The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform

Stephan Klinzing - One of the best experts on this subject based on the ideXlab platform.

  • Determination of the side-separated pulmonary right-to-left shunt volume.
    The journal of medical investigation : JMI, 2020
    Co-Authors: Thomas Lesser, Harald Schubert, Stephan Klinzing
    Abstract:

    With the present method of intrapulmonary right-to-left shunt volume calculation, no differentiation can be made between the shunt volume shares of the right and left lungs. For a better understanding of pathophysiological processes during Thorax Surgery with side-separated ventilation, a side-separated shunt volume determination would be useful. In 14 young female pigs, catheters were implanted into the left atrium after left thoracotomy. After transient clamping of the ipsilateral pulmonary veins, pulmonary venous blood was selectively obtained from the right lung. Cardiac output (CO) and side-separated pulmonary perfusion were determined with flowprobes at the pulmonary trunk and the left pulmonary artery. The shunt volumes were determined before and after thoracotomy during two-lung ventilation (Two-LV), after one-lung (right) ventilation (One-LV) with a continuous positive airway pressure (CPAP) of +7.5, +5.0 cm H(2)O, and under atelectasis of the non-dependent left lung (NDL). After thoracotomy in lateral decubitus position and Two-LV, the shunt volumes of the two lungs differ. The right lung holds the major share (11.0 +/- 1.7% CO) [mean +/- SD]. The share of the left NDL is only 3.3 +/- 1.4. Under One-LV (right) and CPAP in the NDL, the total pulmonary shunt volume rises. This is caused by the increase in the NDL shunt volume share to 8.8 +/- 5.2 under CPAP +7.5 (p<0.05) and to 9.7 +/- 2.5 under CPAP +5.0 (p < 0.05). The new intraoperative method of side-separated arterial blood gas analysis in conjunction with side-separated perfusion measurement makes side- separated right-to-left shunt volume determination possible and may lead to interesting new pathophysiological insights.

  • Determination of the side-separated pulmonary right-to-left shunt volume.
    The Journal of Medical Investigation, 2008
    Co-Authors: Thomas Lesser, Harald Schubert, Stephan Klinzing
    Abstract:

    Background : With the present method of intrapulmonary right-to-left shunt volume calculation, no differentiation can be made between the shunt volume shares of the right and left lungs. For a better understanding of pathophysiological processes dur- ing Thorax Surgery with side-separated ventilation, a side-separated shunt volume deter- mination would be useful. Materials and Methods : In 14 young female pigs, catheters were implanted into the left atrium after left thoracotomy. After transient clamping of the ip- silateral pulmonary veins, pulmonary venous blood was selectively obtained from the right lung. Cardiac output (CO) and side-separated pulmonary perfusion were determined with flowprobes at the pulmonary trunk and the left pulmonary artery. The shunt volumes were determined before and after thoracotomy during two-lung ventilation (Two-LV), after one-lung (right) ventilation (One-LV) with a continuous positive airway pressure (CPAP) of +7.5, +5.0 cm H2O, and under atelectasis of the non-dependent left lung (NDL). Results : After thoracotomy in lateral decubitus position and Two-LV, the shunt volumes of the two lungs differ. The right lung holds the major share (11.0 1.7% O) (mean SD). The share of the left NDL is only 3.3 1.4. Under One-LV (right) and CPAP in the NDL, the total pulmonary shunt volume rises. This is caused by the increase in the NDL shunt vol- ume share to 8.8 5.2 under CPAP +7.5 (p 0.05) and to 9.7 2.5 under CPAP +5.0 (p 0.05). Conclusions : The new intraoperative method of side-separated arterial blood gas analy- sis in conjunction with side-separated perfusion measurement makes side- separated right- to-left shunt volume determination possible and may lead to interesting new pathophysi- ological insights. J. Med. Invest. 55 : 44-50, February, 2008

Thomas Lesser - One of the best experts on this subject based on the ideXlab platform.

  • Determination of the side-separated pulmonary right-to-left shunt volume.
    The journal of medical investigation : JMI, 2020
    Co-Authors: Thomas Lesser, Harald Schubert, Stephan Klinzing
    Abstract:

    With the present method of intrapulmonary right-to-left shunt volume calculation, no differentiation can be made between the shunt volume shares of the right and left lungs. For a better understanding of pathophysiological processes during Thorax Surgery with side-separated ventilation, a side-separated shunt volume determination would be useful. In 14 young female pigs, catheters were implanted into the left atrium after left thoracotomy. After transient clamping of the ipsilateral pulmonary veins, pulmonary venous blood was selectively obtained from the right lung. Cardiac output (CO) and side-separated pulmonary perfusion were determined with flowprobes at the pulmonary trunk and the left pulmonary artery. The shunt volumes were determined before and after thoracotomy during two-lung ventilation (Two-LV), after one-lung (right) ventilation (One-LV) with a continuous positive airway pressure (CPAP) of +7.5, +5.0 cm H(2)O, and under atelectasis of the non-dependent left lung (NDL). After thoracotomy in lateral decubitus position and Two-LV, the shunt volumes of the two lungs differ. The right lung holds the major share (11.0 +/- 1.7% CO) [mean +/- SD]. The share of the left NDL is only 3.3 +/- 1.4. Under One-LV (right) and CPAP in the NDL, the total pulmonary shunt volume rises. This is caused by the increase in the NDL shunt volume share to 8.8 +/- 5.2 under CPAP +7.5 (p<0.05) and to 9.7 +/- 2.5 under CPAP +5.0 (p < 0.05). The new intraoperative method of side-separated arterial blood gas analysis in conjunction with side-separated perfusion measurement makes side- separated right-to-left shunt volume determination possible and may lead to interesting new pathophysiological insights.

  • Determination of the side-separated pulmonary right-to-left shunt volume.
    The Journal of Medical Investigation, 2008
    Co-Authors: Thomas Lesser, Harald Schubert, Stephan Klinzing
    Abstract:

    Background : With the present method of intrapulmonary right-to-left shunt volume calculation, no differentiation can be made between the shunt volume shares of the right and left lungs. For a better understanding of pathophysiological processes dur- ing Thorax Surgery with side-separated ventilation, a side-separated shunt volume deter- mination would be useful. Materials and Methods : In 14 young female pigs, catheters were implanted into the left atrium after left thoracotomy. After transient clamping of the ip- silateral pulmonary veins, pulmonary venous blood was selectively obtained from the right lung. Cardiac output (CO) and side-separated pulmonary perfusion were determined with flowprobes at the pulmonary trunk and the left pulmonary artery. The shunt volumes were determined before and after thoracotomy during two-lung ventilation (Two-LV), after one-lung (right) ventilation (One-LV) with a continuous positive airway pressure (CPAP) of +7.5, +5.0 cm H2O, and under atelectasis of the non-dependent left lung (NDL). Results : After thoracotomy in lateral decubitus position and Two-LV, the shunt volumes of the two lungs differ. The right lung holds the major share (11.0 1.7% O) (mean SD). The share of the left NDL is only 3.3 1.4. Under One-LV (right) and CPAP in the NDL, the total pulmonary shunt volume rises. This is caused by the increase in the NDL shunt vol- ume share to 8.8 5.2 under CPAP +7.5 (p 0.05) and to 9.7 2.5 under CPAP +5.0 (p 0.05). Conclusions : The new intraoperative method of side-separated arterial blood gas analy- sis in conjunction with side-separated perfusion measurement makes side- separated right- to-left shunt volume determination possible and may lead to interesting new pathophysi- ological insights. J. Med. Invest. 55 : 44-50, February, 2008

Harald Schubert - One of the best experts on this subject based on the ideXlab platform.

  • Determination of the side-separated pulmonary right-to-left shunt volume.
    The journal of medical investigation : JMI, 2020
    Co-Authors: Thomas Lesser, Harald Schubert, Stephan Klinzing
    Abstract:

    With the present method of intrapulmonary right-to-left shunt volume calculation, no differentiation can be made between the shunt volume shares of the right and left lungs. For a better understanding of pathophysiological processes during Thorax Surgery with side-separated ventilation, a side-separated shunt volume determination would be useful. In 14 young female pigs, catheters were implanted into the left atrium after left thoracotomy. After transient clamping of the ipsilateral pulmonary veins, pulmonary venous blood was selectively obtained from the right lung. Cardiac output (CO) and side-separated pulmonary perfusion were determined with flowprobes at the pulmonary trunk and the left pulmonary artery. The shunt volumes were determined before and after thoracotomy during two-lung ventilation (Two-LV), after one-lung (right) ventilation (One-LV) with a continuous positive airway pressure (CPAP) of +7.5, +5.0 cm H(2)O, and under atelectasis of the non-dependent left lung (NDL). After thoracotomy in lateral decubitus position and Two-LV, the shunt volumes of the two lungs differ. The right lung holds the major share (11.0 +/- 1.7% CO) [mean +/- SD]. The share of the left NDL is only 3.3 +/- 1.4. Under One-LV (right) and CPAP in the NDL, the total pulmonary shunt volume rises. This is caused by the increase in the NDL shunt volume share to 8.8 +/- 5.2 under CPAP +7.5 (p<0.05) and to 9.7 +/- 2.5 under CPAP +5.0 (p < 0.05). The new intraoperative method of side-separated arterial blood gas analysis in conjunction with side-separated perfusion measurement makes side- separated right-to-left shunt volume determination possible and may lead to interesting new pathophysiological insights.

  • Determination of the side-separated pulmonary right-to-left shunt volume.
    The Journal of Medical Investigation, 2008
    Co-Authors: Thomas Lesser, Harald Schubert, Stephan Klinzing
    Abstract:

    Background : With the present method of intrapulmonary right-to-left shunt volume calculation, no differentiation can be made between the shunt volume shares of the right and left lungs. For a better understanding of pathophysiological processes dur- ing Thorax Surgery with side-separated ventilation, a side-separated shunt volume deter- mination would be useful. Materials and Methods : In 14 young female pigs, catheters were implanted into the left atrium after left thoracotomy. After transient clamping of the ip- silateral pulmonary veins, pulmonary venous blood was selectively obtained from the right lung. Cardiac output (CO) and side-separated pulmonary perfusion were determined with flowprobes at the pulmonary trunk and the left pulmonary artery. The shunt volumes were determined before and after thoracotomy during two-lung ventilation (Two-LV), after one-lung (right) ventilation (One-LV) with a continuous positive airway pressure (CPAP) of +7.5, +5.0 cm H2O, and under atelectasis of the non-dependent left lung (NDL). Results : After thoracotomy in lateral decubitus position and Two-LV, the shunt volumes of the two lungs differ. The right lung holds the major share (11.0 1.7% O) (mean SD). The share of the left NDL is only 3.3 1.4. Under One-LV (right) and CPAP in the NDL, the total pulmonary shunt volume rises. This is caused by the increase in the NDL shunt vol- ume share to 8.8 5.2 under CPAP +7.5 (p 0.05) and to 9.7 2.5 under CPAP +5.0 (p 0.05). Conclusions : The new intraoperative method of side-separated arterial blood gas analy- sis in conjunction with side-separated perfusion measurement makes side- separated right- to-left shunt volume determination possible and may lead to interesting new pathophysi- ological insights. J. Med. Invest. 55 : 44-50, February, 2008

Zahra Rajai - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of the results of Surgery treatment in patients with congenital chest deformity
    Indian Journal of Thoracic and Cardiovascular Surgery, 2018
    Co-Authors: Seyed Hossein Fattahi Masoom, Marziyeh Nouri Dalouee, Marziyeh Abrahimzadeh, Zahra Rajai
    Abstract:

    Purpose Present study is designed to evaluate usefulness of sternochondroplasty and other surgical techniques in repairing congenital chest deformity. Materials and methods This study were considered in 51 patients undergoing congenital chest deformity repair with sternochondroplasty and other surgical techniques that had been referred to Thorax Surgery ward of Gaem Hospital in Mashhad University of Medical Sciences between 1992 and 2012. Variables included were gender, age, symptoms, complications, recurrence, and cosmetic results. Results We studied 51 patients (male/female = 36/15) with mean age of 12.39 years (in 50 patients). The patient with central syndrome is 1 day old. Distribution of patients was 20 cases with pectus excavatum, 14 cases with pectus carinatum, 3 cases with sternal cleft, 3 cases with Poland syndrome, and one case with central syndrome. Congenital anomalies associated with patients included cardiac anomaly in 3 patients, ectopic testis in 1 patient, hand anomaly in 1 patient, skeletal anomaly in 1patient, and ear deformity in 1 patient. Complication after Surgery was pneumoThorax in 1 patient. Recurrence did not occur in patients. In 96% of cases, cosmetic result was excellent. Two hospital mortalities were reported. Conclusion Sternochondroplasty is an appropriate procedure in repairing congenital chest deformity. We did photography for most of patients before and after operation in order to compare results. We measured the distance between the deepest area on sternum and upper area on the chest wall with ruler .This way is simpler than CT scan imaging for measuring the degree of defect in pectus excavatum. Sternochondroplasty has the fewest complications. Cosmetic results are excellent. We had no recurrence after 2 years of follow-up. Patients with upper sternal cleft were repaired with apposition of sternal bars using steel wire, although in one patient we used prosthetic mesh because of extensive defect area. In patients with Poland syndrome we used latissimus dorsi for repairing of defect, and we recommended using autologous tissue for repair of defective area. Cantrell pentad is very rare disease and we have a little experience in treatment.

Martin Fischer - One of the best experts on this subject based on the ideXlab platform.

  • Prefrontal left--dominant hemisphere--gamma and delta oscillators in general anaesthesia with volatile anaesthetics during open thoracic Surgery.
    Neuro endocrinology letters, 2020
    Co-Authors: Beata Saniova, Michal Drobny, Eva Drobna, Julian Hamzik, Erika Bakosova, Martin Fischer
    Abstract:

    The main objective was to indicate sufficient general anaesthesia (GA) inhibition for negative experience rejection in GA. We investigated the group of patients (n = 17, mean age 63.59 years, 9 male--65.78 years, 8 female - 61.13 years) during GA in open Thorax Surgery and analyzed EEG signal by power spectrum (pEEG) delta (DR), and gamma rhythms (GR). EEG was performed: OPO - the day before Surgery and in Surgery phases OP1-OP5 during GA. Particular GA phases: OP1 = after pre- medication, OP2 = Surgery onset, OP3 = Surgery with one-side lung ventilation, OP4 = end of Surgery, both sides ventilation, OP5 = end of GA. pEEG registering in the left frontal region Fp1-A1 montage in 17 right handed persons. Mean DR power in OP2 phase is significantly higher than in phase OP5 and mean DR power in OP3 is higher than in OP5. One-lung ventilation did not change minimal alveolar concentration and gases should not accelerate decrease in mean DR power. Higher mean value of GR power in OPO than in OP3 was statistically significant. Mean GR power in OP3 is statistically significantly lower than in OP4 correlating with the same gases concentration in OP3 and OP4. Our results showed DR power decreased since OP2 till the end of GA it means inhibition represented by power DR fluently decreasing is sufficient for GA depth. GR power decay near the working memory could reduce conscious cognition and unpleasant explicit experience in GA.

  • Gamma Coherences in the Default Mode Resting State as a Measure of Consciousness Level
    Activitas Nervosa Superior, 2016
    Co-Authors: Peter Jombik, Beata Saniova, Michal Drobny, Martin Fischer, Petra Kaderjakova
    Abstract:

    Recent findings indicate that the default mode resting state network (DMRSN) is closely associated with conscious awareness. Thus changes in consciousness level could be reflected in turn in the DMRSN functional state. One of the most important requirements for proper network function is connectivity within the network structural constituents. One of the measures of functional connectivity is analysis of the EEG coherences. In this study we have examined changes in the mean coherences in the gamma spectral band 30–45 Hz in the DMRSN during general anaesthesia (GA) in the open Thorax Surgery were investigated in twenty patients. They were compared with physiologic EEG findings in twenty alert subjects and the mathematical model of brain death. Results of this study indicate that the decrease in coherences in the physiologic EEG and the patients with one lung ventilation (OLV) groups was roughly proportional to the increasing distance between the electrodes. This created some kind of a structure in the DMRSN. In the OLV group the main finding was a decrease in the coherences in the gamma band. Ten of the anaesthetized subjects showed a clear burst suppression pattern. During this condition the coherences in the pairs connecting the posterior parts of the network decreased. Moreover, the differences between the connections of the anterior to posterior parts of the DMRSN and connections between the posterior parts of the DMRSN were almost lost. However, they showed still highly significant differences in all items when compared with the mathematical model of brain death. In summary the results suggest that the functional connectivity in the DMRSN assessed by mean coherences could be a reliable method for assessing the depth of GA and may be useful for understanding disorders of consciousness in general.

  • Gamma Coherences in the Default Mode Resting State as a Measure of Consciousness Level
    Activitas nervosa superior, 2016
    Co-Authors: Peter Jombik, Beata Saniova, Michal Drobny, Martin Fischer, Petra Kaderjakova
    Abstract:

    12.00 Recent findings indicate that the default mode resting state network (DMRSN) is closely associated with conscious awareness. Thus changes in consciousness level could be reflected in turn in the DMRSN functional state. One of the most important requirements for proper network function is connectivity within the network structural constituents. One of the measures of functional connectivity is analysis of the EEG coherences. In this study we have examined changes in the mean coherences in the gamma spectral band 30-45 Hz in the DMRSN during general anaesthesia (GA) in the open Thorax Surgery were investigated in twenty patients. They were compared with physiologic EEG findings in twenty alert subjects and the mathematical model of brain death. Results of this study indicate that the decrease in coherences in the physiologic EEG and the patients with one lung ventilation (OLV) groups was roughly proportional to the increasing distance between the electrodes. This created some kind of a structure in the DMRSN. In the OLV group the main finding was a decrease in the coherences in the gamma band. Ten of the anaesthetized subjects showed a clear burst suppression pattern. During this condition the coherences in the pairs connecting the posterior parts of the network decreased. Moreover, the differences between the connections of the anterior to posterior parts of the DMRSN and connections between the posterior parts of the DMRSN were almost lost. However, they showed still highly significant differences in all items when compared with the mathematical model of brain death. In summary the results suggest that the functional connectivity in the DMRSN assessed by mean coherences could be a reliable method for assessing the depth of GA and may be useful for understanding disorders of consciousness in general. Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normalni tabulka"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; text-indent:1.25in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}