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Candida Aparecida Leite Kassuya - One of the best experts on this subject based on the ideXlab platform.
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contribution of Spathulenol to the anti nociceptive effects of psidium guineense
Nutritional Neuroscience, 2020Co-Authors: Elisangela Dos Santos, Kamilla Felipe Do Nascimento, Joyce Alencar Santos Radai, Anelise Samara Nazari Formagio, Natalia De Matos Balsalobre, Edward B Ziff, Elisabete Castelon Konkiewitz, Candida Aparecida Leite KassuyaAbstract:Objectives: Araca-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of t...
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antioxidant anti inflammatory antiproliferative and antimycobacterial activities of the essential oil of psidium guineense sw and Spathulenol
Journal of Ethnopharmacology, 2018Co-Authors: Kamilla Felipe Do Nascimento, Ana Lucia Tasca Gois Ruiz, Claudia Andrea Lima Cardoso, Flora Martinez Figueira Moreira, Joyce Alencar Santos, Candida Aparecida Leite Kassuya, Julio Croda, Maria Do Carmo Vieira, Mary Ann FoglioAbstract:Abstract Ethnopharmacological relevance Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence demonstrating this activity. Aim of the study To evaluate the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of P. guineense and Spathulenol (a major constituent). The study was conducted in part to provide evidence supporting the ethnobotanical use of the leaves of this species. Material and methods The essential oil (EOPG) was extracted from the leaves of P. guineense by hydrodistillation and analysed by gas chromatography-mass spectrometry (GC–MS). The major compound, Spathulenol (PG-1), was isolated in a chromatographic column and characterized by nuclear magnetic resonance (NMR). EOPG and PG-1 were evaluated in vitro for antioxidant activity by DPPH, ABTS and MDA methods; anti-inflammatory potential was assessed using two models, including pleurisy and edema, in mice. The impact of EOPG and PG-1 on cell proliferation was determined via spectrophotometric quantification of the cellular protein content using a sulforhodamine B assay, and anti- Mycobacterium tuberculosis activity was determined using the REMA method. Results A total of 38 components were identified from the EOPG, with the sesquiterpenic alcohol Spathulenol (PG-1) (80.7%) being the major constituent. EOPG and PG-1 exhibited the highest antioxidant activities in the DPPH and MDA system compared with reference standard, with IC 50 values ranging from 26.13–85.60 μg/mL. Oral administration of EOPG and PG-1 showed significant inhibition in the Cg-induced mice paw oedema and pleurisy model. The EOPG (GI 50 = 0.89 μg/mL) and PG-1 (GI 50 = 49.30 μg/mL) were particularly effective against the ovarian cancer cell line. Both showed moderate antimycobacterial activity. Conclusion For the first time, this study demonstrated the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial properties of the essential oil of P. guineense (leaves were collected in Dourados-MS) and Spathulenol, collaborating the etnhopharmacologycal use of this plant due to its an anti-inflammatory effect.
Paulo Roberto Hrihorowitsch Moreno - One of the best experts on this subject based on the ideXlab platform.
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chemical composition and antimicrobial activity of the essential oil from croton heterocalyx baill euphorbiaceae s s leaves
Journal of Essential Oil Research, 2009Co-Authors: Paulo Roberto Hrihorowitsch Moreno, M Lima, Maria Beatriz Rossi Caruzo, Daniela Santos Carneiro Torres, Ines Cordeiro, Maria Claudia Marx YoungAbstract:Abstract The chemical composition and the antimicrobial activity of the essential oil from Croton heterocalyx leaves were evaluated. The oil which was analyzed by GC and GC/MS was found to contain germacrene D (12.5%), bicycloger-macrene (11.2%), δ-elemene (9.2%) β-elemene (8.2%), Spathulenol (6.9%), linalool (5.4%) and 1,8-cineole (3.7%) as major components. Croton heterocalyx oil displayed a high inhibitory activity against the fungi Aspergillus niger (16404) and Candida albicans (ATCC 10231) as well as the Gram-positive bacterium Staphylococcus aureus (ATCC 6538), but a very weak activity was observed for the Gram-negative bacteria Escherichia coli (ATCC 8739) and Pseudomonas aeruginosa (ATCC 9027).
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analysis of the volatile oil from pilocarpus pennatifolius lemmaire rutaceae leaves by gc ms
Flavour and Fragrance Journal, 2004Co-Authors: Ana Paula Santos, Melânia Cornélio Lopes, Renata Pereira Limberger, Miriam Anders Apel, Amélia T. Henriques, Paulo Roberto Hrihorowitsch MorenoAbstract:The oil obtained by steam distillation of dried and powdered Pilocarpus pennatifolius Lemmaire leaves was analysed by GC and GC–MS. The major components were tridecane (56.7%) and pentadecane (25.5%). Additionally, γ-muurolene (6.6%), Spathulenol (2.6%), β-elemene (2.1%), β-caryophyllene (1.2%) and eugenol (0.3%) were also found in the crude oil. Copyright © 2004 John Wiley & Sons, Ltd.
Kamilla Felipe Do Nascimento - One of the best experts on this subject based on the ideXlab platform.
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contribution of Spathulenol to the anti nociceptive effects of psidium guineense
Nutritional Neuroscience, 2020Co-Authors: Elisangela Dos Santos, Kamilla Felipe Do Nascimento, Joyce Alencar Santos Radai, Anelise Samara Nazari Formagio, Natalia De Matos Balsalobre, Edward B Ziff, Elisabete Castelon Konkiewitz, Candida Aparecida Leite KassuyaAbstract:Objectives: Araca-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of t...
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antioxidant anti inflammatory antiproliferative and antimycobacterial activities of the essential oil of psidium guineense sw and Spathulenol
Journal of Ethnopharmacology, 2018Co-Authors: Kamilla Felipe Do Nascimento, Ana Lucia Tasca Gois Ruiz, Claudia Andrea Lima Cardoso, Flora Martinez Figueira Moreira, Joyce Alencar Santos, Candida Aparecida Leite Kassuya, Julio Croda, Maria Do Carmo Vieira, Mary Ann FoglioAbstract:Abstract Ethnopharmacological relevance Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence demonstrating this activity. Aim of the study To evaluate the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of P. guineense and Spathulenol (a major constituent). The study was conducted in part to provide evidence supporting the ethnobotanical use of the leaves of this species. Material and methods The essential oil (EOPG) was extracted from the leaves of P. guineense by hydrodistillation and analysed by gas chromatography-mass spectrometry (GC–MS). The major compound, Spathulenol (PG-1), was isolated in a chromatographic column and characterized by nuclear magnetic resonance (NMR). EOPG and PG-1 were evaluated in vitro for antioxidant activity by DPPH, ABTS and MDA methods; anti-inflammatory potential was assessed using two models, including pleurisy and edema, in mice. The impact of EOPG and PG-1 on cell proliferation was determined via spectrophotometric quantification of the cellular protein content using a sulforhodamine B assay, and anti- Mycobacterium tuberculosis activity was determined using the REMA method. Results A total of 38 components were identified from the EOPG, with the sesquiterpenic alcohol Spathulenol (PG-1) (80.7%) being the major constituent. EOPG and PG-1 exhibited the highest antioxidant activities in the DPPH and MDA system compared with reference standard, with IC 50 values ranging from 26.13–85.60 μg/mL. Oral administration of EOPG and PG-1 showed significant inhibition in the Cg-induced mice paw oedema and pleurisy model. The EOPG (GI 50 = 0.89 μg/mL) and PG-1 (GI 50 = 49.30 μg/mL) were particularly effective against the ovarian cancer cell line. Both showed moderate antimycobacterial activity. Conclusion For the first time, this study demonstrated the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial properties of the essential oil of P. guineense (leaves were collected in Dourados-MS) and Spathulenol, collaborating the etnhopharmacologycal use of this plant due to its an anti-inflammatory effect.
Celik S. - One of the best experts on this subject based on the ideXlab platform.
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Chemical composition of the essential oils of Centaurea tomentella Hand.-Mazz. and C. haussknechtii Boiss. (Asteraceae) collected wild in Turkey and their activity on microorganisms affecting historical art craft
'Informa UK Limited', 2019Co-Authors: Bruno M., Modica A., Catinella G., Canli C., Arasoglu T., Celik S.Abstract:In the present study the chemical composition of the essential oils from aerial parts of Centaurea tomentella Hand.-Mazz. and C. haussknechtii Boiss. collected in Turkey was evaluated by GC and GC-MS. The main components of C. tomentella L. were hexadecanoic acid (19.7%), caryophyllene oxide (6.6%) and Spathulenol (4.8%) whereas C. haussknechtii was rich in hexadecanoic acid (26.2%), (Z,Z)-9,12-octadecadienoic acid (19.3%), heptacosane (5.3%) and nonacosane (5.1%). Antibacterial and antifungal activities against some microorganisms infesting historical art craft, were also determined
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Composition of the Essential Oil of Some Centaurea L.
'Asian Journal of Chemistry', 2014Co-Authors: Akkurt A., Celik S.Abstract:WOS: 000343766300079Composition of the water-distilled oil of Centaurea kurdica, C. antochia var. antochia and Centaurea albonitens in Turkey, were analyzed by GC and GC-MS. In essential oil of Centaurea kurdica, caryophyllene 14.4 %, a - humulene 4.62 %; germacrene 11.95 %; beta-farnesene 9.78 %; Spathulenol 7.73 %; glubulol 5.58 %; beta-eudesmol 4.04 %; in essential oil of C. antiochia var. antiochia caryophyllene 18.23 %; germacrene 27.37 %; Spathulenol 29.86 %; hexadecanoic acid 7.21 % and in essential oil of C. albonitens gamma-elemene 4.45 %; caryophyllene 7.75 %; germacrene 9.23 %; Spathulenol 7.97 %; caryophyllene oxide 16.45 %; cembrene 6.25 %; phytol 4.75 %; beta-selinenol 4.57 % were the main constituents
Bijen Kıvçak - One of the best experts on this subject based on the ideXlab platform.
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Essential Oil Composition of Three Centaurea Species from Turkey: Centaurea aggregata Fisch. & Mey. ex. DC.subsp. aggregata, C. balsamita Lam. and C. behen L.
2017Co-Authors: Tuğçe Erdoğan, Burcu Sümer, Özge Özçınar, Uğur Çakılcıoğlu, Betül Demirci, Kemal Hüsnü Can Başer, Bijen KıvçakAbstract:The essential oils of Centaurea aggregata subsp. aggregata, C. balsamita and C. behen collected in the same habitat from Turkey, have been investigated. A total of 26, 54 and 26 components were identified in C. aggregata subsp. aggregata, C. balsamita and C. behen, respectively. The main constituents of the investigated populations of the three taxa have been revealed as follows: Centaurea aggregata subsp. aggregata: hexadecanoic acid (35.8%), phytol (7.2%), caryophyllene oxide(6.0%), Spathulenol (6.0%); C. balsamita: hexadecanoic acid (23.0%), Spathulenol (8.9%), germacrene D (2.1%); C. behen: hexadecanoic acid (32.7%), germacrene D (14.8%), and phytol (12.3%)The essential oils of Centaurea aggregata subsp. aggregata, C. balsamita and C. behen collected in the same habitat from Turkey, have been investigated. A total of 26, 54 and 26 components were identified in C. aggregata subsp. aggregata, C. balsamita and C. behen, respectively. The main constituents of the investigated populations of the three taxa have been revealed as follows: Centaurea aggregata subsp. aggregata: hexadecanoic acid (35.8%), phytol (7.2%), caryophyllene oxide(6.0%), Spathulenol (6.0%); C. balsamita: hexadecanoic acid (23.0%), Spathulenol (8.9%), germacrene D (2.1%); C. behen: hexadecanoic acid (32.7%), germacrene D (14.8%), and phytol (12.3%
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Essential Oil Composition of Three Centaurea Species from Turkey: Centaurea aggregata Fisch. & Mey. ex. DC. subsp. aggregata, C. balsamita Lam. and C. behen L.
ACG Publications, 2017Co-Authors: Tuğçe Erdoğan, Burcu Sümer, Özge Özçınar, Uğur Çakılcıoğlu, Betül Demirci, Kemal Hüsnü Can Başer, Bijen KıvçakAbstract:The essential oils of Centaurea aggregata subsp. aggregata, C. balsamita and C. behen collected in the same habitat from Turkey, have been investigated. A total of 26, 54 and 26 components were identified in C. aggregata subsp. aggregata, C. balsamita and C. behen, respectively. The main constituents of the investigated populations of the three taxa have been revealed as follows: Centaurea aggregata subsp. aggregata: hexadecanoic acid (35.8%), phytol (7.2%), caryophyllene oxide(6.0%), Spathulenol (6.0%); C. balsamita: hexadecanoic acid (23.0%), Spathulenol (8.9%), germacrene D (2.1%); C. behen: hexadecanoic acid (32.7%), germacrene D (14.8%), and phytol (12.3%)
