The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Nebojsa Banjac - One of the best experts on this subject based on the ideXlab platform.
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reversed phase tlc and hplc retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives
Molecular Pharmaceutics, 2011Co-Authors: Nada Perisicjanjic, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S Uscumlic, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants R(M)⁰ and log k(w), which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, R(M)⁰ and log k(w), and the in silico calculated bioactivity descriptors, in particular HIA (human intestinal absorption) and PPB (plasma protein binding) parameters. The R(M)⁰ and log k(w) values of the investigated compounds have been recommended for description of their lipophilicity and evaluating pharmacokinetic properties. In view of results of this study the newly synthesized Succinimide agents meet pharmacokinetic criteria of preselection of drug candidates and hence qualify for pharmacodynamic phase of antiepileptic drug development. Best compromising human intestinal absorption and plasma protein binding features appear to be compounds A4, A5, A10 and A11.
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Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives.
Molecular Pharmaceutics, 2011Co-Authors: Nada Perišić-janjić, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S. Ušćumlić, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants RM0 and log kw, which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, RM0 ...
Roman Kaliszan - One of the best experts on this subject based on the ideXlab platform.
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reversed phase tlc and hplc retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives
Molecular Pharmaceutics, 2011Co-Authors: Nada Perisicjanjic, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S Uscumlic, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants R(M)⁰ and log k(w), which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, R(M)⁰ and log k(w), and the in silico calculated bioactivity descriptors, in particular HIA (human intestinal absorption) and PPB (plasma protein binding) parameters. The R(M)⁰ and log k(w) values of the investigated compounds have been recommended for description of their lipophilicity and evaluating pharmacokinetic properties. In view of results of this study the newly synthesized Succinimide agents meet pharmacokinetic criteria of preselection of drug candidates and hence qualify for pharmacodynamic phase of antiepileptic drug development. Best compromising human intestinal absorption and plasma protein binding features appear to be compounds A4, A5, A10 and A11.
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Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives.
Molecular Pharmaceutics, 2011Co-Authors: Nada Perišić-janjić, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S. Ušćumlić, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants RM0 and log kw, which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, RM0 ...
Pawel Wiczling - One of the best experts on this subject based on the ideXlab platform.
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reversed phase tlc and hplc retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives
Molecular Pharmaceutics, 2011Co-Authors: Nada Perisicjanjic, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S Uscumlic, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants R(M)⁰ and log k(w), which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, R(M)⁰ and log k(w), and the in silico calculated bioactivity descriptors, in particular HIA (human intestinal absorption) and PPB (plasma protein binding) parameters. The R(M)⁰ and log k(w) values of the investigated compounds have been recommended for description of their lipophilicity and evaluating pharmacokinetic properties. In view of results of this study the newly synthesized Succinimide agents meet pharmacokinetic criteria of preselection of drug candidates and hence qualify for pharmacodynamic phase of antiepileptic drug development. Best compromising human intestinal absorption and plasma protein binding features appear to be compounds A4, A5, A10 and A11.
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Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives.
Molecular Pharmaceutics, 2011Co-Authors: Nada Perišić-janjić, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S. Ušćumlić, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants RM0 and log kw, which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, RM0 ...
Natasa Milosevic - One of the best experts on this subject based on the ideXlab platform.
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reversed phase tlc and hplc retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives
Molecular Pharmaceutics, 2011Co-Authors: Nada Perisicjanjic, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S Uscumlic, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants R(M)⁰ and log k(w), which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, R(M)⁰ and log k(w), and the in silico calculated bioactivity descriptors, in particular HIA (human intestinal absorption) and PPB (plasma protein binding) parameters. The R(M)⁰ and log k(w) values of the investigated compounds have been recommended for description of their lipophilicity and evaluating pharmacokinetic properties. In view of results of this study the newly synthesized Succinimide agents meet pharmacokinetic criteria of preselection of drug candidates and hence qualify for pharmacodynamic phase of antiepileptic drug development. Best compromising human intestinal absorption and plasma protein binding features appear to be compounds A4, A5, A10 and A11.
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Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant Succinimide derivatives.
Molecular Pharmaceutics, 2011Co-Authors: Nada Perišić-janjić, Roman Kaliszan, Pawel Wiczling, Natasa Milosevic, Gordana S. Ušćumlić, Nebojsa BanjacAbstract:The properties relevant to pharmacokinetics of two series of newly synthesized Succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants RM0 and log kw, which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of Succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, RM0 ...
Yi Li - One of the best experts on this subject based on the ideXlab platform.
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N-Heterocyclic Carbene Catalyzed Ring Expansion of 4-Formyl-β-lactams: Synthesis of Succinimide Derivatives
Organic Letters, 2007Co-Authors: Gong-qiang Li, Yi LiAbstract:N-Heterocyclic carbene (NHC) has been employed as an efficient catalyst for ring expansion of 4-formyl-β-lactams, allowing the facile synthesis of Succinimide derivatives. This organocatalytic process features readily availability of the catalyst, low catalyst loading, and mild reaction conditions.
