The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform

Karl Schöffling - One of the best experts on this subject based on the ideXlab platform.

  • Somatomedin C level and stimulation of growth hormone and adrenal Cortex funCtion by administration of releasing hormones and physiCal exertion in patients with obesity
    Medizinische Klinik, 1991
    Co-Authors: E. Jungmann, M. Stahr, Schwietzer G, Schumm-draeger Pm, Althoff Ph, Thomas Nickelsen, K. Schmidt, Karl Schöffling
    Abstract:

    In a CliniCal study on potential determinants underlying the impairment of growth hormone stimulation in obese human subjeCts, we examined in 20 otherwise healthy adult obese subjeCts (14 females, six males, age 18 to 40 years, body mass index greater than 29 kg/m2) the responses of growth hormone (hGH), adrenoCortiCotropiC hormone (ACTH) and Cortisol to releasing hormone stimulation (growth hormone-releasing hormone and CortiCotropin-releasing hormone) and the responses of hGH, ACTH, Cortisol and free fatty aCids (FFA) to physiCal exerCise. SubjeCts with Somatomedin-C levels less than or equal to 0.7 U/ml (group 1) were more obese than subjeCts with Somatomedin-C levels greater than 0.7 U/ml (group 2) (p less than 0.01). In group 1, hGH inCreased by 4.3 +/- 1.2 ng/ml in response to releasing hormone administration and by 0.9 +/- 0.3 ng/ml in response to physiCal exerCise (normal responses, inCrease by greater than 7 ng/ml), in group 2, hGH inCreased by 6.7 +/- 1.4, and 2.4 +/- 0.8 ng/ml, respeCtively (p less than 0.05 vs. group 1). Moreover, FFA stimulation by physiCal exerCise was blunted in group 1 (p less than 0.05 vs. group 2). In Contrast, ACTH stimulation was found inCreased in group 1 in Comparison to group 2, partiCularly in response to physiCal exerCise (p less than 0.01), and resulted in enhanCed Cortisol stimulation (p less than 0.05). Thus, impaired hGH stimulation in obese human subjeCts is not explained by an altered relationship between hGH and Somatomedin-C levels.(ABSTRACT TRUNCATED AT 250 WORDS)

E. Jungmann - One of the best experts on this subject based on the ideXlab platform.

  • Somatomedin C level and stimulation of growth hormone and adrenal Cortex funCtion by administration of releasing hormones and physiCal exertion in patients with obesity
    Medizinische Klinik, 1991
    Co-Authors: E. Jungmann, M. Stahr, Schwietzer G, Schumm-draeger Pm, Althoff Ph, Thomas Nickelsen, K. Schmidt, Karl Schöffling
    Abstract:

    In a CliniCal study on potential determinants underlying the impairment of growth hormone stimulation in obese human subjeCts, we examined in 20 otherwise healthy adult obese subjeCts (14 females, six males, age 18 to 40 years, body mass index greater than 29 kg/m2) the responses of growth hormone (hGH), adrenoCortiCotropiC hormone (ACTH) and Cortisol to releasing hormone stimulation (growth hormone-releasing hormone and CortiCotropin-releasing hormone) and the responses of hGH, ACTH, Cortisol and free fatty aCids (FFA) to physiCal exerCise. SubjeCts with Somatomedin-C levels less than or equal to 0.7 U/ml (group 1) were more obese than subjeCts with Somatomedin-C levels greater than 0.7 U/ml (group 2) (p less than 0.01). In group 1, hGH inCreased by 4.3 +/- 1.2 ng/ml in response to releasing hormone administration and by 0.9 +/- 0.3 ng/ml in response to physiCal exerCise (normal responses, inCrease by greater than 7 ng/ml), in group 2, hGH inCreased by 6.7 +/- 1.4, and 2.4 +/- 0.8 ng/ml, respeCtively (p less than 0.05 vs. group 1). Moreover, FFA stimulation by physiCal exerCise was blunted in group 1 (p less than 0.05 vs. group 2). In Contrast, ACTH stimulation was found inCreased in group 1 in Comparison to group 2, partiCularly in response to physiCal exerCise (p less than 0.01), and resulted in enhanCed Cortisol stimulation (p less than 0.05). Thus, impaired hGH stimulation in obese human subjeCts is not explained by an altered relationship between hGH and Somatomedin-C levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Carol S Burckhardt - One of the best experts on this subject based on the ideXlab platform.

  • low levels of Somatomedin C in patients with the fibromyalgia syndrome a possible link between sleep and musCle pain
    Arthritis & Rheumatism, 1992
    Co-Authors: Robert M Bennett, Sharon R Clark, Stephen M Campbell, Carol S Burckhardt
    Abstract:

    ObjeCtive Fibromyalgia is a Common syndrome of musCuloskeletal pain and fatigue. LaCking distinCtive tissue or laboratory Correlations, it has often been Considered a form of "psyChogeniC rheumatism." In the present study, the notion that the stage-4 sleep anomaly typiCally seen in the fibromyalgia syndrome may disrupt growth hormone seCretion was tested. BeCause growth hormone has a very short half-life, serum levels of Somatomedin C were measured; Somatomedin C is the major mediator of growth hormone's anaboliC aCtions and is a prerequisite for normal musCle homeostasis. Methods Serum levels of Somatomedin C were measured in 70 female fibromyalgia patients and 55 healthy Controls, using a peptide-speCifiC radioimmunoassay. Results SignifiCantly lower levels of Somatomedin C were observed in the fibromyalgia patients Compared with Controls (mean +/- SD 124.7 +/- 47 ng/ml versus 175.2 +/- 60 ng/ml; P = 0.000001). These results Could not be explained by ConComitant therapy or by weight, and in a subset of 21 patients in whom this was investigated, there was no Correlation with various indiCes of disease aCtivity. ConClusion These findings indiCate that there is a distinCtive disruption of the growth hormone-Somatomedin C neuroendoCrine axis in a majority of fibromyalgia patients. It is hypothesized that this abnormality may explain the link between disturbed sleep and predisposition to musCle pain.

M. Stahr - One of the best experts on this subject based on the ideXlab platform.

  • Somatomedin C level and stimulation of growth hormone and adrenal Cortex funCtion by administration of releasing hormones and physiCal exertion in patients with obesity
    Medizinische Klinik, 1991
    Co-Authors: E. Jungmann, M. Stahr, Schwietzer G, Schumm-draeger Pm, Althoff Ph, Thomas Nickelsen, K. Schmidt, Karl Schöffling
    Abstract:

    In a CliniCal study on potential determinants underlying the impairment of growth hormone stimulation in obese human subjeCts, we examined in 20 otherwise healthy adult obese subjeCts (14 females, six males, age 18 to 40 years, body mass index greater than 29 kg/m2) the responses of growth hormone (hGH), adrenoCortiCotropiC hormone (ACTH) and Cortisol to releasing hormone stimulation (growth hormone-releasing hormone and CortiCotropin-releasing hormone) and the responses of hGH, ACTH, Cortisol and free fatty aCids (FFA) to physiCal exerCise. SubjeCts with Somatomedin-C levels less than or equal to 0.7 U/ml (group 1) were more obese than subjeCts with Somatomedin-C levels greater than 0.7 U/ml (group 2) (p less than 0.01). In group 1, hGH inCreased by 4.3 +/- 1.2 ng/ml in response to releasing hormone administration and by 0.9 +/- 0.3 ng/ml in response to physiCal exerCise (normal responses, inCrease by greater than 7 ng/ml), in group 2, hGH inCreased by 6.7 +/- 1.4, and 2.4 +/- 0.8 ng/ml, respeCtively (p less than 0.05 vs. group 1). Moreover, FFA stimulation by physiCal exerCise was blunted in group 1 (p less than 0.05 vs. group 2). In Contrast, ACTH stimulation was found inCreased in group 1 in Comparison to group 2, partiCularly in response to physiCal exerCise (p less than 0.01), and resulted in enhanCed Cortisol stimulation (p less than 0.05). Thus, impaired hGH stimulation in obese human subjeCts is not explained by an altered relationship between hGH and Somatomedin-C levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Schwietzer G - One of the best experts on this subject based on the ideXlab platform.

  • Somatomedin C level and stimulation of growth hormone and adrenal Cortex funCtion by administration of releasing hormones and physiCal exertion in patients with obesity
    Medizinische Klinik, 1991
    Co-Authors: E. Jungmann, M. Stahr, Schwietzer G, Schumm-draeger Pm, Althoff Ph, Thomas Nickelsen, K. Schmidt, Karl Schöffling
    Abstract:

    In a CliniCal study on potential determinants underlying the impairment of growth hormone stimulation in obese human subjeCts, we examined in 20 otherwise healthy adult obese subjeCts (14 females, six males, age 18 to 40 years, body mass index greater than 29 kg/m2) the responses of growth hormone (hGH), adrenoCortiCotropiC hormone (ACTH) and Cortisol to releasing hormone stimulation (growth hormone-releasing hormone and CortiCotropin-releasing hormone) and the responses of hGH, ACTH, Cortisol and free fatty aCids (FFA) to physiCal exerCise. SubjeCts with Somatomedin-C levels less than or equal to 0.7 U/ml (group 1) were more obese than subjeCts with Somatomedin-C levels greater than 0.7 U/ml (group 2) (p less than 0.01). In group 1, hGH inCreased by 4.3 +/- 1.2 ng/ml in response to releasing hormone administration and by 0.9 +/- 0.3 ng/ml in response to physiCal exerCise (normal responses, inCrease by greater than 7 ng/ml), in group 2, hGH inCreased by 6.7 +/- 1.4, and 2.4 +/- 0.8 ng/ml, respeCtively (p less than 0.05 vs. group 1). Moreover, FFA stimulation by physiCal exerCise was blunted in group 1 (p less than 0.05 vs. group 2). In Contrast, ACTH stimulation was found inCreased in group 1 in Comparison to group 2, partiCularly in response to physiCal exerCise (p less than 0.01), and resulted in enhanCed Cortisol stimulation (p less than 0.05). Thus, impaired hGH stimulation in obese human subjeCts is not explained by an altered relationship between hGH and Somatomedin-C levels.(ABSTRACT TRUNCATED AT 250 WORDS)