The Experts below are selected from a list of 99 Experts worldwide ranked by ideXlab platform
Mats Eriksson - One of the best experts on this subject based on the ideXlab platform.
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reverse cholesterol transport in man promotion of fecal Steroid Excretion by infusion of reconstituted hdl
Atherosclerosis Supplements, 2002Co-Authors: Bo Angelin, Paolo Parini, Mats ErikssonAbstract:Abstract Reverse cholesterol transport is a complex process, which transfers cholesterol from peripheral cells to the liver for subsequent elimination as bile acids and neutral Steroids. Although apo A-I in high density lipoproteins (HDL) is believed to have a crucial role in this process, clinical conditions with very low HDL cholesterol levels appear to maintain normal cholesterol Excretion. On the other hand, infusion of ‘artificial HDL’ in the form of recombinant proapo A-I (4 g) liposome complexes results in increased fecal Steroid Excretion, corresponding to a removal of ≈0.5 g cholesterol daily for up to 9 days. This occurs without evidence of increased cholesterol synthesis, and could not be reproduced by infusion of liposomes only. These data indicate that stimulation of reverse cholesterol transport may be induced by infusion of ‘artificial HDL’ in humans, and that a more detailed knowledge of this process may be useful in the treatment of atherosclerosis.
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stimulation of fecal Steroid Excretion after infusion of recombinant proapolipoprotein a i potential reverse cholesterol transport in humans
Circulation, 1999Co-Authors: Mats Eriksson, Tatu A. Miettinen, Lars A Carlson, Bo AngelinAbstract:Background—Apolipoprotein (apo) A-I is the major protein component of HDL, a cholesterol transport particle that protects against atherosclerosis. Apo A-I is believed to promote reverse cholesterol transport, transferring cholesterol from peripheral cells to the liver for subsequent elimination. To test this hypothesis in humans, we measured fecal Steroid Excretion before and after the intravenous infusion of human proapo A-I (precursor of apo A-I) liposome complexes. Methods and Results—Four subjects with heterozygous familial hypercholesterolemia were studied under standardized conditions. The fecal Excretion of bile acids and neutral sterols was determined for 9 days before and 9 days after an intravenous infusion of recombinant human proapo A-I (4 g protein) liposome complexes. Plasma apoA-I and HDL cholesterol levels increased transiently (mean peak concentrations were 64% and 35% above baseline, respectively) during the first 24 hours. Mean lipoprotein lipid and apolipoprotein levels were not differ...
Bo Angelin - One of the best experts on this subject based on the ideXlab platform.
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reverse cholesterol transport in man promotion of fecal Steroid Excretion by infusion of reconstituted hdl
Atherosclerosis Supplements, 2002Co-Authors: Bo Angelin, Paolo Parini, Mats ErikssonAbstract:Abstract Reverse cholesterol transport is a complex process, which transfers cholesterol from peripheral cells to the liver for subsequent elimination as bile acids and neutral Steroids. Although apo A-I in high density lipoproteins (HDL) is believed to have a crucial role in this process, clinical conditions with very low HDL cholesterol levels appear to maintain normal cholesterol Excretion. On the other hand, infusion of ‘artificial HDL’ in the form of recombinant proapo A-I (4 g) liposome complexes results in increased fecal Steroid Excretion, corresponding to a removal of ≈0.5 g cholesterol daily for up to 9 days. This occurs without evidence of increased cholesterol synthesis, and could not be reproduced by infusion of liposomes only. These data indicate that stimulation of reverse cholesterol transport may be induced by infusion of ‘artificial HDL’ in humans, and that a more detailed knowledge of this process may be useful in the treatment of atherosclerosis.
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stimulation of fecal Steroid Excretion after infusion of recombinant proapolipoprotein a i potential reverse cholesterol transport in humans
Circulation, 1999Co-Authors: Mats Eriksson, Tatu A. Miettinen, Lars A Carlson, Bo AngelinAbstract:Background—Apolipoprotein (apo) A-I is the major protein component of HDL, a cholesterol transport particle that protects against atherosclerosis. Apo A-I is believed to promote reverse cholesterol transport, transferring cholesterol from peripheral cells to the liver for subsequent elimination. To test this hypothesis in humans, we measured fecal Steroid Excretion before and after the intravenous infusion of human proapo A-I (precursor of apo A-I) liposome complexes. Methods and Results—Four subjects with heterozygous familial hypercholesterolemia were studied under standardized conditions. The fecal Excretion of bile acids and neutral sterols was determined for 9 days before and 9 days after an intravenous infusion of recombinant human proapo A-I (4 g protein) liposome complexes. Plasma apoA-I and HDL cholesterol levels increased transiently (mean peak concentrations were 64% and 35% above baseline, respectively) during the first 24 hours. Mean lipoprotein lipid and apolipoprotein levels were not differ...
Helmut F Erbersdobler - One of the best experts on this subject based on the ideXlab platform.
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impact of β cyclodextrin and resistant starch on bile acid metabolism and fecal Steroid Excretion in regard to their hypolipidemic action in hamsters
Biochimica et Biophysica Acta, 1999Co-Authors: Elke A Trautwein, Karin Forgbert, Dorte Rieckhoff, Helmut F ErbersdoblerAbstract:Abstract To examine the impact on bile acid metabolism and fecal Steroid Excretion as a mechanism involved in the lipid-lowering action of β-cyclodextrin and resistant starch in comparison to cholestyramine, male golden Syrian hamsters were fed 0% (control), 8% or 12% of β-cyclodextrin or resistant starch or 1% cholestyramine. Resistant starch, β-cyclodextrin and cholestyramine significantly lowered plasma total cholesterol and triacylglycerol concentrations compared to control. Distinct changes in the bile acid profile of gallbladder bile were caused by resistant starch, β-cyclodextrin and cholestyramine. While cholestyramine significantly reduced chenodeoxycholate independently of its taurine–glycine conjugation, β-cyclodextrin and resistant starch decreased especially the percentage of taurochenodeoxycholate by −75% and −44%, respectively. As a result, the cholate:chenodeoxycholate ratio was significantly increased by 100% with β-cyclodextrin and by 550% with cholestyramine while resistant starch revealed no effect on this ratio. β-Cyclodextrin and resistant starch, not cholestyramine, significantly increased the glycine:taurine conjugation ratio demonstrating the predominance of glycine conjugated bile acids. Daily fecal Excretion of bile acids was 4-times higher with 8% β-cyclodextrin and 19-times with 1% cholestyramine compared to control. β-Cyclodextrin and cholestyramine also induced a 2-fold increase in fecal neutral sterol Excretion, demonstrating the sterol binding capacity of these two compounds. Resistant starch had only a modest effect on fecal bile acid Excretion (80% increase) and no effect on Excretion of neutral sterols, suggesting a weak interaction with intestinal Steroid absorption. These data demonstrate the lipid-lowering potential of β-cyclodextrin and resistant starch. An impaired reabsorption of circulating bile acids and intestinal cholesterol absorption leading to an increase in fecal bile acid and neutral sterol Excretion is most likely the primary mechanism responsible for the lipid-lowering action of β-cyclodextrin. In contrast, other mechanisms involving the alterations in the biliary bile acid profile or repressed hepatic lipogenesis, e.g., VLDL production, appear to be involved in the hypolipidemic effect of resistant starch.
Adrian A Franke - One of the best experts on this subject based on the ideXlab platform.
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urinary sex Steroid Excretion levels during a soy intervention among young girls a pilot study
Nutrition and Cancer, 2005Co-Authors: Gertraud Maskarinec, Yukiko Morimoto, Rachel Novotny, Frank J Nordt, Frank Z Stanczyk, Adrian A FrankeAbstract:Soy intake early in life may protect against breast cancer later in life, possibly by altering sex hormone metabolism. We evaluated the feasibility of assessing urinary sex Steroid Excretion among 20 young girls aged 8–14 yr in an 8-wk trial. The girls consumed one daily soy serving, collected weekly overnight urine samples, and reported Tanner stages for breast and pubic hair development. Sex Steroid Excretion was measured in duplicate by gas chromatography-mass spectrometry and adjusted for urinary creatinine. The respective coefficients of variation for estrone, estradiol, estriol, testosterone, pregnanediol were 11.4%, 10.4%, 8.4%, 12.8%, and 4.6%. The statistical analysis included t-tests, Spearman's correlations, and analysis of variance. Seventeen girls completed the study and showed good compliance with the intervention strategy. We observed nonsignificant increases in total androgens (0.11 μg/mg creatinine) and total estrogens (0.001 μg/mg creatinine) and a nonsignificant decrease in pregnanediol ( −0.03 μg/mg creatinine) during the study period. Higher Tanner stages for pubic hair development were associated with ninefold higher estrogen, fourfold higher androgen, and twofold higher pregnanediol Excretions (P = 0.01, P < 0.001, and P = 0.047, respectively). Similar differences were observed after stratification by breast development and menarcheal status. The association of sex Steroid levels with pubertal development supports the validity of the sex Steroid measurements.
T J Cole - One of the best experts on this subject based on the ideXlab platform.
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comparative effects of four legume species on plasma lipids and faecal Steroid Excretion in hypercholesterolaemic pigs
British Journal of Nutrition, 1993Co-Authors: Susan M Kingman, Ann F Walker, Ian E Sambrook, R W Owen, T J ColeAbstract:The effect of four species of legume seeds on plasma cholesterol levels and faecal Steroid Excretion was studied in pigs. Thirty-six growing boars were randomly allocated in groups of six to six diets which they ate continuously for 42 d. The diets fed were: 1, a semi-purified (SP; control group 1) diet; 2, SP 10 g cholesterol/kg (control group 2); 3, 4, 5, 6, SP + cooked legumes (70:30, w/w; respectively baked beans (Phaseolus vulgaris), peas (Pisum sativum), lentils (Lens culinaris Medik.), butter beans (Phaseolus lunatus)) + 10 g cholesterol/kg. Fasting blood samples were taken on days 0, 14, 28, and 42 for the determination of total plasma cholesterol, high-density-lipoprotein (HDL)-cholesterol and triacylglycerols. Between days 7 and 11 and days 28 and 32 complete 5 d faecal collections were made for the measurement of neutral, acidic and conjugated Steroids. After 42 d total cholesterol and HDL-cholesterol levels were raised significantly in all groups, but to different extents. In comparison with control group 2, diet-induced hypercholesterolaemia was significantly inhibited in the groups consuming baked beans, peas and butter beans, although HDL-cholesterol levels were maintained. Faecal Steroid Excretion by the legume groups was not significantly different from that of control group 2. The results suggest that the mechanism for the hypocholesterolaemic effect does not involve increased hepatic bile acid synthesis and thereby increased cholesterol clearance via the intestinal route.