The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Barbara Imperiali - One of the best experts on this subject based on the ideXlab platform.
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Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes
ACS chemical biology, 2018Co-Authors: Amaël G. E. Madec, Nathaniel S. Schocker, Silvano Sanchini, Gadam Myratgeldiyev, Debasis Das, Barbara ImperialiAbstract:The privileged uptake of nucleosides into cells has generated interest in the development of nucleoside-analog libraries for mining new inhibitors. Of particular interest are applications in the discovery of substrate mimetic inhibitors for the growing number of identified glycan-Processing enzymes in bacterial pathogens. However, the high polarity and the need for appropriate protecting group strategies for nucleosides challenges the development of synthetic approaches. Here, we report an accessible, user-friendly synthesis that branches from a common solid phase-immobilized uridinyl-amine intermediate, which can be used as a starting point for diversity-oriented synthesis. We demonstrate the generation of five series of uridinyl nucleoside analogs for investigating inhibitor structure–activity relationships. This library was screened for inhibition of representative enzymes from three functional families including a phosphoglycosyl transferase, a UDP-aminoSugar acetyltransferase, and a glycosyltransfera...
Amaël G. E. Madec - One of the best experts on this subject based on the ideXlab platform.
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Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes
ACS chemical biology, 2018Co-Authors: Amaël G. E. Madec, Nathaniel S. Schocker, Silvano Sanchini, Gadam Myratgeldiyev, Debasis Das, Barbara ImperialiAbstract:The privileged uptake of nucleosides into cells has generated interest in the development of nucleoside-analog libraries for mining new inhibitors. Of particular interest are applications in the discovery of substrate mimetic inhibitors for the growing number of identified glycan-Processing enzymes in bacterial pathogens. However, the high polarity and the need for appropriate protecting group strategies for nucleosides challenges the development of synthetic approaches. Here, we report an accessible, user-friendly synthesis that branches from a common solid phase-immobilized uridinyl-amine intermediate, which can be used as a starting point for diversity-oriented synthesis. We demonstrate the generation of five series of uridinyl nucleoside analogs for investigating inhibitor structure–activity relationships. This library was screened for inhibition of representative enzymes from three functional families including a phosphoglycosyl transferase, a UDP-aminoSugar acetyltransferase, and a glycosyltransfera...
Dennis Randall Ownby - One of the best experts on this subject based on the ideXlab platform.
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Occupational asthma in a beet Sugar Processing plant.
Chest, 1992Co-Authors: Kenneth D. Rosenman, Mary Hart, Dennis Randall OwnbyAbstract:A patient with occupational asthma in the beet Sugar Processing industry is described. Symptomatology, skin testing, immunologic testing, and specific bronchoprovocation testing indicate exposure to moldy Sugar beet pulp was the cause of the patient's occupational asthma. Cooperation between the treating physician and public health authorities is encouraged.
Umesh Kumar - One of the best experts on this subject based on the ideXlab platform.
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composting of Sugar cane waste by products through treatment with microorganisms and subsequent vermicomposting
Bioresource Technology, 2010Co-Authors: Rahul Kumar, Deepshikha Verma, Bhanu L Singh, Umesh KumarAbstract:Abstract The waste by-products of the Sugar-cane industry, bagasse (b), pressmud (p) and trash (t) have been subjected to bioinoculation followed by vermicomposting to shorten stabilization time and improve product quality. Press-mud alone and in combination with other by-products of Sugar Processing industries was pre-decomposed for 30 days by inoculation with combination of Pleurotus sajorcaju, Trichoderma viridae, Aspergillus niger and Pseudomonas striatum. This treatment was followed by vermicomposting for 40 days with the native earthworm, Drawida willsi. The combination of both treatments reduced the overall time required for composting to 20 days and accelerated the degradation process of waste by-products of Sugar Processing industry, thereby producing a nutrient-enriched compost product useful for sustaining high crop yield, minimizing soil depletion and value added disposal of waste materials.
Rahul Kumar - One of the best experts on this subject based on the ideXlab platform.
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composting of Sugar cane waste by products through treatment with microorganisms and subsequent vermicomposting
Bioresource Technology, 2010Co-Authors: Rahul Kumar, Deepshikha Verma, Bhanu L Singh, Umesh KumarAbstract:Abstract The waste by-products of the Sugar-cane industry, bagasse (b), pressmud (p) and trash (t) have been subjected to bioinoculation followed by vermicomposting to shorten stabilization time and improve product quality. Press-mud alone and in combination with other by-products of Sugar Processing industries was pre-decomposed for 30 days by inoculation with combination of Pleurotus sajorcaju, Trichoderma viridae, Aspergillus niger and Pseudomonas striatum. This treatment was followed by vermicomposting for 40 days with the native earthworm, Drawida willsi. The combination of both treatments reduced the overall time required for composting to 20 days and accelerated the degradation process of waste by-products of Sugar Processing industry, thereby producing a nutrient-enriched compost product useful for sustaining high crop yield, minimizing soil depletion and value added disposal of waste materials.
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Integrating microbial composting and vermicomposting for effective utilization of by-products of Sugar cane-Processing industries.
Bioremediation Journal, 2010Co-Authors: Shweta, Rahul Kumar, Birender Singh, Verma DeepshikhaAbstract:In recent years integrated system of composting, with bioinoculants and subsequent vermicomposting, to overcome the problem of lignocellulosic waste degradation of different crop residues and waste industrial by-products is receiving worldwide attention of scientists. However, there appears no report available on the technical viability of the approach on waste by-products of Sugar-cane industry. Therefore, in the present study, the waste by-products of Sugar-cane industry viz. bagasse (b), press-mud (p), and trash (t) have been subjected to bioinoculation followed by vermicomposting with a view to shorten stabilization time, and improve the product quality. The substrate (press-mud alone and in combination of other by-products of Sugar-Processing industries) was predecomposed for 30 days by inoculating it with Pleurotus sajorcaju, Trichoderma viridae, Aspergillus niger, and Pseudomonas striatum in different combinations. This was followed by vermicomposting for 40 days using Drawida willsi species of the native earthworms. Results indicated that the combinations of both the systems reduced the overall time required for composting to 20 days and accelerated the degradation process of waste by-products of Sugar-Processing industry, thereby producing a nutrient-enriched compost product.
