The Experts below are selected from a list of 63525 Experts worldwide ranked by ideXlab platform
Fumie Sato - One of the best experts on this subject based on the ideXlab platform.
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intramolecular nucleophilic acyl Substitution Reactions mediated by reagent synthesis of vinyltitanium compounds having a lactone and or an ester group from acetylenic carbonates
Tetrahedron Letters, 1995Co-Authors: Aleksandr Kasatkin, Sentaro Okamoto, Fumie SatoAbstract:Abstract The carbonates of acetylenic alcohols reacted with diisopropoxy( η 2 -propene)titanium to give the alkenyltitanium compounds containing lactone ring and/or an ester group by intramolecular nucleophilic acyl Substitution Reaction. Condensation of the Reaction products with aldehydes afforded substituted butenolides.
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Diastereoselective synthesis of trans-1,2-disubstituted cyclopropanols from homoallyl or bis-homoallyl esters via tandem intramolecular nucleophilic acyl Substitution and intramolecular carbonyl addition Reactions mediated by Ti(OPr-i)4 / 2 i-PrMgBr
Tetrahedron Letters, 1995Co-Authors: Aleksandr Kasatkin, Fumie SatoAbstract:Reactions of homoallyl or bis-homoallyl esters with Ti(OPr-i)4/2 i-PrMgBr reagent resulted in intramolecular nucleophilic acyl Substitution Reaction and successive intramolecular carbonyl addition Reaction providing trans-1,2-disubstituted cyclopropanols stereoselectively in excellent yields.
Sujit Roy - One of the best experts on this subject based on the ideXlab platform.
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a multimetallic piano stool ir sn3 catalyst for nucleophilic Substitution Reaction of γ hydroxy lactams through n acyliminium ions
Journal of Organic Chemistry, 2012Co-Authors: Arnab Kumar Maity, Sujit RoyAbstract:A multimetallic piano-stool complex [Cp*Ir(SnCl3)2{SnCl2(H2O)2}] (1) having Ir–Sn3 motif has been synthesized from [Cp*IrCl2]2 and SnCl2. The multimetallic complex catalytically promotes the nucleophilic Substitution Reaction (here after α-amidoalkylation Reaction) of γ-hydroxylactams generated from phthalimidals to obtain decorated isoindolinones in excellent yields. Succinamidals, however, lead to the substituted pyrrolidinones (thermodynamic control product) via SN1-type path as well as eliminated pyrrolinones (kinetic control product) via an E1-type path, depending on the Reaction parameters. A straightforward application of this methodology is to synthesize benzo-fused indolizidine alkaloid mimics.
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A Multimetallic Piano-Stool Ir–Sn3 Catalyst for Nucleophilic Substitution Reaction of γ-Hydroxy Lactams through N-Acyliminium Ions
2012Co-Authors: Arnab Kumar Maity, Sujit RoyAbstract:A multimetallic piano-stool complex [Cp*Ir(SnCl3)2{SnCl2(H2O)2}] (1) having Ir–Sn3 motif has been synthesized from [Cp*IrCl2]2 and SnCl2. The multimetallic complex catalytically promotes the nucleophilic Substitution Reaction (here after α-amidoalkylation Reaction) of γ-hydroxylactams generated from phthalimidals to obtain decorated isoindolinones in excellent yields. Succinamidals, however, lead to the substituted pyrrolidinones (thermodynamic control product) via SN1-type path as well as eliminated pyrrolinones (kinetic control product) via an E1-type path, depending on the Reaction parameters. A straightforward application of this methodology is to synthesize benzo-fused indolizidine alkaloid mimics
Aleksandr Kasatkin - One of the best experts on this subject based on the ideXlab platform.
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intramolecular nucleophilic acyl Substitution Reactions mediated by reagent synthesis of vinyltitanium compounds having a lactone and or an ester group from acetylenic carbonates
Tetrahedron Letters, 1995Co-Authors: Aleksandr Kasatkin, Sentaro Okamoto, Fumie SatoAbstract:Abstract The carbonates of acetylenic alcohols reacted with diisopropoxy( η 2 -propene)titanium to give the alkenyltitanium compounds containing lactone ring and/or an ester group by intramolecular nucleophilic acyl Substitution Reaction. Condensation of the Reaction products with aldehydes afforded substituted butenolides.
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Diastereoselective synthesis of trans-1,2-disubstituted cyclopropanols from homoallyl or bis-homoallyl esters via tandem intramolecular nucleophilic acyl Substitution and intramolecular carbonyl addition Reactions mediated by Ti(OPr-i)4 / 2 i-PrMgBr
Tetrahedron Letters, 1995Co-Authors: Aleksandr Kasatkin, Fumie SatoAbstract:Reactions of homoallyl or bis-homoallyl esters with Ti(OPr-i)4/2 i-PrMgBr reagent resulted in intramolecular nucleophilic acyl Substitution Reaction and successive intramolecular carbonyl addition Reaction providing trans-1,2-disubstituted cyclopropanols stereoselectively in excellent yields.
Piotr Cmoch - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of esters of cyclopropane carboxylic acids via tandem vicarious nucleophilic Substitution michael addition process
Journal of Organic Chemistry, 2015Co-Authors: Mieczyslaw Mąkosza, Karol Bester, Piotr CmochAbstract:α-Chlorocarbanions generated via base-induced vicarious nucleophilic Substitution Reaction of alkyl dichloroacetates with nitroarenes react with Michael acceptors to give esters of cyclopropane carboxylic acids substituted with p-nitroaromatic rings.
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One-Pot Synthesis of Esters of Cyclopropane Carboxylic Acids via Tandem Vicarious Nucleophilic Substitution–Michael Addition Process
2015Co-Authors: Mieczysław Mąkosza, Karol Bester, Piotr CmochAbstract:α-Chlorocarbanions generated via base-induced vicarious nucleophilic Substitution Reaction of alkyl dichloroacetates with nitroarenes react with Michael acceptors to give esters of cyclopropane carboxylic acids substituted with p-nitroaromatic rings
Mahito Atobe - One of the best experts on this subject based on the ideXlab platform.
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a new approach to anodic Substitution Reaction using acoustic emulsification
Organic and Biomolecular Chemistry, 2008Co-Authors: Ryosuke Asami, Toshio Fuchigami, Mahito AtobeAbstract:We have developed a novel electrolytic system for anodic Substitution Reactions using acoustic emulsification. This new system involves the generation of a carbocation by anodic oxidation of a substrate, and then its Reaction with a nucleophile droplet formed by ultrasonication. In this system, even if the oxidation potential of the nucleophile is lower than that of the substrate, the substrate was predominantly oxidized to give the corresponding cation intermediate because the nucleophile phase, which was insoluble in the electrolytic medium, was electro-inactive. In addition, the overoxidation of the desired products was considerably suppressed by the extraction of products from the electrolyte solution into the nucleophile phase. As a result, the anodic Substitution Reaction of several carbamates with allyltrimethylsilane was carried out to provide the corresponding products in good to moderate yields.
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development of an anodic Substitution Reaction system using acoustic emulsification
Chemical Communications, 2008Co-Authors: Ryosuke Asami, Toshio Fuchigami, Mahito AtobeAbstract:The anodic Substitution Reaction proceeded smoothly without affecting the oxidation of the nucleophile in a one-step electrochemical operation using acoustic emulsification.
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a new approach to anodic Substitution Reaction using parallel laminar flow in a micro flow reactor
Journal of the American Chemical Society, 2007Co-Authors: Daisuke Horii, Toshio Fuchigami, Mahito AtobeAbstract:We have developed a novel electrosynthetic system for anodic Substitution Reaction using a micro-flow reactor. This system enables nucleophilic Reactions to overcome the restraints such as the oxidation potential of nucleophiles and the stability of carbocations by the combined use of ionic liquids as Reaction media and the parallel laminar flow in the reactor.
