The Experts below are selected from a list of 1239 Experts worldwide ranked by ideXlab platform
James Q. Del Rosso - One of the best experts on this subject based on the ideXlab platform.
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the use of sodium Sulfacetamide 10 sulfur 5 emollient foam in the treatment of acne vulgaris
The Journal of clinical and aesthetic dermatology, 2009Co-Authors: James Q. Del RossoAbstract:Acne vulgaris is the most common disorder encountered in ambulatory clinical practice comprising 11.3 percent of office visits to dermatologists in 2005.(1) By comparison, eczematous dermatoses, psoriasis, and skin cancer accounted for 6.2, 3.5, and 10 percent of office visits, respectively.(1) A variety of topical therapeutic options are available for treatment of acne vulgaris, including benzoyl peroxide, antibiotics, retinoids, azelaic acid, and sodium Sulfacetamide-sulfur.(2,3) Sodium Sulfacetamide 10%-sulfur 5% has been used for the topical treatment of seborrheic dermatitis, acne vulgaris, and rosacea since the mid-1950s and is available in a variety of formulations, including lotions, creams, cleansers, and emollient foams.(4) Recently, an emollient foam sodium Sulfacetamide 10%-sulfur 5% formulation indicated for topical therapy of acne vulgaris, rosacea, and seborrheic dermatitis has become available.(5) This article provides an overview of the sodium Sulfacetamide 10%-sulfur 5% emollient foam and reports the results of a case report series of patients with acne vulgaris treated with sodium Sulfacetamide 10%-sulfur 5% emollient foam as monotherapy or in combination with other topical acne products.
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The use of sodium Sulfacetamide 10%-sulfur 5% emollient foam in the treatment of acne vulgaris
Journal of Clinical and Aesthetic Dermatology, 2009Co-Authors: James Q. Del RossoAbstract:Acne vulgaris is the most common disorder encountered in ambulatory clinical practice comprising 11.3 percent of office visits to dermatologists in 2005.(1) By comparison, eczematous dermatoses, psoriasis, and skin cancer accounted for 6.2, 3.5, and 10 percent of office visits, respectively.(1) A variety of topical therapeutic options are available for treatment of acne vulgaris, including benzoyl peroxide, antibiotics, retinoids, azelaic acid, and sodium Sulfacetamide-sulfur.(2,3) Sodium Sulfacetamide 10%-sulfur 5% has been used for the topical treatment of seborrheic dermatitis, acne vulgaris, and rosacea since the mid-1950s and is available in a variety of formulations, including lotions, creams, cleansers, and emollient foams.(4) Recently, an emollient foam sodium Sulfacetamide 10%-sulfur 5% formulation indicated for topical therapy of acne vulgaris, rosacea, and seborrheic dermatitis has become available.(5) This article provides an overview of the sodium Sulfacetamide 10%-sulfur 5% emollient foam and reports the results of a case report series of patients with acne vulgaris treated with sodium Sulfacetamide 10%-sulfur 5% emollient foam as monotherapy or in combination with other topical acne products.
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Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium Sulfacetamide and sulfur formulations.
Cutis, 2004Co-Authors: James Q. Del RossoAbstract:The combination of sodium Sulfacetamide and sulfur is unique in the rosacea armamentarium because of its dual use as topical therapy and therapeutic cleanser. Several formulations of Sulfacetamide 10% and sulfur 5% are now available as topical lotions and cleansers. The Sulfacetamide/sulfur cleansers serve as adjunctive therapy by providing additive effects to other topical and oral therapies for rosacea with favorable tolerability and cosmetic appeal.
Zoe Diana Draelos - One of the best experts on this subject based on the ideXlab platform.
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the multifunctionality of 10 sodium Sulfacetamide 5 sulfur emollient foam in the treatment of inflammatory facial dermatoses
Journal of Drugs in Dermatology, 2010Co-Authors: Zoe Diana DraelosAbstract:Prior to 1962, some of the most versatile drugs in dermatology were approved by the U.S. Food and Drug Administration (FDA) solely on the basis of safety. One of these is the combination 10% sodium Sulfacetamide and 5% sulfur. Sodium Sulfacetamide possesses anti-inflammatory and antibacterial properties while sulfur is a nonspecific antibacterial and antifungal. A new emollient foam formulation of 10% sodium Sulfacetamide and 5% sulfur allows a thinner application film and leaves behind no residue on hair bearing or non-hair bearing skin. The sulfur smell is also more quickly dissipated with reduced irritation. This uncontrolled, observational, prospective, open-label, single site, eight-week study enrolled 24 subjects (eight with rosacea, eight with seborrheic dermatitis, eight with acne vulgaris) to evaluate the safety and efficacy of this novel foam formulation. At eight weeks, statistically significant improvement was seen in inflammatory rosacea lesion counts and the signs of seborrheic dermatitis. A 50% reduction was noted in the total acne lesion counts. These findings confirm the versatility of an emollient 10% sodium Sulfacetamide and 5% sulfur foam.
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The multifunctionality of 10% sodium Sulfacetamide, 5% sulfur emollient foam in the treatment of inflammatory facial dermatoses
J Drugs Dermatol, 2010Co-Authors: Zoe Diana DraelosAbstract:Prior to 1962, some of the most versatile drugs in dermatology were approved by the U.S. Food and Drug Administration (FDA) solely on the basis of safety. One of these is the combination 10% sodium Sulfacetamide and 5% sulfur. Sodium Sulfacetamide possesses anti-inflammatory and antibacterial properties while sulfur is a nonspecific antibacterial and antifungal. A new emollient foam formulation of 10% sodium Sulfacetamide and 5% sulfur allows a thinner application film and leaves behind no residue on hair bearing or non-hair bearing skin. The sulfur smell is also more quickly dissipated with reduced irritation. This uncontrolled, observational, prospective, open-label, single site, eight-week study enrolled 24 subjects (eight with rosacea, eight with seborrheic dermatitis, eight with acne vulgaris) to evaluate the safety and efficacy of this novel foam formulation. At eight weeks, statistically significant improvement was seen in inflammatory rosacea lesion counts and the signs of seborrheic dermatitis. A 50% reduction was noted in the total acne lesion counts. These findings confirm the versatility of an emollient 10% sodium Sulfacetamide and 5% sulfur foam.
K Van Horn - One of the best experts on this subject based on the ideXlab platform.
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Topical bactrim versus trimethoprim and sulfonamide against nocardia keratitis.
Cornea, 2001Co-Authors: L H Lee, G W Zaidman, K Van HornAbstract:Purpose The conventional treatment of Nocardia keratitis is with topical sulfonamides. Recently, topical trimethoprim and sulfamethoxazole (Bactrim) has been suggested as treatment. This study compares the in vitro efficacy against Nocardia asteroides of Bactrim and various ratios of trimethoprim and a sulfonamide. Methods Antibiotic disks were soaked with various ratios of trimethoprim and Sulfacetamide sodium. They contained trimethoprim alone, Sulfacetamide sodium alone, and both trimethoprim and Sulfacetamide sodium at ratios of 1:40, 1:20, and 1:5. Disks containing Bactrim were also prepared. Each disk was placed on blood agar plates streaked with N. asteroides. The plates were incubated at 37 degrees C for 72 hours and then examined. Results Trimethoprim alone showed minimal effect. Sulfacetamide sodium alone had a clearance zone of 12 mm. The plates of trimethoprim and Sulfacetamide sodium at ratios of 1:40, 1:20, and 1:5 had clearance zones of 14 mm, 17 mm, and 27 mm, respectively. Bactrim had a clearance zone of 70 mm. Conclusion Trimethoprim or Sulfacetamide sodium alone is not as effective as both drugs together. As the ratio of the two drugs was changed, potency differed against Nocardia organisms. Bactrim was the most effective antibiotic against Nocardia organisms. It should be the recommended agent for the treatment of Nocardia keratitis.
C. Chazalette - One of the best experts on this subject based on the ideXlab platform.
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N-Germyl derivatives of Sulfacetamide and ortho-(sulfonamido)phenylamines: characterization of N-[o-(N′,N′-dimethylsulfonamido)phenyl]-N-dimesitylgermaimine
Applied Organometallic Chemistry, 2003Co-Authors: C. Chazalette, Abdelhay Khallaayoun, Monique Rivière-baudet, F. El BazAbstract:Triethylgermylation of Sulfacetamide occurs on the sulfonamido nitrogen in competition with the 1,2 addition of the starting triethylgermyl dimethylamine on the carbonyl group. Thermal decomposition in the presence of dimethylamine yields N-triethylgermylsulfanilamide. Stable 1:1 Sulfacetamide–DBU and 1:1 Sulfacetamide–Et3N complexes were isolated and fully characterized in the course of dehydrochlorination reactions. o-Sulfonamidophenylamine yields N,N′-bis-triethylgermylated derivatives, whereas o-(N,N-dimethylsulfonamido)phenylamine leads to monogermylated compounds. The N-dimethylaminodimesitylgermyl derivative is thermally stable. Dehydrohalogenation of the N-dimesitylfluorogermyl compound leads to the thermally stable but water sensitive N-[o-(N′,N′-dimethylsulfonamido)phenyl]-N-dimesitylgermaimine. Copyright © 2003 John Wiley & Sons, Ltd.
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n germyl derivatives of Sulfacetamide and ortho sulfonamido phenylamines characterization of n o n n dimethylsulfonamido phenyl n dimesitylgermaimine
Applied Organometallic Chemistry, 2003Co-Authors: C. Chazalette, Abdelhay Khallaayoun, M Rivierebaudet, El F BazAbstract:Triethylgermylation of Sulfacetamide occurs on the sulfonamido nitrogen in competition with the 1,2 addition of the starting triethylgermyl dimethylamine on the carbonyl group. Thermal decomposition in the presence of dimethylamine yields N-triethylgermylsulfanilamide. Stable 1:1 Sulfacetamide–DBU and 1:1 Sulfacetamide–Et3N complexes were isolated and fully characterized in the course of dehydrochlorination reactions. o-Sulfonamidophenylamine yields N,N′-bis-triethylgermylated derivatives, whereas o-(N,N-dimethylsulfonamido)phenylamine leads to monogermylated compounds. The N-dimethylaminodimesitylgermyl derivative is thermally stable. Dehydrohalogenation of the N-dimesitylfluorogermyl compound leads to the thermally stable but water sensitive N-[o-(N′,N′-dimethylsulfonamido)phenyl]-N-dimesitylgermaimine. Copyright © 2003 John Wiley & Sons, Ltd.
Jalil Khara - One of the best experts on this subject based on the ideXlab platform.
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Drought Tolerance Induced by Foliar Application of Abscisic Acid and Sulfonamide Compounds in Tomato
Journal of Stress Physiology & Biochemistry, 2014Co-Authors: Leila Zeinali Yadegari, Reza Heidari, Fatemeh Rahmani, Jalil KharaAbstract:The effects of exogenous abscisic acid and two sulfonamide compounds: Sulfacetamide and Sulfasalazine were studied on tolerance of tomato (Lycopersicon esculentum Mill. cv. Super chief) under drought stress and compared with abscisic acid effects. Eight-week old plants were treated with ABA (10 and 25 mg/L), Sulfacetamide (25, 50 and 100 mg/L) and Sulfasalazine (25, 50 and 100 mg/L). Solutions were sprayed daily and sampling was done at 0 h, 48 h, 96 h, 144 h and 48 h after re-watering (recovery phase or 192 h). Treated plants showed relatively greater drought tolerance. This indicates that, Sulfacetamide and Sulfasalazine may improve resistance in tomato, like ABA, increasing levels of proline, glycine betaine and malondialdehyde and the activity of ascorbate peroxidase. Daily application of Sulfasalazine and Sulfacetamide during drought stress period was effective in increasing tomato plants tolerance to drought as was ABA.
