The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Amit Kumar Nayak - One of the best experts on this subject based on the ideXlab platform.
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Sterculia Gum Based Multiple Units for Oral Drug Delivery
Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery, 2019Co-Authors: Amit Kumar Nayak, Saquib HasnainAbstract:SG is generally called as karaya gum (Gauthami and Bhat in A monograph on gum karay, 1992; Nayak et al. in Gelled microparticles/beads of Sterculia gum and tamarind gum for sustained drug release. Springer International Publishing, Switzerland, pp. 361–414, 2018). It is a plant-derived polysaccharide having medicinal importance. It has a high molecular weight and is water soluble (Nayak and Pal in Sterculia gum-based hydrogels for drug delivery applications. Springer International Publishing, Switzerland, pp. 105–151, 2016).
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Gelled Microparticles/Beads of Sterculia Gum and Tamarind Gum for Sustained Drug Release
Polymer Gels, 2018Co-Authors: Amit Kumar Nayak, M. Saquib Hasnain, Dilipkumar PalAbstract:In recent years, a variety of biocompatible natural polysaccharides are extensively investigated as pharmaceutical excipients in designing various pharmaceutical formulations. Among these, Sterculia gum and tamarind gum have emerged as two popular biopolymer candidates, which have found their applications in designing of various sustained drug releasing dosage forms. Presently, both Sterculia gum and tamarind gum have been employed to design oral multiple unit sustained release systems such as microparticles, beads. The present chapter deals with a helpful and comprehensive discussion on already reported different microparticles/beads made of Sterculia gum and tamarind gum, which have shown a promise in sustained drug releasing capacity over a longer period after oral administration. This chapter will be helpful in applying appropriate strategies or achieving desired controlled sustained drug release profiles from microparticles/beads made of Sterculia gum and tamarind gum.
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gelled microparticles beads of Sterculia gum and tamarind gum for sustained drug release
2018Co-Authors: Amit Kumar Nayak, Saquib M Hasnain, Dilipkumar PalAbstract:In recent years, a variety of biocompatible natural polysaccharides are extensively investigated as pharmaceutical excipients in designing various pharmaceutical formulations. Among these, Sterculia gum and tamarind gum have emerged as two popular biopolymer candidates, which have found their applications in designing of various sustained drug releasing dosage forms. Presently, both Sterculia gum and tamarind gum have been employed to design oral multiple unit sustained release systems such as microparticles, beads. The present chapter deals with a helpful and comprehensive discussion on already reported different microparticles/beads made of Sterculia gum and tamarind gum, which have shown a promise in sustained drug releasing capacity over a longer period after oral administration. This chapter will be helpful in applying appropriate strategies or achieving desired controlled sustained drug release profiles from microparticles/beads made of Sterculia gum and tamarind gum.
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Sterculia Gum-Based Hydrogels for Drug Delivery Applications
Polymeric Hydrogels as Smart Biomaterials, 2015Co-Authors: Amit Kumar Nayak, Dilipkumar PalAbstract:Sterculia gum is one of the medicinally important plant-derived water soluble polysaccharides obtained from the exudate of the tree, Sterculia urens (Family: Sterculiaceae). It is recognized as a promising biodegradable material in the development of various biomedical applications including drug delivery applications, wound dressing applications, etc. Sterculia gum is also employed as excipient in the designing of various pharmaceutical applications. In recent years, several attempts for the modification of Sterculia gum have been undertaken to develop Sterculia gum-based hydrogels for controlling the rate of hydration and swelling, and also tailoring the release profile of various types of drugs. In the development of these Sterculia gum-based hydrogels, modifications of Sterculia gum through polymer blending, cross-linking, interpenetrated polymer network (IPN) formation, polymer grafting, etc., were investigated for improved drug delivery applications. Most of these already reported Sterculia gum-based hydrogels were found effective for gastroretentive deliveries as wound dressings for sustained release of various drugs. The current chapter deals with a comprehensive and useful discussion on already investigated Sterculia gum-based hydrogels for the use in drug delivery applications, where the first portion of the chapter contains source, composition, and properties of Sterculia gum and the latter portion contains discussion on the formulations of various Sterculia gum-based hydrogel systems used for various types of drug delivery applications.
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oil entrapped Sterculia gum alginate buoyant systems of aceclofenac development and in vitro evaluation
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: Pravat Ranjan Guru, Amit Kumar Nayak, Rajendra Kumar SahuAbstract:Abstract The current investigation deals with the development and optimization of oil-entrapped Sterculia gum–alginate buoyant beads containing aceclofenac by ionotropic emulsion–gelation technique using 3 2 factorial design. The effect of polymer to drug ratio and sodium alginate to Sterculia gum ratio on the drug entrapment efficiency (%), and cumulative drug release after 7 h (%) was optimized. The optimized oil-entrapped Sterculia gum–alginate buoyant beads containing aceclofenac (F-O) showed drug entrapment efficiency of 90.92 ± 2.34%, cumulative drug release of 41.65 ± 3.97% after 7 h in simulated gastric fluid (pH 1.2), and well buoyancy over 8 h in simulated gastric fluid (pH 1.2) with 5.20 min buoyant lag-time. The in vitro drug release from these buoyant beads followed Korsmeyer–Peppas model ( R 2 = 0.9866–0.9995) with anomalous (non-Fickian) diffusion drug release mechanism. These new Sterculia gum–alginate buoyant beads containing aceclofenac were also characterized using SEM, FTIR, and P-XRD analysis.
Steve W. Cui - One of the best experts on this subject based on the ideXlab platform.
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Structural analysis of a pectic polysaccharide from boat-fruited Sterculia seeds
International journal of biological macromolecules, 2013Co-Authors: Steve W. CuiAbstract:The chemical structure of a water-soluble pectic polysaccharide (Sterculia APS) isolated from boat-fruited Sterculia seeds (Semen Sterculiae Lychnophorae) was elucidated using partial acid hydrolysis, methylation analysis and 1D/2D nuclear magnetic resonance (NMR) spectroscopy. The results of partial acid hydrolysis revealed that Sterculia APS contained galacturonic acids and rhamnose units in the backbone, and arabinose, galactose and xylose residues in the branched chains. Combined the methylation analysis results with NMR spectroscopy, a possible structure of APS was proposed as follow: the backbone consisted of the homogalacturonan (HG) named "smooth" regions by linear linkage of 1,4-α-D-GalpA, and the rhamnogalacturonan-I (RG-I) called "hairy" ones by the linkage of →4)-α-D-GalpA-(1→2)-α-L-Rhap-(1→partially substituted at O-4 of rhamnose units. The GalpA residues were partially methyl esterified and O-acetylated on C-2 and/or C-3. The side chains were mainly composed of araban and arabinogalactan by the linkages of T-, 1,3-, 1,5-L-Araf and T-, 1,4-, 1,6-, 1,3,6-, 1,3,4-D-Galp, attached to O-4 of the backbone rhamnose units.
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structure characteristics and rheological properties of acidic polysaccharide from boat fruited Sterculia seeds
Carbohydrate Polymers, 2012Co-Authors: Steve W. Cui, Qi Wang, Jian TangAbstract:Abstract An acidic polysaccharide (APS) was extracted from the boat-fruited Sterculia seeds ( Semen Sterculiae Lychnophorae ). It consisted mainly of galacturonic acid (40.1%, w/w) along with rhamnose, arabinose, galactose, xylose and glucose as minor components, indicating a pectic polysaccharide which was confirmed by FT-IR spectra. The degree of esterification of APS determined by FT-IR method was 68%. The shear-thinning and viscoelastic behaviors of APS have been investigated by steady shear and small amplitude oscillatory experiments, respectively. Steady-shear rheological measurement in a range of shear rate (1–1000 s −1 ) showed increase in pseudoplasticity (or non-Newtonian shear-thinning flow behavior) with the increase in APS concentration (1.0–10%, w/v). APS itself could not form a gel; however, thermal irreversible gels were obtained in the presence of sucrose at low pH (pH G ′ and loss modulus G ″ during heating and cooling cycles indicated that G ′ was nearly reversible at temperature >30 °C while G ″ exhibited thermal hysteresis.
Baljit Singh - One of the best experts on this subject based on the ideXlab platform.
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Mechanistic implication for cross-linking in Sterculia-based hydrogels and their use in GIT drug delivery.
Biomacromolecules, 2009Co-Authors: Baljit Singh, Nisha SharmaAbstract:Sterculia gum has been used as a therapeutic agent to cure diverticulitis. Hydrogels developed from Sterculia gum to release the therapeutic agent will be double curing in action. Therefore, in the present study, an attempt has been made to synthesize novel hydrogels for the release of the model drug ciprofloxacin, a drug for diverticulitis. This paper discusses the synthesis, characterization, and in vitro release of ciprofloxacin from drug-loaded hydrogels in solutions of different pHs and simulated gastric and intestinal fluid. A non-Fickian diffusion mechanism has been observed for the release of the drug from drug-loaded hydrogels. This article also discusses the mechanistic implications of the cross-linking of Sterculia gum with methacrylamide in the presence of N,N'-methylenebisacrylamide (N,N'-MBAAm) cross-linker.
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Synthesis and Characterization of Sterculia Gum Based pH Responsive Drug Delivery System for Use in Colon Cancer
Journal of Macromolecular Science Part A, 2009Co-Authors: Baljit Singh, Nisha SharmaAbstract:The present study deals with the modification of Sterculia gum to develop the novel colon specific delivery system for use in colon cancer. The Sterculia and acrylic acid based hydrogels were synthesized and characterized with FTIR, SEMs, TGA and swelling behavior. Swelling studies of the hydrogels were carried out as a function of reaction parameters such as monomer concentration, initiator concentration, amount of Sterculia gum and crosslinker concentration and nature of swelling mediums. Swelling kinetics of the hydrogels and in vitro release dynamics of anticancer model drug methotrexate from the hydrogels were studied to evaluate the swelling mechanism and drug release mechanism from the drug-loaded hydrogels. The values of diffusion exponent for the release of drug were 0.883, 0.910 and 0.787 in distilled water, pH 2.2 buffer and pH 7.4 buffer, respectively. The release of drug from the polymer matrix occurred through a non -Fickian type diffusion mechanism.
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Development of Sterculia gum based wound dressings for use in drug delivery
European Polymer Journal, 2008Co-Authors: Baljit Singh, Lok PalAbstract:Abstract The present study deals with the modification of Sterculia gum to develop the novel wounds dressing for the delivery of antimicrobial agent (tetracycline hydrochloride). The Sterculia crosslinked PVA (Sterculia- cl -PVA) hydrogels were characterized by FTIR and swelling studies. For the evaluation of swelling and drug release mechanism, the swelling kinetics and in vitro release dynamics of model drug from this matrix were studied in solution of different pH and simulated wounds fluid. Per gram of polymer has taken (8.3 ± 0.1) g of simulated wounds fluid and has released (0.820 ± 0.6) mg of drug in the simulated fluid. The value of the ‘ n ’ (0.84) indicates the non-Fickian diffusion mechanism for the release of drug in simulated fluids.
Paulo A Z Suarez - One of the best experts on this subject based on the ideXlab platform.
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thermal behavior of Sterculia striata oil
Thermochimica Acta, 2013Co-Authors: Maria Beatriz Pereira Mangas, Vinicius M Mello, Paulo A Z SuarezAbstract:Abstract The thermal behavior of Sterculia striata oil, which is rich in fatty acids containing a cyclopropenyl ring in their chain, mainly malvalic acid (7-(2-octylcycloprop-1-en-1-yl) heptanoic acid) and sterculic acid (8-(2-octylcycloprop-1-en-1-yl) octanoic acid), is evaluated. Thermogravimetric analysis (TGA) has shown that weight loss occurs from 280 °C. Differential scanning calorimetric (DSC) analysis indicates two exothermic events: one related to the ring opening in cyclopropenoids fatty acids chains and another to the pyrolitic decomposition of the oil, mainly the cracking of the ester groups. 1H NMR analysis revealed that the opening process of the cyclopropenyl ring starts at 150 °C, probably via either a di-radical or a vinylcarbene intermediates. This process leads to the formation of a six members ring with a double bond in a terminal chain. After 280 °C, the pyrolysis starts to decompose the ester groups into carboxylic acids. FT-IR analysis corroborated the results found by the other techniques.
Dilipkumar Pal - One of the best experts on this subject based on the ideXlab platform.
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Gelled Microparticles/Beads of Sterculia Gum and Tamarind Gum for Sustained Drug Release
Polymer Gels, 2018Co-Authors: Amit Kumar Nayak, M. Saquib Hasnain, Dilipkumar PalAbstract:In recent years, a variety of biocompatible natural polysaccharides are extensively investigated as pharmaceutical excipients in designing various pharmaceutical formulations. Among these, Sterculia gum and tamarind gum have emerged as two popular biopolymer candidates, which have found their applications in designing of various sustained drug releasing dosage forms. Presently, both Sterculia gum and tamarind gum have been employed to design oral multiple unit sustained release systems such as microparticles, beads. The present chapter deals with a helpful and comprehensive discussion on already reported different microparticles/beads made of Sterculia gum and tamarind gum, which have shown a promise in sustained drug releasing capacity over a longer period after oral administration. This chapter will be helpful in applying appropriate strategies or achieving desired controlled sustained drug release profiles from microparticles/beads made of Sterculia gum and tamarind gum.
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gelled microparticles beads of Sterculia gum and tamarind gum for sustained drug release
2018Co-Authors: Amit Kumar Nayak, Saquib M Hasnain, Dilipkumar PalAbstract:In recent years, a variety of biocompatible natural polysaccharides are extensively investigated as pharmaceutical excipients in designing various pharmaceutical formulations. Among these, Sterculia gum and tamarind gum have emerged as two popular biopolymer candidates, which have found their applications in designing of various sustained drug releasing dosage forms. Presently, both Sterculia gum and tamarind gum have been employed to design oral multiple unit sustained release systems such as microparticles, beads. The present chapter deals with a helpful and comprehensive discussion on already reported different microparticles/beads made of Sterculia gum and tamarind gum, which have shown a promise in sustained drug releasing capacity over a longer period after oral administration. This chapter will be helpful in applying appropriate strategies or achieving desired controlled sustained drug release profiles from microparticles/beads made of Sterculia gum and tamarind gum.
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Sterculia Gum-Based Hydrogels for Drug Delivery Applications
Polymeric Hydrogels as Smart Biomaterials, 2015Co-Authors: Amit Kumar Nayak, Dilipkumar PalAbstract:Sterculia gum is one of the medicinally important plant-derived water soluble polysaccharides obtained from the exudate of the tree, Sterculia urens (Family: Sterculiaceae). It is recognized as a promising biodegradable material in the development of various biomedical applications including drug delivery applications, wound dressing applications, etc. Sterculia gum is also employed as excipient in the designing of various pharmaceutical applications. In recent years, several attempts for the modification of Sterculia gum have been undertaken to develop Sterculia gum-based hydrogels for controlling the rate of hydration and swelling, and also tailoring the release profile of various types of drugs. In the development of these Sterculia gum-based hydrogels, modifications of Sterculia gum through polymer blending, cross-linking, interpenetrated polymer network (IPN) formation, polymer grafting, etc., were investigated for improved drug delivery applications. Most of these already reported Sterculia gum-based hydrogels were found effective for gastroretentive deliveries as wound dressings for sustained release of various drugs. The current chapter deals with a comprehensive and useful discussion on already investigated Sterculia gum-based hydrogels for the use in drug delivery applications, where the first portion of the chapter contains source, composition, and properties of Sterculia gum and the latter portion contains discussion on the formulations of various Sterculia gum-based hydrogel systems used for various types of drug delivery applications.
