The Experts below are selected from a list of 124899 Experts worldwide ranked by ideXlab platform
Eric A Accili - One of the best experts on this subject based on the ideXlab platform.
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evolutionary analyses of kcnq1 and herg voltage gated potassium channel sequences reveal location Specific Susceptibility and augmented chemical severities of arrhythmogenic mutations
BMC Evolutionary Biology, 2008Co-Authors: Heather A Jackson, Eric A AcciliAbstract:Background Mutations in HERG and KCNQ1 potassium channels have been associated with Long QT syndrome and atrial fibrillation, and more recently with sudden infant death syndrome and sudden unexplained death. In other proteins, disease-associated amino acid mutations have been analyzed according to the chemical severity of the changes and the locations of the altered amino acids according to their conservation over metazoan evolution. Here, we present the first such analysis of arrhythmia-associated mutations (AAMs) in the HERG and KCNQ1 potassium channels.
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evolutionary analyses of kcnq1 and herg voltage gated potassium channel sequences reveal location Specific Susceptibility and augmented chemical severities of arrhythmogenic mutations
BMC Evolutionary Biology, 2008Co-Authors: Heather A Jackson, Eric A AcciliAbstract:Mutations in HERG and KCNQ1 potassium channels have been associated with Long QT syndrome and atrial fibrillation, and more recently with sudden infant death syndrome and sudden unexplained death. In other proteins, disease-associated amino acid mutations have been analyzed according to the chemical severity of the changes and the locations of the altered amino acids according to their conservation over metazoan evolution. Here, we present the first such analysis of arrhythmia-associated mutations (AAMs) in the HERG and KCNQ1 potassium channels. Using evolutionary analyses, AAMs in HERG and KCNQ1 were preferentially found at evolutionarily conserved sites and unevenly distributed among functionally conserved domains. Non-synonymous single nucleotide polymorphisms (nsSNPs) are under-represented at evolutionarily conserved sites in HERG, but distribute randomly in KCNQ1. AAMs are chemically more severe, according to Grantham's Scale, than changes observed in evolution and their severity correlates with the expected chemical severity of the involved codon. Expected chemical severity of a given amino acid also correlates with its relative contribution to arrhythmias. At evolutionarily variable sites, the chemical severity of the changes is also correlated with the expected chemical severity of the involved codon. Unlike nsSNPs, AAMs preferentially locate to evolutionarily conserved, and functionally important, sites and regions within HERG and KCNQ1, and are chemically more severe than changes which occur in evolution. Expected chemical severity may contribute to the overrepresentation of certain residues in AAMs, as well as to evolutionary change.
Rod Foroozan - One of the best experts on this subject based on the ideXlab platform.
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perioperative posterior ischemic optic neuropathy review of the literature
American Journal of Ophthalmology, 2005Co-Authors: Lawrence M Buono, Rod ForoozanAbstract:Posteriorc ischemic optic neuropathy (PION) is an uncommon cause of perioperative visual loss which is usually devastating. This thorough review summarizes most cases published in the English literature. Perioperative PION has been most frequently reported after spinal surgery and radical neck dissection. The visual loss typically presents immediately after recovery from anesthesia, although it may be delayed by several days. Visual loss is often bilateral and profound with count fingers vision or worse. The examination findings are consistent with an optic neuropathy; however, the funduscopic examination is initially normal. The cause is unknown, although patient-Specific Susceptibility to perioperative hemodynamic derangements is likely. No treatment has proven to be effective. The prognosis for visual recovery is generally poor. — Valerie Biousse.
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perioperative posterior ischemic optic neuropathy review of the literature
Survey of Ophthalmology, 2005Co-Authors: Lawrence M Buono, Rod ForoozanAbstract:Posterior ischemic optic neuropathy (PION) is an uncommon cause of perioperative visual loss. Perioperative PION has been most frequently reported after spinal surgery and radical neck dissection. The visual loss typically presents immediately after recovery from anesthesia, although it may be delayed by several days. Visual loss is often bilateral and profound with count fingers vision or worse. The examination findings are consistent with an optic neuropathy; however the funduscopic examination is initially normal. The cause is unknown, although patient-Specific Susceptibility to perioperative hemodynamic derangements is likely. No treatment has proven to be effective. The prognosis for visual recovery is generally poor.
Heather A Jackson - One of the best experts on this subject based on the ideXlab platform.
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evolutionary analyses of kcnq1 and herg voltage gated potassium channel sequences reveal location Specific Susceptibility and augmented chemical severities of arrhythmogenic mutations
BMC Evolutionary Biology, 2008Co-Authors: Heather A Jackson, Eric A AcciliAbstract:Background Mutations in HERG and KCNQ1 potassium channels have been associated with Long QT syndrome and atrial fibrillation, and more recently with sudden infant death syndrome and sudden unexplained death. In other proteins, disease-associated amino acid mutations have been analyzed according to the chemical severity of the changes and the locations of the altered amino acids according to their conservation over metazoan evolution. Here, we present the first such analysis of arrhythmia-associated mutations (AAMs) in the HERG and KCNQ1 potassium channels.
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evolutionary analyses of kcnq1 and herg voltage gated potassium channel sequences reveal location Specific Susceptibility and augmented chemical severities of arrhythmogenic mutations
BMC Evolutionary Biology, 2008Co-Authors: Heather A Jackson, Eric A AcciliAbstract:Mutations in HERG and KCNQ1 potassium channels have been associated with Long QT syndrome and atrial fibrillation, and more recently with sudden infant death syndrome and sudden unexplained death. In other proteins, disease-associated amino acid mutations have been analyzed according to the chemical severity of the changes and the locations of the altered amino acids according to their conservation over metazoan evolution. Here, we present the first such analysis of arrhythmia-associated mutations (AAMs) in the HERG and KCNQ1 potassium channels. Using evolutionary analyses, AAMs in HERG and KCNQ1 were preferentially found at evolutionarily conserved sites and unevenly distributed among functionally conserved domains. Non-synonymous single nucleotide polymorphisms (nsSNPs) are under-represented at evolutionarily conserved sites in HERG, but distribute randomly in KCNQ1. AAMs are chemically more severe, according to Grantham's Scale, than changes observed in evolution and their severity correlates with the expected chemical severity of the involved codon. Expected chemical severity of a given amino acid also correlates with its relative contribution to arrhythmias. At evolutionarily variable sites, the chemical severity of the changes is also correlated with the expected chemical severity of the involved codon. Unlike nsSNPs, AAMs preferentially locate to evolutionarily conserved, and functionally important, sites and regions within HERG and KCNQ1, and are chemically more severe than changes which occur in evolution. Expected chemical severity may contribute to the overrepresentation of certain residues in AAMs, as well as to evolutionary change.
Lawrence M Buono - One of the best experts on this subject based on the ideXlab platform.
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perioperative posterior ischemic optic neuropathy review of the literature
American Journal of Ophthalmology, 2005Co-Authors: Lawrence M Buono, Rod ForoozanAbstract:Posteriorc ischemic optic neuropathy (PION) is an uncommon cause of perioperative visual loss which is usually devastating. This thorough review summarizes most cases published in the English literature. Perioperative PION has been most frequently reported after spinal surgery and radical neck dissection. The visual loss typically presents immediately after recovery from anesthesia, although it may be delayed by several days. Visual loss is often bilateral and profound with count fingers vision or worse. The examination findings are consistent with an optic neuropathy; however, the funduscopic examination is initially normal. The cause is unknown, although patient-Specific Susceptibility to perioperative hemodynamic derangements is likely. No treatment has proven to be effective. The prognosis for visual recovery is generally poor. — Valerie Biousse.
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perioperative posterior ischemic optic neuropathy review of the literature
Survey of Ophthalmology, 2005Co-Authors: Lawrence M Buono, Rod ForoozanAbstract:Posterior ischemic optic neuropathy (PION) is an uncommon cause of perioperative visual loss. Perioperative PION has been most frequently reported after spinal surgery and radical neck dissection. The visual loss typically presents immediately after recovery from anesthesia, although it may be delayed by several days. Visual loss is often bilateral and profound with count fingers vision or worse. The examination findings are consistent with an optic neuropathy; however the funduscopic examination is initially normal. The cause is unknown, although patient-Specific Susceptibility to perioperative hemodynamic derangements is likely. No treatment has proven to be effective. The prognosis for visual recovery is generally poor.
Niel Hens - One of the best experts on this subject based on the ideXlab platform.
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socrates an online tool leveraging a social contact data sharing initiative to assess mitigation strategies for covid 19
BMC Research Notes, 2020Co-Authors: Lander Willem, Thang Van Hoang, Sebastian Funk, Pietro Coletti, Philippe Beutels, Niel HensAbstract:Establishing a social contact data sharing initiative and an interactive tool to assess mitigation strategies for COVID-19. We organized data sharing of published social contact surveys via online repositories and formatting guidelines. We analyzed this social contact data in terms of weighted social contact matrices, next generation matrices, relative incidence and R$$_{0}$$. We incorporated location-Specific physical distancing measures (e.g. school closure or at work) and capture their effect on transmission dynamics. All methods have been implemented in an online application based on R Shiny and applied to COVID-19 with age-Specific Susceptibility and infectiousness. Using our online tool with the available social contact data, we illustrate that physical distancing could have a considerable impact on reducing transmission for COVID-19. The effect itself depends on assumptions made about disease-Specific characteristics and the choice of intervention(s).
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socrates an online tool leveraging a social contact data sharing initiative to assess mitigation strategies for covid 19
medRxiv, 2020Co-Authors: Lander Willem, Thang Van Hoang, Sebastian Funk, Pietro Coletti, Philippe Beutels, Niel HensAbstract:Objective: Establishing a social contact data sharing initiative and an interactive tool to assess mitigation strategies for COVID-19. Results: We organized data sharing of published social contact surveys via online repositories and formatting guidelines. We analyzed this social contact data in terms of weighted social contact matrices, next generation matrices, relative incidence and R0. We incorporated location-Specific isolation measures (e.g. school closure or telework) and capture their effect on transmission dynamics. All methods have been implemented in an online application based on R Shiny and applied to COVID-19 with age-Specific Susceptibility and infectiousness. Using our online tool with the available social contact data, we illustrate that social distancing could have a considerable impact on reducing transmission for COVID-19. The effect itself depends on assumptions made about disease-Specific characteristics and the choice of intervention(s). Keywords: social contact data, user interface, transmission dynamics, infectious diseases, epidemics, social distancing, behavioral changes, data sharing initiative, open-source, COVID-19
