The Experts below are selected from a list of 54564 Experts worldwide ranked by ideXlab platform
Robert A Dekemp - One of the best experts on this subject based on the ideXlab platform.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
Journal of Nuclear Cardiology, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min−1) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL·min−1). The generator yield (82Rb) and production efficiency (82Rb yield/82Sr parent activity) were measured and compared after this conversion to a common scale. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~ 24% at 50 mL·min−1. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~ 7% lower than RUBY-FILL® over the full period of clinical use.
-
comparing yield and efficiency of two approved rubidium 82 generators for pet imaging
The Journal of Nuclear Medicine, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:1499 Introduction: The exact amount of delivered radioisotopes for perfusion positron emission tomography (PET) is a defining parameter for imaging accuracy and repeatability. In this study the yield and efficiency of two Strontium-82/rubidium-82 (82Sr/82Rb) generators were sought for. Methods: The sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were collected for 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) was measured and compared after this conversion to a common scale. Results: At the start of clinical use, the 82Rb activity measured during daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001). Dose-calibrator ‘maximum’ values were found to under-estimate the integrated ‘total’ activity by ~24% at 50 mL/min. After converting the CardioGen-82® values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). Conclusions: 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. At the common scale of integrated total activity, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
viXra, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
manufacture of Strontium 82 rubidium 82 generators and quality control of rubidium 82 chloride for myocardial perfusion imaging in patients using positron emission tomography
Applied Radiation and Isotopes, 1999Co-Authors: Teresa M Alvarezdiez, Robert A Dekemp, Rob S. Beanlands, J VincentAbstract:Abstract We describe a protocol to manufacture 82 Sr/ 82 Rb generators and 82 RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82 Sr. The generators produced sterile and non-pyrogenic 82 RbCl for i.v. injection. No significant 82 Sr/ 85 Sr breakthroughs were observed after elution with 20 l of saline. The automated system delivered human doses of 82 RbCl accurately.
Ali Ahmadi - One of the best experts on this subject based on the ideXlab platform.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
Journal of Nuclear Cardiology, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min−1) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL·min−1). The generator yield (82Rb) and production efficiency (82Rb yield/82Sr parent activity) were measured and compared after this conversion to a common scale. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~ 24% at 50 mL·min−1. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~ 7% lower than RUBY-FILL® over the full period of clinical use.
-
comparing yield and efficiency of two approved rubidium 82 generators for pet imaging
The Journal of Nuclear Medicine, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:1499 Introduction: The exact amount of delivered radioisotopes for perfusion positron emission tomography (PET) is a defining parameter for imaging accuracy and repeatability. In this study the yield and efficiency of two Strontium-82/rubidium-82 (82Sr/82Rb) generators were sought for. Methods: The sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were collected for 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) was measured and compared after this conversion to a common scale. Results: At the start of clinical use, the 82Rb activity measured during daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001). Dose-calibrator ‘maximum’ values were found to under-estimate the integrated ‘total’ activity by ~24% at 50 mL/min. After converting the CardioGen-82® values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). Conclusions: 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. At the common scale of integrated total activity, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
viXra, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
Rob S. Beanlands - One of the best experts on this subject based on the ideXlab platform.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
Journal of Nuclear Cardiology, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min−1) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL·min−1). The generator yield (82Rb) and production efficiency (82Rb yield/82Sr parent activity) were measured and compared after this conversion to a common scale. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~ 24% at 50 mL·min−1. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~ 7% lower than RUBY-FILL® over the full period of clinical use.
-
comparing yield and efficiency of two approved rubidium 82 generators for pet imaging
The Journal of Nuclear Medicine, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:1499 Introduction: The exact amount of delivered radioisotopes for perfusion positron emission tomography (PET) is a defining parameter for imaging accuracy and repeatability. In this study the yield and efficiency of two Strontium-82/rubidium-82 (82Sr/82Rb) generators were sought for. Methods: The sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were collected for 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) was measured and compared after this conversion to a common scale. Results: At the start of clinical use, the 82Rb activity measured during daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001). Dose-calibrator ‘maximum’ values were found to under-estimate the integrated ‘total’ activity by ~24% at 50 mL/min. After converting the CardioGen-82® values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). Conclusions: 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. At the common scale of integrated total activity, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
viXra, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
manufacture of Strontium 82 rubidium 82 generators and quality control of rubidium 82 chloride for myocardial perfusion imaging in patients using positron emission tomography
Applied Radiation and Isotopes, 1999Co-Authors: Teresa M Alvarezdiez, Robert A Dekemp, Rob S. Beanlands, J VincentAbstract:Abstract We describe a protocol to manufacture 82 Sr/ 82 Rb generators and 82 RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82 Sr. The generators produced sterile and non-pyrogenic 82 RbCl for i.v. injection. No significant 82 Sr/ 85 Sr breakthroughs were observed after elution with 20 l of saline. The automated system delivered human doses of 82 RbCl accurately.
Howard C Lewin - One of the best experts on this subject based on the ideXlab platform.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
Journal of Nuclear Cardiology, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min−1) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL·min−1). The generator yield (82Rb) and production efficiency (82Rb yield/82Sr parent activity) were measured and compared after this conversion to a common scale. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~ 24% at 50 mL·min−1. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~ 7% lower than RUBY-FILL® over the full period of clinical use.
-
comparing yield and efficiency of two approved rubidium 82 generators for pet imaging
The Journal of Nuclear Medicine, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:1499 Introduction: The exact amount of delivered radioisotopes for perfusion positron emission tomography (PET) is a defining parameter for imaging accuracy and repeatability. In this study the yield and efficiency of two Strontium-82/rubidium-82 (82Sr/82Rb) generators were sought for. Methods: The sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were collected for 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) was measured and compared after this conversion to a common scale. Results: At the start of clinical use, the 82Rb activity measured during daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001). Dose-calibrator ‘maximum’ values were found to under-estimate the integrated ‘total’ activity by ~24% at 50 mL/min. After converting the CardioGen-82® values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). Conclusions: 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. At the common scale of integrated total activity, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
viXra, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
Ran Klein - One of the best experts on this subject based on the ideXlab platform.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
Journal of Nuclear Cardiology, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. N = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min−1) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL·min−1). The generator yield (82Rb) and production efficiency (82Rb yield/82Sr parent activity) were measured and compared after this conversion to a common scale. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~ 24% at 50 mL·min−1. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~ 7% lower than RUBY-FILL® over the full period of clinical use.
-
comparing yield and efficiency of two approved rubidium 82 generators for pet imaging
The Journal of Nuclear Medicine, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:1499 Introduction: The exact amount of delivered radioisotopes for perfusion positron emission tomography (PET) is a defining parameter for imaging accuracy and repeatability. In this study the yield and efficiency of two Strontium-82/rubidium-82 (82Sr/82Rb) generators were sought for. Methods: The sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were collected for 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) was measured and compared after this conversion to a common scale. Results: At the start of clinical use, the 82Rb activity measured during daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001). Dose-calibrator ‘maximum’ values were found to under-estimate the integrated ‘total’ activity by ~24% at 50 mL/min. After converting the CardioGen-82® values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). Conclusions: 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. At the common scale of integrated total activity, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
-
rubidium 82 generator yield and efficiency for pet perfusion imaging comparison of two clinical systems
viXra, 2020Co-Authors: Ali Ahmadi, Ran Klein, Rob S. Beanlands, Howard C Lewin, Robert A DekempAbstract:Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
