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Harold G Koenige - One of the best experts on this subject based on the ideXlab platform.

  • cross cultural adaptation of the Spinal Cord Lesion related coping strategies questionnaire for use in iran
    Injury-international Journal of The Care of The Injured, 2015
    Co-Authors: Mohsen Saffari, Amir H Pakpour, Mohammad Yaghobidoot, Faten Al Zaben, Harold G Koenige
    Abstract:

    Abstract Introduction This study examined the validity and reliability of the Iranian version of the Spinal Cord Lesion-related coping strategies questionnaire (SCL CSQ-I) in persons with Spinal Cord injury (SCI). Methods Consecutive patients with SCI (n = 220) were recruited into the study. A standard forward-backward translation procedure was used to translate the SCL CSQ from English into Persian. Participants also completed the Short Form Health Survey (SF-12), Hospital Anxiety and Depression Scale (HADS), Spinal Cord Independence Measure (SCIM III), Community Integration Questionnaire (CIQ), and SCL CSQ-I. Psychometric properties examined were internal consistency, test–retest reliability, convergent validity, discriminant validity, and construct validity. Results Cronbach alphas for the SCL CSQ-I subscales ranged from 0.68 to 0.89, indicating acceptable internal reliability, and intraclass correlation coefficients ranged from 0.74 to 0.89, indicating good test–retest reliability. The SCL CSQ-I subscales significantly correlated with scores on the SF-12, HADS, SCIM III and CIQ, indicating solid convergent validity. Each item of the SCL CSQ-I within a hypothesized dimension correlated strongly with the total score for that dimension. Exploratory and confirmatory factor analyses identified a three-factor model. The SCL CSQ-I subscales correlated significantly with clinical and socio-demographic characteristics. Conclusion The Iranian version of the SCL CSQ is a reliable and valid tool for measuring coping strategies in persons with SCI.

F Bieringsorensen - One of the best experts on this subject based on the ideXlab platform.

  • medication before and after a Spinal Cord Lesion
    Spinal Cord, 2014
    Co-Authors: E K Jensen, F Bieringsorensen
    Abstract:

    To map the impact of Spinal Cord Lesion (SCL) on medication. Registration of medication for 72 patients before SCL and at discharge from the Department for Spinal Cord Injuries. Department for Spinal Cord Injuries, East Denmark. The changes in medication for each Anatomical Therapeutic Chemical (ATC) Classification System group were registered for all patients, who were discharged from Department for Spinal Cord Injuries during 2010. The changes in medication per se were calculated for different parts of the population: non-traumatic, traumatic patients, men, women, paraplegia, tetraplegia, American Spinal Injury Association Impairment Scale (AIS) A, B or C, AIS D, age 0–45, 46–60 and 60+. In addition, comparisons of changes in medication were made between complementary parts of the population. The overall increase in medication after SCL was 3.29 times (P<0.001). Statistically significant increases were seen for most medicine categories. When studying subgroups of the population, the increase was most constantly seen for the medicine in the groups ‘Alimentary tract and metabolism’ and ‘Nervous system’. The highest overall increases were seen in patients with AIS A, B and C compared with AIS D (P<0.05). There was no difference between traumatic and non-traumatic SCL, men and women, and younger compared with older patients. SCL elicits a general massive need for medicine. The relative increase is most pronounced for the more severely injured (AIS A, B and C). The increase in medication may have implications for side effects and for the economy of all involved.

  • reduction of common synaptic drive to ankle dorsiflexor motoneurons during walking in patients with Spinal Cord Lesion
    Journal of Neurophysiology, 2005
    Co-Authors: Naja Liv Hansen, F Bieringsorensen, B A Conway, David M Halliday, Simon Hansen, Henrik S Pyndt, Jens Nielsen
    Abstract:

    It is possible to obtain information about the synaptic drive to motoneurons during walking by analyzing motor-unit coupling in the time and frequency domains. The purpose of the present study was to compare motor-unit coupling during walking in healthy subjects and patients with incomplete Spinal Cord Lesion to obtain evidence of differences in the motoneuronal drive that result from the Lesion. Such information is of importance for development of new strategies for gait restoration. Twenty patients with incomplete Spinal Cord Lesion (SCL) participated in the study. Control experiments were performed in 11 healthy subjects. In all healthy subjects, short-term synchronization was evident in the discharge of tibialis anterior (TA) motor units during the swing phase of treadmill walking. This was identified from the presence of a narrow central peak in cumulant densities constructed from paired EMG reCordings and from the presence of significant coherence between these signals in the 10- to 20-Hz band. Such indicators of short-term synchrony were either absent or very small in the patient group. The relationship between the amount of short-term synchrony and the magnitude of the 10- to 20-Hz coherence in the patients is discussed in relation to gait ability. It is suggested that supraSpinal drive to the Spinal Cord is responsible for short-term synchrony and coherence in the 10- to 20-Hz frequency band during walking in healthy subjects. Absence or reduction of these features may serve as physiological markers of impaired supraSpinal control of gait in SCL patients. Such markers could have diagnostic and prognostic value in relation to the recovery of locomotion in patients with central motor Lesions.

  • antispastic effect of penile vibration in men with Spinal Cord Lesion
    Archives of Physical Medicine and Rehabilitation, 2004
    Co-Authors: Line Laessoe, Jens Nielsen, F Bieringsorensen, Jens Sonksen
    Abstract:

    Abstract Laessoe L, Nielsen JB, Biering-Sorensen F, Sonksen J. Antispastic effect of penile vibration in men with Spinal Cord Lesion. Arch Phys Med Rehabil 2004;85:919–24. Objective To evaluate the possible antispastic effect of penile vibratory stimulation (PVS) in men with Spinal Cord Lesion (SCL). Design Unblinded, before-after trial. Setting Ambulatory care. Participants Nine men with SCLs from C2 to T8 were randomly allocated into 2 groups. Intervention Twenty-four hours of electromyographic reCordings from the quadriceps and tibialis anterior muscles were taken, followed by PVS or no treatment and another 24 hours of electromyographic reCordings. The presence of electromyographic activity of an amplitude 4 times the baseline, with a duration of more than 5 seconds, was taken to signify a spasm. The number of spasms per hour was calculated before and after PVS and no treatment. Spasticity was evaluated by the Modified Ashworth Scale (MAS). Main outcome measure Reduction in spasticity and spasms. Results The electromyographic data showed a significant reduction in the frequency of leg spasms up to 3 hours ( P P Conclusions PVS may be useful as an antispastic therapy.

  • urinary tract infection in individuals with Spinal Cord Lesion
    Current Opinion in Urology, 2002
    Co-Authors: F Bieringsorensen
    Abstract:

    Urinary tract infection is the most frequently reported secondary impairment in individuals with Spinal Cord Lesion. The most prevalent risk indicator is an indwelling catheter. Hydrophilic catheters for clean intermittent catheterization may induce lower rates of bacteriuria and long-term urethral complications. Due to chronic bacterial infection within biofilms, an antibacterial treatment based on a urinary culture of bacteria in the urine and its antimicrobial susceptibility may fail to eradicate catheter-associated urinary tract infection. No commercially available drugs are sufficiently active against the bacteria in a mature biofilm. Biomaterials may be modified to decrease the formation of a biofilm. Silver alloy catheters are effective in preventing urinary tract infection when indwelling urinary catheterization is necessary. The risk of systemic argyria in long-term use needs to be evaluated. Suprapubic cystostomy drainage in patients with neurogenic bladder is preferred to an indwelling urethral catheter. In cases of recurring urinary tract infection in patients with a permanent urinary catheter, it may be beneficial to change the catheter every 1 or 2 weeks. There is some evidence that cranberry products may prevent urinary tract infection. In the future, bacterial interference and vaccination may be a possibility for prevention of urinary tract infection.

John H Peacock - One of the best experts on this subject based on the ideXlab platform.

  • Spinal Cord infarction during use of zolmitriptan a case report
    Headache, 2000
    Co-Authors: N Vijayan, John H Peacock
    Abstract:

    A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a Spinal Cord Lesion following the use of zolmitriptan. The partial Lesion of the Cord at T7 predominantly involved the spinothalamic pathways on the left side. Clinical features suggested that the Lesion was an ischemic infarct, and this was confirmed by an MRI scan. There were no other known risk factors for vascular disease. There has been mild improvement of her symptoms, but most of the symptoms did not resolve. There are isolated case reports of stroke secondary to the use of triptans, however, this is the first case of Spinal Cord infarction reported following the use of this group of drugs. The temporal relationship suggests that the Spinal Cord infarction may be related to the use of zolmitriptan.

Ricardo Fadic - One of the best experts on this subject based on the ideXlab platform.

Allan I Basbaum - One of the best experts on this subject based on the ideXlab platform.

  • regeneration of sensory axons within the injured Spinal Cord induced by intraganglionic camp elevation
    Neuron, 2002
    Co-Authors: Simona Neumann, Frank Bradke, Marc Tessierlavigne, Allan I Basbaum
    Abstract:

    The peripheral branch of primary sensory neurons regenerates after injury, but there is no regeneration when their central branch is severed by Spinal Cord injury. Here we show that microinjection of a membrane-permeable analog of cAMP in lumbar dorsal root ganglia markedly increases the regeneration of injured central sensory branches. The injured axons regrow into the Spinal Cord Lesion, often traversing the injury site. This result mimics the effect of a conditioning peripheral nerve Lesion. We also demonstrate that sensory neurons exposed to cAMP in vivo, when subsequently cultured in vitro, show enhanced growth of neurites and an ability to overcome inhibition by CNS myelin. Thus, stimulating cAMP signaling increases the intrinsic growth capacity of injured sensory axons. This approach may be useful in promoting regeneration after Spinal Cord injury.