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Mh Pittler - One of the best experts on this subject based on the ideXlab platform.
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the efficacy and safety of feverfew Tanacetum parthenium l an update of a systematic review
Public Health Nutrition, 2000Co-Authors: E Ernst, Mh PittlerAbstract:Objective Feverfew ( Tanacetum parthenium L.) is a popular herbal remedy often advocated for the prevention of migraine. The aims of this systematic review are to update the evidence from rigorous clinical trials for or against the efficacy of feverfew for migraine prevention and to provide a safety profile of this herbal remedy. Design Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM and the Cochrane Library (all from their inception to December 1999). Only randomized, placebo-controlled, double-blind trials of feverfew mono-preparations for the prevention of migraine in human subjects were included. All articles were read by two independent reviewers. Data were extracted in a pre-defined, standardized fashion. The methodological quality of the trials was evaluated by the Jadad score. For the assessment of safety issues, major reference texts were also consulted. Results Six trials met the inclusion/exclusion criteria. The majority favour feverfew over placebo. Yet important caveats exist. The data also suggest that feverfew is associated with only mild and transient adverse effects and few other safety concerns. Conclusions Feverfew is likely to be effective in the prevention of migraine. There are no major safety problems.
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The efficacy and safety of feverfew ( Tanacetum parthenium L.): an update of a systematic review *
Public health nutrition, 2000Co-Authors: E Ernst, Mh PittlerAbstract:Objective Feverfew ( Tanacetum parthenium L.) is a popular herbal remedy often advocated for the prevention of migraine. The aims of this systematic review are to update the evidence from rigorous clinical trials for or against the efficacy of feverfew for migraine prevention and to provide a safety profile of this herbal remedy. Design Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM and the Cochrane Library (all from their inception to December 1999). Only randomized, placebo-controlled, double-blind trials of feverfew mono-preparations for the prevention of migraine in human subjects were included. All articles were read by two independent reviewers. Data were extracted in a pre-defined, standardized fashion. The methodological quality of the trials was evaluated by the Jadad score. For the assessment of safety issues, major reference texts were also consulted. Results Six trials met the inclusion/exclusion criteria. The majority favour feverfew over placebo. Yet important caveats exist. The data also suggest that feverfew is associated with only mild and transient adverse effects and few other safety concerns. Conclusions Feverfew is likely to be effective in the prevention of migraine. There are no major safety problems.
E Ernst - One of the best experts on this subject based on the ideXlab platform.
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the efficacy and safety of feverfew Tanacetum parthenium l an update of a systematic review
Public Health Nutrition, 2000Co-Authors: E Ernst, Mh PittlerAbstract:Objective Feverfew ( Tanacetum parthenium L.) is a popular herbal remedy often advocated for the prevention of migraine. The aims of this systematic review are to update the evidence from rigorous clinical trials for or against the efficacy of feverfew for migraine prevention and to provide a safety profile of this herbal remedy. Design Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM and the Cochrane Library (all from their inception to December 1999). Only randomized, placebo-controlled, double-blind trials of feverfew mono-preparations for the prevention of migraine in human subjects were included. All articles were read by two independent reviewers. Data were extracted in a pre-defined, standardized fashion. The methodological quality of the trials was evaluated by the Jadad score. For the assessment of safety issues, major reference texts were also consulted. Results Six trials met the inclusion/exclusion criteria. The majority favour feverfew over placebo. Yet important caveats exist. The data also suggest that feverfew is associated with only mild and transient adverse effects and few other safety concerns. Conclusions Feverfew is likely to be effective in the prevention of migraine. There are no major safety problems.
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The efficacy and safety of feverfew ( Tanacetum parthenium L.): an update of a systematic review *
Public health nutrition, 2000Co-Authors: E Ernst, Mh PittlerAbstract:Objective Feverfew ( Tanacetum parthenium L.) is a popular herbal remedy often advocated for the prevention of migraine. The aims of this systematic review are to update the evidence from rigorous clinical trials for or against the efficacy of feverfew for migraine prevention and to provide a safety profile of this herbal remedy. Design Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM and the Cochrane Library (all from their inception to December 1999). Only randomized, placebo-controlled, double-blind trials of feverfew mono-preparations for the prevention of migraine in human subjects were included. All articles were read by two independent reviewers. Data were extracted in a pre-defined, standardized fashion. The methodological quality of the trials was evaluated by the Jadad score. For the assessment of safety issues, major reference texts were also consulted. Results Six trials met the inclusion/exclusion criteria. The majority favour feverfew over placebo. Yet important caveats exist. The data also suggest that feverfew is associated with only mild and transient adverse effects and few other safety concerns. Conclusions Feverfew is likely to be effective in the prevention of migraine. There are no major safety problems.
Krisztina Végh - One of the best experts on this subject based on the ideXlab platform.
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Three newly identified lipophilic flavonoids in Tanacetum parthenium supercritical fluid extract penetrating the Blood-Brain Barrier.
Journal of pharmaceutical and biomedical analysis, 2017Co-Authors: Krisztina Végh, Eszter Riethmüller, Levente Hosszú, András Darcsi, Judit Müller, Ágnes Alberti, Anita Tóth, Szabolcs Béni, Árpád Könczöl, György T. BaloghAbstract:Abstract Feverfew (Tanacetum parthenium L.) as a perennial herb has been known for centuries due to its medicinal properties. The main sesquiterpene lactone, parthenolide is considered to be responsible for the migraine prophylactic effect, however the pharmacological benefits of the lipophilic flavonoid components can not be neglected. Supercritical fluid extraction (7% ethanol, 22 MPa, 64 °C) was carried out on the leaves of Tanacetum parthenium L. from which the presence of methylated flavonoids beside parthenolide and other sesquiterpene lactones were indicated by preliminary LC–MS analyses. Specific Parallel Artificial Membrane Permeability Assay (PAMPA) was applied to identify the components capable to cross the Blood-Brain Barrier (BBB). Three lipophilic flavonoids were detected on the acceptor side, that were isolated (Prep-HPLC) and identified as sudachitin, aceronin and nevadensin (LC–MS/MS, NMR). These flavonoids were also characterized individually by PAMPA-BBB model. The presence of sudachitin and nevadensin was proven in the Asteraceae family, but neither of the three flavonoids were reported in Tanacetum parthenium L.
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Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.
Biomedical chromatography : BMC, 2016Co-Authors: Krisztina Végh, Eszter Riethmüller, Ágnes Alberti, Anita Tóth, Szabolcs Béni, József Balla, Ágnes KéryAbstract:Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra-high-performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective. The method was validated for specificity, accuracy (100.2%), repeatability and intermediate precision, linearity (r2 > 0.999), limit of detection (2.055 μg/mL), limit of quantification (6.228 μg/mL) and robustness. The common range of accuracy and linearity was between 0.125 and 1.000 mg/mL. Steam distillation was carried out in order to study the essential oil yield of three different T. parthenium L. samples originating from Hungarian medicinal herb collections. The camphor content of the essential oils from the aerial parts of feverfew samples from different origin was compared. Although the composition of the essential oil is well reported, a validated quantitative UHPSFC method for the determination of the constituents is presented herein for the first time.
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Supercritical fluid extraction and convergence chromatographic determination of parthenolide in Tanacetum parthenium L.: Experimental design, modeling and optimization
The Journal of Supercritical Fluids, 2014Co-Authors: Krisztina Végh, Eszter Riethmüller, Ágnes Alberti, Anita Tóth, Szabolcs Béni, Ágnes KéryAbstract:Abstract Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraines, headaches and rheumatoid arthritis. The herb contains various potentially active constituents such as sesquiterpene-γ-lactones, flavonoids and volatile oil. The main sesquiterpene-lactone in feverfew is parthenolide which is considered to be responsible for the therapeutical effects. Supercritical CO2 extraction was carried out at different pressures (10–30 MPa), temperatures (40–80 °C) and co-solvent contents (0–10% ethanol) in order to study the extraction yield and the parthenolide recovery of the extracts. Leaves collected before and during flowering and flower heads were investigated. A factorial experiment using a full 33 design was followed during the experiments and response surface methodology was implemented to analyze the influence of the variables and optimize the extraction. The critical values of parthenolide content were found to be 7% EtOH, 22 MPa and 64 °C in case of all three samples. It was determined, that the optimal conditions of the extraction, where the maximum parthenolide content and extract yield can be reached, do not coincide. The highest yield of parthenolide was obtained in the flower heads (0.604 wt.%)
Lotfollah Rezagholizadeh - One of the best experts on this subject based on the ideXlab platform.
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renoprotective effects of the methanolic extract of Tanacetum parthenium against carbon tetrachloride induced renal injury in rats
avicenna journal of phytomedicine, 2018Co-Authors: Mohammad Mazani, Yavar Mahmoodzadeh, Lotfollah Rezagholizadeh, Mir Mehdi Chinifroush Asl, Shokofeh Banaei, Alireza MohammadniaAbstract:Objective: Studies have demonstrated that carbon tetrachloride (CCl4) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney, heart, lung, brain, and liver. The major aim of the present study was to evaluate the protective activity of Tanacetum parthenium extract (TPE) in renal tissues of CCl4-intoxicated rats. Materials and Methods: Animals were divided into seven groups of six rats. Group 1 was the control group that was not treated with CCl4. The rats in the other groups were intraperitoneally injected with CCl4 (1.5 ml/kg, 1:1 in olive oil) on day 14. Rats in the groups bTPE40, bTPE80, and bTPE120 were gavaged with 40, 80, and 120 mg/kg of TPE, respectively for 14 constitutive days on a daily basis, before CCl4 administration. Rats in groups aTPE80 and aTPE120 were gavaged with 80 and 120 mg/kg of TPE, respectively, 2, 6, 24 and 48 hr after receiving CCl4. Blood samples were collected at the end of the 16th day through an intracardiac puncture and then serums were separated. Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). But administration of TPE to rats either before or after exposure to CCl4, attenuated these changes when compared with CCl4 control group (p Conclusion: TPE had potent nephroprotective effects against oxygen free radicals produced through CCl4 metabolism.
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Renoprotective effects of the methanolic extract of Tanacetum parthenium against carbon tetrachloride-induced renal injury in rats.
Avicenna journal of phytomedicine, 2018Co-Authors: Mohammad Mazani, Yavar Mahmoodzadeh, Lotfollah Rezagholizadeh, Mir Mehdi Chinifroush Asl, Shokofeh Banaei, Alireza MohammadniaAbstract:Objective: Studies have demonstrated that carbon tetrachloride (CCl4) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney, heart, lung, brain, and liver. The major aim of the present study was to evaluate the protective activity of Tanacetum parthenium extract (TPE) in renal tissues of CCl4-intoxicated rats. Materials and Methods: Animals were divided into seven groups of six rats. Group 1 was the control group that was not treated with CCl4. The rats in the other groups were intraperitoneally injected with CCl4 (1.5 ml/kg, 1:1 in olive oil) on day 14. Rats in the groups bTPE40, bTPE80, and bTPE120 were gavaged with 40, 80, and 120 mg/kg of TPE, respectively for 14 constitutive days on a daily basis, before CCl4 administration. Rats in groups aTPE80 and aTPE120 were gavaged with 80 and 120 mg/kg of TPE, respectively, 2, 6, 24 and 48 hr after receiving CCl4. Blood samples were collected at the end of the 16th day through an intracardiac puncture and then serums were separated. Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p
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Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4-induced liver damage in rats
Toxicology reports, 2017Co-Authors: Yavar Mahmoodzadeh, Mohammad Mazani, Lotfollah RezagholizadehAbstract:The purpose of this study was to investigate the effects of Tanacetum parthenium Extract (TPE) on Lipid peroxidation, antioxidant enzymes, biochemical factors, and liver enzymes in the rats damaged by Carbon Tetrachloride (CCl4). 54 male Wistar rats were divided into 9 groups each consisting of 6 rats. Two of the groups were control groups (normal and damage control groups), 4 of them were exposure groups which were respectively administered with 40, 80, and 120 mg/kg of TPE and silymarin for 14 days before being damaged by CCl4, and the other 3 groups were post-treatment groups which received 80 and 120 mg/kg of TPE and silymarin 2, 6, 24, and 48 h after being injected with CCl4. At the end of the study, biochemical factors, serum liver enzymes, malondialdehyde level, antioxidant enzymes, and liver morphology were assayed. Pre- and post-treatment with TPE could significantly decrease ALT, AST, ALP, TG, LDL, TC, and glucose levels and increase HDL, and albumin levels and catalase, SOD, and GPx activities compared to the CCl4-damaged control group. The results of this study are indicative of the antioxidant activity of TPE, its potential hepatoprotective effects, and its probable therapeutic properties for laboratory animals damaged by CCl4.
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Effect of Tanacetum parthenium Extract on Total Antioxidant Capacity of Tissues Damaged by Carbon Tetrachloride in Rats
Ardabil University of Medical Sciences, 2017Co-Authors: Yavar Mahmoodzadeh, Mohammad Mazani, Lotfollah Rezagholizadeh, Aliasghar Abbaspour, Eslam Zabihi, Pirooz PourmohammadAbstract:Background & objectives: Some herbs contain compounds with antioxidant activity and can be used to protect or cure damages caused by chemical toxins. The aim of this study was to evaluate the effects of carbon tetrachloride (CCl4) on total antioxidants in various tissues and Tanacetum parthenium impacts on reducing devastating effects of carbon tetrachloride. Methods: A total of 42 male Wistar rats were divided into seven groups of six animals in each group: normal control, damaged control, three groups that treated with 40, 80, and 120 mg/kg of Tanacetum parthenium extract 14 days before CCl4 injection and two groups served as post-treatment groups that received 80 and 120 mg/kg extract 2, 6, 24, and 48 h after CCl4 injection. At the end of study the liver, kidney, testis, and heart were removed and then homogenized and then the antioxidant activity of the tissues assessed using FRAP method. Results were analyzed by one-way ANOVA test. Results: The results showed that the injection of carbon tetrachloride significantly decreasestotal antioxidant in both liver (p
Celso Vataru Nakamura - One of the best experts on this subject based on the ideXlab platform.
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evaluation of anti hsv 1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium l sch bip asteraceae
Phytomedicine, 2019Co-Authors: Erica Benassizanqueta, Benedito Prado Dias Filho, Izabel Cristina Piloto Ferreira, Celso Vataru Nakamura, Caroline Fernandes Marques, Larissa Machado Valone, Bruna Luiza Pellegrini, Anelize Bauermeister, Norberto Peporine Lopes, Maria Raquel Marcal NataliAbstract:Abstract Background Herpes simplex type 1 (HSV-1) is widely distributed throughout the world's population. The virus spreads through direct contact with an infected individual. After primary infection, the virus remains in a latent state, and the recurrence of herpetic lesions is common. Standard treatment is performed with nucleoside analogues, but the selection of resistant strains have occurred, thus requiring the continual search for new antiviral agents. Plant extracts, fractions, and isolated compounds are a good source for studying possible antiviral compounds. Hypothesis Among plants with antiviral activity, the crude extract of aerial parts of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae) have previously shown to inhibit HSV-1 infection in vitro. Methods The present study investigated the chemical composition of a crude hydroethanolic extract (CHE) of T. parthenium, and in vivo safety and therapeutic efficacy against HSV-1 infection. Results Liquid chromatography-mass spectrometry showed that the CHE was composed of phenolic acids (chlorogenic acids) and sesquiterpene lactones (parthenolide). Acute and subchronic toxicity and genotoxicity tests in vivo showed that oral CHE administration did not result in signs of toxicity, with no genotoxic potential. The CHE was also safe for topical administration, in which no irritation of the epidermis was observed in treated animals. Tests of topical and oral therapeutic efficacy showed that the CHE was effective against HSV-1 infection. Topical administration was the most effective, the results for which were comparable to acyclovir. Conclusion These findings indicate that the CHE from aerial parts of Tanacetum parthenium has in vivo anti-HSV-1 activity and is safe for oral and topical application.
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Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae)
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018Co-Authors: Érica Benassi-zanqueta, Benedito Prado Dias Filho, Izabel Cristina Piloto Ferreira, Celso Vataru Nakamura, Caroline Fernandes Marques, Larissa Machado Valone, Bruna Luiza Pellegrini, Anelize Bauermeister, Norberto Peporine Lopes, Maria Raquel Marcal NataliAbstract:Herpes simplex type 1 (HSV-1) is widely distributed throughout the world's population. The virus spreads through direct contact with an infected individual. After primary infection, the virus remains in a latent state, and the recurrence of herpetic lesions is common. Standard treatment is performed with nucleoside analogues, but the selection of resistant strains have occurred, thus requiring the continual search for new antiviral agents. Plant extracts, fractions, and isolated compounds are a good source for studying possible antiviral compounds. Among plants with antiviral activity, the crude extract of aerial parts of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae) have previously shown to inhibit HSV-1 infection in vitro. The present study investigated the chemical composition of a crude hydroethanolic extract (CHE) of T. parthenium, and in vivo safety and therapeutic efficacy against HSV-1 infection. Liquid chromatography-mass spectrometry showed that the CHE was composed of phenolic acids (chlorogenic acids) and sesquiterpene lactones (parthenolide). Acute and subchronic toxicity and genotoxicity tests in vivo showed that oral CHE administration did not result in signs of toxicity, with no genotoxic potential. The CHE was also safe for topical administration, in which no irritation of the epidermis was observed in treated animals. Tests of topical and oral therapeutic efficacy showed that the CHE was effective against HSV-1 infection. Topical administration was the most effective, the results for which were comparable to acyclovir. These findings indicate that the CHE from aerial parts of Tanacetum parthenium has in vivo anti-HSV-1 activity and is safe for oral and topical application. Copyright © 2018 Elsevier GmbH. All rights reserved.
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In vitro and in vivo antileishmania activity of sesquiterpene lactone-rich dichloromethane fraction obtained from Tanacetum parthenium (L.) Schultz-Bip.
Experimental parasitology, 2014Co-Authors: Mirela Fulgencio Rabito, Celso Vataru Nakamura, Elizandra Aparecida Britta, Bruna Luíza Pelegrini, Débora Botura Scariot, Mariana Bortholazzi Almeida, Suzana Lucy Nixdorf, Izabel Cristina Piloto FerreiraAbstract:Abstract The discovery of new treatments for neglected diseases, including leishmaniasis, is a substantial challenge for scientific research. Plant extracts have shown potential in the selective treatment of tropical diseases. The present study evaluated the in vitro and in vivo antileishmania effects of a sesquiterpene lactone-rich dichloromethane fraction (DF) obtained from the aerial parts of Tanacetum parthenium (L.) Schultz-Bip. In vitro studies of the DF indicated an IC 50 of 2.40 ± 0.76 μg mL −1 against the promastigote form and 1.76 ± 0.25 μg mL −1 against the axenic amastigote form of Leishmania amazonensis . In vivo intramuscular treatment with DF decreased the growth and size of footpad lesions in mice. The DF also significantly decreased the parasite population compared with animals that were treated with the reference drug. Plasma malondialdehyde levels were increased slightly by the DF, attributable to its parthenolide-rich composition that causes cellular apoptosis, compared with the control group, demonstrating treatment efficacy without toxicity or genotoxicity. Because the isolation and purification of plant compounds are costly and time-consuming and generate low yields, extract fractions, such as the DF studied herein, represent a promising alternative for the treatment of leishmaniasis.
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Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazole.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012Co-Authors: Juliana Cogo, Benedito Prado Dias Filho, Izabel Cristina Piloto Ferreira, Tânia Ueda-nakamura, Angelo De Oliveira Caleare, Celso Vataru NakamuraAbstract:Abstract In the present study, we evaluated the in vitro antiprotozoal activity of a guaianolide (11,13-dehydrocompressanolide) isolated from Tanacetum parthenium against Trypanosoma cruzi and investigated the possible combinational effect of guaianolide and benznidazole. The isolated compound was shown to be effective against T. cruzi, with IC50 values of 18.1 ± 0.8 and 66.6 ± 1.3 μM against the multiplicative epimastigote and amastigote forms, respectively. The best results were obtained against trypomastigotes, with an EC50 of 5.7 ± 0.7 μM. The guaianolide presented no toxicity in LLCMK2 cells (CC50 of 93.5 μM) and was 16.4-fold more selective for trypomastigotes. The study of the combinational effect of benznidazole and guaianolide revealed the presence of a synergistic effect against the epimastigote form and marginal additive effect against the trypomastigote form. Striking morphological changes were observed in epimastigotes treated with guaianolide, such as thinning and stretching of the cell body and flagellum and changes in the format of the cell body with apparent leakage of the cytoplasmic content in trypomastigote forms. The ultrastructural analysis of epimastigotes revealed the presence of membranes that involved organelles and formation of myelin-like figures. Flow cytometry revealed a cell volume reduction and decrease in mitochondrial membrane potential. However, no major changes in cell membrane integrity were found in the epimastigote form treated with guaianolide.
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Antileishmanial activity of a guaianolide from Tanacetum parthenium (L.) Schultz Bip
Parasitology international, 2010Co-Authors: Bruna Polacchine Da Silva, Benedito Prado Dias Filho, Celso Vataru Nakamura, Diógenes Aparício Garcia Cortez, Thaisa Yume Violin, Tânia Ueda-nakamura, Izabel Cristina Piloto FerreiraAbstract:Abstract Leishmaniasis is one of the major infectious diseases affecting the poorest regions of the world. The present study evaluated the antileishmanial activity of a guaianolide purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium (L.) Schultz Bip. The isolated compound showed activity against the promastigote form of Leishmania amazonensis , with 50% inhibition (IC 50 ) of cell growth at a concentration of 2.6 μg/ml. For the intracellular amastigote form, this guaianolide reduced by 10% the survival index of parasites in macrophages when it was used at 20.0 μg/ml. The selective index (SI) ratio (CC 50 for J774G8 cells/IC 50 for protozoans) was 385, showing that it is more selective against the parasite than mammalian cells. Morphological alterations of protozoans treated with IC 50 included changes in size, shape, and structure (more than one nucleus and flagellum) under both light and scanning electron microscopies.
