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Stephen Francis Mcclanahan - One of the best experts on this subject based on the ideXlab platform.
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Anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice.
Journal of clinical periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, J. Leslie Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p
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anti gingivitis efficacy of a stabilized 0 454 Stannous Fluoride sodium hexametaphosphate dentifrice
Journal of Clinical Periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, Leslie J Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p<0.001), 57.1% less bleeding (p<0.001), and 6.9% less plaque (p=0.01) on average compared with the negative control group. No adverse oral soft-hard-tissue effects or extrinsic tooth staining was observed in the study. Conclusion: The results demonstrate that use of the stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice over a 6-month period provided statistically significant reductions in gingivitis, gingival bleeding, and plaque when compared with a negative control dentifrice.
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Reversal of incipient and radiographic caries through the use of sodium and Stannous Fluoride dentifrices in a clinical trial.
The Journal of clinical dentistry, 1998Co-Authors: Aaron R Biesbrock, Robert D Bartizek, Robert Vincent Faller, Stephen Francis McclanahanAbstract:Experimental evidence has clearly demonstrated that the early stages of lesion formation (enamel demineralization) are reversible following exposure to saliva and/or Fluoride. Clinical evidence for remineralization has also been reported extensively in the literature. However, the literature is lacking with respect to data from well-controlled clinical studies regarding the quantitative contribution of remineralization to arrestment and reversal of caries. Retrospective analysis of an existing clinical trial database provided an opportunity to examine the incidence of clinical lesion reversals in a placebo-controlled, double-blinded caries clinical study. The clinical study examined three treatment groups: 1) 0.243% sodium Fluoride/silica dentifrice, 2) 0.4% Stannous Fluoride/calcium pyrophosphate (positive control) dentifrice and 3) non-fluoridated placebo/calcium pyrophosphate (negative control) dentifrice. Clinical measures in this study included both radiographic and visual-tactile assessments of caries. Examination of all subjects revealed a statistically greater frequency for caries reversals in the sodium Fluoride group as compared to the placebo group at Year 3, for both total and radiographic caries. In contrast, while caries reversals in the Stannous Fluoride group occurred with greater frequency than in the placebo group at Year 3, for both total and radiographic caries, the differences were not statistically significant. When only subjects who were "at risk" for potential reversals (i.e., those with a minimum of one carious lesion at baseline) were examined, a statistically greater frequency in caries reversals was observed in both the sodium Fluoride (total, incipient, and radiographic caries) and Stannous Fluoride (total and radiographic caries) groups as compared to the placebo group at Year 3. Collectively, these data confirm the ability of both 0.243% sodium Fluoride/silica and 0.4% Stannous Fluoride/calcium pyrophosphate dentifrices to clinically reverse caries. The results suggest that sodium Fluoride may deliver a greater frequency of caries reversals than Stannous Fluoride, although these treatments were not found to be significantly different.
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The comparative efficacy of stabilized Stannous Fluoride dentifrice, peroxide/baking soda dentifrice and essential oil mouthrinse for the prevention of gingivitis.
The Journal of clinical dentistry, 1997Co-Authors: Stephen Francis Mcclanahan, Robert D Bartizek, Lori Ann Bacca, Donald James WhiteAbstract:This double-blind parallel-design clinical study compared the efficacy of a stabilized Stannous Fluoride dentifrice (Crest Plus Gum Care), baking soda and peroxide (NaF) dentifrice (Mentadent), and essential oil mouthrinse (Listerine) to a conventional NaF dentifrice (Crest) for the control of plaque, gingivitis and gingival bleeding over six months. Following an initial baseline examination and stratification, subjects received a complete oral prophylaxis and were distributed assigned test products. Following three and six months, subjects re-visited the clinic for examinations. Evaluations at baseline and at 3 and 6 months included soft tissue status. Loe-Silness gingivitis/gingival bleeding, Silness-Loe plaque and dental stain. Results subsequent to six months of product use were as follows: At six months, the stabilized Stannous Fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice. The combination of sodium Fluoride dentifrice and essential oil mouthrinse produced statistically significant reductions of 7.4% in gingivitis and 10.8% in plaque as compared with the NaF dentifrice. The stabilized Stannous Fluoride dentifrice produced statistically significant reductions in both gingivitis (10.8%) and gingival bleeding (23.0%) relative to the combination of sodium Fluoride dentifrice and essential oil mouthrinse. The baking soda and peroxide (NaF) dentifrice did not provide reductions in gingivitis, plaque or gingival bleeding as compared with the conventional NaF dentifrice. The stabilized Stannous Fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following six months of use, and both the essential oil mouthrinse and stabilized Stannous Fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following three months of use. These results support: 1) the efficacy of stabilized Stannous Fluoride dentifrice and the combination of sodium Fluoride dentifrice and essential oil mouthrinse for the prevention of gingivitis; 2) the superior activity of stabilized Stannous Fluoride dentifrice as compared with a combination of sodium Fluoride dentifrice and essential oil mouthrinse for the control of gingivitis and gingival bleeding; and 3) the lack of efficacy for baking soda and peroxide dentifrice for the control of plaque, gingivitis and gingival bleeding as compared with conventional fluoridated dentifrice.
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the comparative efficacy of stabilized Stannous Fluoride dentifrice peroxide baking soda dentifrice and essential oil mouthrinse for the prevention of gingivitis
The Journal of clinical dentistry, 1997Co-Authors: B B Beiswanger, Robert D Bartizek, Stephen Francis Mcclanahan, A. C. Lanzalaco, Lori Ann Bacca, Donald James WhiteAbstract:This double-blind parallel-design clinical study compared the efficacy of a stabilized Stannous Fluoride dentifrice (Crest Plus Gum Care), baking soda and peroxide (NaF) dentifrice (Mentadent), and essential oil mouthrinse (Listerine) to a conventional NaF dentifrice (Crest) for the control of plaque, gingivitis and gingival bleeding over six months. Following an initial baseline examination and stratification, subjects received a complete oral prophylaxis and were distributed assigned test products. Following three and six months, subjects re-visited the clinic for examinations. Evaluations at baseline and at 3 and 6 months included soft tissue status. Loe-Silness gingivitis/gingival bleeding, Silness-Loe plaque and dental stain. Results subsequent to six months of product use were as follows: At six months, the stabilized Stannous Fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice. The combination of sodium Fluoride dentifrice and essential oil mouthrinse produced statistically significant reductions of 7.4% in gingivitis and 10.8% in plaque as compared with the NaF dentifrice. The stabilized Stannous Fluoride dentifrice produced statistically significant reductions in both gingivitis (10.8%) and gingival bleeding (23.0%) relative to the combination of sodium Fluoride dentifrice and essential oil mouthrinse. The baking soda and peroxide (NaF) dentifrice did not provide reductions in gingivitis, plaque or gingival bleeding as compared with the conventional NaF dentifrice. The stabilized Stannous Fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following six months of use, and both the essential oil mouthrinse and stabilized Stannous Fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following three months of use. These results support: 1) the efficacy of stabilized Stannous Fluoride dentifrice and the combination of sodium Fluoride dentifrice and essential oil mouthrinse for the prevention of gingivitis; 2) the superior activity of stabilized Stannous Fluoride dentifrice as compared with a combination of sodium Fluoride dentifrice and essential oil mouthrinse for the control of gingivitis and gingival bleeding; and 3) the lack of efficacy for baking soda and peroxide dentifrice for the control of plaque, gingivitis and gingival bleeding as compared with conventional fluoridated dentifrice.
Robert D Bartizek - One of the best experts on this subject based on the ideXlab platform.
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extrinsic stain removal efficacy of a Stannous Fluoride dentifrice with sodium hexametaphosphate
The Journal of clinical dentistry, 2007Co-Authors: Tao He, Eros Chaves, Robert D Bartizek, Robert A. Baker, Aaron R Biesbrock, Geza T. TerezhalmyAbstract: Objective: Two randomized, six-week, double-blind, parallel group, clinical trials were independently conducted to compare the extrinsic stain removal efficacy of a novel whitening therapeutic dentifrice containing 0.454% Stannous Fluoride and sodium hexametaphosphate in a formulation with high cleaning silica, relative to a positive control whitening dentifrice. Methodology: Generally healthy adults, 56 for study 1 and 60 for study 2, with visible extrinsic tooth stain were enrolled in the studies. At the baseline visit, stain was assessed on the facial surfaces of the eight central and lateral incisors using the modified Lobene Stain Index. Oral soft and hard tissue examinations were also conducted. In each study, subjects were randomized to either the Stannous Fluoride + sodium hexametaphosphate toothpaste (Crest ® Pro-Health ® ) or the positive control toothpaste (Colgate ® Total ® Plus Whitening) to use twice per day for six weeks. Stain and safety were reassessed at weeks three and six. Results: Fifty-two and 58 subjects completed studies 1 and 2, respectively. In each study, there were no statistically significant differences in Lobene composite stain scores between the two treatment groups across all three visits. Both groups showed statistically significant reductions in Lobene composite stain scores at week three (p < 0.0001) and week six (p < 0.0001) relative to baseline. The percent of Lobene composite scores with a greater than 0.5 unit reduction from baseline at week six was 86% for study 1 and 97% for study 2 for the Stannous Fluoride + sodium hexametaphosphate dentifrice group. Conclusion: Collectively, these two stain removal clinical trials demonstrate the statistically significant extrinsic stain removal efficacy for the Stannous Fluoride + sodium hexametaphosphate dentifrice relative to baseline. There were no statistically significant differences between the Stannous Fluoride + sodium hexametaphosphate dentifrice and positive control treatment group.
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Anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice.
Journal of clinical periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, J. Leslie Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p
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anti gingivitis efficacy of a stabilized 0 454 Stannous Fluoride sodium hexametaphosphate dentifrice
Journal of Clinical Periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, Leslie J Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p<0.001), 57.1% less bleeding (p<0.001), and 6.9% less plaque (p=0.01) on average compared with the negative control group. No adverse oral soft-hard-tissue effects or extrinsic tooth staining was observed in the study. Conclusion: The results demonstrate that use of the stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice over a 6-month period provided statistically significant reductions in gingivitis, gingival bleeding, and plaque when compared with a negative control dentifrice.
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Reversal of incipient and radiographic caries through the use of sodium and Stannous Fluoride dentifrices in a clinical trial.
The Journal of clinical dentistry, 1998Co-Authors: Aaron R Biesbrock, Robert D Bartizek, Robert Vincent Faller, Stephen Francis McclanahanAbstract:Experimental evidence has clearly demonstrated that the early stages of lesion formation (enamel demineralization) are reversible following exposure to saliva and/or Fluoride. Clinical evidence for remineralization has also been reported extensively in the literature. However, the literature is lacking with respect to data from well-controlled clinical studies regarding the quantitative contribution of remineralization to arrestment and reversal of caries. Retrospective analysis of an existing clinical trial database provided an opportunity to examine the incidence of clinical lesion reversals in a placebo-controlled, double-blinded caries clinical study. The clinical study examined three treatment groups: 1) 0.243% sodium Fluoride/silica dentifrice, 2) 0.4% Stannous Fluoride/calcium pyrophosphate (positive control) dentifrice and 3) non-fluoridated placebo/calcium pyrophosphate (negative control) dentifrice. Clinical measures in this study included both radiographic and visual-tactile assessments of caries. Examination of all subjects revealed a statistically greater frequency for caries reversals in the sodium Fluoride group as compared to the placebo group at Year 3, for both total and radiographic caries. In contrast, while caries reversals in the Stannous Fluoride group occurred with greater frequency than in the placebo group at Year 3, for both total and radiographic caries, the differences were not statistically significant. When only subjects who were "at risk" for potential reversals (i.e., those with a minimum of one carious lesion at baseline) were examined, a statistically greater frequency in caries reversals was observed in both the sodium Fluoride (total, incipient, and radiographic caries) and Stannous Fluoride (total and radiographic caries) groups as compared to the placebo group at Year 3. Collectively, these data confirm the ability of both 0.243% sodium Fluoride/silica and 0.4% Stannous Fluoride/calcium pyrophosphate dentifrices to clinically reverse caries. The results suggest that sodium Fluoride may deliver a greater frequency of caries reversals than Stannous Fluoride, although these treatments were not found to be significantly different.
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The comparative efficacy of stabilized Stannous Fluoride dentifrice, peroxide/baking soda dentifrice and essential oil mouthrinse for the prevention of gingivitis.
The Journal of clinical dentistry, 1997Co-Authors: Stephen Francis Mcclanahan, Robert D Bartizek, Lori Ann Bacca, Donald James WhiteAbstract:This double-blind parallel-design clinical study compared the efficacy of a stabilized Stannous Fluoride dentifrice (Crest Plus Gum Care), baking soda and peroxide (NaF) dentifrice (Mentadent), and essential oil mouthrinse (Listerine) to a conventional NaF dentifrice (Crest) for the control of plaque, gingivitis and gingival bleeding over six months. Following an initial baseline examination and stratification, subjects received a complete oral prophylaxis and were distributed assigned test products. Following three and six months, subjects re-visited the clinic for examinations. Evaluations at baseline and at 3 and 6 months included soft tissue status. Loe-Silness gingivitis/gingival bleeding, Silness-Loe plaque and dental stain. Results subsequent to six months of product use were as follows: At six months, the stabilized Stannous Fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice. The combination of sodium Fluoride dentifrice and essential oil mouthrinse produced statistically significant reductions of 7.4% in gingivitis and 10.8% in plaque as compared with the NaF dentifrice. The stabilized Stannous Fluoride dentifrice produced statistically significant reductions in both gingivitis (10.8%) and gingival bleeding (23.0%) relative to the combination of sodium Fluoride dentifrice and essential oil mouthrinse. The baking soda and peroxide (NaF) dentifrice did not provide reductions in gingivitis, plaque or gingival bleeding as compared with the conventional NaF dentifrice. The stabilized Stannous Fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following six months of use, and both the essential oil mouthrinse and stabilized Stannous Fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following three months of use. These results support: 1) the efficacy of stabilized Stannous Fluoride dentifrice and the combination of sodium Fluoride dentifrice and essential oil mouthrinse for the prevention of gingivitis; 2) the superior activity of stabilized Stannous Fluoride dentifrice as compared with a combination of sodium Fluoride dentifrice and essential oil mouthrinse for the control of gingivitis and gingival bleeding; and 3) the lack of efficacy for baking soda and peroxide dentifrice for the control of plaque, gingivitis and gingival bleeding as compared with conventional fluoridated dentifrice.
Clemens Walter - One of the best experts on this subject based on the ideXlab platform.
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development of resistance of mutans streptococci and porphyromonas gingivalis to chlorhexidine digluconate and amine Fluoride Stannous Fluoride containing mouthrinses in vitro
Clinical Oral Investigations, 2015Co-Authors: Eva M. Kulik, Tuomas Waltimo, Roland Weiger, Irene Schweizer, Krystyna Lenkeit, Elisabeth Filipuzzijenny, Clemens WalterAbstract:The aim if this study was to determine the minimal inhibitory concentrations of chlorhexidine digluconate and an amine Fluoride/Stannous Fluoride-containing mouthrinse against Porphyromonas gingivalis and mutans streptococci during an experimental long-term subinhibitory exposition. Five P. gingivalis strains and four mutans streptococci were subcultivated for 20–30 passages in subinhibitory concentrations of chlorhexidine digluconate or an amine Fluoride/Stannous Fluoride-containing mouthrinse. Pre-passaging minimal inhibitory concentrations for chlorhexidine ranged from 0.5 to 2 mg/l for mutans streptococci and from 2 to 4 mg/l for the P. gingivalis isolates. For the amine Fluoride/Stannous Fluoride-containing mouthrinse minimal inhibitory values from 0.125 to 0.25 % for the mutans streptococci and from 0.063 to 0.125 % for the P. gingivalis isolates were determined. Two- to fourfold increased minimal inhibitory concentrations against chlorhexidine were detected for two of the five P. gingivalis isolates, whereas no increase in minimal inhibitory concentrations was found for the mutans streptococci after repeated passaging through subinhibitory concentrations. Repeated exposure to subinhibitory concentrations of the amine Fluoride/Stannous Fluoride-containing mouthrinse did not alter the minimally inhibitory concentrations of the bacterial isolates tested. Chlorhexidine and the amine Fluoride/Stannous Fluoride-containing mouthrinse are effective inhibitory agents against the oral bacterial isolates tested. No general development of resistance against chlorhexidine or the amine Fluoride/Stannous Fluoride-containing mouthrinse was detected. However, some strains showed potential to develop resistance against chlorhexidine after prolonged exposure. The use of chlorhexidine should be limited to short periods of time. The amine Fluoride/Stannous Fluoride-containing mouthrinse appears to have the potential to be used on a long-term basis.
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Development of resistance of mutans streptococci and Porphyromonas gingivalis to chlorhexidine digluconate and amine Fluoride/Stannous Fluoride-containing mouthrinses, in vitro.
Clinical oral investigations, 2014Co-Authors: Eva M. Kulik, Tuomas Waltimo, Roland Weiger, Irene Schweizer, Krystyna Lenkeit, Elisabeth Filipuzzi-jenny, Clemens WalterAbstract:The aim if this study was to determine the minimal inhibitory concentrations of chlorhexidine digluconate and an amine Fluoride/Stannous Fluoride-containing mouthrinse against Porphyromonas gingivalis and mutans streptococci during an experimental long-term subinhibitory exposition. Five P. gingivalis strains and four mutans streptococci were subcultivated for 20–30 passages in subinhibitory concentrations of chlorhexidine digluconate or an amine Fluoride/Stannous Fluoride-containing mouthrinse. Pre-passaging minimal inhibitory concentrations for chlorhexidine ranged from 0.5 to 2 mg/l for mutans streptococci and from 2 to 4 mg/l for the P. gingivalis isolates. For the amine Fluoride/Stannous Fluoride-containing mouthrinse minimal inhibitory values from 0.125 to 0.25 % for the mutans streptococci and from 0.063 to 0.125 % for the P. gingivalis isolates were determined. Two- to fourfold increased minimal inhibitory concentrations against chlorhexidine were detected for two of the five P. gingivalis isolates, whereas no increase in minimal inhibitory concentrations was found for the mutans streptococci after repeated passaging through subinhibitory concentrations. Repeated exposure to subinhibitory concentrations of the amine Fluoride/Stannous Fluoride-containing mouthrinse did not alter the minimally inhibitory concentrations of the bacterial isolates tested. Chlorhexidine and the amine Fluoride/Stannous Fluoride-containing mouthrinse are effective inhibitory agents against the oral bacterial isolates tested. No general development of resistance against chlorhexidine or the amine Fluoride/Stannous Fluoride-containing mouthrinse was detected. However, some strains showed potential to develop resistance against chlorhexidine after prolonged exposure. The use of chlorhexidine should be limited to short periods of time. The amine Fluoride/Stannous Fluoride-containing mouthrinse appears to have the potential to be used on a long-term basis.
Suru M. Mankodi - One of the best experts on this subject based on the ideXlab platform.
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Anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice.
Journal of clinical periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, J. Leslie Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p
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anti gingivitis efficacy of a stabilized 0 454 Stannous Fluoride sodium hexametaphosphate dentifrice
Journal of Clinical Periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, Leslie J Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p<0.001), 57.1% less bleeding (p<0.001), and 6.9% less plaque (p=0.01) on average compared with the negative control group. No adverse oral soft-hard-tissue effects or extrinsic tooth staining was observed in the study. Conclusion: The results demonstrate that use of the stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice over a 6-month period provided statistically significant reductions in gingivitis, gingival bleeding, and plaque when compared with a negative control dentifrice.
Leslie J Winston - One of the best experts on this subject based on the ideXlab platform.
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desensitizing effect of a stabilized Stannous Fluoride sodium hexametaphosphate dentifrice
Compendium of continuing education in dentistry, 2005Co-Authors: Thomas Schiff, Robert A. Baker, Lisa Saletta, Leslie J WinstonAbstract:Stannous Fluoride (0.4%) has been incorporated into oral hygiene products to reduce dentinal hypersensitivity since the 1960s. The present study was designed to assess the desensitizing efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice compared to a sodium Fluoride control dentifrice. This was a double-blind, parallel-group, randomized clinical trial conducted according to the American Dental Association Guidelines for the Acceptance of Products for the Treatment of Dentinal Hypersensitivity. Seventy-seven subjects who met the entrance criteria were stratified based on age, gender, and air-sensitivity scores and randomly assigned to either the stabilized Stannous Fluoride/sodium hexametaphosphate dentifrice or the sodium Fluoride control dentifrice. Subjects were instructed to brush twice daily for 8 weeks. Oral soft tissue examination and efficacy assessments including tactile (Yeaple probe) and thermal (Schiff Air Index) sensitivity were made at baseline, week 4, and week 8. The mean sensitivity score based on the Schiff Air Index for the experimental group was statistically significantly lower than that of the sodium Fluoride control group, at both weeks 4 and 8 (P < .0001). The mean sensitivity score based on the Yeaple Probe Index for the Stannous Fluoride/sodium hexametaphosphate group was statistically significantly higher, indicating a reduction in sensitivity, than that of the sodium Fluoride control group, at both weeks 4 and 8 (P < .0001). The results demonstrate that the stabilized Stannous Fluoride/sodium hexametaphosphate dentifrice provides clinically and statistically significant reductions in dentinal hypersensitivity when compared to the sodium Fluoride control dentifrice.
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anticalculus efficacy and safety of a stabilized Stannous Fluoride sodium hexametaphosphate dentifrice
Compendium of continuing education in dentistry, 2005Co-Authors: Thomas Schiff, Robert A. Baker, Lisa Saletta, Leslie J WinstonAbstract:The purpose of this study wa as to assess the anticalculus effi- - cacy and long-term safety of a new Stannous Fluoride dentifrice contain- - ing sodium hexametaphosphate. This s trial was a randomized, double- bliind, parallel-group, 6-month sttudy where, after r a prophylaxis, subjects brushed twice daily with either a stabilized 0.454% Stannous fluo- - ride/13% sodium hexameta aphosphate dentifrice (Crest ® Pro-H Health) or a marketed multibenefit triclosan n//copolymer conttrol dentifrice. Study sub- - jects were known to form supragingival calculus and had previiously demonstratted the ability to form at least 1.5 mm using the Volpe- Manhold Calculus Index over a 2-month pretest period. Comparisons between treatments for anticalculus efficacy were perfo ormed using analy- - sis of covariance. Eighty subjects we ere randomized into one of two treat- - ment groups after strattification on gender and baseline calculus scores and d then monitored for calculus formation, soft tissue e tolerance, and extrinsic stain. The mean calculus score for the Stannous Fluoride/sodi- - um hexametaphosphate gr roup was statistically significantly lower than that of the triclosan/copolymer group at both months 3 and 6 (P < .01). At month 3, the Stannous s Fluoride/sodium hexametaphosphate group had an adjusted mean 54% lower than that of the triclosan/copolymer group. At month 6, the Stannous s Fluoride/sodium hexametaphosphate group had an adjusted mean 56% lower than that of the triclosan/copolymer group. Both dentifrices were welll tolerated and neither dentifrice group devel- - oped appreciab ble extrinsic stain over the 6-month trial pe eriod. Overall, the Stannous Fluoride/sodium hexametaphosphate dentifrice had superior anticalculus efficacy relativ ve to the marketed triclosan/copolymer control and a com mparable soft tissue safety and extrinsic stain pr rofille.
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anti gingivitis efficacy of a stabilized 0 454 Stannous Fluoride sodium hexametaphosphate dentifrice
Journal of Clinical Periodontology, 2005Co-Authors: Suru M. Mankodi, Robert D Bartizek, Aaron R Biesbrock, Leslie J Winston, Stephen Francis McclanahanAbstract:Objective: Stannous Fluoride is a broad-spectrum anti-microbial agent that has been used in dentistry as a chemical adjunct to prevent dental caries and gingivitis. The objective of this study was to assess the anti-gingivitis efficacy of a stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice relative to a negative control. Methods: This was a randomized, 6-month, double-blind, parallel-group gingivitis study conducted according to the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were then instructed to brush twice daily for 60 s using their assigned product. Oral soft-hard-tissue examinations and clinical examinations using the Modified Gingival Index, Gingival Bleeding Index, and the Turesky modification of the Quigley–Hein Plaque Index were performed at baseline, 3 and 6 months post-treatment. Results: A total of 143 subjects were enrolled and 130 of them completed the 6-month study. After 6 months of product usage, the experimental group had 21.7% less gingivitis (p<0.001), 57.1% less bleeding (p<0.001), and 6.9% less plaque (p=0.01) on average compared with the negative control group. No adverse oral soft-hard-tissue effects or extrinsic tooth staining was observed in the study. Conclusion: The results demonstrate that use of the stabilized 0.454% Stannous Fluoride/sodium hexametaphosphate dentifrice over a 6-month period provided statistically significant reductions in gingivitis, gingival bleeding, and plaque when compared with a negative control dentifrice.
