Teratology

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The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform

Thomas Knudsen - One of the best experts on this subject based on the ideXlab platform.

Jane Adams - One of the best experts on this subject based on the ideXlab platform.

  • the neurobehavioral Teratology of retinoids a 50 year history
    Birth Defects Research Part A-clinical and Molecular Teratology, 2010
    Co-Authors: Jane Adams
    Abstract:

    This review of the central nervous system (CNS) and behavioral Teratology of the retinoids over the last 50 years is a commemorative retrospective organized by decade to show the prominent research focus within each period and the most salient findings. In the 1960s, research focused on the gross CNS malformations associated with exposure and the delineation of dose-response and stage-specific responses in rodent models. Relevant scientific events before and during the 1960s are also discussed to provide the zeitgeist in which the field of neurobehavioral Teratology emerged in the 1970s. During this period, studies demonstrated that adverse effects on postnatal behavior could be produced in animals exposed to doses of vitamin A lower than those that were teratogenic or impacted growth. Work during the 1980s showed an overrepresentation of behavioral studies focused on the reliability of screening methods, while the marked effects of human exposure were illustrated in children born to women treated with isotretinoin during pregnancy. The human catastrophe invigorated research during the 1990s, a period when technological advances allowed more elegant examinations of the developing CNS, of biochemical, cellular, and molecular developmental events and regulatory actions, and of the effects of direct genetic manipulations. Likewise, research in the 1990s reflected a reinvigoration of research in neurobehavioral Teratology evinced in studies that used animal models to try to better understand human vulnerability. These foci continued in the 2000-2010 period while examinations of the role of retinoids in brain development and lifelong functioning became increasingly sophisticated and broader in scope. This review of the work on retinoids also provides a lens on the more general ontogeny of the field of neurobehavioral Teratology. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.

  • The neurobehavioral Teratology of retinoids: A 50‐year history
    Birth defects research. Part A Clinical and molecular teratology, 2010
    Co-Authors: Jane Adams
    Abstract:

    This review of the central nervous system (CNS) and behavioral Teratology of the retinoids over the last 50 years is a commemorative retrospective organized by decade to show the prominent research focus within each period and the most salient findings. In the 1960s, research focused on the gross CNS malformations associated with exposure and the delineation of dose-response and stage-specific responses in rodent models. Relevant scientific events before and during the 1960s are also discussed to provide the zeitgeist in which the field of neurobehavioral Teratology emerged in the 1970s. During this period, studies demonstrated that adverse effects on postnatal behavior could be produced in animals exposed to doses of vitamin A lower than those that were teratogenic or impacted growth. Work during the 1980s showed an overrepresentation of behavioral studies focused on the reliability of screening methods, while the marked effects of human exposure were illustrated in children born to women treated with isotretinoin during pregnancy. The human catastrophe invigorated research during the 1990s, a period when technological advances allowed more elegant examinations of the developing CNS, of biochemical, cellular, and molecular developmental events and regulatory actions, and of the effects of direct genetic manipulations. Likewise, research in the 1990s reflected a reinvigoration of research in neurobehavioral Teratology evinced in studies that used animal models to try to better understand human vulnerability. These foci continued in the 2000-2010 period while examinations of the role of retinoids in brain development and lifelong functioning became increasingly sophisticated and broader in scope. This review of the work on retinoids also provides a lens on the more general ontogeny of the field of neurobehavioral Teratology. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.

C Cook - One of the best experts on this subject based on the ideXlab platform.

  • Ocular Teratology.
    Survey of ophthalmology, 1991
    Co-Authors: K Strömland, M Miller, C Cook
    Abstract:

    The principles of Teratology are described, and animal models for research in abnormal ocular development and clinical studies of human teratogens are surveyed. A review is made of presumed ocular teratogenic agents: radiation; external environmental teratogens; maternal conditions such as infections, diabetes, and epilepsy; alcohol and drugs such as thalidomide, retinoic acid, and coumarin anticoagulants; and other agents, such as cigarettes.

Steve Barton - One of the best experts on this subject based on the ideXlab platform.

  • Teratology testing under REACH.
    Methods in molecular biology (Clifton N.J.), 2012
    Co-Authors: Steve Barton
    Abstract:

    REACH guidelines may require Teratology testing for new and existing chemicals. This chapter discusses procedures to assess the need for Teratology testing and the conduct and interpretation of Teratology tests where required.

Gloria E. Mao - One of the best experts on this subject based on the ideXlab platform.

  • Teratology of retinoids.
    Annual review of pharmacology and toxicology, 1999
    Co-Authors: Michael D. Collins, Gloria E. Mao
    Abstract:

    Either an excess or a deficiency of vitamin A and related compounds (retinoids) causes abnormal morphological development (teratogenesis). Potential retinoid sources come from dietary intake, nutritional supplements, and some therapeutic drugs. Therefore, understanding the mechanisms of retinoid teratogenesis is important. This review first gives an overview of the principles of Teratology as they apply to retinoid-induced malformations. It then describes relevant aspects of the biochemical pathway and signal transduction of retinoids. The teratogenic activity of various retinoid compounds, the role of the retinoid receptors, and important toxicokinetic parameters in teratogenesis are reviewed.

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