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Francisco Capani - One of the best experts on this subject based on the ideXlab platform.
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Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model.
Neural plasticity, 2017Co-Authors: María Inés Herrera, Matilde Otero-losada, Lucas Udovin, Carlos Federico Kusnier, Rodolfo Alberto Kölliker-frers, Wanderley De Souza, Francisco CapaniAbstract:Birth Asphyxia also termed Perinatal Asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by Perinatal Asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal Asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in Perinatal Asphyxia physiopathology, little is known about the synaptic alterations induced by Perinatal Asphyxia. Nearly 25% of the newborns who survive Perinatal Asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with Perinatal Asphyxia on the basis of updated evidence from an experimental model.
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Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons.
Frontiers in aging neuroscience, 2016Co-Authors: Tamara Logica, Mariana Inés Holubiec, George E. Barreto, Stéphanie Rivière, Rocío Castilla, Francisco CapaniAbstract:Perinatal Asphyxia represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. The interaction between neurons, astrocytes and endothelial cells plays a central role coupling energy supply with changes in neuronal activity. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related to the damage mechanisms of Perinatal Asphyxia. Astrocytes carry out a number of functions that are critical to normal nervous system function, including uptake of neurotransmitters, regulation of pH and ion concentrations, and metabolic support for neurons. In this work, we aim to review metabolic neuron-astrocyte interactions with the purpose of encourage further research in this area in the context of Perinatal Asphyxia, which is highly complex and its mechanisms and pathways have not been fully elucidated to this day.
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Chapter 8 – Neuroprotection with Estradiol in Experimental Perinatal Asphyxia: A New Approach
Estrogen Effects on Traumatic Brain Injury, 2015Co-Authors: George E. Barreto, Janneth Gonzalez, Rocío Castilla, Ezequiel Saraceno, Rodolfo Kolliker, Francisco CapaniAbstract:Perinatal Asphyxia is an obstetric complication that can induce serious complications in the central nervous system. Between 15% and 20% of newborns die immediately after birth and 25% survive with varied neurological deficits such as cerebral palsy, mental retardation and developmental delay. Although different treatments have been used, thus far only hypothermia is recommended as a routine treatment in clinical practice. In this chapter we will discuss the use of estradiol and its impact on the long-term deficits induced by Perinatal Asphyxia.
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Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
Journal of Advanced Neuroscience Research, 2014Co-Authors: María Inés Herrera, Juan Ignacio Romero, Fernando Rodríguez De Fonseca, Eduardo Blanco Calvo, Francisco CapaniAbstract:Perinatal Asphyxia (PA) is still a serious health problem associated with neuronal loss and morbidity. PA pathophysiology implies oxidative stress, cell damage and over activation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. Oleoylethanolamide (OEA), a cannabinoid agonist that exerts anti-inflammatory actions through PPARα activation, could be a possible target for neuroprotection. However, its role in Perinatal hypoxic brain injury remains still unknown. In this study, we evaluated the behavioral consequences of OEA treatment in 30 days-old asphyctic rats. Results indicated that rats subjected to OEA administration showed an improvement in exploratory locomotion. This data suggests a possible neuroprotective role of OEA in severe Perinatal Asphyxia modifications.
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Dual role of astrocytes in Perinatal Asphyxia injury and neuroprotection
Neuroscience letters, 2013Co-Authors: Juan Ignacio Romero, Javier Muñiz, T. Logica Tornatore, Mariana Inés Holubiec, Janneth Gonzalez, George E. Barreto, Laura Ruth Guelman, Christopher Horst Lillig, Eduardo Blanco, Francisco CapaniAbstract:Perinatal Asphyxia represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. However, at the moment, most of the therapeutic strategies were not well targeted toward the processes that induced the brain injury during Perinatal Asphyxia. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related with the damage mechanisms of Perinatal Asphyxia. In this work, we propose to review possible protective as well as deleterious roles of astrocytes in the asphyctic brain with the aim to stimulate further research in this area of Perinatal Asphyxia still not well studied.
Enrico Lopriore - One of the best experts on this subject based on the ideXlab platform.
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Perinatal Asphyxia in Monochorionic versus Dichorionic Twins: Incidence, Risk Factors and Outcome
Fetal diagnosis and therapy, 2014Co-Authors: A. Van Steenis, Sylke J. Steggerda, H.e. Kromhout, Marieke Sueters, M. Rijken, Dick Oepkes, Enrico LoprioreAbstract:Objective: To estimate the incidence, risk factors, severity and outcome after Perinatal Asphyxia in monochorionic (MC) versus dichorionic (DC) twins. Methods: We included all consecutive near-term MC and DC twins with Perinatal Asphyxia admitted to our neonatal ward between 2004 and 2013 and compared the Perinatal characteristics and neonatal outcome between both groups. Results: The incidence of Perinatal Asphyxia in MC and DC twin infants was 4.0 (11/272) and 4.0% (8/200; p = 1.00). In contrast to DC twins, Asphyxia in MC twins was strongly associated with acute exsanguination and anemia at birth; 64% (7/11) in MC twins and 0% (0/8) in DC twins (p < 0.01). Median hemoglobin level at birth in the MC and DC groups was 11.5 and 18.6 g/dl, respectively (p < 0.01). Conclusions: Perinatal Asphyxia in MC twins is often associated with severe anemia at birth due to acute hemorrhage through the placental vascular anastomoses.
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Early-onset thrombocytopenia in near-term and term infants with Perinatal Asphyxia
Vox sanguinis, 2013Co-Authors: N. Boutaybi, Sylke J. Steggerda, Vivianne E.h.j. Smits-wintjens, E. W. Van Zwet, Frans J. Walther, Enrico LoprioreAbstract:Background Neonates after Perinatal Asphyxia are at increased risk of thrombocytopenia. The correlation between Perinatal Asphyxia and the risk and severity of early-onset thrombocytopenia is not well known. Objective To estimate the incidence, severity and risk factors for early-onset thrombocytopenia in neonates after Perinatal Asphyxia. Methods We included all newborns (gestational age ≥ 36 weeks) admitted to our neonatal nursery due to Perinatal Asphyxia in this retrospective study. We collected platelet counts that were obtained within the first 48 h of life to estimate the incidence and severity of early-onset thrombocytopenia. Results A total number of 171 neonates with Perinatal Asphyxia were included in the study. The incidence of early-onset thrombocytopenia (platelet count
Amos Lanir - One of the best experts on this subject based on the ideXlab platform.
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Neonatal urinary uric acid/ceratinine ratio as an additional marker of Perinatal Asphyxia
European journal of pediatrics, 1995Co-Authors: David Bader, David Gozal, Marta Weinger-abend, Anna Berger, Amos LanirAbstract:The diagnosis and evaluation of Perinatal Asphyxia can be problematic and objective means of assessing its severity are lacking. To study the validity of urinary uric acid as a marker of the degree of Perinatal Asphyxia, the ratio of urinary uric acid to creatinine (UA/Cr) in urine specimens obtained after birth was measured in two groups of infants. Eighteen term infants with Apgar scores ≤ 5 at 5 min and/or an umbilical cord blood pH ≤ 7.2, and a base deficit ≽ 12 meq/1 were compared to 50 healthy controls. The severity of the Perinatal Asphyxia was determined by using an Asphyxia SCORE. The UA/Cr was higher in the Asphyxiated group when compared to controls. (2.06 ± 1.12, vs. 0.64 ± 0.48;P < 0.001). Within the Perinatal Asphyxia group, a significant correlation was found between the UA/Cr ratio and the Asphyxia score. (r = 0.86,P < 0.01).
Bethou Adhisivam - One of the best experts on this subject based on the ideXlab platform.
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Inflammatory Mediators as Predictors of Outcome in Perinatal Asphyxia
Indian journal of pediatrics, 2014Co-Authors: B. Bharathi, B. Vishnu Bhat, V. S. Negi, Bethou AdhisivamAbstract:OBJECTIVES To identify biomarkers for neuronal injury and outcome in Perinatal Asphyxia. METHODS This prospective cohort study was done in authors' level III NICU involving 80 neonates - 40 babies with Perinatal Asphyxia and 40 weight and gender matched normal neonates. Levels of cytokines IL-6, IL -1β, IL-2 and TNF -α in cord blood of these neonates were estimated and correlated with the severity of Asphyxia and developmental outcome at 6 mo using Baroda Developmental Score. RESULTS The baseline parameters revealed that there was no statistically significant difference between the two groups in terms of maternal age, parity, gestational age, gender and birth weight. The levels of cytokines IL-6 (p
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Therapeutic Cooling for Perinatal Asphyxia-Indian Experience
Indian journal of pediatrics, 2014Co-Authors: B. Vishnu Bhat, Bethou AdhisivamAbstract:Therapeutic hypothermia (TH) has been established as standard of care for term babies with Perinatal Asphyxia in developed countries. However, it is yet to gain momentum in India. This review summarizes some of the TH trials conducted in India and the various related issues in adapting the same for the Indian context.
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Evaluation of renal function in term babies with Perinatal Asphyxia.
Indian journal of pediatrics, 2013Co-Authors: Jayom Karlo, B. Vishnu Bhat, B. C. Koner, Bethou AdhisivamAbstract:Objective To study the renal function in term newborns with Perinatal Asphyxia including urinary excretion of β2 microglobulin (β2M).
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Antenatal and intrapartum risk factors for Perinatal Asphyxia: A case controlstudy.
Current Pediatric Research, 2013Co-Authors: Bahubali D Gane, Vishnu Bhat B, Ramach, Ra Rao, Akumar S, Bethou Adhisivam, Rojo Joy, Prasad P, Shruti SAbstract:We have studied risk factors for Perinatal Asphyxia among babies fulfilling the inclusion criteria and compared them with matched controls. Maternal or antepartum factors included were maternal age, gestational age, hypertension, diabetes mellitus and antenatal clinic (ANC) visits less than 3. Intrapartum factors included malpresentation, mode of delivery, meconium stained amniotic fluid, Chorioamnionitis and Prolonged rupture of membranes. Factors independently associated with Perinatal Asphyxia using multiple logistic regression analysis were instrumental delivery, inadequate antenatal care, maternal anemia and meconium stained amniotic fluid. Identifying the risk factors and taking appropriate measure could help in reducing the incidence of Perinatal Asphyxia.
M A Bhat - One of the best experts on this subject based on the ideXlab platform.
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Re: Therapeutic hypothermia following Perinatal Asphyxia.
Archives of disease in childhood. Fetal and neonatal edition, 2006Co-Authors: M A BhatAbstract:The article written by Edwards and Azzopadi1 is excellent. Whole-body hypothermia is proving to be the treatment of choice for neonates with Perinatal Asphyxia. 2,3 Not only is there benefit to the babies aged 18 months …
