The Experts below are selected from a list of 492 Experts worldwide ranked by ideXlab platform
Daisuke Sawamura - One of the best experts on this subject based on the ideXlab platform.
-
late onset eruptive Syringoma in an elderly man correlation with carbamazepine
Acta Dermato-venereologica, 2012Co-Authors: Ayumi Korekawa, Koji Nakajima, Yohei Nishikawa, Yasushi Matsuzaki, Hajime Nakano, Daisuke SawamuraAbstract:Syringomas are benign neoplasms of the eccrine sweat gland ducts that commonly appear around the eyelids in women. Clinically, they manifest as small, skin-coloured or slightly pigmented papules. Syringoma is classified into four clinical types: localized; familial; Down’s syn-drome associated; and generalized, which encompasses multiple and eruptive Syringomas (1). Furthermore, clear cell Syringoma, which is characterized by histological proliferation of clear cells, has been reported to be asso-ciated with diabetes mellitus (2). Eruptive Syringoma is a rare variant and usually appears before or during puberty (3). The lesions occur in large numbers and in successive crops on the neck, chest, abdomen, maxillae and genitalia. We describe here a case of late-onset eruptive Syringoma in a 69-year-old man and discuss its possible association with an anti-epileptic drug. CASE REpoRTA 69-year-old man was referred to our department for the evaluation of skin lesions, which he had first noti-ced at the age of approximately 60 years. The lesions had first appeared on his abdomen, and3 years ago the
Ilhan Gunalp - One of the best experts on this subject based on the ideXlab platform.
-
a rare case of atypical chondroid Syringoma of the lower eyelid and review of the literature
Survey of Ophthalmology, 2006Co-Authors: Kaan Gunduz, Sibel Demirel, Aylin Okcu Heper, Ilhan GunalpAbstract:A 46-year-old man presented with a painless firm mass in the eyelid margin of the left lower eyelid, which had been present for 9 years. Biopsy nine years previously had not established a diagnosis. We performed excisional biopsy of the lesion and lateral advancement skin flap for reconstruction of the skin defect. Histopathologic and immunohistochemical findings were consistent with atypical chondroid Syringoma with eccrine differentiation. The systemic metastatic work-up was negative, and no recurrence or metastasis was present at 30-month follow-up. Chondroid Syringoma is a rare skin tumor that occurs, very rarely, in the eyelids, especially the lower eyelid. Only 26 cases of chondroid Syringoma in the periorbital area, including our case, have been reported, with various characteristics. Chondroid Syringomas are classified as two types, the apocrine type characterized by tubular and cystic branching lumina lined by two layers of epithelial cells, and the eccrine type, which has small tubular lumina lined by a single layer of epithelial cells. The tumor can have benign, atypical, and malignant variants. Our patient had the atypical variant, which is characterized by benign cytological features, as well as the presence of infiltrative margins and/or satellite nodules. Even benign chondroid Syringomas, if incompletely excised, can recur with malignant transformation; thus, complete excision and regular follow-up is recommended for all chondroid Syringomas.
Stavroula J Theodorou - One of the best experts on this subject based on the ideXlab platform.
-
giant chondroid Syringoma presenting as a growing subcutaneous mass in the upper arm mri findings with pathologic correlation
Joint Bone Spine, 2009Co-Authors: Yousuke Kakitsubata, Stavroula J Theodorou, Daphne J Theodorou, Mayumi Nakahara, Yasuhiro Yuki, Tetsuhiro YokouchiAbstract:Chondroid Syringoma of skin is a rare type of soft tissue tumor originating from the sweat glands. We report a documented case of giant chondroid Syringoma occurring in the upper arm, which developed over the course of one year. The radiographic, sonographic, MR imaging, gross pathologic, and histologic findings of the tumor are described. Because the clinical suggestion of such a tumor was low, we present the imaging appearances of chondroid Syringoma that could be used to make a presumptive diagnosis, and discuss the many entertained differential diagnostic possibilities.
Valda N Kaye - One of the best experts on this subject based on the ideXlab platform.
-
plaque type Syringoma two cases misdiagnosed as microcystic adnexal carcinoma
Journal of Cutaneous Pathology, 2008Co-Authors: Pitiporn Suwattee, Matthew C Mcclelland, Erin E Huiras, Erin M Warshaw, Peter K Lee, Valda N KayeAbstract:Background: Plaque-type Syringoma is a rare variant of Syringoma. This benign neoplasm may be easily misdiagnosed as microcystic adnexal carcinoma (MAC), potentially resulting in unnecessary surgery with disfiguring consequences. Methods: We report two cases of plaque-type Syringoma that were initially diagnosed as MAC. Microscopically, these lesions were composed of nests of cuboidal cells arrayed within sclerotic collagen in the upper dermis. The deep reticular dermis was spared. No perineural involvement was observed. Results and Conclusions: Our cases are discussed in the context of histopathologic diagnosis. Detailed histopathologic findings of Syringoma, as well as other considerations in the differential diagnosis, are reviewed. We also include a review of all cases of plaque-type Syringoma published to date.
Hongshang Hong - One of the best experts on this subject based on the ideXlab platform.
-
vulvar Syringoma a clinicopathologic and immunohistologic study of 18 patients and results of treatment
Journal of The American Academy of Dermatology, 2003Co-Authors: Yuhuei Huang, Yahui Chuang, Tsengtong Kuo, Licheng Yang, Hongshang HongAbstract:Abstract Background: Syringoma of the vulva has been rarely reported. No effective treatment modality has been documented. Objective: The purpose of this study was to describe the clinicopathologic features of vulvar Syringoma, to investigate the hormonal influence on its growth, and to establish an effective treatment modality. Methods: A total of 18 cases of vulvar Syringoma were selected from the surgical pathologic file at Chang Gung Memorial Hospital. In all, 15 formalin-fixed, paraffin-embedded specimens were examined by immunohistochemical staining for estrogen receptor and progesterone receptor. Results: The age of first presentation at our vulvar clinic ranged from 21 to 60 years with a median age of 29.5 years. Of patients, 13 (72%) had vulvar pruritus and 7 noticed aggravation during summer or during menstruation. The most common clinical appearance was multiple flesh-colored or brownish papules on bilateral sides of the vulva (9 of 18). One third of our series was found to have coexisting eyelid Syringoma and 4 of them also had a family history of periorbital Syringoma. Immunohistochemical stainings for estrogen receptor and progesterone receptor were all negative on the 15 cases studied. Of our patients, 7 with intense pruritus were treated with carbon dioxide laser vaporization. Their lesions resolved and pruritus subsided. Conclusion: Vulvar Syringoma is not very rare and should be considered in the differential diagnosis of vulvar pruritus. In our study, estrogen receptor and progesterone receptor were not detected in vulvar Syringoma. Carbon dioxide laser was an effective therapeutic modality in treating patients with intractable symptoms. (J Am Acad Dermatol 2003;48:735-9.)
