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Raymond L. Barnhill - One of the best experts on this subject based on the ideXlab platform.
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Spitz Nevus and Variants
Pathology of Melanocytic Nevi and Malignant Melanoma, 2004Co-Authors: Raymond L. Barnhill, Klaus J. BusamAbstract:Spitz Nevus is also known as Spitz tumor, spindle and epithelioid cell Nevus of large spindle and/or epithelioid cells, spindle cell Nevus, juvenile melanoma, and benign juvenile melanoma. The Spitz Nevus is a benign melanocytic neoplasm usually acquired with a distinct histopathologic appearance. The characteristic that sets this lesion apart from other nevi is the presence of large epithelioid and/or spindle cells in varying proportions. The lesion is frequently misdiagnosed as malignant melanoma.
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Plexiform Spitz Nevus: an intradermal Spitz Nevus with plexiform growth pattern.
The American Journal of dermatopathology, 1999Co-Authors: Alain Spatz, Steve Peterse, Christopher D.m. Fletcher, Raymond L. BarnhillAbstract:Two cases of a distinctive variant of Spitz (spindle and epithelioid cell) Nevus are described. One lesion developed on the lower leg of a 17-year-old boy and the other lesion on the back of a 52-year-old man. The microscopic appearance was characterized by a plexiform arrangement of bundles and lobules of enlarged spindle to epithelioid melanocytes throughout the superficial and deep dermis. Intraepidermal melanocytic proliferation was unappreciated. Some lobules were circumscribed by a thin rim of compressed fibrous tissue. In both cases a myxoid stroma was present. The cells had abundant eosinophilic cytoplasm with well-defined borders. The nuclei were enlarged, consistently ovoid and vesicular, with small nucleoli. Both cases contained scattered multinucleate giant cells similar to those observed in classical form of Spitz nevi. No melanin pigment was detectable by light microscopy. No mitoses were observed in one case and a rare mitosis was present in the other. Tumor cells were strongly immunoreactive for S-100, but not for HMB-45, desmin, and actin. The differential diagnosis of this distinctive tumor includes desmoplastic/neurotropic melanoma, plexiform spindle cell Nevus, cellular blue Nevus, plexiform neurofibroma, and cellular neurothekeoma. The designation of "plexiform Spitz Nevus" is chosen to emphasize its distinctive plexiform growth pattern.
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pagetoid Spitz Nevus intraepidermal Spitz tumor with prominent pagetoid spread
The American Journal of Surgical Pathology, 1995Co-Authors: Klaus J. Busam, Raymond L. BarnhillAbstract:A distinctive variant of melanocytic growth pattern is described, which appears to be related to Spitz Nevus and is characterized by a mainly intraepidermal proliferation of large epithelioid melanocytes with a predominantly pagetoid distribution. This melanocytic lesion appears clinically as a small (<0.4 cm) pigmented macule in young patients. Histologically, this lesion needs to be distinguished primarily from in situ or microinvasive malignant melanoma with pagetoid spread. Features favoring Nevus over melanoma include small size, circumscription, symmetry, even distribution of cells, and lack of marked cytologic atypia.
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Pagetoid Spitz Nevus: intraepidermal Spitz tumor with prominent pagetoid spread
The American Journal of Surgical Pathology, 1995Co-Authors: Klaus J. Busam, Raymond L. BarnhillAbstract:A distinctive variant of melanocytic growth pattern is described, which appears to be related to Spitz Nevus and is characterized by a mainly intraepidermal proliferation of large epithelioid melanocytes with a predominantly pagetoid distribution. This melanocytic lesion appears clinically as a small (
Klaus J. Busam - One of the best experts on this subject based on the ideXlab platform.
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compound clear cell sarcoma misdiagnosed as a Spitz Nevus
Journal of Cutaneous Pathology, 2013Co-Authors: Meera Hameed, Maija Ht Kiuru, Klaus J. BusamAbstract:Clear cell sarcoma (CCS) typically presents as a tumor in the deep soft tissue of extremities, but when centered in the dermis it may be confused with a melanocytic Nevus, primary nodular or metastatic melanoma. Compound variants of CCS, i.e. tumor cells present in both the epidermis and underlying soft tissue have not yet been described. Herein we report such a case, which initially presented as a nodule on the left wrist of a young woman at 19 years of age. The lesion was then interpreted as 'Spitz Nevus, compound type'. Twelve years later the patient noticed an enlarged lymph node in the right axilla. The excised lymph node was nearly completely replaced by malignant tumor cells, which were immunoreactive for S100 protein. They resembled the tumor cells of the wrist lesion. Cytogenetic analysis of the metastatic tumor revealed a t(12;22) translocation. Fluorescence in situ hybridization confirmed Ewing's sarcoma breakpoint region 1 (EWSR1) rearrangement in 70% of the tumor cells, thereby supporting the diagnosis of metastatic CCS. Our case is of interest because it documents that CCS can involve the epidermis. This observation expands the morphological spectrum associated with this tumor.
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Spitz Nevus and Variants
Pathology of Melanocytic Nevi and Malignant Melanoma, 2004Co-Authors: Raymond L. Barnhill, Klaus J. BusamAbstract:Spitz Nevus is also known as Spitz tumor, spindle and epithelioid cell Nevus of large spindle and/or epithelioid cells, spindle cell Nevus, juvenile melanoma, and benign juvenile melanoma. The Spitz Nevus is a benign melanocytic neoplasm usually acquired with a distinct histopathologic appearance. The characteristic that sets this lesion apart from other nevi is the presence of large epithelioid and/or spindle cells in varying proportions. The lesion is frequently misdiagnosed as malignant melanoma.
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pagetoid Spitz Nevus intraepidermal Spitz tumor with prominent pagetoid spread
The American Journal of Surgical Pathology, 1995Co-Authors: Klaus J. Busam, Raymond L. BarnhillAbstract:A distinctive variant of melanocytic growth pattern is described, which appears to be related to Spitz Nevus and is characterized by a mainly intraepidermal proliferation of large epithelioid melanocytes with a predominantly pagetoid distribution. This melanocytic lesion appears clinically as a small (<0.4 cm) pigmented macule in young patients. Histologically, this lesion needs to be distinguished primarily from in situ or microinvasive malignant melanoma with pagetoid spread. Features favoring Nevus over melanoma include small size, circumscription, symmetry, even distribution of cells, and lack of marked cytologic atypia.
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Pagetoid Spitz Nevus: intraepidermal Spitz tumor with prominent pagetoid spread
The American Journal of Surgical Pathology, 1995Co-Authors: Klaus J. Busam, Raymond L. BarnhillAbstract:A distinctive variant of melanocytic growth pattern is described, which appears to be related to Spitz Nevus and is characterized by a mainly intraepidermal proliferation of large epithelioid melanocytes with a predominantly pagetoid distribution. This melanocytic lesion appears clinically as a small (
Michael K Yoon - One of the best experts on this subject based on the ideXlab platform.
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Spitz Nevus arising in the eyelid of a teenager
Survey of Ophthalmology, 2016Co-Authors: Patrick W Shields, Frederick A Jakobiec, Anna M Stagner, Michael K YoonAbstract:Abstract A 16-year-old boy developed over a 2-month interval a lightly pigmented left upper eyelid lesion measuring 1.5 mm in greatest diameter that, when excised, microscopically was hypercellular and composed almost exclusively of nonpigmented epithelioid cells that created florid, large intraepidermal junctional nests and sheets and nests of subepidermal cells. The diagnosis was a Spitz Nevus. HMB-45, MART-1, and microphthalmia-associated transcription factor were all positive and established the melanocytic nature of the benign tumor. The Ki-67 proliferation index (5%) and 2 mitoses/mm 2 were both low; p16 protein was immunohistochemically identified in the nevoid cells. We review the clinical, histopathologic, and other immunohistochemical features of this entity and provide a brief differential diagnosis (including separation from a Spitzoid melanoma). This is only the third eyelid Spitz Nevus reported in the literature and is the most fully characterized immunohistochemically. At their present stage of development, contemporary immunohistochemical biomarkers, while providing supplemental information, nonetheless remain less than definitive in terms of reliably distinguishing benign from malignant Spitz lesions.
Juan Rosai - One of the best experts on this subject based on the ideXlab platform.
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Spitz Nevus of the tongue with pseudoepitheliomatous hyperplasia: report of three cases of a pseudomalignant condition.
The American journal of surgical pathology, 2002Co-Authors: Tshering Dorji, Alberto Cavazza, Oscar Nappi, Juan RosaiAbstract:Three cases of Spitz Nevus of the tongue associated with pseudoepitheliomatous hyperplasia are reported: two occurring in children and one in an adult. The location at an unusual site and the complex pattern resulting from the intimate admixture of the neoplastic melanocytic component and the hyperplastic keratinocytic component led in each case to consider diagnoses such as malignant melanoma and invasive squamous cell carcinoma. Staining for S-100 protein and keratin was useful to identify and separate the two components. Spitz Nevus of the tongue carries some intriguing similarities with granular cell tumor, suggesting a possible histogenetic and pathogenetic relationship.
Wolter J. Mooi - One of the best experts on this subject based on the ideXlab platform.
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Spitz Nevus versus Spitzoid melanoma: diagnostic difficulties, conceptual controversies.
Advances in anatomic pathology, 2006Co-Authors: Wolter J. Mooi, Thomas KrauszAbstract:The histologic distinction of Spitz Nevus and Spitzoid melanoma is notoriously difficult, and an additional complication is provided by the fact that there may be a group of Spitz tumors that has the propensity to spread regionally, but not to distant sites.The interpretation of regional spread is s
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Spitz Nevus and its Histologic Simulators
Advances in anatomic pathology, 2002Co-Authors: Wolter J. MooiAbstract:Spitz nevi continue to pose a considerable diagnostic challenge to the histopathologist. Key features of Spitz Nevus and its variants are discussed and contrasted with the telltale signs of malignancy of "Spitzoid" melanomas. The importance of the histologic features of the deep, rather than superficial, part of the lesions is emphasized.
