FM 100). In both visual search tasks, the patients were statistically highly significantly (p
Ronan Garlantézec - One of the best experts on this subject based on the ideXlab platform.
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occupational Solvent Exposure during pregnancy and child behaviour at age 2
Occupational and Environmental Medicine, 2013Co-Authors: Fabienne Pelé, Ronan Garlantézec, Gina Muckle, Nathalie Costet, Christine Monfort, Luc Multigner, Florence Rouget, Sylvaine CordierAbstract:OBJECTIVES: Many women who work during pregnancy are occupationally exposed to toxicants. The developing central nervous system is highly vulnerable to neurotoxicants such as Solvents. Although the neurotoxicity of Solvents to adults is well established, very few studies have examined their effects on children's behaviour following prenatal Exposure. METHODS: Women from the Perturbateurs endocriniens: Etude Longitudinale sur les Anomalies de la Grossesse, l'Infertilite et l'Enfance (PELAGIE) mother-child cohort (including 3005 working women) were recruited in Brittany (France) between 2002 and 2006, at the beginning of pregnancy, to assess occupational Exposure to Solvents at that time. Child behaviour was documented at age 2 by mothers (n=1278) assessing components of attention deficit/hyperactivity, aggression, opposition and emotionality. We used a multiple linear regression analysis to evaluate the association between occupational Solvent Exposure and children's behaviour. Complementary sensitivity analyses allowed us to handle missing data, due mostly to attrition. RESULTS: 20% of women reported occasional Exposure and 31% regular Exposure to Solvents. Children prenatally exposed were more likely to have higher scores of attention deficit/hyperactivity and aggression, and dose-response relations were observed. CONCLUSIONS: The dose-response effect and the high prevalence of children potentially exposed to Solvents from their mother's workplace Exposure underline the public health relevance of this result. Our results should be replicated in further studies designed to identify which Solvents are most deleterious and to assess child behaviour at school age.
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Occupational Solvent Exposure during pregnancy and child behaviour at age 2.
Occupational and Environmental Medicine, 2013Co-Authors: Fabienne Pelé, Ronan Garlantézec, Gina Muckle, Nathalie Costet, Christine Monfort, Luc Multigner, Florence Rouget, Sylvaine CordierAbstract:OBJECTIVES: Many women who work during pregnancy are occupationally exposed to toxicants. The developing central nervous system is highly vulnerable to neurotoxicants such as Solvents. Although the neurotoxicity of Solvents to adults is well established, very few studies have examined their effects on children's behaviour following prenatal Exposure. METHODS: Women from the Perturbateurs endocriniens: Étude Longitudinale sur les Anomalies de la Grossesse, l'Infertilité et l'Enfance (PELAGIE) mother-child cohort (including 3005 working women) were recruited in Brittany (France) between 2002 and 2006, at the beginning of pregnancy, to assess occupational Exposure to Solvents at that time. Child behaviour was documented at age 2 by mothers (n=1278) assessing components of attention deficit/hyperactivity, aggression, opposition and emotionality. We used a multiple linear regression analysis to evaluate the association between occupational Solvent Exposure and children's behaviour. Complementary sensitivity analyses allowed us to handle missing data, due mostly to attrition. RESULTS: 20% of women reported occasional Exposure and 31% regular Exposure to Solvents. Children prenatally exposed were more likely to have higher scores of attention deficit/hyperactivity and aggression, and dose-response relations were observed. CONCLUSIONS: The dose-response effect and the high prevalence of children potentially exposed to Solvents from their mother's workplace Exposure underline the public health relevance of this result. Our results should be replicated in further studies designed to identify which Solvents are most deleterious and to assess child behaviour at school age.
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Combined effect of prenatal Solvent Exposure and GSTT1 or GSTM1 polymorphisms in the risk of birth defects.
Birth Defects Research Part A: Clinical and Molecular Teratology, 2012Co-Authors: Ronan Garlantézec, Cécile Chevrier, Isabelle Coiffec, Catherine Celebi, Sylvaine CordierAbstract:Exposure to Solvents during pregnancy has long been suspected to increase the risk of congenital malformations. Glutathione S-transferases (GSTs) are enzymes essential for the detoxification of various chemicals. Our objective here was to assess whether GST polymorphisms might modify the association between maternal Solvent Exposure and the risk of birth defects. A prospective cohort included 3421 pregnant women in Brittany, France (2002-2006). Occupational Exposure to Solvents was assessed from a job-Exposure matrix. Congenital malformations were diagnosed among livebirths, stillbirths, and medical pregnancy terminations. Using a nested case-control design, 32 babies with major birth defects were compared to 348 normal births for babies' cord blood genotypes (at GSTT1 and GSTM1) and maternal occupational Solvent Exposure. Logistic models were used to adjust for potential confounders. The risk of major defects increased significantly in women with Solvent Exposure (20% of controls and 34% of cases). Frequencies of the null genotype of both the GSTT1 and GSTM1 genes were similar among controls and cases. There was a significantly increased risk of birth defects in GSTM1 not-null cord-blood genotype in pregnancies exposed to Solvents (odds ratio [OR], 1.0 for not-null, not-exposed; OR, 4.0 for not-null, exposed; 95% confidence interval [CI], 1.4-11.2; OR, 1.6 for null, not-exposed; 95% CI, 0.6-3.9; OR, 1.0 for null, exposed; 95% CI, 0.2-4.7; p = 0.05). This nested case-control study suggests that the child's GSTM1 genotype modifies the risk of major birth defects among offspring of Solvent-exposed women. Replication and additional investigations are necessary to confirm and elucidate these findings.
