The Experts below are selected from a list of 117 Experts worldwide ranked by ideXlab platform
Pavel K Mykhailiuk - One of the best experts on this subject based on the ideXlab platform.
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scalable approach to fluorinated heterocycles with Sulfur Tetrafluoride sf4
2021Co-Authors: Serhii Trofymchuk, Maksym Ya Bugera, Anton A Klipkov, Volodymyr Ahunovych, Bohdan Razhyk, Sergey Semenov, Andrii Boretskyi, Karen V Tarasenko, Pavel K MykhailiukAbstract:A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with Sulfur Tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
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Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
2021Co-Authors: Serhii Trofymchuk, Maksym Ya Bugera, Anton A Klipkov, Volodymyr Ahunovych, Bohdan Razhyk, Sergey Semenov, Andrii Boretskyi, Karen Tarasenko, Pavel K MykhailiukAbstract:A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with Sulfur Tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized
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“Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles
2016Co-Authors: Igor I. Gerus, Roman X. Mironetz, Ivan S. Kondratov, Andrei V. Bezdudny, Yurii V. Dmytriv, Oleg V. Shishkin, Viktoriia S. Starova, Olga A. Zaporozhets, Andrey A. Tolmachev, Pavel K MykhailiukAbstract:Straightforward practical synthetic approaches to 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles have been developed. The key step of the both syntheses is a transformation of the carboxylic group in a pyrazole core into the trifluoromethyl group by Sulfur Tetrafluoride. The elaborated synthetic protocols allow gram-scale preparation of the target products. The obtained compounds are comprehensively characterized by means of crystallographic analysis, determination of pKa values and fluorescence measurements
Michael Gerken - One of the best experts on this subject based on the ideXlab platform.
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a new synthetic route to rhenium and iodine oxide fluoride anions the reaction between oxoanions and Sulfur Tetrafluoride
2015Co-Authors: James T Goettel, Douglas Turnbull, Michael GerkenAbstract:One-step preparation of [Ag(MeCN)x][ReVIIO2F4] (x = 0, 2, 4) is achieved by addition of excess SF4 to a frozen MeCN solution of Ag[ReO4] at -196 °C followed by warming up to room temp.
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a new synthetic route to rhenium and iodine oxide fluoride anions the reaction between oxoanions and Sulfur Tetrafluoride
2015Co-Authors: James T Goettel, Douglas Turnbull, Michael GerkenAbstract:Abstract Sulfur Tetrafluoride is a reagent for the one-step syntheses of [ReVIIO2F4]−, [IVOF4]−, and [IVIIO2F4]− salts. Pure Ag[ReO2F4] as well as its CH3CN coordination compounds were obtained from CH3CN solvent. The Ag[ReO2F4], [Ag(CH3CN)2][ReO2F4], and [Ag(CH3CN)4][ReO2F4] salts were characterized by Raman spectroscopy. The [Ag(CH3CN)4][ReO2F4]·2CH3CN coordination compound was characterized by single-crystal X-ray diffraction. The reaction of SF4 with KIO4 in anhydrous HF gave the known K[IO2F4] salt. The reaction of [N(CH3)4]IO3 with SF4 in CH3CN yielded the new [N(CH3)4][IOF4] salt, which was characterized by Raman spectroscopy.
James T Goettel - One of the best experts on this subject based on the ideXlab platform.
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a new synthetic route to rhenium and iodine oxide fluoride anions the reaction between oxoanions and Sulfur Tetrafluoride
2015Co-Authors: James T Goettel, Douglas Turnbull, Michael GerkenAbstract:One-step preparation of [Ag(MeCN)x][ReVIIO2F4] (x = 0, 2, 4) is achieved by addition of excess SF4 to a frozen MeCN solution of Ag[ReO4] at -196 °C followed by warming up to room temp.
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a new synthetic route to rhenium and iodine oxide fluoride anions the reaction between oxoanions and Sulfur Tetrafluoride
2015Co-Authors: James T Goettel, Douglas Turnbull, Michael GerkenAbstract:Abstract Sulfur Tetrafluoride is a reagent for the one-step syntheses of [ReVIIO2F4]−, [IVOF4]−, and [IVIIO2F4]− salts. Pure Ag[ReO2F4] as well as its CH3CN coordination compounds were obtained from CH3CN solvent. The Ag[ReO2F4], [Ag(CH3CN)2][ReO2F4], and [Ag(CH3CN)4][ReO2F4] salts were characterized by Raman spectroscopy. The [Ag(CH3CN)4][ReO2F4]·2CH3CN coordination compound was characterized by single-crystal X-ray diffraction. The reaction of SF4 with KIO4 in anhydrous HF gave the known K[IO2F4] salt. The reaction of [N(CH3)4]IO3 with SF4 in CH3CN yielded the new [N(CH3)4][IOF4] salt, which was characterized by Raman spectroscopy.
Serhii Trofymchuk - One of the best experts on this subject based on the ideXlab platform.
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scalable approach to fluorinated heterocycles with Sulfur Tetrafluoride sf4
2021Co-Authors: Serhii Trofymchuk, Maksym Ya Bugera, Anton A Klipkov, Volodymyr Ahunovych, Bohdan Razhyk, Sergey Semenov, Andrii Boretskyi, Karen V Tarasenko, Pavel K MykhailiukAbstract:A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with Sulfur Tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
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Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
2021Co-Authors: Serhii Trofymchuk, Maksym Ya Bugera, Anton A Klipkov, Volodymyr Ahunovych, Bohdan Razhyk, Sergey Semenov, Andrii Boretskyi, Karen Tarasenko, Pavel K MykhailiukAbstract:A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with Sulfur Tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized
Thomas E. Nickson - One of the best experts on this subject based on the ideXlab platform.
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fluorinations with Sulfur Tetrafluoride and hf 1 a reactor design for safe routine handling of sf4 and hf
1991Co-Authors: Thomas E. NicksonAbstract:Abstract A reactor has been designed and built to handle anhydrous HF and SF 4 safely for routineuse in organic synthesis. The system described is completely contained and remotelyoperated so as to minimize any possible exposure to these dangerous materials. Furthermore,it features controls that allow the experimentalist to accurately add HF andSF 4 , monitor the reaction progress and sample ff necessary, as well as allowing flexibilityin the work-up of the reaction.
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Fluorinations with Sulfur Tetrafluoride and HF. 2. Preparation of trifluoromethylated thiazoles and isothiazoles
1991Co-Authors: Thomas E. NicksonAbstract:Abstract Several new trifluoromethylated thiazoles and isothiazoles have been prepared using SF4on precursor carboxylic acids. This chemistry demonstrates the usefulness and applicabilityof the Sulfur Tetrafluoride fluorination to the preparation of novel thiazoles and isothiazoles.