The Experts below are selected from a list of 1329 Experts worldwide ranked by ideXlab platform
Kelly M Mcmasters - One of the best experts on this subject based on the ideXlab platform.
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the Sunbelt melanoma trial
Annals of Surgical Oncology, 2020Co-Authors: Michael E Egger, Charles R Scoggins, Kelly M McmastersAbstract:The Sunbelt Melanoma Trial, a multicenter, prospective randomized clinical study, evaluated the role of high-dose interferon alfa-2b (HDI) therapy for patients with a single positive sentinel lymph node (SLN) metastasis treated with a completion lymph node dissection (CLND). A second protocol in the trial evaluated the prognostic significance of using molecular markers to identify submicroscopic metastases in sentinel lymph nodes that were negative by routine pathologic analysis. The role of CLND with or without adjuvant HDI was evaluated in this group of patients. The results of the study demonstrated that adjuvant HDI offered no survival benefit for patients with a single positive SLN in terms of disease-free or overall survival. Molecular staging using polymerase chain reaction (PCR) for melanoma markers did not identify a high-risk group of patients at increased risk of melanoma recurrence. Additional treatment of these patients who were PCR-positive with either CLND alone or CLND plus HDI did not improve their survival. Additional studies from the Sunbelt Melanoma Trial helped to validate the operational standards of the SLN biopsy procedure and defined the complication rates for both SLN biopsy and CLND. A prognostic risk calculator has been developed from trial data, and the importance of different micrometastatic tumor burden measurements was reported. Although the Sunbelt Melanoma Trial did not demonstrate an improvement in survival with HDI, it is an important trial that highlights the significance of surgeon-initiated randomized clinical trials that incorporate surgical techniques, molecular biomarkers, and adjuvant therapy.
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Scalp Melanoma: The Sunbelt Melanoma Trial
Laryngoscope, 2009Co-Authors: Adam C. Augenstein, Kelly M Mcmasters, Jeffrey M. BumpousAbstract:Eighty‐eight patients were enrolled with scalp melanoma. Men (79.5%) and Caucasians (100%) predominated with an average age of 49.8 years. The most common histologic subtypes were superficial spreading (39.7%), nodular (27.3%) and lentigo maligna (10.2%). The average thickness was 2.4 mm (+1.66) and 25% were ulcerated. Sentinel lymph node (SLN) positivity was seen in 20.9% of scalp melanoma patients, was more likely in younger patients (44.7 vs. 50.8 years, p = 0.04) and in those with a Breslow thickness of 2‐4 mm (p = 0.005). The incidence of locoregional and distant recurrence between the scalp and non‐scalp groups were similar. Overall survival for scalp melanoma patients was significantly impacted by SLN positivity (p = 0.03), while Breslow thickness and ulceration status predicted survival in non‐scalp melanoma patients (p = 0.005, p 4.0 mm 2.1 (1.0, 4.3), p = 0.04 1.0 (0.3, 3.5), p = 0.96 2.0 – 4.0 mm Reference Reference 0.0 – 2.0 mm ‐ ‐ Breslow Thickness Non‐Scalp Hazard Ratio (N = 235) Scalp Hazard Ratio (N = 61) Variable
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final results of the Sunbelt melanoma trial
Journal of Clinical Oncology, 2008Co-Authors: Kelly M Mcmasters, Douglas S Reintgen, James S Goydos, Peter D Beitsch, Jeffrey J Sussman, Merrick I Ross, Michael J Edwards, Robert D Noyes, Marshall M Urist, Robert C G MartinAbstract:9003 Background: The Sunbelt Melanoma Trial is a multicenter prospective randomized prospective trial to evaluate the role of high-dose interferon alfa-2b (IFN) or completion lymph node dissection (CLND) in patients with melanoma staged by sentinel lymph node (SLN) biopsy. Methods: Eligible patients aged 18 to 70 years with primary melanoma ≥1.0 mm Breslow thickness underwent SLN biopsy. In Protocol A, patients with a single tumor-positive lymph node after SLN biopsy and CLND were randomized to observation vs. high dose IFN (20 MU/m2/d i.v. x 4 wks followed by 10 MU/m2 s.q. TIW x 48 wks). In Protocol B, patients with tumor-negative SLN by standard histopathology and immunohistochemistry underwent molecular staging of the SLN by reverse transcriptase polymerase chain reaction (RT-PCR) to detect melanoma- specific mRNA (tyrosinase, MART 1, MAGE 3, gp100); patients with RT-PCR-positive SLN were randomized to observation vs. CLND vs. CLND + IFN (20 MU/m2/d i.v. x 4 wks only). Randomization was stratified for ...
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lessons learned from the Sunbelt melanoma trial
Journal of Surgical Oncology, 2004Co-Authors: Kelly M Mcmasters, Dirk R Noyes, Douglas S Reintgen, James S Goydos, Peter D Beitsch, Scott B Davidson, Jeffrey J Sussman, Jeffrey E Gershenwald, Merrick I RossAbstract:The Sunbelt Melanoma Trial is an ongoing multicenter prospective randomized trial that involves 79 centers and over 3600 patients from across the United States and Canada. This is one of the first large randomized studies to incorporate molecular staging using reverse transcriptase polymerase chain reaction (RT-PCR). While the results related to the primary endpoints of the study are not yet available, several analyses have shed light on many aspects of sentinel lymph node (SLN) biopsy and melanoma prognostic factors. In particular, we have developed a practical definition of sentinel nodes based on the degree of radioactivity. We have established the low rate of postoperative complications associated with SLN biopsy as compared to complete lymph node dissection. We have identified factors that predict the presence of SLN metastases. In contrast, we have been unable to identify factors that indicate a low risk of non-sentinel node metastases in patients with a positive sentinel node, suggesting that completion lymphadenectomy is appropriate for such patients. We have further established the value of identifying interval or in-transit sentinel nodes, which can be the only site of nodal metastasis. We have evaluated the particular challenges associated with SLN biopsy of head and neck melanomas, have evaluated the patterns of early recurrence, and have identified an interesting correlation between increasing patient age and a number of prognostic factors. Future analyses will evaluate the benefit of early therapeutic lymphadenectomy and early institution of adjuvant interferon alfa-2b therapy, as well as the validity of molecular staging.
Ryan Reft - One of the best experts on this subject based on the ideXlab platform.
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sunburnt cities the great recession depopulation and urban planning in the american Sunbelt
Planning Perspectives, 2013Co-Authors: Ryan ReftAbstract:Sunburnt cities: the great recession, depopulation, and urban planning in the American Sunbelt, by Justin Hollander, Abingdon, Routledge, 2011, 192 pp., US$44.95 (paperback) In recent years, exhibi...
Merrick I Ross - One of the best experts on this subject based on the ideXlab platform.
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final results of the Sunbelt melanoma trial
Journal of Clinical Oncology, 2008Co-Authors: Kelly M Mcmasters, Douglas S Reintgen, James S Goydos, Peter D Beitsch, Jeffrey J Sussman, Merrick I Ross, Michael J Edwards, Robert D Noyes, Marshall M Urist, Robert C G MartinAbstract:9003 Background: The Sunbelt Melanoma Trial is a multicenter prospective randomized prospective trial to evaluate the role of high-dose interferon alfa-2b (IFN) or completion lymph node dissection (CLND) in patients with melanoma staged by sentinel lymph node (SLN) biopsy. Methods: Eligible patients aged 18 to 70 years with primary melanoma ≥1.0 mm Breslow thickness underwent SLN biopsy. In Protocol A, patients with a single tumor-positive lymph node after SLN biopsy and CLND were randomized to observation vs. high dose IFN (20 MU/m2/d i.v. x 4 wks followed by 10 MU/m2 s.q. TIW x 48 wks). In Protocol B, patients with tumor-negative SLN by standard histopathology and immunohistochemistry underwent molecular staging of the SLN by reverse transcriptase polymerase chain reaction (RT-PCR) to detect melanoma- specific mRNA (tyrosinase, MART 1, MAGE 3, gp100); patients with RT-PCR-positive SLN were randomized to observation vs. CLND vs. CLND + IFN (20 MU/m2/d i.v. x 4 wks only). Randomization was stratified for ...
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lessons learned from the Sunbelt melanoma trial
Journal of Surgical Oncology, 2004Co-Authors: Kelly M Mcmasters, Dirk R Noyes, Douglas S Reintgen, James S Goydos, Peter D Beitsch, Scott B Davidson, Jeffrey J Sussman, Jeffrey E Gershenwald, Merrick I RossAbstract:The Sunbelt Melanoma Trial is an ongoing multicenter prospective randomized trial that involves 79 centers and over 3600 patients from across the United States and Canada. This is one of the first large randomized studies to incorporate molecular staging using reverse transcriptase polymerase chain reaction (RT-PCR). While the results related to the primary endpoints of the study are not yet available, several analyses have shed light on many aspects of sentinel lymph node (SLN) biopsy and melanoma prognostic factors. In particular, we have developed a practical definition of sentinel nodes based on the degree of radioactivity. We have established the low rate of postoperative complications associated with SLN biopsy as compared to complete lymph node dissection. We have identified factors that predict the presence of SLN metastases. In contrast, we have been unable to identify factors that indicate a low risk of non-sentinel node metastases in patients with a positive sentinel node, suggesting that completion lymphadenectomy is appropriate for such patients. We have further established the value of identifying interval or in-transit sentinel nodes, which can be the only site of nodal metastasis. We have evaluated the particular challenges associated with SLN biopsy of head and neck melanomas, have evaluated the patterns of early recurrence, and have identified an interesting correlation between increasing patient age and a number of prognostic factors. Future analyses will evaluate the benefit of early therapeutic lymphadenectomy and early institution of adjuvant interferon alfa-2b therapy, as well as the validity of molecular staging.
Daniel Lentz - One of the best experts on this subject based on the ideXlab platform.
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Mixed-Use and Mini-Vans: When New Urbanism Meets Sunbelt Consumer Preference: A Case Study Analysis of Mixed-Use in Dallas,
2016Co-Authors: Daniel LentzAbstract:Lentz. D. (2008). Mixed-use and mini-vans: When new urbanism meets Sunbelt consumer preference: A case study analysis of mixed
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mixed use and mini vans when new urbanism meets Sunbelt consumer preference a case study analysis of mixed use in dallas texas
Cornell Real Estate Review, 2008Co-Authors: Daniel LentzAbstract:What happens when the ideology commonly referred to as “New Urbanism” meets the dreaded consumer preferences of automobile-addicted Sunbelt cities such as Dallas, Texas? New Urbanist ideology permeates current planning policies and influences many discussions in the development community around sustainability and sprawl. Yet policies and hopes often take on a different identity entirely once molded by the preferences of the American consumer. New Urbanism offers potential solutions to many of the problems associated with suburban sprawl in the United States, but it is no panacea. Ideologues and opponents may debate its merits and shortcomings, but it is the consumers’ votes in dollars and cents that ultimately render the verdict in practice. The market dynamics of Sunbelt cities present challenges and preferences different in many ways from higher density cities on either the west or east coasts. Recent developments show that New Urbanism, and mixed-use development in particular, offers competitive differentiation and may be extremely successful in the Sunbelt. Yet the ideology does not meet all needs of this market, and the development community must carefully analyze what elements of New Urbanism will work in practice and which will not. This paper will provide the background of New Urbanism and explore the view points of its proponents and opponents. Finally, two developments in Dallas, Texas will be used as case studies to illustrate how the debate has manifested itself in the Sunbelt and what each teaches about the viability of New Urbanism in this type of market.
Timothy D. Hogan - One of the best experts on this subject based on the ideXlab platform.
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Sunbelt growth and the knowledge economy an exploratory approach
The Journal of Regional Analysis and Policy, 2008Co-Authors: Dennis L Hoffman, Timothy D. HoganAbstract:Focusing on the narrower concept of a knowledgeeconomy-based growth strategy, this paper explores whether a strong link between a college-educated population and a region’s economic performance was an important ingredient in the growth experience of the Sunbelt during the 1990s. The issue is addressed through analysis of two different datasets. First, the education and income characteristics of the people moving to the Sunbelt region are examined using migration data from the 2000 census. Then we look at the link between the knowledge-economy metric of the share of college educated adults and economic growth in the Sunbelt in the 1990s using data for 116 Sunbelt MSAs.
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elderly migration to the Sunbelt seasonal versus permanent
Journal of Applied Gerontology, 1993Co-Authors: Timothy D. Hogan, Donald N SteinnesAbstract:A substantial body of research has focused on the interstate migration of elderly households to the Sunbelt. Most of this research has concentrated on permanent moves, but seasonal migration of elderly households to Sunbelt locations has become an increasingly important social phenomenon. Although some have suggested that such temporary migration serves as a precursor ofpermanent locations, recent analyses have found that such seasonal migration constitutes an alternative elderly life-style. Using 1980 census data, this study empirically examines the similarities and differences in these two types of elderly migration flows to a Sunbelt state such as Arizona. The statistical results indicate that seasonal and permanent migration are correlated in different ways to the variables usually found to be determinants of elderly migration flows and suggest the two types of elderly migration are related but separate phenomena.
