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Alberto G Ayala - One of the best experts on this subject based on the ideXlab platform.
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renal collision tumor composed of oncocytoma and mucinous tubular and Spindle Cell Carcinoma case report of an unprecedented entity
Human Pathology, 2018Co-Authors: Komal Arora, Steven S Shen, Ross A Miller, Seema Mullick, Alberto G AyalaAbstract:Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial Cells. Mucinous tubular and Spindle Cell Carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization renal Cell Carcinoma (RCC) classification as a distinct entity. Current studies suggest that the tumor originates from the proximal nephron, although it is still controversial. The presence of concurrent oncocytoma with conventional (clear Cell) RCC, chromophobe RCC, and papillary RCC has been previously described. However, the association of oncocytoma with MTSCC has not yet been reported to our knowledge. Herein, we report the first case of a renal collision tumor composed of oncocytoma and MTSCC.
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renal collision tumor composed of oncocytoma and mucinous tubular and Spindle Cell Carcinoma case report of an unprecedented entity
Human Pathology, 2018Co-Authors: Komal Arora, Steven S Shen, Ross A Miller, Seema Mullick, Alberto G AyalaAbstract:Primary renal collision tumors composed of two histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial Cells. Mucinous tubular and Spindle Cell Carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization RCC classification as a distinct entity. Current studies suggest the tumor originates from the proximal nephron, although it is still controversial. The presence of concurrent oncocytoma with conventional (clear Cell) RCC, chromophobe RCC and papillary RCC has been previously described. However, the association of oncocytoma with MTSCC has not yet been reported to our knowledge. Herein, we report the first case of a renal collision tumor composed of oncocytoma and MTSCC.
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mucinous tubular and Spindle Cell Carcinoma of kidney is probably a variant of papillary renal Cell Carcinoma with Spindle Cell features
Annals of Diagnostic Pathology, 2007Co-Authors: Steven S Shen, Pheroze Tamboli, Luan D Truong, Qihui Zhai, Soo Jin Jung, Rita Tibbs, Nelson G Ordonez, Alberto G AyalaAbstract:Abstract Mucinous tubular and Spindle Cell Carcinoma is a rare and newly described type of renal Cell Carcinoma (RCC) with a relatively indolent behavior. However, its histogenetic origin or line of differentiation remains unclear. Twelve cases of mucinous tubular and Spindle Cell Carcinoma were identified and retrieved from the files of 3 institutions. Detailed morphological features, as well as their immunohistochemical profile established with markers of proximal renal tubules (RCC marker antigen, CD15, and α -methylacyl-CoA racemase) and of distal renal tubules (kidney-specific cadherin and cytokeratin 7), were studied. The age range of the patients was 35 to 73 years with a median of 56 years. The male to female ratio was 1:3. All of the patients were alive with follow-up between 4 and 38 months. All the tumors were confined to the kidney with a mean tumor size of 6.9 cm (range, 1.8-17 cm). The tumors were composed of variable proportions of tubular and Spindle Cell areas with focal to prominent mucinous or myxoid stroma. Foamy macrophages were seen in 10 cases and were prominent in 4 cases. A focal compressed tubulopapillary growth pattern was seen in 10 cases. The tumor Cells were uniformly cuboidal with ovoid to round nuclei and inconspicuous nucleoli (Furhman nuclear grade 3 in 6 cases). Focal necrosis was seen in 3 cases. Immunostains showed that tumors were positive for RCC marker antigen (11/12), α -methylacyl-CoA racemase (11/12), CD15 (8/12), CD10 (2/12), kidney-specific cadherin (1/12), and cytokeratin 7 (11/12). Its morphological features as well as a strong preferential expression of proximal tubule markers suggest that this tumor is a type of RCC with proximal tubular differentiation, which appears closely related to or represents a morphological variant of papillary RCC.
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mucinous tubular and Spindle Cell Carcinoma of the kidney with neuroendocrine differentiation report of two cases
American Journal of Clinical Pathology, 2006Co-Authors: Soo Jin Jung, Hye Kyoung Yoon, Jae Il Chung, Alberto G AyalaAbstract:We encountered 2 cases of mucinous tubular and Spindle Cell Carcinoma (MTSCC) during a short time. In a 61-year-old man who had macroscopic hematuria for 1 month, the 14.5 x 14.0 x 12.0-cm resected tumor involved the right middle aspect of the renal parenchyma and compressed the renal pelvis. In an asymptomatic 47-year-old man, a renal tumor was found during an annual physical examination. The 3.5 x 3.0 x 2.0-cm tumor was located at the upper pole of the right kidney. The histologic findings in both cases were similar Tumors consisted of tightly packed, small, elongated tubules separated by pale mucinous stroma. The tumor Cells were cuboidal to Spindled with eosinophilic cytoplasm and low nuclear grade. Mitoses were few or nonexistent and without abnormal figures. Both tumors were immunoreactive for cytokeratin (CK) cocktail (AE1/AE3), high-molecular-weight CK (34betaE12), low-molecular-weight CK (35betaH11), CK7, epithelial membrane antigen, E-cadherin, and vimentin. The tumor Cells also were reactive for neuron-specific enolase, chromogranin, and synaptophysin. The ultrastructure of the tumor Cells contained abundant mitochondria, junctional complex, and dense-core neurosecretory granules. We present 2 additional cases of MTSCC showing typical morphologic features with neuroendocrine differentiation.
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low grade fibromatosis like Spindle Cell Carcinoma of the breast
The American Journal of Surgical Pathology, 2001Co-Authors: Nour Sneige, Nelson G Ordonez, Hadi Yaziji, Srinivas R Mandavilli, Edward R Perez, Allen M Gown, Alberto G AyalaAbstract:Abstract Spindle Cell Carcinoma of the breast, a variant of metaplastic Carcinoma, includes a wide spectrum of lesions with histomorphologic and nuclear features ranging from overtly malignant to mildly atypical. Spindle Cell Carcinomas with mildly atypical features may resemble fasciitis, fibromatosis, or myofibroblastic tumors and therefore are often misinterpreted as such. A recent study has suggested that Spindle Cell Carcinomas with a dominant fibromatosis-like phenotype, unlike Spindle Cell Carcinomas in general, have no propensity for distant metastasis and should be termed "tumors" rather than "Carcinomas." To investigate the question of fibromatosis-like Spindle Cell breast Carcinoma (FLSpCCs) metastatic potential, we studied cases of FLSpCC seen at the University of Texas M.D. Anderson Cancer Center between 1987 and 2000. Clinical, pathologic, and immunophenotypic features were reviewed, with emphasis on biologic behavior and predictors of clinical outcome. Our series included 24 women who ranged in age from 55 to 85 years (mean 66 years). Tumor size ranged from 1.0 to 5 cm (mean 2.8 cm). Most tumors were grossly well defined but had microscopic infiltrative borders. Tumors showed a dominant fibromatosis-like or myofibroblastic-like growth pattern with prominent collagenization. Inflammatory infiltrate was noted in the majority of tumors. Cytokeratin-positive Cells were seen in all cases and usually appeared as cords or sheets of polygonal Cells; isolated cytokeratin-positive Cells were rare. In most tumors immunoreactivity for smooth muscle actin (SMA) was confined to the cytokeratin-negative Cells. In five cases intense co-expression of cytokeratin and SMA was noted. None of the tumors showed immunoreactivity for smooth muscle heavy chain myosin, estrogen receptors, progesterone receptors, or HER-2/neu. Ki-67 expression was noted in fewer than 5% of tumor Cells. Treatment consisted of local excision (seven cases) or modified radical mastectomy (13 cases). Treatment was unknown in four cases. In patients who underwent axillary nodal dissection, no lymph node metastases were found. Two of the six patients who underwent local excision developed local recurrence. Two patients who underwent modified radical mastectomy developed lung metastases within 2 years after the initial diagnosis. The metastatic tumors were histologically similar to the primary tumors. Our findings indicate that FLSpCCs have the potential for local recurrence and distant metastasis and should be treated accordingly. Because FLSpCCs may be underdiagnosed as benign, the use of immunohistochemical studies, especially for cytokeratins and SMA, is essential in the evaluation of any Spindle Cell proliferations of the breast.
Steven S Shen - One of the best experts on this subject based on the ideXlab platform.
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renal collision tumor composed of oncocytoma and mucinous tubular and Spindle Cell Carcinoma case report of an unprecedented entity
Human Pathology, 2018Co-Authors: Komal Arora, Steven S Shen, Ross A Miller, Seema Mullick, Alberto G AyalaAbstract:Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial Cells. Mucinous tubular and Spindle Cell Carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization renal Cell Carcinoma (RCC) classification as a distinct entity. Current studies suggest that the tumor originates from the proximal nephron, although it is still controversial. The presence of concurrent oncocytoma with conventional (clear Cell) RCC, chromophobe RCC, and papillary RCC has been previously described. However, the association of oncocytoma with MTSCC has not yet been reported to our knowledge. Herein, we report the first case of a renal collision tumor composed of oncocytoma and MTSCC.
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renal collision tumor composed of oncocytoma and mucinous tubular and Spindle Cell Carcinoma case report of an unprecedented entity
Human Pathology, 2018Co-Authors: Komal Arora, Steven S Shen, Ross A Miller, Seema Mullick, Alberto G AyalaAbstract:Primary renal collision tumors composed of two histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial Cells. Mucinous tubular and Spindle Cell Carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization RCC classification as a distinct entity. Current studies suggest the tumor originates from the proximal nephron, although it is still controversial. The presence of concurrent oncocytoma with conventional (clear Cell) RCC, chromophobe RCC and papillary RCC has been previously described. However, the association of oncocytoma with MTSCC has not yet been reported to our knowledge. Herein, we report the first case of a renal collision tumor composed of oncocytoma and MTSCC.
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mucinous tubular and Spindle Cell Carcinoma of kidney is probably a variant of papillary renal Cell Carcinoma with Spindle Cell features
Annals of Diagnostic Pathology, 2007Co-Authors: Steven S Shen, Pheroze Tamboli, Luan D Truong, Qihui Zhai, Soo Jin Jung, Rita Tibbs, Nelson G Ordonez, Alberto G AyalaAbstract:Abstract Mucinous tubular and Spindle Cell Carcinoma is a rare and newly described type of renal Cell Carcinoma (RCC) with a relatively indolent behavior. However, its histogenetic origin or line of differentiation remains unclear. Twelve cases of mucinous tubular and Spindle Cell Carcinoma were identified and retrieved from the files of 3 institutions. Detailed morphological features, as well as their immunohistochemical profile established with markers of proximal renal tubules (RCC marker antigen, CD15, and α -methylacyl-CoA racemase) and of distal renal tubules (kidney-specific cadherin and cytokeratin 7), were studied. The age range of the patients was 35 to 73 years with a median of 56 years. The male to female ratio was 1:3. All of the patients were alive with follow-up between 4 and 38 months. All the tumors were confined to the kidney with a mean tumor size of 6.9 cm (range, 1.8-17 cm). The tumors were composed of variable proportions of tubular and Spindle Cell areas with focal to prominent mucinous or myxoid stroma. Foamy macrophages were seen in 10 cases and were prominent in 4 cases. A focal compressed tubulopapillary growth pattern was seen in 10 cases. The tumor Cells were uniformly cuboidal with ovoid to round nuclei and inconspicuous nucleoli (Furhman nuclear grade 3 in 6 cases). Focal necrosis was seen in 3 cases. Immunostains showed that tumors were positive for RCC marker antigen (11/12), α -methylacyl-CoA racemase (11/12), CD15 (8/12), CD10 (2/12), kidney-specific cadherin (1/12), and cytokeratin 7 (11/12). Its morphological features as well as a strong preferential expression of proximal tubule markers suggest that this tumor is a type of RCC with proximal tubular differentiation, which appears closely related to or represents a morphological variant of papillary RCC.
Komal Arora - One of the best experts on this subject based on the ideXlab platform.
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renal collision tumor composed of oncocytoma and mucinous tubular and Spindle Cell Carcinoma case report of an unprecedented entity
Human Pathology, 2018Co-Authors: Komal Arora, Steven S Shen, Ross A Miller, Seema Mullick, Alberto G AyalaAbstract:Primary renal collision tumors composed of two histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial Cells. Mucinous tubular and Spindle Cell Carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization RCC classification as a distinct entity. Current studies suggest the tumor originates from the proximal nephron, although it is still controversial. The presence of concurrent oncocytoma with conventional (clear Cell) RCC, chromophobe RCC and papillary RCC has been previously described. However, the association of oncocytoma with MTSCC has not yet been reported to our knowledge. Herein, we report the first case of a renal collision tumor composed of oncocytoma and MTSCC.
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renal collision tumor composed of oncocytoma and mucinous tubular and Spindle Cell Carcinoma case report of an unprecedented entity
Human Pathology, 2018Co-Authors: Komal Arora, Steven S Shen, Ross A Miller, Seema Mullick, Alberto G AyalaAbstract:Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial Cells. Mucinous tubular and Spindle Cell Carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization renal Cell Carcinoma (RCC) classification as a distinct entity. Current studies suggest that the tumor originates from the proximal nephron, although it is still controversial. The presence of concurrent oncocytoma with conventional (clear Cell) RCC, chromophobe RCC, and papillary RCC has been previously described. However, the association of oncocytoma with MTSCC has not yet been reported to our knowledge. Herein, we report the first case of a renal collision tumor composed of oncocytoma and MTSCC.
John R Srigley - One of the best experts on this subject based on the ideXlab platform.
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mucinous tubular and Spindle Cell Carcinoma of kidney without sarcomatoid change showing metastases to liver and retroperitoneal lymph node
Human Pathology, 2011Co-Authors: Nafisa A Ursani, John R Srigley, Rocke A Robertson, Steven M Schieman, Terry C BainbridgeAbstract:Mucinous tubular and Spindle Cell Carcinoma (MTSCC) is an uncommon, newly recognized tumor that in its classic histological form shows tightly packed, elongated tubules with transition into Spindle Cell areas and pale mucinous stroma. The current data suggest that the great majority of MTSCCs have a favorable prognosis; however, the follow-up data are limited and the full biologic potential of this tumor remains to be established. There are a few examples of MTSCCs metastatic to lymph nodes and rare cases with sarcomatoid differentiation associated with distant metastases. We report on a case of MTSCC of kidney with concurrent nodal and liver metastases. The metastatic nodules were well circumscribed and showed morphological and immunophenotypic features similar to those of the primary tumor. Extensive sampling revealed no evidence of sarcomatoid morphology. To our knowledge, this is the first case of MTSCC without sarcomatoid differentiation showing parenchymal metastasis.
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immunohistochemical analysis of mucinous tubular and Spindle Cell Carcinoma and papillary renal Cell Carcinoma of the kidney significant immunophenotypic overlap warrants diagnostic caution
The American Journal of Surgical Pathology, 2006Co-Authors: Gladell P Paner, John R Srigley, Anuradha Radhakrishnan, Cynthia Cohen, Brian Skinnider, Satish K Tickoo, Andrew N Young, Mahul B AminAbstract:Abstract:Mucinous tubular and Spindle Cell Carcinoma, a rare, recently described distinctive subtype of renal Cell Carcinoma, may have some morphologic similarities to the more common papillary renal Cell Carcinoma, particularly the basophilic (type 1) tumors with prominent solid growth pattern. Tum
Yiran Huang - One of the best experts on this subject based on the ideXlab platform.
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renal mucinous tubular and Spindle Cell Carcinoma a report of 8 cases and review of the literature
Diagnostic Pathology, 2013Co-Authors: Yonghui Chen, Jianjun Sha, Ling Zhao, Jiwei Huang, Dongming Liu, Yiran HuangAbstract:Background Mucinous tubular and Spindle Cell Carcinoma of kidney (MTSCC-K) is a rare variant of renal tumor. The current data show most of MTSCCs are of low malignant potential and rare cases metastatic to lymph nodes have been reported; however, the recorded computed tomography (CT) and follow up data are limited.
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renal mucinous tubular and Spindle Cell Carcinoma a report of 8 cases and review of the literature
Diagnostic Pathology, 2013Co-Authors: Yonghui Chen, Jianjun Sha, Ling Zhao, Jiwei Huang, Dongming Liu, Yiran HuangAbstract:Mucinous tubular and Spindle Cell Carcinoma of kidney (MTSCC-K) is a rare variant of renal tumor. The current data show most of MTSCCs are of low malignant potential and rare cases metastatic to lymph nodes have been reported; however, the recorded computed tomography (CT) and follow up data are limited. In the present study, we retrospectively analyzed CT and clinicopathological data of eight patients with renal MTSCC-K. A total of eight cases, including six females and two males, were included in this analysis with a mean age of 48.4 (range 25 to 81) years. Mean tumor size was 4.2 (range 2.5 to 10.0) cm. Preoperative CT demonstrated that all tumors were slightly enhanced on both corticomedullary and nephrographic phase, which was different from many other renal Cell Carcinomas. Three of them were treated with open radical nephrectomy, three with laparoscopic radical nephrectomy and the other two with laparoscopic partial nephrectomy. No postoperative therapy was applied. Patients were followed up for 15 to 64 months and there was no evidence of recurrence and metastasis. The MTSCC-K has special clinicopathological characteristics, low degree of malignancy and relative good prognosis. The diagnosis mainly depends on the histopathological examination and CT may help to differentiate with papillary renal Cell Carcinoma. Surgical treatment is recommended and additional therapies are not necessary. The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8435581771088249 .