The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Tobias Eisenberg - One of the best experts on this subject based on the ideXlab platform.

  • Acute Tetraplegia Caused by Rat Bite Fever in Snake Keeper and Transmission of Streptobacillus moniliformis
    Emerging Infectious Diseases, 2017
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Simon Poignant, Youenn Jouan, Christa Ewers, Laurent Mereghetti, Antoine Guillon
    Abstract:

    We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based evidence for infection with the same strain, and identified diagnostic difficulties concerning infection with this microorganism.

  • phylogenetic and comparative genomics of the family leptotrichiaceae and introduction of a novel fingerprinting mlva for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    Background The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis, the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties.

  • phylogenetic and comparative genomics of the family leptotrichiaceae and introduction of a novel fingerprinting mlva for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis, the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties. Our data provide a novel and reliable basis of support for previously established phylogeny from this group and give a deeper insight into characteristics of genome structure and gene functions. Full genome analyses revealed that most S. moniliformis strains under study form a heterogeneous population without any significant clustering. Analysis of infra-species variability for this highly pathogenic rat bite fever organism led to the detection of three specific variable number tandem analysis loci with high discriminatory power. This highly useful and economical tool can be directly employed in clinical samples without laborious prior cultivation. Our and prospective case-specific data can now easily be compared by using a newly established MLVA database in order to gain a better insight into the epidemiology of this presumably under-reported zoonosis.

  • Phylogenetic and comparative genomics of the family Leptotrichiaceae and introduction of a novel fingerprinting MLVA for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    Background The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis , the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties. Results Our data provide a novel and reliable basis of support for previously established phylogeny from this group and give a deeper insight into characteristics of genome structure and gene functions. Full genome analyses revealed that most S. moniliformis strains under study form a heterogeneous population without any significant clustering. Analysis of infra-species variability for this highly pathogenic rat bite fever organism led to the detection of three specific variable number tandem analysis loci with high discriminatory power. Conclusions This highly useful and economical tool can be directly employed in clinical samples without laborious prior cultivation. Our and prospective case-specific data can now easily be compared by using a newly established MLVA database in order to gain a better insight into the epidemiology of this presumably under-reported zoonosis.

  • Streptobacillus felis sp nov isolated from a cat with pneumonia and emended descriptions of the genus Streptobacillus and of Streptobacillus moniliformis
    International Journal of Systematic and Evolutionary Microbiology, 2015
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Stefanie P Glaeser, Norman Mauder, Matthias Contzen, Khayrieh Aledelbi, Peter Kampfer
    Abstract:

    A pleomorphic, Gram-stain-negative, rod-shaped, indole-, oxidase- and catalase-negative, non-spore-forming, non-motile bacterium (strain 131000547T) was isolated from the lungs of a cat with pneumonia. On the basis of 16S rRNA gene sequence analyses the strain was assigned to the genus Streptobacillus with 97.6  % sequence similarity to the type strain of Streptobacillus moniliformis and 94.6  % to that of Streptobacillus hongkongensis. The clear differentiation of strain 131000547T from Streptobacillus moniliformis and Streptobacillus hongkongensis was also supported by gyrB, groEL, and recA nucleotide and amino acid sequence analysis. DNA–DNA hybridization demonstrated ≤ 19.9  % (reciprocal 28.7  %) DNA–DNA relatedness between strain 131000547T and Streptobacillus moniliformis DSM 12112T. Physiological data confirmed the allocation of strain 131000547T to the family Leptotrichiaceae. Strain 131000547T has a unique profile of enzyme activities allowing differentiation from the most closely related species. Within the genus Streptobacillus, isolate 131000547T could also unambiguously be separated from Streptobacillus moniliformis and Streptobacillus hongkongensis by both matrix-assisted laser desorption ionization time-of-flight mass spectrometry and Fourier transform-infrared spectroscopy. On the basis of these data, a novel species of the genus Streptobacillus, Streptobacillus felis sp. nov., is proposed with the type strain 131000547T ( = DSM 29248T = CCUG 66203T = CCM 8542T). Emended descriptions of the genus Streptobacillus and of Streptobacillus moniliformis are also given.

Christa Ewers - One of the best experts on this subject based on the ideXlab platform.

  • Acute Tetraplegia Caused by Rat Bite Fever in Snake Keeper and Transmission of Streptobacillus moniliformis
    Emerging Infectious Diseases, 2017
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Simon Poignant, Youenn Jouan, Christa Ewers, Laurent Mereghetti, Antoine Guillon
    Abstract:

    We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based evidence for infection with the same strain, and identified diagnostic difficulties concerning infection with this microorganism.

  • phylogenetic and comparative genomics of the family leptotrichiaceae and introduction of a novel fingerprinting mlva for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    Background The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis, the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties.

  • phylogenetic and comparative genomics of the family leptotrichiaceae and introduction of a novel fingerprinting mlva for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis, the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties. Our data provide a novel and reliable basis of support for previously established phylogeny from this group and give a deeper insight into characteristics of genome structure and gene functions. Full genome analyses revealed that most S. moniliformis strains under study form a heterogeneous population without any significant clustering. Analysis of infra-species variability for this highly pathogenic rat bite fever organism led to the detection of three specific variable number tandem analysis loci with high discriminatory power. This highly useful and economical tool can be directly employed in clinical samples without laborious prior cultivation. Our and prospective case-specific data can now easily be compared by using a newly established MLVA database in order to gain a better insight into the epidemiology of this presumably under-reported zoonosis.

  • Phylogenetic and comparative genomics of the family Leptotrichiaceae and introduction of a novel fingerprinting MLVA for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    Background The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis , the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties. Results Our data provide a novel and reliable basis of support for previously established phylogeny from this group and give a deeper insight into characteristics of genome structure and gene functions. Full genome analyses revealed that most S. moniliformis strains under study form a heterogeneous population without any significant clustering. Analysis of infra-species variability for this highly pathogenic rat bite fever organism led to the detection of three specific variable number tandem analysis loci with high discriminatory power. Conclusions This highly useful and economical tool can be directly employed in clinical samples without laborious prior cultivation. Our and prospective case-specific data can now easily be compared by using a newly established MLVA database in order to gain a better insight into the epidemiology of this presumably under-reported zoonosis.

  • Physiological characteristics of field isolates and reference strains from Streptobacillus moniliformis and of reference strains from Streptobacillus felis 131000547T, Streptobacillus hongkongensis DSM 26322T and Sebaldella termitidis NCTC 11300T.
    2015
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Norman Mauder, Matthias Contzen, Khayrieh Aledelbi, Torsten Semmler, Jorg Rau, Nicola Hofmann, Christa Ewers
    Abstract:

    Physiological characteristics were obtained by an individual panel of eleven# discriminatory reactions designed for the identification of Streptobacillus spp. (Micronaut Strep2 and RPO; all Merlin Diagnostika GmbH)*, VITEK2-compact with the NHI card†, API-ZYM‡ (both bioMeriéux) and haemolytic properties on Columbia agar with 5% sheep blood; for congruent results see text; +: positive;-: negative; w: weak reaction;§ potential discriminatory character for species identificationPhysiological characteristics of field isolates and reference strains from Streptobacillus moniliformis and of reference strains from Streptobacillus felis 131000547T, Streptobacillus hongkongensis DSM 26322T and Sebaldella termitidis NCTC 11300T.

Samson Sy Wong - One of the best experts on this subject based on the ideXlab platform.

  • Streptobacillus moniliformis septic arthritis: a clinical entity distinct from rat-bite fever?
    BMC infectious diseases, 2007
    Co-Authors: Teresa Kf Wang, Samson Sy Wong
    Abstract:

    Background Streptobacillus moniliformis is a zoonotic agent associated with rodent contacts. Although it is more commonly reported to cause rat-bite fever with reactive arthritides, it can also lead to pyogenic infection of the joints.

  • Streptobacillus moniliformis septic arthritis a clinical entity distinct from rat bite fever
    BMC Infectious Diseases, 2007
    Co-Authors: Teresa Kf Wang, Samson Sy Wong
    Abstract:

    Streptobacillus moniliformis is a zoonotic agent associated with rodent contacts. Although it is more commonly reported to cause rat-bite fever with reactive arthritides, it can also lead to pyogenic infection of the joints. We present a lady with past history of osteoarthritis developing streptobacillary septic arthritides of the right knee and left wrist, and required antibiotic and arthrotomy for treatment. We also review 11 previously reported cases of streptobacillary septic arthritis to discuss the characteristics, treatment, prognosis of the infection, and illustrates the differences between streptobacillary rat-bite fever and septic arthritis. Among this patient population, most patients had potential contact with rats (91.6%). The knee is the most commonly affected joint (58.3%), and 83.3% patients having polyarticular involvement. As opposed to rat-bite fever, fever and rash was only present in 58.3% and 16.7% of patients respectively. S. moniliformis bacteremia is uncommon (8.4%) and the prognosis is good. Arthrocentesis is useful in distinguishing streptobacillary septic arthritis from reactive arthritis of rat-bite fever. The sole use of commercial media containing sodium polyanethol sulfonate may render the bacterial culture negative. A detailed history of possible exposure to rodents should be elicited from patients with arthritis in order to facilitate microbiologic diagnosis.

Werner Nicklas - One of the best experts on this subject based on the ideXlab platform.

  • Acute Tetraplegia Caused by Rat Bite Fever in Snake Keeper and Transmission of Streptobacillus moniliformis
    Emerging Infectious Diseases, 2017
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Simon Poignant, Youenn Jouan, Christa Ewers, Laurent Mereghetti, Antoine Guillon
    Abstract:

    We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based evidence for infection with the same strain, and identified diagnostic difficulties concerning infection with this microorganism.

  • phylogenetic and comparative genomics of the family leptotrichiaceae and introduction of a novel fingerprinting mlva for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    Background The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis, the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties.

  • phylogenetic and comparative genomics of the family leptotrichiaceae and introduction of a novel fingerprinting mlva for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis, the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties. Our data provide a novel and reliable basis of support for previously established phylogeny from this group and give a deeper insight into characteristics of genome structure and gene functions. Full genome analyses revealed that most S. moniliformis strains under study form a heterogeneous population without any significant clustering. Analysis of infra-species variability for this highly pathogenic rat bite fever organism led to the detection of three specific variable number tandem analysis loci with high discriminatory power. This highly useful and economical tool can be directly employed in clinical samples without laborious prior cultivation. Our and prospective case-specific data can now easily be compared by using a newly established MLVA database in order to gain a better insight into the epidemiology of this presumably under-reported zoonosis.

  • Phylogenetic and comparative genomics of the family Leptotrichiaceae and introduction of a novel fingerprinting MLVA for Streptobacillus moniliformis
    BMC Genomics, 2016
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Ahmad Fawzy, Torsten Semmler, Christa Ewers
    Abstract:

    Background The Leptotrichiaceae are a family of fairly unnoticed bacteria containing both microbiota on mucous membranes as well as significant pathogens such as Streptobacillus moniliformis , the causative organism of streptobacillary rat bite fever. Comprehensive genomic studies in members of this family have so far not been carried out. We aimed to analyze 47 genomes from 20 different member species to illuminate phylogenetic aspects, as well as genomic and discriminatory properties. Results Our data provide a novel and reliable basis of support for previously established phylogeny from this group and give a deeper insight into characteristics of genome structure and gene functions. Full genome analyses revealed that most S. moniliformis strains under study form a heterogeneous population without any significant clustering. Analysis of infra-species variability for this highly pathogenic rat bite fever organism led to the detection of three specific variable number tandem analysis loci with high discriminatory power. Conclusions This highly useful and economical tool can be directly employed in clinical samples without laborious prior cultivation. Our and prospective case-specific data can now easily be compared by using a newly established MLVA database in order to gain a better insight into the epidemiology of this presumably under-reported zoonosis.

  • Streptobacillus felis sp nov isolated from a cat with pneumonia and emended descriptions of the genus Streptobacillus and of Streptobacillus moniliformis
    International Journal of Systematic and Evolutionary Microbiology, 2015
    Co-Authors: Tobias Eisenberg, Werner Nicklas, Stefanie P Glaeser, Norman Mauder, Matthias Contzen, Khayrieh Aledelbi, Peter Kampfer
    Abstract:

    A pleomorphic, Gram-stain-negative, rod-shaped, indole-, oxidase- and catalase-negative, non-spore-forming, non-motile bacterium (strain 131000547T) was isolated from the lungs of a cat with pneumonia. On the basis of 16S rRNA gene sequence analyses the strain was assigned to the genus Streptobacillus with 97.6  % sequence similarity to the type strain of Streptobacillus moniliformis and 94.6  % to that of Streptobacillus hongkongensis. The clear differentiation of strain 131000547T from Streptobacillus moniliformis and Streptobacillus hongkongensis was also supported by gyrB, groEL, and recA nucleotide and amino acid sequence analysis. DNA–DNA hybridization demonstrated ≤ 19.9  % (reciprocal 28.7  %) DNA–DNA relatedness between strain 131000547T and Streptobacillus moniliformis DSM 12112T. Physiological data confirmed the allocation of strain 131000547T to the family Leptotrichiaceae. Strain 131000547T has a unique profile of enzyme activities allowing differentiation from the most closely related species. Within the genus Streptobacillus, isolate 131000547T could also unambiguously be separated from Streptobacillus moniliformis and Streptobacillus hongkongensis by both matrix-assisted laser desorption ionization time-of-flight mass spectrometry and Fourier transform-infrared spectroscopy. On the basis of these data, a novel species of the genus Streptobacillus, Streptobacillus felis sp. nov., is proposed with the type strain 131000547T ( = DSM 29248T = CCUG 66203T = CCM 8542T). Emended descriptions of the genus Streptobacillus and of Streptobacillus moniliformis are also given.

Teresa Kf Wang - One of the best experts on this subject based on the ideXlab platform.

  • Streptobacillus moniliformis septic arthritis: a clinical entity distinct from rat-bite fever?
    BMC infectious diseases, 2007
    Co-Authors: Teresa Kf Wang, Samson Sy Wong
    Abstract:

    Background Streptobacillus moniliformis is a zoonotic agent associated with rodent contacts. Although it is more commonly reported to cause rat-bite fever with reactive arthritides, it can also lead to pyogenic infection of the joints.

  • Streptobacillus moniliformis septic arthritis a clinical entity distinct from rat bite fever
    BMC Infectious Diseases, 2007
    Co-Authors: Teresa Kf Wang, Samson Sy Wong
    Abstract:

    Streptobacillus moniliformis is a zoonotic agent associated with rodent contacts. Although it is more commonly reported to cause rat-bite fever with reactive arthritides, it can also lead to pyogenic infection of the joints. We present a lady with past history of osteoarthritis developing streptobacillary septic arthritides of the right knee and left wrist, and required antibiotic and arthrotomy for treatment. We also review 11 previously reported cases of streptobacillary septic arthritis to discuss the characteristics, treatment, prognosis of the infection, and illustrates the differences between streptobacillary rat-bite fever and septic arthritis. Among this patient population, most patients had potential contact with rats (91.6%). The knee is the most commonly affected joint (58.3%), and 83.3% patients having polyarticular involvement. As opposed to rat-bite fever, fever and rash was only present in 58.3% and 16.7% of patients respectively. S. moniliformis bacteremia is uncommon (8.4%) and the prognosis is good. Arthrocentesis is useful in distinguishing streptobacillary septic arthritis from reactive arthritis of rat-bite fever. The sole use of commercial media containing sodium polyanethol sulfonate may render the bacterial culture negative. A detailed history of possible exposure to rodents should be elicited from patients with arthritis in order to facilitate microbiologic diagnosis.