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Andreas H. Mahnken - One of the best experts on this subject based on the ideXlab platform.

  • Variability of aortic valve calcification measurement with multislice Spiral Computed Tomography.
    Investigative radiology, 2006
    Co-Authors: K. M. Ruhl, Marco Das, Ralf Koos, Georg Mühlenbruch, Thomas Flohr, Joachim E. Wildberger, Rolf W. Günther, Andreas H. Mahnken
    Abstract:

    Objectives: We sought to assess the variability of aortic valve calcifications (AVCs) regarding the reconstruction window at different heart phases using multislice-Spiral Computed Tomography. Materials and Methods: A total of 46 patients (26 men; mean age. 65 years) underwent AVC scoring with multislice-Spiral Computed Tomography (12 × 0.75 mm, 120 kV, 133 mAs eff ). Image reconstruction was performed every 10% of the RR-interval (0-90%). AVC was quantified using Agatston score, calcium volume, and calcium mass. Images were assessed for least motion artifacts. Coefficients of variation and Wilcoxon test were calculated. Results: AVC scores are lowest at 60% and highest at 0% of the RR-interval (P < 0.001). Mean coefficients of variation were 36.2% (Agatston score), 38.7% (calcium volume), and 32.9% (calcium mass). At 60% (50-70%). minimal motion artifacts and the lowest variability of the scores were found. Conclusions: AVC scores show large variability depending on the point of image reconstruction. Diastolic image reconstruction at 60% of the RR-interval is recommended.

  • Quantification of aortic valve calcification using multislice Spiral Computed Tomography: comparison with atomic absorption spectroscopy.
    Investigative radiology, 2006
    Co-Authors: Ralf Koos, Georg Mühlenbruch, Andreas H. Mahnken, Harald P. Kühl, Vera Mevissen, Ludwig Stork, Richard Dronskowski, G. Langebartels, Riidiger Autschbach, Jan R. Ortlepp
    Abstract:

    Objectives:Multislice Spiral Computed Tomography (MSCT) allows the in vivo detection of valvular calcification. The aim of this study was to validate the quantification of aortic valve calcification (AVC) by MSCT with in vitro measurements by atomic absorption spectroscopy.Methods:In 18 patients wit

  • Preliminary experience in the assessment of aortic valve calcification by ECG-gated multislice Spiral Computed Tomography.
    International journal of cardiology, 2005
    Co-Authors: Ralf Koos, Joachim E. Wildberger, Andreas H. Mahnken, Anil M. Sinha, Rainer Hoffmann, Harald P. Kühl
    Abstract:

    Abstract Background The aim was to correlate the degree of valvular calcification in patients with aortic stenosis determined by retrospectively electrocardiogram (ECG)-gated multislice Spiral Computed Tomography with stenosis severity assessed by cardiac catheterization. Methods Prospective study on 41 patients (18 men, mean age 71±8 years) with aortic stenosis, who underwent four detector row multislice Spiral Computed Tomography and cardiac catheterization. Severity of aortic stenosis was classified by cardiac catheterization. Aortic valve area, peak to peak and mean transvalvular gradients were correlated with the degree of calcification determined by multislice Spiral Computed Tomography. Aortic valve calcification was assessed using aortic Agatston score, aortic mass score and aortic volume score. Results All measured aortic valve calcification scores were significantly higher in patients with severe aortic stenosis ( n =29) than in patients with moderate ( n =7) or mild aortic stenosis ( n =5, p r =−0.49, p =0.001 for aortic mass score) and with peak to peak ( r =0.68, p r =0.60, p Conclusions Severity of aortic valve calcification assessed by cardiac multislice Spiral Computed Tomography is inversely related to aortic valve area and positively correlated with transvalvular gradients. Based on this preliminary data larger studies should be performed with echocardiography as a reference standard in order to validate this new information and its utility in the clinical management of the patient.

  • Multislice Spiral Computed Tomography of the Heart: Technique, Current Applications, and Perspective
    CardioVascular and Interventional Radiology, 2005
    Co-Authors: Andreas H. Mahnken, Ralf Koos, Joachim E. Wildberger, Rolf W. Günther
    Abstract:

    Multislice Spiral Computed Tomography (MSCT) is a rapidly evolving, noninvasive technique for cardiac imaging. Knowledge of the principle of electrocardiogram–gated MSCT and its limitations in clinical routine are needed to optimize image quality. Therefore, the basic technical principle including essentials of image postprocessing is described. Cardiac MSCT imaging was initially focused on coronary calcium scoring, MSCT coronary angiography, and analysis of left ventricular function. Recent studies also evaluated the ability of cardiac MSCT to visualize myocardial infarction and assess valvular morphology. In combination with experimental approaches toward the assessment of aortic valve function and myocardial viability, cardiac MSCT holds the potential for a comprehensive examination of the heart using one single examination technique.

  • Determination of Cardiac Output With Multislice Spiral Computed Tomography: A Validation Study
    Investigative radiology, 2004
    Co-Authors: Andreas H. Mahnken, Joachim E. Wildberger, Dietrich Henzler, F. Ernst Klotz, A. Hennemuth, Rolf W. Günther
    Abstract:

    Objective:To validate and to determine the reproducibility of cardiac output (CO) measurements based on a test-bolus examination in multislice Spiral Computed Tomography (MSCT) in comparison with invasively measured CO using the thermal dilution technique.Material and Methods:In 8 swine, CO was dete

Ralf Koos - One of the best experts on this subject based on the ideXlab platform.

  • Variability of aortic valve calcification measurement with multislice Spiral Computed Tomography.
    Investigative radiology, 2006
    Co-Authors: K. M. Ruhl, Marco Das, Ralf Koos, Georg Mühlenbruch, Thomas Flohr, Joachim E. Wildberger, Rolf W. Günther, Andreas H. Mahnken
    Abstract:

    Objectives: We sought to assess the variability of aortic valve calcifications (AVCs) regarding the reconstruction window at different heart phases using multislice-Spiral Computed Tomography. Materials and Methods: A total of 46 patients (26 men; mean age. 65 years) underwent AVC scoring with multislice-Spiral Computed Tomography (12 × 0.75 mm, 120 kV, 133 mAs eff ). Image reconstruction was performed every 10% of the RR-interval (0-90%). AVC was quantified using Agatston score, calcium volume, and calcium mass. Images were assessed for least motion artifacts. Coefficients of variation and Wilcoxon test were calculated. Results: AVC scores are lowest at 60% and highest at 0% of the RR-interval (P < 0.001). Mean coefficients of variation were 36.2% (Agatston score), 38.7% (calcium volume), and 32.9% (calcium mass). At 60% (50-70%). minimal motion artifacts and the lowest variability of the scores were found. Conclusions: AVC scores show large variability depending on the point of image reconstruction. Diastolic image reconstruction at 60% of the RR-interval is recommended.

  • Quantification of aortic valve calcification using multislice Spiral Computed Tomography: comparison with atomic absorption spectroscopy.
    Investigative radiology, 2006
    Co-Authors: Ralf Koos, Georg Mühlenbruch, Andreas H. Mahnken, Harald P. Kühl, Vera Mevissen, Ludwig Stork, Richard Dronskowski, G. Langebartels, Riidiger Autschbach, Jan R. Ortlepp
    Abstract:

    Objectives:Multislice Spiral Computed Tomography (MSCT) allows the in vivo detection of valvular calcification. The aim of this study was to validate the quantification of aortic valve calcification (AVC) by MSCT with in vitro measurements by atomic absorption spectroscopy.Methods:In 18 patients wit

  • Preliminary experience in the assessment of aortic valve calcification by ECG-gated multislice Spiral Computed Tomography.
    International journal of cardiology, 2005
    Co-Authors: Ralf Koos, Joachim E. Wildberger, Andreas H. Mahnken, Anil M. Sinha, Rainer Hoffmann, Harald P. Kühl
    Abstract:

    Abstract Background The aim was to correlate the degree of valvular calcification in patients with aortic stenosis determined by retrospectively electrocardiogram (ECG)-gated multislice Spiral Computed Tomography with stenosis severity assessed by cardiac catheterization. Methods Prospective study on 41 patients (18 men, mean age 71±8 years) with aortic stenosis, who underwent four detector row multislice Spiral Computed Tomography and cardiac catheterization. Severity of aortic stenosis was classified by cardiac catheterization. Aortic valve area, peak to peak and mean transvalvular gradients were correlated with the degree of calcification determined by multislice Spiral Computed Tomography. Aortic valve calcification was assessed using aortic Agatston score, aortic mass score and aortic volume score. Results All measured aortic valve calcification scores were significantly higher in patients with severe aortic stenosis ( n =29) than in patients with moderate ( n =7) or mild aortic stenosis ( n =5, p r =−0.49, p =0.001 for aortic mass score) and with peak to peak ( r =0.68, p r =0.60, p Conclusions Severity of aortic valve calcification assessed by cardiac multislice Spiral Computed Tomography is inversely related to aortic valve area and positively correlated with transvalvular gradients. Based on this preliminary data larger studies should be performed with echocardiography as a reference standard in order to validate this new information and its utility in the clinical management of the patient.

  • Multislice Spiral Computed Tomography of the Heart: Technique, Current Applications, and Perspective
    CardioVascular and Interventional Radiology, 2005
    Co-Authors: Andreas H. Mahnken, Ralf Koos, Joachim E. Wildberger, Rolf W. Günther
    Abstract:

    Multislice Spiral Computed Tomography (MSCT) is a rapidly evolving, noninvasive technique for cardiac imaging. Knowledge of the principle of electrocardiogram–gated MSCT and its limitations in clinical routine are needed to optimize image quality. Therefore, the basic technical principle including essentials of image postprocessing is described. Cardiac MSCT imaging was initially focused on coronary calcium scoring, MSCT coronary angiography, and analysis of left ventricular function. Recent studies also evaluated the ability of cardiac MSCT to visualize myocardial infarction and assess valvular morphology. In combination with experimental approaches toward the assessment of aortic valve function and myocardial viability, cardiac MSCT holds the potential for a comprehensive examination of the heart using one single examination technique.

  • ECG-gated multislice Spiral Computed Tomography to clarify lesion severity in a case of left main stenosis. Multislice Spiral Computed Tomography to clarify lesion severity.
    The international journal of cardiovascular imaging, 2003
    Co-Authors: Ralf Koos, Joachim E. Wildberger, Andreas H. Mahnken, Anil-martin Sinha, Rainer Hoffmann
    Abstract:

    This case report describes the use of retrospectively ECG-gated multislice Spiral Computed Tomography (MSCT) for evaluation of lesion severity in a patient with relevant left main stenosis by visual analysis of the coronary angiogram. For further diagnostic evaluation the patient underwent intravascular ultrasound (IVUS) imaging, which showed a maximal 30% area stenosis, and MSCT, which demonstrated a maximal 48% area stenosis. MSCT was useful in this case to defer cardiac surgery and might be used as a noninvasive alternative to IVUS imaging in case of doubtful lesion severity.

Harald P. Kühl - One of the best experts on this subject based on the ideXlab platform.

  • Quantification of aortic valve calcification using multislice Spiral Computed Tomography: comparison with atomic absorption spectroscopy.
    Investigative radiology, 2006
    Co-Authors: Ralf Koos, Georg Mühlenbruch, Andreas H. Mahnken, Harald P. Kühl, Vera Mevissen, Ludwig Stork, Richard Dronskowski, G. Langebartels, Riidiger Autschbach, Jan R. Ortlepp
    Abstract:

    Objectives:Multislice Spiral Computed Tomography (MSCT) allows the in vivo detection of valvular calcification. The aim of this study was to validate the quantification of aortic valve calcification (AVC) by MSCT with in vitro measurements by atomic absorption spectroscopy.Methods:In 18 patients wit

  • Preliminary experience in the assessment of aortic valve calcification by ECG-gated multislice Spiral Computed Tomography.
    International journal of cardiology, 2005
    Co-Authors: Ralf Koos, Joachim E. Wildberger, Andreas H. Mahnken, Anil M. Sinha, Rainer Hoffmann, Harald P. Kühl
    Abstract:

    Abstract Background The aim was to correlate the degree of valvular calcification in patients with aortic stenosis determined by retrospectively electrocardiogram (ECG)-gated multislice Spiral Computed Tomography with stenosis severity assessed by cardiac catheterization. Methods Prospective study on 41 patients (18 men, mean age 71±8 years) with aortic stenosis, who underwent four detector row multislice Spiral Computed Tomography and cardiac catheterization. Severity of aortic stenosis was classified by cardiac catheterization. Aortic valve area, peak to peak and mean transvalvular gradients were correlated with the degree of calcification determined by multislice Spiral Computed Tomography. Aortic valve calcification was assessed using aortic Agatston score, aortic mass score and aortic volume score. Results All measured aortic valve calcification scores were significantly higher in patients with severe aortic stenosis ( n =29) than in patients with moderate ( n =7) or mild aortic stenosis ( n =5, p r =−0.49, p =0.001 for aortic mass score) and with peak to peak ( r =0.68, p r =0.60, p Conclusions Severity of aortic valve calcification assessed by cardiac multislice Spiral Computed Tomography is inversely related to aortic valve area and positively correlated with transvalvular gradients. Based on this preliminary data larger studies should be performed with echocardiography as a reference standard in order to validate this new information and its utility in the clinical management of the patient.

Peter M. T. Pattynama - One of the best experts on this subject based on the ideXlab platform.

  • Noninvasive visualization of atherosclerotic plaque with electron beam and multislice Spiral Computed Tomography.
    Journal of interventional cardiology, 2003
    Co-Authors: Koen Nieman, Peter M. T. Pattynama, Aad Van Der Lugt, Pim J. De Feyter
    Abstract:

    As an alternative to intracoronary modalities, electron beam Computed Tomography (EBCT) and multislice Spiral Computed Tomography (MSCT) are able to noninvasively image the coronary arteries. In addition to stenosis detection by imaging the vessel lumen, MSCT has the ability to visualize the coronary artery wall. By using Computed Tomography (CT), the various components of atherosclerotic plaque may be distinguished and characterized, which holds the promise of, eventually, identifying vulnerable plaque.

  • Noninvasive Angiographic Evaluation of Coronary Stents with Multi-Slice Spiral Computed Tomography
    Herz, 2003
    Co-Authors: Koen Nieman, Peter M. T. Pattynama, Filippo Cademartiri, Rolf Raaijmakers, Pim J. De Feyter
    Abstract:

    The number of patients with obstructive coronary artery disease, who undergo coronary angioplasty with implantation of stents, is ever increasing. As an alternative to catheter-based angiography, ECG-gated multi-slice Spiral Computed Tomography (MSCT) allows noninvasive imaging of the coronary arteries. However, coronary stents have been notoriously difficult to assess by CT.

  • reliable noninvasive coronary angiography with fast submillimeter multislice Spiral Computed Tomography
    Circulation, 2002
    Co-Authors: Koen Nieman, Peter M. T. Pattynama, Filippo Cademartiri, Rolf Raaijmakers, Pedro A Lemos, Pim J. De Feyter
    Abstract:

    Background— Multislice Spiral Computed Tomography (MSCT) is a promising technique for noninvasive coronary angiography, although clinical application has remained limited because of frequently incomplete interpretability, caused by motion artifacts and calcifications. Methods and Results— In 59 patients (53 male, aged 58±12 years) with suspected obstructive coronary artery disease, ECG-gated MSCT angiography was performed with a 16-slice MSCT scanner (0.42-s rotation time, 12×0.75-mm detector collimation). Thirty-four patients were given additional β-blockers (average heart rate: 56±6 min−1). After contrast injection, all data were acquired during an approximately 20-s breath hold. The left main (LM), left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA), including ≥2.0-mm side branches, were independently evaluated by two blinded observers and screened for ≥50% stenoses. The consensus reading was compared with quantitative coronary angiography. MSCT was successful in 58 p...

  • Contrast-enhanced Spiral Computed Tomography of the pulmonary arteries: an overview.
    Seminars in thrombosis and hemostasis, 2001
    Co-Authors: Wouter De Monyé, Peter M. T. Pattynama
    Abstract:

    Spiral Computed Tomography is a new noninvasive diagnostic test for pulmonary embolism. The method provides tomographic images of the thorax in the axial plane, which depict the thoracic wall, the mediastinum, the lungs, and the pulmonary vessels. Thrombotic emboli in the vessels are seen as intraluminal filling defects in the contrast-enhanced pulmonary arteries. The physical principles of Spiral Computed Tomography and several technical considerations concerning image quality will be briefly discussed. The accuracy of Spiral Computed Tomography in the detection of pulmonary embolism is discussed by way of an overview of published validation and clinical outcome studies encompassing Spiral Computed Tomography and the diagnosis of pulmonary embolism.

Joachim E. Wildberger - One of the best experts on this subject based on the ideXlab platform.

  • Variability of aortic valve calcification measurement with multislice Spiral Computed Tomography.
    Investigative radiology, 2006
    Co-Authors: K. M. Ruhl, Marco Das, Ralf Koos, Georg Mühlenbruch, Thomas Flohr, Joachim E. Wildberger, Rolf W. Günther, Andreas H. Mahnken
    Abstract:

    Objectives: We sought to assess the variability of aortic valve calcifications (AVCs) regarding the reconstruction window at different heart phases using multislice-Spiral Computed Tomography. Materials and Methods: A total of 46 patients (26 men; mean age. 65 years) underwent AVC scoring with multislice-Spiral Computed Tomography (12 × 0.75 mm, 120 kV, 133 mAs eff ). Image reconstruction was performed every 10% of the RR-interval (0-90%). AVC was quantified using Agatston score, calcium volume, and calcium mass. Images were assessed for least motion artifacts. Coefficients of variation and Wilcoxon test were calculated. Results: AVC scores are lowest at 60% and highest at 0% of the RR-interval (P < 0.001). Mean coefficients of variation were 36.2% (Agatston score), 38.7% (calcium volume), and 32.9% (calcium mass). At 60% (50-70%). minimal motion artifacts and the lowest variability of the scores were found. Conclusions: AVC scores show large variability depending on the point of image reconstruction. Diastolic image reconstruction at 60% of the RR-interval is recommended.

  • Preliminary experience in the assessment of aortic valve calcification by ECG-gated multislice Spiral Computed Tomography.
    International journal of cardiology, 2005
    Co-Authors: Ralf Koos, Joachim E. Wildberger, Andreas H. Mahnken, Anil M. Sinha, Rainer Hoffmann, Harald P. Kühl
    Abstract:

    Abstract Background The aim was to correlate the degree of valvular calcification in patients with aortic stenosis determined by retrospectively electrocardiogram (ECG)-gated multislice Spiral Computed Tomography with stenosis severity assessed by cardiac catheterization. Methods Prospective study on 41 patients (18 men, mean age 71±8 years) with aortic stenosis, who underwent four detector row multislice Spiral Computed Tomography and cardiac catheterization. Severity of aortic stenosis was classified by cardiac catheterization. Aortic valve area, peak to peak and mean transvalvular gradients were correlated with the degree of calcification determined by multislice Spiral Computed Tomography. Aortic valve calcification was assessed using aortic Agatston score, aortic mass score and aortic volume score. Results All measured aortic valve calcification scores were significantly higher in patients with severe aortic stenosis ( n =29) than in patients with moderate ( n =7) or mild aortic stenosis ( n =5, p r =−0.49, p =0.001 for aortic mass score) and with peak to peak ( r =0.68, p r =0.60, p Conclusions Severity of aortic valve calcification assessed by cardiac multislice Spiral Computed Tomography is inversely related to aortic valve area and positively correlated with transvalvular gradients. Based on this preliminary data larger studies should be performed with echocardiography as a reference standard in order to validate this new information and its utility in the clinical management of the patient.

  • Multislice Spiral Computed Tomography of the Heart: Technique, Current Applications, and Perspective
    CardioVascular and Interventional Radiology, 2005
    Co-Authors: Andreas H. Mahnken, Ralf Koos, Joachim E. Wildberger, Rolf W. Günther
    Abstract:

    Multislice Spiral Computed Tomography (MSCT) is a rapidly evolving, noninvasive technique for cardiac imaging. Knowledge of the principle of electrocardiogram–gated MSCT and its limitations in clinical routine are needed to optimize image quality. Therefore, the basic technical principle including essentials of image postprocessing is described. Cardiac MSCT imaging was initially focused on coronary calcium scoring, MSCT coronary angiography, and analysis of left ventricular function. Recent studies also evaluated the ability of cardiac MSCT to visualize myocardial infarction and assess valvular morphology. In combination with experimental approaches toward the assessment of aortic valve function and myocardial viability, cardiac MSCT holds the potential for a comprehensive examination of the heart using one single examination technique.

  • Determination of Cardiac Output With Multislice Spiral Computed Tomography: A Validation Study
    Investigative radiology, 2004
    Co-Authors: Andreas H. Mahnken, Joachim E. Wildberger, Dietrich Henzler, F. Ernst Klotz, A. Hennemuth, Rolf W. Günther
    Abstract:

    Objective:To validate and to determine the reproducibility of cardiac output (CO) measurements based on a test-bolus examination in multislice Spiral Computed Tomography (MSCT) in comparison with invasively measured CO using the thermal dilution technique.Material and Methods:In 8 swine, CO was dete

  • ECG-gated multislice Spiral Computed Tomography to clarify lesion severity in a case of left main stenosis. Multislice Spiral Computed Tomography to clarify lesion severity.
    The international journal of cardiovascular imaging, 2003
    Co-Authors: Ralf Koos, Joachim E. Wildberger, Andreas H. Mahnken, Anil-martin Sinha, Rainer Hoffmann
    Abstract:

    This case report describes the use of retrospectively ECG-gated multislice Spiral Computed Tomography (MSCT) for evaluation of lesion severity in a patient with relevant left main stenosis by visual analysis of the coronary angiogram. For further diagnostic evaluation the patient underwent intravascular ultrasound (IVUS) imaging, which showed a maximal 30% area stenosis, and MSCT, which demonstrated a maximal 48% area stenosis. MSCT was useful in this case to defer cardiac surgery and might be used as a noninvasive alternative to IVUS imaging in case of doubtful lesion severity.