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Jean-pierre Fossion - One of the best experts on this subject based on the ideXlab platform.

  • Sequential comorbidity by preselection
    Enzyme and Microbial Technology, 2020
    Co-Authors: Jean-pierre Fossion
    Abstract:

    Abstract Background We lack a common model unifying Western internal medicine with the Chinese Zang-Fu system. Aim Creating a model that helps to understand the Zang-Fu system from a neuroscience point of view. Methods We are establishing a comparative study whereby the neurovegetative dystonias, which appear when anatomical substrates in the central nervous system are experimentally toppled into hyper- or hypoactivity (described by neuroscience), are compared with the signs and symptoms as differentiated by the pattern identification in Chinese syndromes (described by Zang-Fu). In this particular article we limit ourselves to discuss if cephalic signs and symptoms, depending on the Superior Salivary Nucleus, could function as an exemplary case. We discuss salivation, lacrymation, nasopharyngeal vasomotion, vasomotion of the choroid and vasomotion of the anterior half of the tongue. We verified if there is any confirmation in medical literature that Electroacupuncture (EAP) on points St 36 (zusanli), Li 3 (taichong) and Gb 34 (yanglingchuan) would modulate the concerned anatomical substrates. Results We established that the cephalic signs and symptoms of the Chinese syndromes are identical to those resulting from the preselection of neuronal populations in the Superior Salivary Nucleus. Comorbid, those cephalic signs and symptoms may appear together at the same time as neurovegetative dystonias as predicted by Zang-Fu. The acupoints St 36, Li 3 and Gb 34 may activate either the subparafascicular Nucleus, or the parabrachial Nucleus. Both nuclei innervate the Superior Salivary Nucleus amidst their respective sequential targets, therefore the aforementioned acupoints have the potential of modulating the cephalic signs and symptoms in hyper- or hypoactivity of the Salivary Nucleus. Conclusion We propose a model in which TCM-syndromes and Western neurovegetative dystonias explain a sequential comorbidity by preselection of central nervous circuitry and that the treatment by needling intervenes on the level of these preselections.

  • Sequential comorbidity by preselection
    Deutsche Zeitschrift für Akupunktur, 2009
    Co-Authors: Jean-pierre Fossion
    Abstract:

    Hintergrund Die Innere Medizin, wie sie im Westen gelehrt wird, und die von der Traditionellen Chinesischen Medizin beschriebenen Syndrome der Inneren Organe, bekannt unter Zang Fu , lassen auf den ersten Blick keine Gemeinsamkeiten erkennen. Es fehlt ein Modell, das beide Sichtweisen erklären könnte. Zielsetzung Ein Modell zu entwickeln, das helfen soll, das Zang-Fu -System aus neurowissenschaftlicher Sicht zu verstehen. Methodik Wir stellten vergleichende Beobachtungen von neurovegetativen Fehlfunktionen an, die dadurch entstehen, dass das Zentralnervensystem an vorherbestimmten Bahnen eine Hyper-oder Hypoaktivität zeigt, und vergleichen sie mit Symptomen und Zeichen, die als soge-nannte „Muster“ der TCM, als Fehlfunktionen der Inneren Organe (Zang Fu) , in der Literatur aufscheinen. In diesem Artikel beschränken wir uns auf Symptome im Bereich des Kopfes, die von der Funktion des Nucleus salivatorius Superior abhängig sind, und bringen dazu Beispiele. Wir stellen die Funktion der Speicheldrüsen, der Tränendrüsen, Nasensekretion und Versorgung der vorderen Hälfte der Zunge zur Diskussion. Bestätigungen dazu finden sich in der Fachliteratur anhand der Elektroakupunktur an den Akupunkturpunkten Ma 36, Le 3 und Gb 34. Ergebnisse Wir stellten fest, dass sich Symptome im Kopf-bereich, wie sie in der TCM beschrieben sind, sich auf die Funktion bestimmter Neuronen im Nucleus salivatorius Superior zurückführen lassen. Diese Symptome im Kopfbe-reich können zeitgleich gemeinsam auftreten im Sinne einer vegetativen Dysfunktion, wie es die TCM in der Lehre der Zang Fu wiedergibt. Die Akupunkturpunkte Ma 36, Le 3, Gb 34 könnten entweder den subparafasciculären oder den parabrachialen Kern regulieren. Beide Nuclei innervieren den Nucleus salivatorius Superior, deshalb könnten diese Akupunkturpunkte auch die entsprechenden Beschwerden, die durch eine Hyper-oder Hypofunktion dieses Kernes entstanden sind, therapieren. Schlussfolgerung Wir empfehlen ein Modell, welches TCM-Syndrome und neurovegetative Fehlfunktionen als Abfolge gemeinsamer Prozesse in vorherbestimmten Bahnen des ZNS in Einklang bringt. Die Nadelung bestimmter Punkte kann diese vorherbestimmten Bahnen beeinflussen. Background We lack a common model unifying Western internal medicine with the Chinese Zang-Fu system. Aim Creating a model that helps to understand the Zang-Fu system from a neuroscience point of view. Methods We are establishing a comparative study whereby the neurovegetative dystonias, which appear when anatomical substrates in the central nervous system are experimentally toppled into hyper- or hypoactivity (described by neuroscience), are compared with the signs and symptoms as differentiated by the pattern identification in Chinese syndromes (described by Zang-Fu ). In this particular article we limit ourselves to discuss if cephalic signs and symptoms, depending on the Superior Salivary Nucleus, could function as an exemplary case. We discuss salivation, lacrymation, nasopharyngeal vasomotion, vasomotion of the choroid and vasomotion of the anterior half of the tongue. We verified if there is any confirmation in medical literature that Electroacupuncture (EAP) on points St 36 ( zusanli ), Li 3 ( taichong ) and Gb 34 ( yanglingchuan ) would modulate the concerned anatomical substrates. Results We established that the cephalic signs and symptoms of the Chinese syndromes are identical to those resulting from the preselection of neuronal populations in the Superior Salivary Nucleus. Comorbid, those cephalic signs and symptoms may appear together at the same time as neurovegetative dystonias as predicted by Zang-Fu. The acupoints St 36, Li 3 and Gb 34 may activate either the subparafascicular Nucleus, or the parabrachial Nucleus. Both nuclei innervate the Superior Salivary Nucleus amidst their respective sequential targets, therefore the aforementioned acupoints have the potential of modulating the cephalic signs and symptoms in hyper- or hypoactivity of the Salivary Nucleus. Conclusion We propose a model in which TCM-syndromes and Western neurovegetative dystonias explain a sequential comorbidity by preselection of central nervous circuitry and that the treatment by needling intervenes on the level of these preselections.

Samer Narouze - One of the best experts on this subject based on the ideXlab platform.

Qiu Jian - One of the best experts on this subject based on the ideXlab platform.

Bo Hyun Jung - One of the best experts on this subject based on the ideXlab platform.

  • Alcohol ingestion reduced acetylcholine-binding protein in the submandibular gland of the rat
    Oral Biology Research, 2017
    Co-Authors: Bo Hyun Jung
    Abstract:

    Continuous alcohol ingestion may lead to various dental diseases because a hyposalivation. In this study, we investigated changes in pathology and choline acetyltransferase (ChAT, an enzyme for synthesis of acetylcholine) in the brain and acetylcholine-binding protein (AchBP, a protein responsible for modulation of synaptic transmission in cholinergic synapses) in the submandibular gland after alcohol ingestion. There was no change in neuronal death and expression of ChAT in Superior Salivary Nucleus after alcohol ingestion. In the submandibular gland, expression of AchBP were significantly reduced after alcohol ingestion. Therefore, decrease of saliva secretion by alcohol ingestion is less related to damage of neurons in the Superior Salivary Nucleus and decrease of acetylcholine synthesis or cholinergic neurotransmission.

Yoshihiro Aikawa - One of the best experts on this subject based on the ideXlab platform.

  • Reflex choroidal blood flow responses of the eyeball following somatic sensory stimulation in rats
    Autonomic Neuroscience: Basic and Clinical, 2002
    Co-Authors: Mayura Shimura, Sae Uchida, Atsuko Suzuki, Kaori Nakajima, Yoshihiro Aikawa
    Abstract:

    Abstract The effect of cutaneous mechanical stimulation on choroidal blood flow (ChBF) of the eyeball measured using a laser Doppler flowmeter was examined in anesthetized rats. Noxious pinching stimulation of a forepaw for 20 s produced increases in ChBF and mean arterial blood pressure (MAP), whereas brushing of a forelimb produced no changes in either parameter. After spinal transection at the fourth thoracic (T4) level, forepaw pinching stimulation did not produce any MAP changes in 9 of 11 spinalized rats. In these nine spinalized animals, pinching stimulation of a forepaw produced no significant responses in ChBF. After the cutting of cervical sympathetic trunks in five spinal rats, forepaw pinching showed no effect on MAP, but produced an increase in ChBF, which was abolished by an intravenous (i.v.) injection of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a selective inhibitor of neuronal nitric oxide synthase (nNOS). In another four spinalized rats, whose cervical sympathetic trunks were intact and the Superior Salivary Nucleus (SSN) was destroyed, forepaw pinching showed no effect on MAP, but produced a decrease in ChBF, which was abolished by an i.v. injection of phentolamine, an α-adrenoceptor antagonist. The present experiment shows that somatic afferent stimulation can produce reflex responses of the ChBF of the eyeball, either a vasodilative response using parasympathetic efferent fibers or a vasoconstrictive response using sympathetic efferent fibers, independent of systemic blood pressure. It was also shown that the somatically induced vasodilative response was due to a release of nitric oxide (NO) from parasympathetic nerves and the vasoconstrictive response was due to a release of noradrenaline from sympathetic nerves.