The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Lixi Wang - One of the best experts on this subject based on the ideXlab platform.
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highly organocatalytic asymmetric michael ketone aldol dehydration domino reaction Straightforward Approach to construct six membered spirocyclic oxindoles
Chemical Communications, 2010Co-Authors: Liangliang Wang, Li Peng, Qingchu Huang, Lixi WangAbstract:An efficient Michael–ketone aldol–dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).
Piet Herdewijn - One of the best experts on this subject based on the ideXlab platform.
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a short and Straightforward Approach towards 6 amino and 6 aminoalkyl thiazolo 4 5 c pyridazines
ChemInform, 2013Co-Authors: Alessandro Stella, Steven De Jonghe, Kenneth Segers, Piet HerdewijnAbstract:The synthesis of the title heterocycles is based on the cyclization reaction between pyridazine derivatives (I) and isothiocyanates or KSCN.
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a short and Straightforward Approach towards 6 amino and 6 aminoalkyl thiazolo 4 5 c pyridazines
Tetrahedron Letters, 2013Co-Authors: Alessandro Stella, Steven De Jonghe, Kenneth Segers, Piet HerdewijnAbstract:Abstract A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described.
Yingchun Wang - One of the best experts on this subject based on the ideXlab platform.
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metal free meerwein carboarylation of alkenes with anilines a Straightforward Approach to 3 benzyl 3 alkyloxindoles
ChemInform, 2015Co-Authors: Shi Tang, Dong Zhou, Yingchun WangAbstract:A metal-free carboarylation of N-acyl-methacrylamides and closely related substrates with anilines proceeds through radical C-H cyclization to yield 3,3-disubstituted oxindoles.
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metal free meerwein carboarylation of alkenes with anilines a Straightforward Approach to 3 benzyl 3 alkyloxindoles
European Journal of Organic Chemistry, 2014Co-Authors: Shi Tang, Dong Zhou, Yingchun WangAbstract:A metal-free, Straightforward carboarylation reaction of alkenes with anilines was developed that proceeds through a radical C–H cyclization. In the presence of benzoyl peroxide (5 mol-%), tert-butyl nitrite, and an array of anilines, a wide variety of N-arylacrylamides underwent a tandem Meerwein arylation/C–H cyclization to construct the pharmaceutically important 3-benzyl-3-alkyloxindole scaffold in moderate to good yields.
Liangliang Wang - One of the best experts on this subject based on the ideXlab platform.
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asymmetric double michael reaction catalyzed by simple primary amine catalysts a Straightforward Approach to construct spirocyclic oxindoles
Chinese Journal of Chemistry, 2012Co-Authors: Xiya Luo, Liangliang Wang, Lin Peng, Jianfei Bai, Lina Jia, Fang Tian, Lixin WangAbstract:The enantioselective double Michael reaction of N-Boc-3-nonsubstitued oxindoles with dienones catalyzed by chiral monoimide protected cyclohexane-1,2-diamines was developed. A wide range of optically active spirocyclic oxindoles were obtained up to 98% yield and up to 89% ee.
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highly organocatalytic asymmetric michael ketone aldol dehydration domino reaction Straightforward Approach to construct six membered spirocyclic oxindoles
ChemInform, 2011Co-Authors: Liangliang Wang, Lin Peng, Jianfei Bai, Qingchun Huang, Xiaoying Xu, Lixin WangAbstract:The title reaction affords six-membered spirocyclic oxindoles (III), bearing contiguous stereogenic centers in high yields and excellent dia- and enantioselectivities.
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highly organocatalytic asymmetric michael ketone aldol dehydration domino reaction Straightforward Approach to construct six membered spirocyclic oxindoles
Chemical Communications, 2010Co-Authors: Liangliang Wang, Li Peng, Qingchu Huang, Lixi WangAbstract:An efficient Michael–ketone aldol–dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).
Fayna Garcia Martin - One of the best experts on this subject based on the ideXlab platform.
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correction a Straightforward Approach to antibodies recognising cancer specific glycopeptidic neoepitopes
Chemical Science, 2020Co-Authors: Hajime Wakui, Yoshikazu Tanaka, Toyoyuki Ose, Isamu Matsumoto, Koji Kato, Yao Min, Taro Tachibana, Masaharu Sato, Kentaro Naruchi, Fayna Garcia MartinAbstract:Correction for ‘A Straightforward Approach to antibodies recognising cancer specific glycopeptidic neoepitopes’ by Hajime Wakui et al., Chem. Sci., 2020, 11, 4999–5006, DOI: 10.1039/D0SC00317D.
