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F Eckstein - One of the best experts on this subject based on the ideXlab platform.
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clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a u net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Anja Ruhdorfer, Sebastian K. Eder, W Wirth, F Eckstein, Akshay S Chaudhari, Ender KonukogluAbstract:Objective Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study.
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clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a u net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Anja Ruhdorfer, Sebastian K. Eder, W Wirth, F Eckstein, Akshay S Chaudhari, Ender KonukogluAbstract:OBJECTIVE: Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study. MATERIALS AND METHODS: The segmentation method is based on U-Net architecture trained on 250 manually segmented Thighs from the Osteoarthritis Initiative (OAI). The clinical evaluation is performed on a hold-out test set bilateral Thighs of 48 subjects with unilateral knee pain. RESULTS: The segmentation time of the method is < 1 s and demonstrated high agreement with the manual method (dice similarity coeffcient: 0.96 ± 0.01). In the clinical study, the automated method shows that similar to manual segmentation (- 5.7 ± 7.9%, p < 0.001, effect size: 0.69), painful knees display significantly lower quadriceps CSAs than contralateral painless knees (- 5.6 ± 7.6%, p < 0.001, effect size: 0.73). DISCUSSION: Automated segmentation of Thigh Muscle and adipose tissues has high agreement with manual segmentations and can replicate the effect size seen in a clinical study on osteoarthritic pain.
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the role of Thigh Muscle and adipose tissue in knee osteoarthritis progression in women data from the osteoarthritis initiative
Osteoarthritis and Cartilage, 2018Co-Authors: Jana Kemnitz, W Wirth, F Eckstein, Adam G CulvenorAbstract:Summary Objective To determine whether loss in Thigh Muscle strength in women concurrent with knee osteoarthritis progression is associated with reductions of Muscle anatomical cross-sectional area (ACSA) or specific-strength (i.e., isometric force÷ACSA), and to explore relationships with local adiposity. Design Female participants from the Osteoarthritis Initiative with Kellgren–Lawrence grade ≤3, Thigh isometric strength measurements, and Thigh magnetic resonance images at year-two (Y2) and year-four (Y4) (n = 739, age 62 ± 9 years; body mass index measurements (BMI) 28.8 ± 5.9 kg/m2) were grouped into: (1) those with vs without symptomatic progression (≥9 increase in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)-pain [scale: 0–100]); and (2) those with vs without radiographic progression (≥0.7 mm reduction in minimum joint space width). The change in knee extensor and flexor ACSA and specific-strength, and subcutaneous and intermuscular fat (IMF) ACSAs were compared between progressors and non-progressors using analysis of covariance. Results Symptomatic progression was associated with a significantly greater loss (p Conclusion The significant reduction in Thigh Muscle strength concurrent with symptomatic progression in women appears to be associated with loss of extensor Muscle ACSA and flexor specific-strength. In contrast, radiographic progression appears to be unrelated to Muscle properties, but to be associated with local (intermuscular) adiposity gains.
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Thigh Muscle specific strength and the risk of incident knee osteoarthritis the influence of sex and greater body mass index
Arthritis Care and Research, 2017Co-Authors: Adam G Culvenor, T Dannhauer, W Wirth, David T Felson, M Sattler, F EcksteinAbstract:OBJECTIVE: To determine whether lower Thigh Muscle specific-strength increases the risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between Thigh Muscle specific-strength and body mass index (BMI). METHODS: A total of 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA. Thigh Muscle anatomical cross-sectional areas (ACSAs) were determined at baseline using axial magnetic resonance imaging scans. Isometric extensor and flexor Muscle strength was measured at baseline, and specific strength (strength ÷ ACSA) was calculated. Logistic regression assessed the risk of incident RKOA associated with Muscle specific-strength (with and without adjustment for BMI). RESULTS: Lower knee extensor- and flexor-specific strength significantly increased the risk of incident RKOA in women but not in men (odds ratio 1.47 [95% confidence interval (95% CI) 1.10-1.96] and 1.41 [95% CI 1.06-1.89], respectively). The significant relationship in women was lost after adjustment for BMI. Lower specific strength was associated with higher BMI in women (r = -0.29, P < 0.001), but not in men, whereas absolute strength was associated with BMI in men (r = 0.28, P = 0.001), but not in women. CONCLUSION: Lower Thigh Muscle specific-strength predicts incident RKOA in women, with this relationship being confounded by BMI. The sex-specific relationship between Muscle specific-strength and BMI provides a possible explanation why women with Muscle-strength deficits typically have a poorer prognosis than men with similar strength deficits.
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predictive capacity of Thigh Muscle strength in symptomatic and or radiographic knee osteoarthritis progression data from the foundation for the national institutes of health osteoarthritis biomarkers consortium
American Journal of Physical Medicine & Rehabilitation, 2016Co-Authors: Adam G Culvenor, W Wirth, David J Hunter, M Roth, F EcksteinAbstract:ABSTRACTThigh Muscle weakness is a risk factor for incident radiographic and symptomatic knee osteoarthritis (KOA). The role of Thigh Muscle weakness in radiographic and/or symptomatic KOA progression remains elusive. Five hundred twenty-seven knees of 527 Osteoarthritis Initiative participants with
W Wirth - One of the best experts on this subject based on the ideXlab platform.
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clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a u net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Anja Ruhdorfer, Sebastian K. Eder, W Wirth, F Eckstein, Akshay S Chaudhari, Ender KonukogluAbstract:Objective Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study.
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clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a u net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Anja Ruhdorfer, Sebastian K. Eder, W Wirth, F Eckstein, Akshay S Chaudhari, Ender KonukogluAbstract:OBJECTIVE: Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study. MATERIALS AND METHODS: The segmentation method is based on U-Net architecture trained on 250 manually segmented Thighs from the Osteoarthritis Initiative (OAI). The clinical evaluation is performed on a hold-out test set bilateral Thighs of 48 subjects with unilateral knee pain. RESULTS: The segmentation time of the method is < 1 s and demonstrated high agreement with the manual method (dice similarity coeffcient: 0.96 ± 0.01). In the clinical study, the automated method shows that similar to manual segmentation (- 5.7 ± 7.9%, p < 0.001, effect size: 0.69), painful knees display significantly lower quadriceps CSAs than contralateral painless knees (- 5.6 ± 7.6%, p < 0.001, effect size: 0.73). DISCUSSION: Automated segmentation of Thigh Muscle and adipose tissues has high agreement with manual segmentations and can replicate the effect size seen in a clinical study on osteoarthritic pain.
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the role of Thigh Muscle and adipose tissue in knee osteoarthritis progression in women data from the osteoarthritis initiative
Osteoarthritis and Cartilage, 2018Co-Authors: Jana Kemnitz, W Wirth, F Eckstein, Adam G CulvenorAbstract:Summary Objective To determine whether loss in Thigh Muscle strength in women concurrent with knee osteoarthritis progression is associated with reductions of Muscle anatomical cross-sectional area (ACSA) or specific-strength (i.e., isometric force÷ACSA), and to explore relationships with local adiposity. Design Female participants from the Osteoarthritis Initiative with Kellgren–Lawrence grade ≤3, Thigh isometric strength measurements, and Thigh magnetic resonance images at year-two (Y2) and year-four (Y4) (n = 739, age 62 ± 9 years; body mass index measurements (BMI) 28.8 ± 5.9 kg/m2) were grouped into: (1) those with vs without symptomatic progression (≥9 increase in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)-pain [scale: 0–100]); and (2) those with vs without radiographic progression (≥0.7 mm reduction in minimum joint space width). The change in knee extensor and flexor ACSA and specific-strength, and subcutaneous and intermuscular fat (IMF) ACSAs were compared between progressors and non-progressors using analysis of covariance. Results Symptomatic progression was associated with a significantly greater loss (p Conclusion The significant reduction in Thigh Muscle strength concurrent with symptomatic progression in women appears to be associated with loss of extensor Muscle ACSA and flexor specific-strength. In contrast, radiographic progression appears to be unrelated to Muscle properties, but to be associated with local (intermuscular) adiposity gains.
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Thigh Muscle specific strength and the risk of incident knee osteoarthritis the influence of sex and greater body mass index
Arthritis Care and Research, 2017Co-Authors: Adam G Culvenor, T Dannhauer, W Wirth, David T Felson, M Sattler, F EcksteinAbstract:OBJECTIVE: To determine whether lower Thigh Muscle specific-strength increases the risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between Thigh Muscle specific-strength and body mass index (BMI). METHODS: A total of 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA. Thigh Muscle anatomical cross-sectional areas (ACSAs) were determined at baseline using axial magnetic resonance imaging scans. Isometric extensor and flexor Muscle strength was measured at baseline, and specific strength (strength ÷ ACSA) was calculated. Logistic regression assessed the risk of incident RKOA associated with Muscle specific-strength (with and without adjustment for BMI). RESULTS: Lower knee extensor- and flexor-specific strength significantly increased the risk of incident RKOA in women but not in men (odds ratio 1.47 [95% confidence interval (95% CI) 1.10-1.96] and 1.41 [95% CI 1.06-1.89], respectively). The significant relationship in women was lost after adjustment for BMI. Lower specific strength was associated with higher BMI in women (r = -0.29, P < 0.001), but not in men, whereas absolute strength was associated with BMI in men (r = 0.28, P = 0.001), but not in women. CONCLUSION: Lower Thigh Muscle specific-strength predicts incident RKOA in women, with this relationship being confounded by BMI. The sex-specific relationship between Muscle specific-strength and BMI provides a possible explanation why women with Muscle-strength deficits typically have a poorer prognosis than men with similar strength deficits.
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predictive capacity of Thigh Muscle strength in symptomatic and or radiographic knee osteoarthritis progression data from the foundation for the national institutes of health osteoarthritis biomarkers consortium
American Journal of Physical Medicine & Rehabilitation, 2016Co-Authors: Adam G Culvenor, W Wirth, David J Hunter, M Roth, F EcksteinAbstract:ABSTRACTThigh Muscle weakness is a risk factor for incident radiographic and symptomatic knee osteoarthritis (KOA). The role of Thigh Muscle weakness in radiographic and/or symptomatic KOA progression remains elusive. Five hundred twenty-seven knees of 527 Osteoarthritis Initiative participants with
Anja Ruhdorfer - One of the best experts on this subject based on the ideXlab platform.
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Clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a U-Net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Felix Eckstein, Akshay Chaudhari, Anja Ruhdorfer, Wolfgang Wirth, Sebastian K. Eder, Ender KonukogluAbstract:Objective Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study. Materials and methods The segmentation method is based on U-Net architecture trained on 250 manually segmented Thighs from the Osteoarthritis Initiative (OAI). The clinical evaluation is performed on a hold-out test set bilateral Thighs of 48 subjects with unilateral knee pain. Results The segmentation time of the method is
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clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a u net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Anja Ruhdorfer, Sebastian K. Eder, W Wirth, F Eckstein, Akshay S Chaudhari, Ender KonukogluAbstract:OBJECTIVE: Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study. MATERIALS AND METHODS: The segmentation method is based on U-Net architecture trained on 250 manually segmented Thighs from the Osteoarthritis Initiative (OAI). The clinical evaluation is performed on a hold-out test set bilateral Thighs of 48 subjects with unilateral knee pain. RESULTS: The segmentation time of the method is < 1 s and demonstrated high agreement with the manual method (dice similarity coeffcient: 0.96 ± 0.01). In the clinical study, the automated method shows that similar to manual segmentation (- 5.7 ± 7.9%, p < 0.001, effect size: 0.69), painful knees display significantly lower quadriceps CSAs than contralateral painless knees (- 5.6 ± 7.6%, p < 0.001, effect size: 0.73). DISCUSSION: Automated segmentation of Thigh Muscle and adipose tissues has high agreement with manual segmentations and can replicate the effect size seen in a clinical study on osteoarthritic pain.
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clinical evaluation of fully automated Thigh Muscle and adipose tissue segmentation using a u net deep learning architecture in context of osteoarthritic knee pain
Magnetic Resonance Materials in Physics Biology and Medicine, 2019Co-Authors: Jana Kemnitz, Christian F. Baumgartner, Anja Ruhdorfer, Sebastian K. Eder, W Wirth, F Eckstein, Akshay S Chaudhari, Ender KonukogluAbstract:Objective Segmentation of Thigh Muscle and adipose tissue is important for the understanding of musculoskeletal diseases such as osteoarthritis. Therefore, the purpose of this work is (a) to evaluate whether a fully automated approach provides accurate segmentation of Muscles and adipose tissue cross-sectional areas (CSA) compared with manual segmentation and (b) to evaluate the validity of this method based on a previous clinical study.
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longitudinal change in Thigh Muscle strength prior to and concurrent with minimum clinically important worsening or improvement in knee function data from the osteoarthritis initiative
Arthritis & Rheumatism, 2016Co-Authors: Anja Ruhdorfer, W Wirth, F EcksteinAbstract:OBJECTIVE: To investigate whether a clinically relevant change in knee function in patients with or at risk for osteoarthritis (OA) of the knee is associated with concurrent or prior change in Thigh Muscle strength. METHODS: Participants in the Osteoarthritis Initiative (n = 2,675 [1,485 women and 1,190 men]) with available measurements of isometric Muscle strength at baseline, 2-year follow-up, and 4-year follow-up were grouped into those with greater than minimum clinically important worsening (score of ≥6 [of a possible 68] on the Western Ontario and McMaster Universities Osteoarthritis Index function subscale) between 2-year follow-up and 4-year follow-up, those with greater than minimum clinically important improvement, and those without relevant change. Changes in isometric Muscle strength concurrent with function change (between 2-year follow-up and 4-year follow-up) and preceding function change (between baseline and 2-year follow-up), with 95% confidence intervals (95% CIs), were determined, and differences between groups were assessed by analysis of covariance. RESULTS: Concurrent loss in extensor Muscle strength in participants with worsening knee function during the 2-year follow-up-4-year follow-up period differed significantly from that in participants without change in knee function (-4.6% [95% CI -6.8, -2.4] and -2.2% [95% CI -3.0, -1.4], respectively; P = 0.03), as did the concurrent increase in strength among those with functional improvement (2.2% [95% CI -0.3, 4.7]; P < 0.0001). This increase in strength among subjects with improved function remained significantly different from the change in subjects with no change in function after adjustment for covariates, but was preceded by a greater loss in strength (-7.7% [95% CI -10.3, -5.0], P = 0.02) during the baseline-year 2 period compared to those without change in function during the year 2-year 4 period (-4.3% [95% CI -5.2, -3.4]). The decrease in strength during the baseline-year 2 period in those with worsening knee function during the year 2-year 4 period (-4.5% [95% CI -6.9, -2.2]) did not differ significantly from that in patients without a change in function (P = 0.87). No differences in changes in flexor Muscle strength were observed between groups. CONCLUSION: These findings suggest that there is a positive concurrent longitudinal association between change in extensor Muscle strength and worsening/improvement in knee function in patients with knee OA. However, a corresponding change in Thigh Muscle strength preceding the change in function was not observed.
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Thigh Muscle strength predicts knee replacement risk independent of radiographic disease and pain in women data from the osteoarthritis initiative
Arthritis & Rheumatism, 2015Co-Authors: Adam G Culvenor, Anja Ruhdorfer, W Wirth, F EcksteinAbstract:Objective To determine whether Thigh Muscle strength predicts the risk of undergoing knee replacement surgery, independent of radiographic severity of osteoarthritis and pain. Methods Participants in the Osteoarthritis Initiative study who had received a knee replacement between the 12-month and 60-month follow-up visits (cases) were each matched with 1 control subject (who did not receive a knee replacement over 60 months) for age, sex, height, body mass index, baseline radiographic stage, and location of joint space narrowing. Isometric knee extensor and flexor strength was recorded biennially. The strength examination prior to knee replacement (≤2 years) was termed time 0, that 2 years prior to time 0 was termed time −2, and that 4 years prior to time 0 was termed time −4. Muscle strength in patients and controls was compared using paired t-tests and conditional logistic regression analysis adjusted for pain. Results. One hundred thirty-six participants (60% women, mean ± SD age 65 ± 9 years, body mass index 29 ± 4 kg/m2) received a knee replacement during follow-up, had strength data for at least time 0, and had a matched control. Knee extensor strength at time 0 (primary outcome measure) was significantly lower in female patients compared with controls (P < 0.001, pain-adjusted odds ratio [ORadj] 1.72, 95% confidence interval 1.16–2.56), but no significant difference was observed in men. Results were similar for knee flexor strength at time 0 and for longitudinal change in extensor and flexor strength between time −2 and time 0. Thigh Muscle strength at time −2 or time −4, or change between time −4 and time −2, did not predict the risk of undergoing knee replacement surgery in men or women. Conclusion Thigh Muscle strength predicted the risk of undergoing knee replacement surgery in women, but not in men. The results of this study may identify a window during which the risk of undergoing knee replacement surgery in women can be modified.
Adam G Culvenor - One of the best experts on this subject based on the ideXlab platform.
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the role of Thigh Muscle and adipose tissue in knee osteoarthritis progression in women data from the osteoarthritis initiative
Osteoarthritis and Cartilage, 2018Co-Authors: Jana Kemnitz, W Wirth, F Eckstein, Adam G CulvenorAbstract:Summary Objective To determine whether loss in Thigh Muscle strength in women concurrent with knee osteoarthritis progression is associated with reductions of Muscle anatomical cross-sectional area (ACSA) or specific-strength (i.e., isometric force÷ACSA), and to explore relationships with local adiposity. Design Female participants from the Osteoarthritis Initiative with Kellgren–Lawrence grade ≤3, Thigh isometric strength measurements, and Thigh magnetic resonance images at year-two (Y2) and year-four (Y4) (n = 739, age 62 ± 9 years; body mass index measurements (BMI) 28.8 ± 5.9 kg/m2) were grouped into: (1) those with vs without symptomatic progression (≥9 increase in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)-pain [scale: 0–100]); and (2) those with vs without radiographic progression (≥0.7 mm reduction in minimum joint space width). The change in knee extensor and flexor ACSA and specific-strength, and subcutaneous and intermuscular fat (IMF) ACSAs were compared between progressors and non-progressors using analysis of covariance. Results Symptomatic progression was associated with a significantly greater loss (p Conclusion The significant reduction in Thigh Muscle strength concurrent with symptomatic progression in women appears to be associated with loss of extensor Muscle ACSA and flexor specific-strength. In contrast, radiographic progression appears to be unrelated to Muscle properties, but to be associated with local (intermuscular) adiposity gains.
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Thigh Muscle specific strength and the risk of incident knee osteoarthritis the influence of sex and greater body mass index
Arthritis Care and Research, 2017Co-Authors: Adam G Culvenor, T Dannhauer, W Wirth, David T Felson, M Sattler, F EcksteinAbstract:OBJECTIVE: To determine whether lower Thigh Muscle specific-strength increases the risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between Thigh Muscle specific-strength and body mass index (BMI). METHODS: A total of 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA. Thigh Muscle anatomical cross-sectional areas (ACSAs) were determined at baseline using axial magnetic resonance imaging scans. Isometric extensor and flexor Muscle strength was measured at baseline, and specific strength (strength ÷ ACSA) was calculated. Logistic regression assessed the risk of incident RKOA associated with Muscle specific-strength (with and without adjustment for BMI). RESULTS: Lower knee extensor- and flexor-specific strength significantly increased the risk of incident RKOA in women but not in men (odds ratio 1.47 [95% confidence interval (95% CI) 1.10-1.96] and 1.41 [95% CI 1.06-1.89], respectively). The significant relationship in women was lost after adjustment for BMI. Lower specific strength was associated with higher BMI in women (r = -0.29, P < 0.001), but not in men, whereas absolute strength was associated with BMI in men (r = 0.28, P = 0.001), but not in women. CONCLUSION: Lower Thigh Muscle specific-strength predicts incident RKOA in women, with this relationship being confounded by BMI. The sex-specific relationship between Muscle specific-strength and BMI provides a possible explanation why women with Muscle-strength deficits typically have a poorer prognosis than men with similar strength deficits.
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Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index.
Arthritis Care and Research, 2017Co-Authors: Adam G Culvenor, Wolfgang Wirth, T Dannhauer, David T Felson, M Sattler, Felix EcksteinAbstract:OBJECTIVE: To determine whether lower Thigh Muscle specific-strength increases the risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between Thigh Muscle specific-strength and body mass index (BMI). METHODS: A total of 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA. Thigh Muscle anatomical cross-sectional areas (ACSAs) were determined at baseline using axial magnetic resonance imaging scans. Isometric extensor and flexor Muscle strength was measured at baseline, and specific strength (strength ÷ ACSA) was calculated. Logistic regression assessed the risk of incident RKOA associated with Muscle specific-strength (with and without adjustment for BMI). RESULTS: Lower knee extensor- and flexor-specific strength significantly increased the risk of incident RKOA in women but not in men (odds ratio 1.47 [95% confidence interval (95% CI) 1.10-1.96] and 1.41 [95% CI 1.06-1.89], respectively). The significant relationship in women was lost after adjustment for BMI. Lower specific strength was associated with higher BMI in women (r = -0.29, P
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predictive capacity of Thigh Muscle strength in symptomatic and or radiographic knee osteoarthritis progression data from the foundation for the national institutes of health osteoarthritis biomarkers consortium
American Journal of Physical Medicine & Rehabilitation, 2016Co-Authors: Adam G Culvenor, W Wirth, David J Hunter, M Roth, F EcksteinAbstract:ABSTRACTThigh Muscle weakness is a risk factor for incident radiographic and symptomatic knee osteoarthritis (KOA). The role of Thigh Muscle weakness in radiographic and/or symptomatic KOA progression remains elusive. Five hundred twenty-seven knees of 527 Osteoarthritis Initiative participants with
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Thigh Muscle strength predicts knee replacement risk independent of radiographic disease and pain in women data from the osteoarthritis initiative
Arthritis & Rheumatism, 2015Co-Authors: Adam G Culvenor, Anja Ruhdorfer, W Wirth, F EcksteinAbstract:Objective To determine whether Thigh Muscle strength predicts the risk of undergoing knee replacement surgery, independent of radiographic severity of osteoarthritis and pain. Methods Participants in the Osteoarthritis Initiative study who had received a knee replacement between the 12-month and 60-month follow-up visits (cases) were each matched with 1 control subject (who did not receive a knee replacement over 60 months) for age, sex, height, body mass index, baseline radiographic stage, and location of joint space narrowing. Isometric knee extensor and flexor strength was recorded biennially. The strength examination prior to knee replacement (≤2 years) was termed time 0, that 2 years prior to time 0 was termed time −2, and that 4 years prior to time 0 was termed time −4. Muscle strength in patients and controls was compared using paired t-tests and conditional logistic regression analysis adjusted for pain. Results. One hundred thirty-six participants (60% women, mean ± SD age 65 ± 9 years, body mass index 29 ± 4 kg/m2) received a knee replacement during follow-up, had strength data for at least time 0, and had a matched control. Knee extensor strength at time 0 (primary outcome measure) was significantly lower in female patients compared with controls (P < 0.001, pain-adjusted odds ratio [ORadj] 1.72, 95% confidence interval 1.16–2.56), but no significant difference was observed in men. Results were similar for knee flexor strength at time 0 and for longitudinal change in extensor and flexor strength between time −2 and time 0. Thigh Muscle strength at time −2 or time −4, or change between time −4 and time −2, did not predict the risk of undergoing knee replacement surgery in men or women. Conclusion Thigh Muscle strength predicted the risk of undergoing knee replacement surgery in women, but not in men. The results of this study may identify a window during which the risk of undergoing knee replacement surgery in women can be modified.
Edward J Boyko - One of the best experts on this subject based on the ideXlab platform.
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association of Thigh Muscle mass with insulin resistance and incident type 2 diabetes mellitus in japanese americans
Diabetes & Metabolism Journal, 2018Co-Authors: Edward J Boyko, Wilfred Y Fujimoto, Steven E Kahn, Donna L LeonettiAbstract:BACKGROUND: Skeletal Muscle plays a major role in glucose metabolism. We investigated the association between Thigh Muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association. METHODS: This prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of Thigh Muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between Thigh Muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years. RESULTS: Thigh Muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and Thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between Thigh Muscle area and BMI was observed, i.e., greater Thigh Muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels. CONCLUSION: Thigh Muscle mass area was inversely associated with future insulin resistance. Greater Thigh Muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.
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Association of Visceral Fat and Liver Fat, Not Thigh Muscle Area nor Attenuation, with the Incidence of Type 2 Diabetes
Diabetes, 2018Co-Authors: Kyoko Kogawa Sato, Edward J Boyko, Wilfred Y Fujimoto, Shinichiro Uehara, Mikiko Shibata, Yonezo Hikita, Tomoshige HayashiAbstract:Visceral fat, liver, and skeletal Muscle are all major target organs of insulin and play key roles in the pathophysiology of type 2 diabetes. Not known is whether visceral fat, liver fat, and Thigh skeletal Muscle area or fat directly measured by computed tomography (CT) are independently associated with the incidence of type 2 diabetes. In a prospective cohort study, 1228 nondiabetic Japanese men and women were included. Intra-abdominal fat area (IAFA), liver-to-spleen (L/S) attenuation ratio to assess liver fat, and mid-Thigh Muscle area and attenuation were measured by CT. Low CT attenuation of liver and Muscle reflects greater liver and intramuscular lipid content. Insulin resistance was assessed by HOMA-IR. Type 2 diabetes was diagnosed as fasting plasma glucose level ≥126 mg/dL, HbA1c ≥6.5%, or taking oral hypoglycemic medications or insulin. Discrete-time logistic hazard model was used. During the 7686 person-years of follow-up (median follow-up period, 7 years), 95 subjects developed type 2 diabetes. IAFA and L/S ratio, not Thigh Muscle area, were independently associated with the risk of type 2 diabetes. In multiple-adjusted models that included IAFA, L/S ratio, Thigh Muscle area, age, gender, family history of diabetes, HOMA-IR, smoking habit, daily alcohol consumption, and regular physical activity, odds ratios of type 2 diabetes for tertile 2 and 3 of IAFA were 2.23 (95% CI, 0.94-5.31) and 3.16 (1.33-7.52), respectively, compared to tertile 1, and those for tertile 1 and 2 of L/S ratio were 2.01 (1.01-3.97) and 2.(1.04-4.08), respectively, compared to tertile 3. However, those of tertile 2 and 3 of Thigh Muscle area were 0.76 (0.32-1.78) and 0.64 (0.24-1.69), respectively, compared to tertile 1. When Thigh Muscle attenuation was substituted for its area, results was identical to the above model. In conclusion, both greater amounts of visceral and liver fat, not Thigh Muscle area nor attenuation, were independently associated with the risk of type 2 diabetes. Disclosure K. Sato: None. S. Uehara: None. M. Shibata: None. Y. Hikita: None. W.Y. Fujimoto: None. E.J. Boyko: None. T. Hayashi: None.
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effects of combination of change in visceral fat and Thigh Muscle mass on the development of type 2 diabetes
Diabetes Research and Clinical Practice, 2017Co-Authors: Wilfred Y Fujimoto, Steven E Kahn, Donna L Leonetti, Edward J BoykoAbstract:Abstract Aim We investigated the association between combined changes of visceral fat and Thigh Muscle over 5 years and incident type 2 diabetes in a prospective study of Japanese Americans. Methods We followed 420 nondiabetic Japanese American subjects for 5 years and assessed visceral fat and Thigh Muscle by computed tomography (CT) at baseline and at 5 years. We categorized study subjects into 4 body composition change groups: visceral fat loss/Thigh Muscle gain (VF-loss/TM-gain), visceral fat loss/Thigh Muscle loss (VF-loss/TM-loss), visceral fat gain/Thigh Muscle gain (VF-gain/TM-gain), and visceral fat gain/Thigh Muscle loss (VF-gain/TM-loss) by combining changes from baseline in CT measured visceral fat and estimated Thigh Muscle areas. We fit a logistic regression model to examine the association between body composition categories and the development of incident type 2 diabetes at 5 years. Results Cumulative incidence of type 2 diabetes was 9.8% at 5 years. VF-gain/TM-gain and VF-loss/TM-loss groups had higher risk for incident type 2 diabetes in a model adjusted for age, sex, family history of diabetes, and body mass index compared to VF-loss/TM-gain group as the reference category (OR = 6.83 (1.85–25.17), 4.55 (1.06–19.48), respectively). However, the VF-gain/TM-loss group did not show a significant association with the odds of incident diabetes (3.24; 95% CI. 0.78–13.47). Conclusions Concordant gain or loss in visceral fat and Thigh Muscle was related to higher risk of incident type 2 diabetes compared to the reference combination of loss of visceral fat and gain of Thigh Muscle in Japanese Americans.