The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
David R Stapells - One of the best experts on this subject based on the ideXlab platform.
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monotic versus dichotic multiple Stimulus auditory steady state responses in young children
Ear and Hearing, 2013Co-Authors: Jennifer L Hatton, David R StapellsAbstract:In their recent study on infant multiple auditory steady state responses (ASSR), the authors found that ASSR amplitudes unexpectedly decreased when switching from 1-ear stimulation to 2-ear stimulation, a result not present in adults. In addition, residual EEG noise levels increased in the 2-ear Condition. In the present study, to determine whether to use 1-ear or 2-ear multiple ASSR Protocols clinically, the authors tested a new group of 19 young children to determine whether these unexpected findings could be replicated. ASSR amplitude and EEG noise were compared for 1-ear (4 stimuli) versus 2-ear (8 stimuli) multiple stimuli presented at 60 dBHL. Results indicated a small but significant decrease in amplitudes going from 1-ear (40.1 nV) to 2-ear (37.9 nV) multiple stimuli. EEG noise was not significantly different between the 2 Conditions. Despite small amplitude decreases, the 2-ear Stimulus Condition was more efficient for infants and young children with normal hearing.
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the efficiency of the single versus multiple Stimulus auditory steady state responses in infants
Ear and Hearing, 2011Co-Authors: Jennifer L Hatton, David R StapellsAbstract:Objectives: Multiple auditory steady state responses (ASSRs) will likely be included in the diagnostic test battery for estimating infant auditory thresholds in the near future; however, the effects of single- versus multiple-Stimulus presentation in infants has never been investigated. In adults, there are no interactions (reduced amplitudes) between responses to multiple simultaneous stimuli presented at 60 dB SPL or lower. Maturational differences, however, may lead to greater interactions in infants; thus, it is unknown whether the single-Stimulus technique or the multiple-Stimulus technique is more efficient for testing infants. Two studies were carried out to address this issue. Design: All infants in study A participated in three Stimulus Conditions, which differed in the number of stimuli presented simultaneously. The monotic single (MS) Condition consisted of 500, 1000, 2000, and 4000 Hz tones, which were presented singly to one ear. The monotic multiple (MM) Condition was composed of four tones (500, 1000, 2000, and 4000 Hz) presented to one ear simultaneously. The dichotic multiple (DM) Condition consisted of eight tones presented simultaneously to both ears (four tones to each ear). ASSR amplitudes were obtained from 15 normal infants (mean age: 23.1 wks) in response to multiple (MM, DM) and single (MS) air conduction amplitude-modulated (AM) tones (77 to 105 Hz modulation rates; 60 dB SPL). In study B, ASSR thresholds were determined for 500-Hz stimuli in the single- and DM-Stimulus Conditions (14 infants; mean age: 20.2 wks). Results: Mean single-Stimulus ASSR amplitudes for 500, 1000, 2000, and 4000 Hz were 30, 39, 45 and 43 nV, respectively. Presentation of multiple AM tones (i.e., four octave-spaced frequencies) to one ear resulted in ASSR amplitudes that were 97%, 87%, 82%, and 70% (for 500, 1000, 2000, and 4000 Hz, respectively) of the single-Stimulus ASSR amplitudes. Results for the dichotic presentation of eight AM tones show ASSR amplitudes that were 70%, 77%, 67%, and 67% relative to the MS Condition. Although decreases in amplitude occurred using multiple stimuli in infants, the multiple ASSR remained more efficient than the single-Stimulus ASSR (i.e., multiple-Stimulus amplitudes were greater than single-Stimulus amplitudes divided by √K, where K is the number of stimuli). Results from study B indicate that ASSR thresholds for 500 Hz presented in the DM Condition were elevated 3 dB compared with that obtained in the 500-Hz single-Stimulus Condition. This statistically nonsignificant difference is within the range of acceptable test-retest variability and is thus not of clinical significance. Conclusions: The amplitude reductions seen in the multiple-Stimulus Conditions in infants, not seen in adults, could be related to maturational differences in the ear canal, middle ear, cochlea, and/or brain stem. Because greater interactions occur in the DM-Stimulus Condition compared with the monotic multiple-Stimulus Condition and baseline single-Stimulus Condition, brain stem origins of these interactions are likely. Study B revealed statistically nonsignificant differences between threshold for 500 Hz when presented in the single- and DM-Stimulus Conditions. In summary, as with adults, multiple-Stimulus presentation in infants is more efficient than single AM tones, at least for 60 dB SPL stimuli.
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the effect of brief tone Stimulus duration on the brain stem auditory steady state response
Ear and Hearing, 2007Co-Authors: David R StapellsAbstract:OBJECTIVE To investigate the effect of brief-tone Stimulus duration on the amplitude of the brain stem auditory steady-state response (ASSR), both in single- and multiple-Stimulus Conditions. DESIGN In Experiment 1, the primary stimuli were Blackman-windowed 500- and 2000-Hz brief tones presented using repetition rates of 79 and 83 Hz, respectively. Stimuli had durations ranging from 0.5 to 12 msec. In the single-Stimulus Condition, these two stimuli were presented dichotically, whereas in the four-Stimulus multiple-Stimulus Condition, instead of being presented alone, each Stimulus was combined with three interfering stimuli, which were also Blackman-windowed brief tones spaced one octave apart, and presented at rates of 77 to 96 Hz. In Experiment 2, the effect of brief-tone duration and the effect of interfering stimuli were further studied by systematically removing interfering stimuli from the multiple stimuli, with the goal of determining which specific stimuli in the multiple stimuli were responsible for the interference. In both experiments, stimuli were presented at 75 ppe dB SPL. The subjects were normal-hearing adults, who relaxed or slept during the recording sessions. RESULTS Experiment 1: ASSR amplitudes increased as Stimulus duration decreased in the single-Stimulus Condition, for both 500 and 2000 Hz. However, amplitudes did not significantly increase until stimuli were quite brief (2 msec for 2000 Hz; 6 msec for 500 Hz). In the four-Stimulus multiple-Stimulus Condition, the pattern of amplitude increase with decreasing Stimulus duration at 2000 Hz was similar to that in the single-Stimulus Condition, although amplitudes at all durations were reduced. However, for 500-Hz stimuli in the four-Stimulus multiple-Stimulus Condition, ASSR amplitudes showed no change as Stimulus duration decreased. Experiment 2: for 2000-Hz stimuli, the 4000-Hz interfering stimuli resulted in the largest change in amplitude, the 1000-Hz interfering stimuli had a small effect, and the 500-Hz interfering stimuli had no effect. For 500-Hz stimuli, the 1000-Hz interfering stimuli had the greatest effect, the 2000-Hz interfering stimuli the next largest, and the 4000-Hz interfering stimuli a small effect. The interference effects for 500-Hz stimuli occurred only for brief (< or =6 msec) stimuli, with no effects of the interfering stimuli when the 500-Hz stimuli were 8 or 12 msec in duration. CONCLUSION Although brief tones may result in larger-amplitude ASSRs, their duration must be quite brief (not more than three to four cycles) to show a significant amplitude increase. Moreover, when presented together with other stimuli in the multiple-Stimulus technique, response interference reduces the amplitudes of ASSRs, and for 500 Hz removes the amplitude gain normally seen with decreasing duration. Brief-tone stimuli, therefore, may not be optimal for ASSR threshold estimation, especially because of the compromise in frequency specificity accompanying the use of very brief tones.
Jennifer L Hatton - One of the best experts on this subject based on the ideXlab platform.
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monotic versus dichotic multiple Stimulus auditory steady state responses in young children
Ear and Hearing, 2013Co-Authors: Jennifer L Hatton, David R StapellsAbstract:In their recent study on infant multiple auditory steady state responses (ASSR), the authors found that ASSR amplitudes unexpectedly decreased when switching from 1-ear stimulation to 2-ear stimulation, a result not present in adults. In addition, residual EEG noise levels increased in the 2-ear Condition. In the present study, to determine whether to use 1-ear or 2-ear multiple ASSR Protocols clinically, the authors tested a new group of 19 young children to determine whether these unexpected findings could be replicated. ASSR amplitude and EEG noise were compared for 1-ear (4 stimuli) versus 2-ear (8 stimuli) multiple stimuli presented at 60 dBHL. Results indicated a small but significant decrease in amplitudes going from 1-ear (40.1 nV) to 2-ear (37.9 nV) multiple stimuli. EEG noise was not significantly different between the 2 Conditions. Despite small amplitude decreases, the 2-ear Stimulus Condition was more efficient for infants and young children with normal hearing.
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the efficiency of the single versus multiple Stimulus auditory steady state responses in infants
Ear and Hearing, 2011Co-Authors: Jennifer L Hatton, David R StapellsAbstract:Objectives: Multiple auditory steady state responses (ASSRs) will likely be included in the diagnostic test battery for estimating infant auditory thresholds in the near future; however, the effects of single- versus multiple-Stimulus presentation in infants has never been investigated. In adults, there are no interactions (reduced amplitudes) between responses to multiple simultaneous stimuli presented at 60 dB SPL or lower. Maturational differences, however, may lead to greater interactions in infants; thus, it is unknown whether the single-Stimulus technique or the multiple-Stimulus technique is more efficient for testing infants. Two studies were carried out to address this issue. Design: All infants in study A participated in three Stimulus Conditions, which differed in the number of stimuli presented simultaneously. The monotic single (MS) Condition consisted of 500, 1000, 2000, and 4000 Hz tones, which were presented singly to one ear. The monotic multiple (MM) Condition was composed of four tones (500, 1000, 2000, and 4000 Hz) presented to one ear simultaneously. The dichotic multiple (DM) Condition consisted of eight tones presented simultaneously to both ears (four tones to each ear). ASSR amplitudes were obtained from 15 normal infants (mean age: 23.1 wks) in response to multiple (MM, DM) and single (MS) air conduction amplitude-modulated (AM) tones (77 to 105 Hz modulation rates; 60 dB SPL). In study B, ASSR thresholds were determined for 500-Hz stimuli in the single- and DM-Stimulus Conditions (14 infants; mean age: 20.2 wks). Results: Mean single-Stimulus ASSR amplitudes for 500, 1000, 2000, and 4000 Hz were 30, 39, 45 and 43 nV, respectively. Presentation of multiple AM tones (i.e., four octave-spaced frequencies) to one ear resulted in ASSR amplitudes that were 97%, 87%, 82%, and 70% (for 500, 1000, 2000, and 4000 Hz, respectively) of the single-Stimulus ASSR amplitudes. Results for the dichotic presentation of eight AM tones show ASSR amplitudes that were 70%, 77%, 67%, and 67% relative to the MS Condition. Although decreases in amplitude occurred using multiple stimuli in infants, the multiple ASSR remained more efficient than the single-Stimulus ASSR (i.e., multiple-Stimulus amplitudes were greater than single-Stimulus amplitudes divided by √K, where K is the number of stimuli). Results from study B indicate that ASSR thresholds for 500 Hz presented in the DM Condition were elevated 3 dB compared with that obtained in the 500-Hz single-Stimulus Condition. This statistically nonsignificant difference is within the range of acceptable test-retest variability and is thus not of clinical significance. Conclusions: The amplitude reductions seen in the multiple-Stimulus Conditions in infants, not seen in adults, could be related to maturational differences in the ear canal, middle ear, cochlea, and/or brain stem. Because greater interactions occur in the DM-Stimulus Condition compared with the monotic multiple-Stimulus Condition and baseline single-Stimulus Condition, brain stem origins of these interactions are likely. Study B revealed statistically nonsignificant differences between threshold for 500 Hz when presented in the single- and DM-Stimulus Conditions. In summary, as with adults, multiple-Stimulus presentation in infants is more efficient than single AM tones, at least for 60 dB SPL stimuli.
Youichi Saitoh - One of the best experts on this subject based on the ideXlab platform.
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analgesic effects of repetitive transcranial magnetic stimulation at different Stimulus parameters for neuropathic pain a randomized study
Neuromodulation, 2021Co-Authors: Nobuhiko Mori, Koichi Hosomi, Asaya Nishi, Satoru Oshino, Haruhiko Kishima, Youichi SaitohAbstract:Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1-rTMS) using different stimulation parameters to explore the optimal Stimulus Condition for treating neuropathic pain. Materials and methods We conducted a randomized, blinded, crossover exploratory study. Four single sessions of M1-rTMS at different parameters were administered in random order. The tested stimulation Conditions were as follows: 5-Hz with 500 pulses per session, 10-Hz with 500 pulses per session, 10-Hz with 2000 pulses per session, and sham stimulation. Analgesic effects were assessed by determining the visual analog scale (VAS) pain intensity score and Short-Form McGill Pain Questionnaire 2 (SF-MPQ2) score immediately before and immediately after intervention. Results We enrolled 22 adults (age: 59.8 ± 12.1 years) with intractable neuropathic pain. Linear-effects models showed significant effects of the stimulation Condition on changes in VAS pain intensity (p = 0.03) and SF-MPQ2 (p = 0.01). Tukey multiple comparison tests revealed that 10-Hz rTMS with 2000 pulses provided better pain relief than sham stimulation, with greater decreases in VAS pain intensity (p = 0.03) and SF-MPQ2 (p = 0.02). Conclusions The results of this study suggest that high-dose stimulation (specifically, 10-Hz rTMS at 2000 pulses) is more effective than lower-dose stimulation for treating neuropathic pain.
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p75 s exploratory study of optimal Stimulus parameters of repetitive transcranial magnetic stimulation for neuropathic pain
Clinical Neurophysiology, 2019Co-Authors: Nobuhiko Mori, Koichi Hosomi, Haruhiko Kishima, Tomoo Mano, Youichi SaitohAbstract:Background The analgesic effect of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) remained modest in patients with neuropathic pain (NP). The aim of the present study was to investigate analgesic effects of M1-rTMS at different Stimulus parameters to explore an optimal stimulation Condition for treating NP. Material and methods We conducted a randomized, blinded, crossover exploratory study. M1-rTMS at different parameters were administered in random order at least two weeks apart. The tested Stimulus Conditions were 5-Hz with 500 pulses per session; 10-Hz with 500 pulses; 10-Hz with 2,000 pulses; and sham stimulation. The outcome measures were a visual analogue scale (VAS), and the Short-form McGill Pain Questionnaire 2 (SF-MPQ-2). Statistical analyses were performed by a mixed-effect model (fixed effect: intervention, order, interaction between intervention and order; random effect: subject) and multiple comparisons. Results We enrolled 23 patients (11 men; mean age, 60.0 years) suffering from intractable neuropathic pain. There was a significant effect of intervention (i.e. Stimulus Condition) on VAS and SF-MPQ-2 (p = 0.03 and 0.01, respectively). Multiple comparisons with correction revealed that 10-Hz rTMS with 2,000 pulses provided better pain relief on VAS and SF-MPQ-2 compared to sham (p = 0.03 and 0.02, respectively). Conclusions The results of this study suggest that Stimulus frequency and number of pulses should be taken into account for trials of M1-rTMS for treating NP.
Nobuhiko Mori - One of the best experts on this subject based on the ideXlab platform.
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analgesic effects of repetitive transcranial magnetic stimulation at different Stimulus parameters for neuropathic pain a randomized study
Neuromodulation, 2021Co-Authors: Nobuhiko Mori, Koichi Hosomi, Asaya Nishi, Satoru Oshino, Haruhiko Kishima, Youichi SaitohAbstract:Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1-rTMS) using different stimulation parameters to explore the optimal Stimulus Condition for treating neuropathic pain. Materials and methods We conducted a randomized, blinded, crossover exploratory study. Four single sessions of M1-rTMS at different parameters were administered in random order. The tested stimulation Conditions were as follows: 5-Hz with 500 pulses per session, 10-Hz with 500 pulses per session, 10-Hz with 2000 pulses per session, and sham stimulation. Analgesic effects were assessed by determining the visual analog scale (VAS) pain intensity score and Short-Form McGill Pain Questionnaire 2 (SF-MPQ2) score immediately before and immediately after intervention. Results We enrolled 22 adults (age: 59.8 ± 12.1 years) with intractable neuropathic pain. Linear-effects models showed significant effects of the stimulation Condition on changes in VAS pain intensity (p = 0.03) and SF-MPQ2 (p = 0.01). Tukey multiple comparison tests revealed that 10-Hz rTMS with 2000 pulses provided better pain relief than sham stimulation, with greater decreases in VAS pain intensity (p = 0.03) and SF-MPQ2 (p = 0.02). Conclusions The results of this study suggest that high-dose stimulation (specifically, 10-Hz rTMS at 2000 pulses) is more effective than lower-dose stimulation for treating neuropathic pain.
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p75 s exploratory study of optimal Stimulus parameters of repetitive transcranial magnetic stimulation for neuropathic pain
Clinical Neurophysiology, 2019Co-Authors: Nobuhiko Mori, Koichi Hosomi, Haruhiko Kishima, Tomoo Mano, Youichi SaitohAbstract:Background The analgesic effect of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) remained modest in patients with neuropathic pain (NP). The aim of the present study was to investigate analgesic effects of M1-rTMS at different Stimulus parameters to explore an optimal stimulation Condition for treating NP. Material and methods We conducted a randomized, blinded, crossover exploratory study. M1-rTMS at different parameters were administered in random order at least two weeks apart. The tested Stimulus Conditions were 5-Hz with 500 pulses per session; 10-Hz with 500 pulses; 10-Hz with 2,000 pulses; and sham stimulation. The outcome measures were a visual analogue scale (VAS), and the Short-form McGill Pain Questionnaire 2 (SF-MPQ-2). Statistical analyses were performed by a mixed-effect model (fixed effect: intervention, order, interaction between intervention and order; random effect: subject) and multiple comparisons. Results We enrolled 23 patients (11 men; mean age, 60.0 years) suffering from intractable neuropathic pain. There was a significant effect of intervention (i.e. Stimulus Condition) on VAS and SF-MPQ-2 (p = 0.03 and 0.01, respectively). Multiple comparisons with correction revealed that 10-Hz rTMS with 2,000 pulses provided better pain relief on VAS and SF-MPQ-2 compared to sham (p = 0.03 and 0.02, respectively). Conclusions The results of this study suggest that Stimulus frequency and number of pulses should be taken into account for trials of M1-rTMS for treating NP.
Haruhiko Kishima - One of the best experts on this subject based on the ideXlab platform.
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analgesic effects of repetitive transcranial magnetic stimulation at different Stimulus parameters for neuropathic pain a randomized study
Neuromodulation, 2021Co-Authors: Nobuhiko Mori, Koichi Hosomi, Asaya Nishi, Satoru Oshino, Haruhiko Kishima, Youichi SaitohAbstract:Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1-rTMS) using different stimulation parameters to explore the optimal Stimulus Condition for treating neuropathic pain. Materials and methods We conducted a randomized, blinded, crossover exploratory study. Four single sessions of M1-rTMS at different parameters were administered in random order. The tested stimulation Conditions were as follows: 5-Hz with 500 pulses per session, 10-Hz with 500 pulses per session, 10-Hz with 2000 pulses per session, and sham stimulation. Analgesic effects were assessed by determining the visual analog scale (VAS) pain intensity score and Short-Form McGill Pain Questionnaire 2 (SF-MPQ2) score immediately before and immediately after intervention. Results We enrolled 22 adults (age: 59.8 ± 12.1 years) with intractable neuropathic pain. Linear-effects models showed significant effects of the stimulation Condition on changes in VAS pain intensity (p = 0.03) and SF-MPQ2 (p = 0.01). Tukey multiple comparison tests revealed that 10-Hz rTMS with 2000 pulses provided better pain relief than sham stimulation, with greater decreases in VAS pain intensity (p = 0.03) and SF-MPQ2 (p = 0.02). Conclusions The results of this study suggest that high-dose stimulation (specifically, 10-Hz rTMS at 2000 pulses) is more effective than lower-dose stimulation for treating neuropathic pain.
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p75 s exploratory study of optimal Stimulus parameters of repetitive transcranial magnetic stimulation for neuropathic pain
Clinical Neurophysiology, 2019Co-Authors: Nobuhiko Mori, Koichi Hosomi, Haruhiko Kishima, Tomoo Mano, Youichi SaitohAbstract:Background The analgesic effect of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) remained modest in patients with neuropathic pain (NP). The aim of the present study was to investigate analgesic effects of M1-rTMS at different Stimulus parameters to explore an optimal stimulation Condition for treating NP. Material and methods We conducted a randomized, blinded, crossover exploratory study. M1-rTMS at different parameters were administered in random order at least two weeks apart. The tested Stimulus Conditions were 5-Hz with 500 pulses per session; 10-Hz with 500 pulses; 10-Hz with 2,000 pulses; and sham stimulation. The outcome measures were a visual analogue scale (VAS), and the Short-form McGill Pain Questionnaire 2 (SF-MPQ-2). Statistical analyses were performed by a mixed-effect model (fixed effect: intervention, order, interaction between intervention and order; random effect: subject) and multiple comparisons. Results We enrolled 23 patients (11 men; mean age, 60.0 years) suffering from intractable neuropathic pain. There was a significant effect of intervention (i.e. Stimulus Condition) on VAS and SF-MPQ-2 (p = 0.03 and 0.01, respectively). Multiple comparisons with correction revealed that 10-Hz rTMS with 2,000 pulses provided better pain relief on VAS and SF-MPQ-2 compared to sham (p = 0.03 and 0.02, respectively). Conclusions The results of this study suggest that Stimulus frequency and number of pulses should be taken into account for trials of M1-rTMS for treating NP.